Cited by 194Lipid metabolism and biosynthesisCancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

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The SREBP Pathway in Drosophila

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Seegmiller, Adam C., Dobrosotskaya, Irina, Goldstein, Joseph L., Ho, Y.K., Brown, Michael S., Rawson, Robert B.·2002·Developmental Cell

DOI 10.1016/s1534-5807(01)00119-8

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Abstract

In mammals, synthesis of cholesterol and unsaturated fatty acids is controlled by SREBPs, a family of membrane-bound transcription factors. Here, we show that the Drosophila genome encodes all components of the SREBP pathway, including a single SREBP (dSREBP), SREBP cleavage-activating protein (dSCAP), and the two proteases that process SREBP at sites 1 and 2 to release the nuclear fragment. In cultured Drosophila S2 cells, dSREBP is processed at sites 1 and 2, and the liberated fragment increases mRNAs encoding enzymes of fatty acid biosynthesis, but not sterol or isoprenoid biosynthesis. Processing requires dSCAP, but is not inhibited by sterols as in mammals. Instead, dSREBP processing is blocked by palmitic acid. These findings suggest that the ancestral SREBP pathway functions to maintain membrane integrity rather than to control cholesterol homeostasis.

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Self-citation
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Authors: Seegmiller, A. C., Dobrosotskaya, I., Goldstein, J. L., Ho, Y. K., Brown, M. S., & Rawson, R. B.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Goldstein, Joseph L.
ORCID: Seegmiller, Adam C.
Dobrosotskaya, Irina
Goldstein, Joseph L.
Brown, Michael S.
Venue: Developmental Cell
Publisher: Elsevier BV
Published: 2002-02
Volume: 2
Issue: 2
Pages: 229-238
ISSN: 1534-5807 (ISSN-L)
DOI: 10.1016/s1534-5807(01)00119-8
OpenAlex: W1993125269
Cited by: 194
References: 45
Citations by year: 2026: 6 · 2025: 2 · 2024: 12 · 2023: 10 · 2022: 8 · 2021: 3 · 2020: 11 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 3 · 2015: 11 · 2014: 3 · 2013: 5 · 2012: 2
FWCI: 6.85
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4184 d)
Locations: Developmental Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL-20948, P01HL020948)
National Institute of General Medical Sciences (GM-08014, T32GM008014)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: SREBP pathway, SCAP, palmitic acid, fatty acid synthesis, sterol biosynthesis, isoprenoid biosynthesis, membrane integrity, cholesterol homeostasis, Drosophila, S2 cells, transcriptional regulation
MeSH terms: Animals, Cell Line, DNA-Binding Proteins, Drosophila, Fatty Acids, Humans, Membrane Proteins, Mutation, Peptide Fragments, Protein Processing, Post-Translational, RNA, Double-Stranded, RNA, Messenger, Sterols, Transcription Factors, Blotting, Western, Polymerase Chain Reaction, Sequence Homology, Amino Acid, Pyruvic Acid, Palmitic Acid, CCAAT-Enhancer-Binding Proteins, Intracellular Signaling Peptides and Proteins, Sterol Regulatory Element Binding Protein 1

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The SREBP Pathway in Drosophila

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