Cited by 1,088Hair Growth and DisordersWnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

WNT Signals Are Required for the Initiation of Hair Follicle Development

Open access

Andl, Thomas, Reddy, Seshamma T., Gaddapara, Trivikram, Millar, Sarah E.·2002·Developmental Cell

DOI 10.1016/s1534-5807(02)00167-3

Open this paper in CoChat — free account Open PDF

Abstract

Hair follicle morphogenesis is initiated by a dermal signal that induces the development of placodes in the overlying epithelium. To determine whether WNT signals are required for initiation of follicular development, we ectopically expressed Dickkopf 1, a potent diffusible inhibitor of WNT action, in the skin of transgenic mice. This produced a complete failure of placode formation prior to morphological or molecular signs of differentiation, and blocked tooth and mammary gland development before the bud stage. This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation.

Integrity signals

Registry

Crossref · 10.1016/s1534-5807(02)00167-3

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,030
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352
Reiterative signaling and patterning during mammalian tooth morphogenesis
Jernvall, J., & Thesleff, I. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00322-6 · Cited by 1,101
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,042
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
DasGupta, R., & Fuchs, E. V. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 995
Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.Preprint
van Genderen, C., Okamura, R. M., Fariñas, I., Quo, R. G., Parslow, T. G., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 972
Molecular Mechanisms Regulating Hair Follicle Development
Millar, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01670.x · Cited by 967
Self-citation
The secret life of the hair follicle
Hardy, M. H. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90350-d · Cited by 931

