Cited by 481interferon and immune responsesCytokine Signaling Pathways and InteractionsImmune Response and Inflammation

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The growing family of interferon regulatory factors

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Nguyen, Hannah, Hiscott, John, Pitha, Paula M.·1997·Cytokine & Growth Factor Reviews

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Abstract

Interferons (IFN) exert their multiple biological effects through the induction of expression of over 30 genes encoding proteins with antiviral, antiproliferative and immunomodulatory functions. Among the many IFN-inducible proteins are the Interferon Regulatory Factors (IRFs), a family of transcription regulators, originally consisting of the well-characterized IRF-1 and IRF-2 proteins; the family has now expanded to over 10 members and is still growing. The present review provides a detailed description of recently characterized IRF family members. Studies analyzing IRF-expressing cell lines and IRF knockout mice reveal that each member of the IRF family exerts distinct roles in biological processes such as pathogen response, cytokine signalling, cell growth regulation and hematopoietic development. Understanding the molecular mechanisms by which the IRFs affect these important cellular events and IFN expression will contribute to a greater understanding of events leading to various viral, immune and malignant disease states and will suggest novel strategies for antiviral and immune modulatory therapy.

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Authors: Nguyen, H., Hiscott, J., & Pitha, P. M.
Affiliations: Lady Davis Institute for Medical Research (CA)
Johns Hopkins University (US)
Corresponding author: Hiscott, John
ORCID: Hiscott, John
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 1997-12
Volume: 8
Issue: 4
Pages: 293-312
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/s1359-6101(97)00019-1
OpenAlex: W2028850807
Cited by: 480
References: 121
Citations by year: 2026: 3 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 6 · 2020: 13 · 2019: 7 · 2018: 5 · 2017: 12 · 2016: 9 · 2015: 4 · 2014: 12 · 2013: 10 · 2012: 17
FWCI: 3.72
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 473 d)
Locations: Cytokine & Growth Factor Reviews (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: Medical Research Council Canada
National Institutes of Health
Medical Research Council
National Cancer Institute
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: interferon regulatory factors, interferon, transcription factors, IRF1, IRF2, cytokine signaling, antiviral response, cell growth regulation, hematopoietic development, antiviral therapy, immunomodulation
MeSH terms: Interferon Regulatory Factor-8, Interferon Regulatory Factor-4, Amino Acid Sequence, Animals, Bacterial Proteins, Cell Division, DNA-Binding Proteins, Gene Expression Regulation, Humans, Immunity, Interferon Type I, Interferons, Molecular Sequence Data, Phosphoproteins, Repressor Proteins, Transcription Factors, Sequence Homology, Amino Acid, Virulence Factors, Interferon-Stimulated Gene Factor 3, Interferon-Stimulated Gene Factor 3, gamma Subunit, Interferon Regulatory Factors, Interferon Regulatory Factor-2, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, Interferon Regulatory Factor-1, Mice

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The growing family of interferon regulatory factors

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