The growing family of interferon regulatory factors

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Functional Role of Type I and Type II Interferons in Antiviral Defense

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Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

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Casein kinase 2: An ‘eminence grise’ in cellular regulation?

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Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

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Cytokine therapeutics: lessons from interferonalpha.

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Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

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Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene

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Deficient signaling in mice devoid of double‐stranded RNA‐dependent protein kinase.

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Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

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Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2

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An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

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Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.

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Subunit of an Alpha-Interferon-Responsive Transcription Factor Is Related to Interferon Regulatory Factor and Myb Families of DNA-Binding Proteins

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Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

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An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

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Interferons and Other Cytokines

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Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1

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Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF‐1 and NF‐κB

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Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF‐1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

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Evidence for a nuclear factor(s), IRF‐1, mediating induction and silencing properties to human IFN‐beta gene regulatory elements.

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Purification and Cloning of Interferon-Stimulated Gene Factor 2 (ISGF2): ISGF2 (IRF-1) Can Bind to the Promoters of Both Beta Interferon- and Interferon-Stimulated Genes but Is Not a Primary Transcriptional Activator of Either

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Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

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Involvement of the IRF-1 Transcription Factor in Antiviral Responses to Interferons

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Structure and Regulation of the Human Interferon Regulatory Factor 1 (IRF-1) and IRF-2 Genes: Implications for a Gene Network in the Interferon System

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α, β, γ, and δ T Cell Antigen Receptor Genes Arose Early in Vertebrate Phylogeny

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Regulation of Type I Interferon Gene Expression by Interferon Regulatory Factor-3

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A Novel Interferon-Inducible Domain: Structural and Functional Analysis of the Human Interferon Regulatory Factor 1 Gene Promoter

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Critical role of a common transcription factor, IRF‐1, in the regulation of IFN‐beta and IFN‐inducible genes.

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Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.

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Essential and non‐redundant roles of p48 (ISGF3γ) and IRF‐1 in both type I and type II interferon responses, as revealed by gene targeting studies

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Activation of the human beta-interferon gene requires an interferon-inducible factor.

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Expression of Gene rrg Is Associated with Reversion of NIH 3Tt3 Transformed by LTR-c-H- ras

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Activation of IFN-βelement by IRF-1 requires a post-translational event in addition to IRF-1 synthesis

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Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)

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A Novel Interferon Regulatory Factor Family Transcription Factor, ICSAT/Pip/LSIRF, That Negatively Regulates the Activity of Interferon-Regulated Genes

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Interferon Consensus sequence-Binding Protein, a Member of the Interferon Regulatory Factor Family, Suppresses Interferon-Induced Gene Transcription

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Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2

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The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds.

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Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity

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Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA

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Regulation of LMP2 and TAP1 Genes by IRF-1 Explains the Paucity of CD8+ T Cells in IRF-1−/− Mice

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Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity

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Isolation and Characterization of a New Mutant Human Cell Line Unresponsive to Alpha and Beta Interferons

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Autocrine Amplification of Type I Interferon Gene Expression Mediated by Interferon Stimulated Gene Factor 3 (ISGF3)

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The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo.

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Two Domains of ISGF3γ That Mediate Protein-DNA and Protein-Protein Interactions during Transcription Factor Assembly Contribute to DNA-Binding Specificity

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IRF-1: the transcription factor linking the interferon response and oncogenesis

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Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation.

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The Ets family of proteins: weak modulators of gene expression in quest for transcriptional partners.

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Constitutive activation of Epstein-Barr virus (EBV) nuclear antigen 1 gene transcription by IRF1 and IRF2 during restricted EBV latency

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Suppression of c-myc or fosB-induced cell transformation by the transcription factor IRF-1

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