Show all 49 references

Research works printed but not linked: 1

Wang, 1996, Murine Wnt10a and Wnt10b, Oncogene, 13, 1537

Sorted by citations

Items 301–400 of 1,000

Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis
Li, Z. J., Nieuwenhuis, E., Nien, W., Zhang, X., Zhang, J., Puviindran, V., Wainwright, B. J., Kim, P. C. W., & Hui, C. (2012) · Development · doi:10.1242/dev.081190 · Cited by 74
Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development
Pispa, J., Pummila, M., Barker, P. A., Thesleff, I., & Mikkola, M. L. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn232 · Cited by 71
Next Stop, the Twilight Zone: Hedgehog Network Regulation of Mammary Gland Development
Lewis, M. T., & Veltmaat, J. M. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000037160.24731.35 · Cited by 71
The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatus
Lin, C., Fisher, A. V., Yin, Y., Maruyama, T., Veith, G. M., Dhandha, M. M., Huang, G. J., Hsu, W., & Ma, L. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.05.002 · Cited by 71
Mesenchymal Wnt/β-catenin signaling limits tooth number
Järvinen, E., Shimomura-Kuroki, J., Balic, A., Jussila, M., & Thesleff, I. (2018) · Development · doi:10.1242/dev.158048 · Cited by 71
Role of the Wnt signaling molecules in the tooth
Tamura, M., & Nemoto, E. (2016) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2016.04.001 · Cited by 70
Role and Mechanisms of Phytochemicals in Hair Growth and Health
Kesika, P., Sivamaruthi, B. S., Thangaleela, S., Bharathi, M., & Chaiyasut, C. (2023) · Pharmaceuticals · doi:10.3390/ph16020206 · Cited by 70
WNT10A missense mutation associated with a complete Odonto-Onycho-Dermal Dysplasia syndrome
Nawaz, S., Klar, J., Wajid, M., Aslam, M. Q., Tariq, M., Schuster, J., Baig, S. M., & Dahl, N. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.81 · Cited by 69
Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling
Guha, U., Mecklenburg, L., Cowin, P., Kan, L., O'Guin, W. M., D'Vizio, D., Pestell, R. G., Paus, R., & Kessler, J. A. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63336-6 · Cited by 70
Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep
Zhang, R., Li, Y., Jia, K., Xu, X., Li, Y., Zhao, Y., Zhang, X., Zhang, J., Liu, G., Deng, S., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2622-x · Cited by 69
The role of Wnt signaling in skin fibrosis
Griffin, M., Huber, J., Fahy, E. J., Quarto, N., & Longaker, M. T. (2021) · Medicinal Research Reviews · doi:10.1002/med.21853 · Cited by 68
Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering
Ohyama, M., & Veraitch, O. K. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.02.004 · Cited by 69
Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
Osorio, K. M., Lilja, K. C., & Tumbar, T. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201006068 · Cited by 68
Concise Review: Mechanisms of Quiescent Hair Follicle Stem Cell Regulation
Yi, R. (2017) · Stem Cells · doi:10.1002/stem.2696 · Cited by 74
Micro RNA s (mi RNA s) in the control of HF development and cycling: the next frontiers in hair research
Andl, T., & Botchkareva, N. V. (2015) · Experimental Dermatology · doi:10.1111/exd.12785 · Cited by 67
Self-citation
m6A RNA methylation impacts fate choices during skin morphogenesis
Xi, L., Carroll, T., Matos, I., Luo, J., Polak, L., Pasolli, H. A., Jaffrey, S. R., & Fuchs, E. V. (2020) · eLife · doi:10.7554/elife.56980 · Cited by 70
Intricate relationship between cancer stemness, metastasis, and drug resistance
Dakal, T. C., Bhushan, R., Xu, C., Gadi, B. R., Cameotra, S. S., Yadav, V., Maciaczyk, J., Schmidt‐Wolf, I. G. H., Kumar, A., & Sharma, A. (2024) · MedComm · doi:10.1002/mco2.710 · Cited by 71
Sostdc1 defines the size and number of skin appendage placodes
Närhi, K. M., Tümmers, M., Ahtiainen, L., Itoh, N., Thesleff, I., & Mikkola, M. L. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.01.026 · Cited by 68
The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis
Hoefert, J. E., Bjerke, G. A., Wang, D., & Yi, R. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201708173 · Cited by 68
Multiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma
Gânier, C., Mazin, P., Herrera-Oropeza, G. E., Du-Harpur, X., Blakeley, M., Gabriel, J., Predeus, A. V., Çakır, B., Prete, M., Harun, N., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2313326120 · Cited by 65
New investigational drugs for androgenetic alopecia
de Sousa, I. C. V. D., & Tosti, A. (2013) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.784743 · Cited by 67
Pygopus and the Wnt signaling pathway: A diverse set of connections
Jessen, S., Gu, B., & Dai, X. (2008) · BioEssays · doi:10.1002/bies.20757 · Cited by 67
Dual Role of Inactivating Lef1 Mutations in Epidermis: Tumor Promotion and Specification of Tumor Type
