Alternative and efficient extraction methods for marine-derived compounds
Open accessAbstract
Marine ecosystems cover more than 70% of the globe's surface. These habitats are occupied by a great diversity of marine organisms that produce highly structural diverse metabolites as a defense mechanism. In the last decades, these metabolites have been extracted and isolated in order to test them in different bioassays and assess their potential to fight human diseases. Since traditional extraction techniques are both solvent- and time-consuming, this review emphasizes alternative extraction techniques, such as supercritical fluid extraction, pressurized solvent extraction, microwave-assisted extraction, ultrasound-assisted extraction, pulsed electric field-assisted extraction, enzyme-assisted extraction, and extraction with switchable solvents and ionic liquids, applied in the search for marine compounds. Only studies published in the 21st century are considered.
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Existing reviews on extraction from algae either provided information only for one type of marine algae, and microalgae were more mentioned than macroalgae because more data are available for microalgae.
“Those reviews showed the application of novel methods for extraction of bioactive compounds from both microalgae and macroalgae, but either of these reviews provided information only for one type of marine algae. However, microalgae were more mentioned than macroalgae because there are more available data in the literature about their bioactive compounds, as well as their potential for being imple”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [30]
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- Authors
- Grosso, C., Valentão, P., Ferreres, F., & Andrade, P.
- Affiliations
- Universidade do Porto (PT)
- REQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, no. 228, Porto 4050-313, Portugal
- Centro de Edafología y Biología Aplicada del Segura (ES)
- Corresponding author
- Andrade, Paula
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2015-05-21
- Volume
- 13
- Issue
- 5
- Pages
- 3182-3230
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC4446625
- OpenAlex
- W1506732456
- Cited by
- 248
- References
- 211
- Citations by year
- 2026: 17 · 2025: 38 · 2024: 29 · 2023: 18 · 2022: 27 · 2021: 29 · 2020: 26 · 2019: 15 · 2018: 17 · 2017: 23 · 2016: 8 · 2015: 1
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Strong
- European Commission (Pest-C/EQB/LA0006/2013, NORTE-07-0124 FEDER-000069)
- CYTED Ciencia y Tecnología para el Desarrollo (112RT0460)
- Fundação para a Ciência e a Tecnologia (COMPETE, NORTE-07-0124-FEDER-000069, PEst-C/EQB/LA0006/2013, IF/01332/2014)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Keywords
- marine natural products, extraction methods, supercritical fluid extraction, accelerated solvent extraction, microwave-assisted extraction, ultrasound-assisted extraction, enzymatic extraction, switchable solvents, ionic liquids, marine metabolites, bioactive compounds
- MeSH terms
- Animals, Biological Products, Humans, Marine Biology, Microwaves, Solvents, Chromatography, Supercritical Fluid, Aquatic Organisms
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