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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

Healy, Daniel G, Falchi, Mario, O'Sullivan, Sean S, Bonifati, Vincenzo, Durr, Alexandra, Bressman, Susan, Brice, Alexis, Aasly, Jan, Zabetian, Cyrus P, Goldwurm, Stefano, Ferreira, Joaquim J, Tolosa, Eduardo, Kay, Denise M, Klein, Christine, Williams, David R, Marras, Connie, Lang, Anthony E, Wszolek, Zbigniew K, Berciano, Jose, Schapira, Anthony HV, Lynch, Timothy, Bhatia, Kailash P, Gasser, Thomas, Lees, Andrew J, Wood, Nicholas W·2008·The Lancet Neurology
DOI 10.1016/s1474-4422(08)70117-0PMC PMC2832754
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Crossref · 10.1016/s1474-4422(08)70117-0

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Figures

Figure 1 Age of PD onset plotted against the cumulative percentage of patients in the PARK2, LRRK2, or QSBB series QSBB=Queen Square brain bank.
Figure 1 Age of PD onset plotted against the cumulative percentage of patients in the PARK2, LRRK2, or QSBB series QSBB=Queen Square brain bank.CC BY · PubMed Central
Figure 2 Point prevalence of neuropsychiatric symptoms in patients with mutations in LRRK2 after various durations of the symptoms of PD
Figure 2 Point prevalence of neuropsychiatric symptoms in patients with mutations in LRRK2 after various durations of the symptoms of PDCC BY · PubMed Central
Figure 3 Age-specific risk of PD Risk is estimated with the Kaplan-Meier method for the whole sample and with the maximum-likelihood estimation (ML) for all patients with mutations in LRRK2 combined.
Figure 3 Age-specific risk of PD Risk is estimated with the Kaplan-Meier method for the whole sample and with the maximum-likelihood estimation (ML) for all patients with mutations in LRRK2 combined.CC BY · PubMed Central

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Cites

Show all 3 references

Research works printed but not linked: 29

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Metadata

Authors
Healy, D. G., Falchi, M., O'Sullivan, S. S., Bonifati, V., Durr, A., Bressman, S., Brice, A., Aasly, J., Zabetian, C. P., Goldwurm, S., Ferreira, J. J., Tolosa, E., Kay, D. M., Klein, C., Williams, D. R., Marras, C., Lang, A. E., Wszolek, Z. K., Berciano, J., Schapira, A. H., Lynch, T., Bhatia, K. P., Gasser, T., Lees, A. J., & Wood, N. W.
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2008-07
Volume
7
Issue
7
Pages
583-590
ISSN
1474-4422
DOI
10.1016/s1474-4422(08)70117-0
PMC
PMC2832754
Cited by
1,425
References
3
Language
en
Licence

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