The DOI matches its Crossref record; 113 of the 121 references it cites were found in a registry or an index.
The growing family of interferon regulatory factors
Open accessAbstract
Interferons (IFN) exert their multiple biological effects through the induction of expression of over 30 genes encoding proteins with antiviral, antiproliferative and immunomodulatory functions. Among the many IFN-inducible proteins are the Interferon Regulatory Factors (IRFs), a family of transcription regulators, originally consisting of the well-characterized IRF-1 and IRF-2 proteins; the family has now expanded to over 10 members and is still growing. The present review provides a detailed description of recently characterized IRF family members. Studies analyzing IRF-expressing cell lines and IRF knockout mice reveal that each member of the IRF family exerts distinct roles in biological processes such as pathogen response, cytokine signalling, cell growth regulation and hematopoietic development. Understanding the molecular mechanisms by which the IRFs affect these important cellular events and IFN expression will contribute to a greater understanding of events leading to various viral, immune and malignant disease states and will suggest novel strategies for antiviral and immune modulatory therapy.
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In the citing paper
“Interferon (IFN) consensus sequence binding protein (ICSBP)/IFN regulatory factor (IRF)-8 is an IFN g -inducible transcription factor of the IRF family and regulates transcription through multiple target DNA elements, such as IFN-stimulated response element (ISRE), Ets/IRF composite element, and IFNg activation site (GAS).”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [2]
In the citing paper
“ICSBP has the DNAbinding domain (DBD) conserved in the IRF family at the Nterminal region and the IRF association domain (IAD) in the C-terminal region (Fig. 1). (2-5)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [2]
In the citing paper
“It belongs to the family of IRF transcription factors, which includes nine mammalian members and four virally encoded homologs. (2,3)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [2]
Citations
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The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
Gerold, G., & Pietschmann, T. (2014) · Digestive Diseases · doi:10.1159/000360830 · Cited by 4,871
Antiviral Actions of Interferons
Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743
Systematic variation in gene expression patterns in human cancer cell lines
Ross, D. T., Scherf, U., Eisen, M. B., Perou, C. M., Rees, C., Spellman, P., Iyer, V., Jeffrey, S. S., Van de Rijn, M., Waltham, M., et al. (2000) · Nature Genetics · doi:10.1038/73432 · Cited by 2,088
Der, S. D., Zhou, A., Williams, B. R. G., & Silverman, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15623 · Cited by 1,840
IRF Family of Transcription Factors as Regulators of Host Defense
Taniguchi, T., Ogasawara, K., Takaoka, A., & Tanaka, N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.623 · Cited by 1,658
Metadata
- Authors
- Nguyen, H., Hiscott, J., & Pitha, P. M.
- Affiliations
- Lady Davis Institute for Medical Research (CA)
- Johns Hopkins University (US)
- Corresponding author
- Hiscott, John
- ORCID
- Hiscott, John
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 8
- Issue
- 4
- Pages
- 293-312
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2028850807
- Cited by
- 480
- References
- 121
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 6 · 2020: 13 · 2019: 7 · 2018: 5 · 2017: 12 · 2016: 9 · 2015: 4 · 2014: 12 · 2013: 10 · 2012: 17
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Medical Research Council Canada
- National Institutes of Health
- Medical Research Council
- National Cancer Institute
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- interferon regulatory factors, interferon, transcription factors, IRF1, IRF2, cytokine signaling, antiviral response, cell growth regulation, hematopoietic development, antiviral therapy, immunomodulation
- MeSH terms
- Interferon Regulatory Factor-8, Interferon Regulatory Factor-4, Amino Acid Sequence, Animals, Bacterial Proteins, Cell Division, DNA-Binding Proteins, Gene Expression Regulation, Humans, Immunity, Interferon Type I, Interferons, Molecular Sequence Data, Phosphoproteins, Repressor Proteins, Transcription Factors, Sequence Homology, Amino Acid, Virulence Factors, Interferon-Stimulated Gene Factor 3, Interferon-Stimulated Gene Factor 3, gamma Subunit, Interferon Regulatory Factors, Interferon Regulatory Factor-2, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, Interferon Regulatory Factor-1, Mice
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