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Cited by 390

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012–14): a retrospective cohort study

Open access
Greninger, Alexander L, Naccache, Samia N, Messacar, Kevin, Clayton, Anna, Yu, Guixia, Somasekar, Sneha, Federman, Scot, Stryke, Doug, Anderson, Christopher, Yagi, Shigeo, Messenger, Sharon, Wadford, Debra, Xia, Dongxiang, Watt, James P, Van Haren, Keith, Dominguez, Samuel R, Glaser, Carol, Aldrovandi, Grace, Chiu, Charles Y·2015·The Lancet Infectious Diseases
DOI 10.1016/s1473-3099(15)70093-9
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Abstract

SUMMARY Background Enterovirus D68 (EV-D68) is implicated in a widespread 2014 outbreak of severe respiratory illness across the United States, and has also been sporadically reported in patients with acute flaccid myelitis (AFM). The association between EV-D68 infection and AFM remains unclear. Methods Here we report metagenomic and molecular epidemiological analyses of 25 AFM cases in California and Colorado from 2012−2014. Findings EV-D68 was detected in respiratory secretions from 7 of 11 (64%) patients comprising two temporally and geographically linked AFM clusters at the height of the 2014 outbreak, and from 12 of 25 (48%) investigated AFM cases overall. Phylogenetic analysis revealed that all AFM-associated EV-D68 sequences grouped into a single novel clade B1 strain that originally emerged in 2010. Out of six observed coding polymorphisms in the clade B1 EV-D68 polyprotein, 5 of 6 polymorphisms were shared between neuropathogenic poliovirus and/or EV-D70. One child with AFM and a sibling with only upper respiratory illness were both infected by identical EV-D68 strains, suggesting a potential role for host-specific factors in differential responses to EV-D68 infection. Notably, EV-D68 viremia was identified in a child experiencing acute neurologic progression of his paralytic illness. Deep metagenomic sequencing of CSF from 14 AFM cases failed to reveal evidence of an alternative infectious etiology to EV-D68. Interpretation Taken together, these findings strengthen the putative association between EV-D68 and AFM, as well as the contention that AFM is a rare yet severe clinical manifestation of EV-D68 infection in susceptible hosts.

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Research works printed but not linked: 24

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Metadata

Authors
Greninger, A. L., Naccache, S. N., Messacar, K., Clayton, A., Yu, G., Somasekar, S., Federman, S., Stryke, D., Anderson, C., Yagi, S., Messenger, S., Wadford, D., Xia, D., Watt, J. P., Van Haren, K., Dominguez, S. R., Glaser, C., Aldrovandi, G., & Chiu, C. Y.
Venue
The Lancet Infectious Diseases
Publisher
Elsevier BV
Published
2015-06
Volume
15
Issue
6
Pages
671-682
ISSN
1473-3099 (ISSN-L)
DOI
10.1016/s1473-3099(15)70093-9
OpenAlex
W2163175680
Cited by
390
References
7
FWCI
43.50
Type
journal article
Language
en
Open access
green
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)

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CoChat. (2026). Citation check: A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012–14): a retrospective cohort study. https://app.cochat.ai/papers/10.1016/s1473-3099(15)70093-9
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Greninger, A. L., Naccache, S. N., Messacar, K., Clayton, A., Yu, G., Somasekar, S., Federman, S., Stryke, D., Anderson, C., Yagi, S., Messenger, S., Wadford, D., Xia, D., Watt, J. P., Van Haren, K., Dominguez, S. R., Glaser, C., Aldrovandi, G., & Chiu, C. Y. (2015). A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012–14): a retrospective cohort study. The Lancet Infectious Diseases. https://doi.org/10.1016/s1473-3099(15)70093-9

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.