Niemann, C., Owens, D. M., Schettina, P., & Watt, F. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3427 · Cited by 67
Hunting the genes in male‐pattern alopecia: how important are they, how close are we and what will they tell us?
Heilmann‐Heimbach, S., Hochfeld, L. M., Paus, R., & Nöthen, M. M. (2016) · Experimental Dermatology · doi:10.1111/exd.12965 · Cited by 67
A Review of the Role of Wnt in Cancer Immunomodulation
Goldsberry, W. N., Londoño, A. I., Randall, T. D., Norian, L. A., & Arend, R. C. (2019) · Cancers · doi:10.3390/cancers11060771 · Cited by 67
Mutations in Exon 3 of the CTNNB1 Gene (β-Catenin Gene) in Cutaneous Adnexal Tumors
Kazakov, D. V., Šíma, R., Vaněček, T., Kutzner, H., Palmedo, G., Kacerovská, D., Grossmann, P., & Michal, M. (2009) · American Journal of Dermatopathology · doi:10.1097/dad.0b013e318198922a · Cited by 66
MMTV-Wnt1 and -ΔN89β-Catenin Induce Canonical Signaling in Distinct Progenitors and Differentially Activate Hedgehog Signaling within Mammary Tumors
Teissedre, B., Pinderhughes, A., Incassati, A., Hatsell, S. J., Hiremath, M., & Cowin, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004537 · Cited by 68
A Mouse Model of Androgenetic Alopecia
Crabtree, J. S., Kilbourne, E. J., Peano, B. J., Chippari, S. M., Kenney, T. F., McNally, C., Wang, W., Harris, H. A., Winneker, R. C., Nagpal, S., et al. (2010) · Endocrinology · doi:10.1210/en.2009-1474 · Cited by 66
Expression of Wnt/β-catenin signaling, stem-cell markers and proliferating cell markers in rat whisker hair follicles
Lin, C., Yuan, Y.-P., Chen, X.-C., Li, H., Cai, B., Liu, Y., Zhang, H., Li, Y., & Huang, K. (2015) · Journal of Molecular Histology · doi:10.1007/s10735-015-9616-5 · Cited by 65
Tooth number abnormality: from bench to bedside
Zhang, H., Gong, X., Xu, X., Wang, X., & Sun, Y. (2023) · International Journal of Oral Science · doi:10.1038/s41368-022-00208-x · Cited by 64
Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis
Fantauzzo, K. A., & Christiano, A. M. (2011) · Development · doi:10.1242/dev.069971 · Cited by 64
Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development
Perdigoto, C. N., Dauber, K. L., Bar, C., Tsai, P.-C., Valdés, V. J., Cohen, I., Santoriello, F. J., Zhao, D., Zheng, D., Hsu, Y., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006151 · Cited by 64
Epidermal stem cells: location, potential and contribution to cancer
Ambler, C. A., & Määttå, A. (2008) · The Journal of Pathology · doi:10.1002/path.2468 · Cited by 63
Great promises yet to be fulfilled: Defining keratin intermediate filament function in vivo
Coulombe, P. A., Tong, X., Mazzalupo, S., Wang, Z., & Wong, P. (2004) · European Journal of Cell Biology · doi:10.1078/0171-9335-00443 · Cited by 62
DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration
Osada, M., Jardine, L., Misir, R., Andl, T., Millar, S. E., & Pezzano, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009062 · Cited by 60
Self-citation
Grainyhead-like factor Get1/Grhl3 regulates formation of the epidermal leading edge during eyelid closure
Yu, Z., Bhandari, A., Männik, J., Pham, T., Xu, X., & D, B. A. M. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.04.001 · Cited by 62
Role of -catenin in Epidermal Stem Cell Expansion, Lineage Selection, and CancerPreprint
Watt, F. M., & Collins, C. A. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.011 · Cited by 60
β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid
Bejaoui, M., Villareal, M. O., & Isoda, H. (2019) · Aging · doi:10.18632/aging.102048 · Cited by 61
m6A Methylation Analysis of Differentially Expressed Genes in Skin Tissues of Coarse and Fine Type Liaoning Cashmere Goats
Wang, Y., Zheng, Y., Guo, D., Zhang, X., Guo, S., Hui, T., Chang, Y., Sun, J., Guo, S., Bai, Z., et al. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2019.01318 · Cited by 60
Principles and mechanisms of regeneration in the mouse model for wound‐induced hair follicle neogenesis
Wang, X., Hsi, T., Guerrero‐Juarez, C. F., Pham, K., Cho, K., McCusker, C., Monuki, E. S., Cho, K. W. Y., Gay, D. L., & Plikus, M. V. (2015) · Regeneration · doi:10.1002/reg2.38 · Cited by 62
Intra-epithelial Requirement of Canonical Wnt Signaling for Tooth Morphogenesis
Zhu, X., Zhao, P., Liu, Y., Zhang, X., Fu, J., Yu, H., Qiu, M. S., Chen, Y., Hsu, W., & Zhang, Z. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.462473 · Cited by 59
Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling
Park, P. J., Moon, B.-S., Lee, S.-H., Kim, S.-N., Kim, A.-R., Kim, H.-J., Park, W.-S., Choi, K., Cho, E., & Lee, T. R. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.09.008 · Cited by 59
Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling
Zhang, H., Nan, W., Wang, S., Zhang, T., Si, H., Yang, F., & Li, G. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000445630 · Cited by 59
In vitro molecular study of wound healing using biosynthesized bacteria nanocellulose/silver nanocomposite assisted by bioinformatics databases
Moniri, M., Moghaddam, A. B., Azizi, S., Rahim, R. A., Zuhainis, S. W., Navaderi, M., & Mohamad, R. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s164573 · Cited by 59
Genome-wide identification and characterization of long non-coding RNAs expressed during sheep fetal and postnatal hair follicle development
Sulayman, A., Tian, K., Huang, X., Tian, Y., Xu, X., Fu, X., Zhao, B., Wu, W., Wang, D., Yasin, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-44600-w · Cited by 57
Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130
Ruiz, S., Segrelles, C., Bravo, A., Santos, M., Pérez, P., Leis, H., Jorcano, J. L., & Paramio, J. M. (2003) · Development · doi:10.1242/dev.00453 · Cited by 58
Wnt signaling: the good and the bad
Chen, X., Yang, J., Evans, P. M., & Liu, C. (2008) · Acta Biochimica et Biophysica Sinica · doi:10.1111/j.1745-7270.2008.00440.x · Cited by 56
Targeting Stem Cells-Clinical Implications for Cancer Therapy
Tu, L. N., Foltz, G., Lin, E. H., Hood, L., & Tian, Q. (2009) · Current Stem Cell Research & Therapy · doi:10.2174/157488809788167373 · Cited by 57
Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat
Wang, S., Li, F., Liu, J., Zhang, Y., Zheng, Y., Ge, W., Qu, L., & Wang, X. (2020) · Cells · doi:10.3390/cells9040969 · Cited by 58
Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists
Jia, S., Kwon, H.-J. E., Lan, Y., Zhou, J., Liu, H., & Jiang, R. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.10.001 · Cited by 57
Photobiomodulation for the management of alopecia: mechanisms of action, patient selection and perspectives
Hamblin, M. R. (2019) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s184979 · Cited by 63
Ectodysplasin regulates the lymphotoxin-β pathway for hair differentiation
Cui, C., Hashimoto, T., Grivennikov, S. I., Piao, Y., Nedospasov, S. A., & Schlessinger, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509678103 · Cited by 57
Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling
Suzuki, K., Yamaguchi, Y., Villacorte-Tabelin, M., Mihara, K., Akiyama, M., Shimizu, H., Taketo, M. M., Nakagata, N., Tsukiyama, T., Yamaguchi, T. P., et al. (2009) · Development · doi:10.1242/dev.021295 · Cited by 58
Exploiting the Keratin 17 Gene Promoter To Visualize Live Cells in Epithelial Appendages of Mice
Bianchi, N., DePianto, D. J., McGowan, K. M., Gu, C., & Coulombe, P. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7249-7259.2005 · Cited by 56
Wnt/β-Catenin Regulates the Activity of Epiprofin/Sp6, SHH, FGF, and BMP to Coordinate the Stages of Odontogenesis
Aurrekoetxea, M., Irastorza, I., García-Gallastegui, P., Jiménez‐Rojo, L., Nakamura, T., Yamada, Y., Ibarretxe, G., & Unda, F. J. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00025 · Cited by 56
Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2
Li, B., Rhéaume, C., Teng, A., Bilanchone, V., Munguia, J. E., Hu, M., Jessen, S., Piccolo, S., Waterman, M. L., & Dai, X. (2007) · genesis · doi:10.1002/dvg.20299 · Cited by 55
Tbx18 Targets Dermal Condensates for Labeling, Isolation, and Gene Ablation during Embryonic Hair Follicle Formation
Grisanti, L., Clavel, C., Cai, X., Rezza, A., Tsai, S., Sennett, R., Mumau, M. D., Cai, C., & Rendl, M. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.329 · Cited by 55
Possible Contribution of Wnt-Responsive Chondroprogenitors to the Postnatal Murine Growth Plate
Usami, Y., Gunawardena, A. T., Francois, N. B., Otsuru, S., Takano, H., Hirose, K., Matsuoka, M., Suzuki, A., Huang, J., Qin, L., et al. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3658 · Cited by 55
Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis
Driskell, R. R., Goodheart, M. J., Neff, T. L., Liu, X., Luo, M., Moothart, C., Sigmund, C. D., Hosokawa, R., Chai, Y., & Engelhardt, J. F. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.01.038 · Cited by 54
Stem Cell Fate Determination during Development and Regeneration of Ectodermal Organs
Jiménez‐Rojo, L., Granchi, Z., Graf, D., & Mitsiadis, T. A. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00107 · Cited by 61
Unveiling Hair Follicle Stem Cells
Yang, L., & Peng, R. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9172-z · Cited by 55
Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis
Augustin, I., Gross, J. C., Baumann, D., Korn, C., Kerr, G., Grigoryan, T., Mauch, C., Birchmeier, W., & Boutros, M. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121871 · Cited by 56
Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin
Riche, A. L., Aberdam, É., Marchand, L., Frank, E., Jahoda, C. A. B., Petit, I., Bordes, S., Closs, B., & Aberdam, D. (2019) · Stem Cells · doi:10.1002/stem.3043 · Cited by 56
An overview on congenital alopecia in domestic animals
Mecklenburg, L. (2006) · Veterinary Dermatology · doi:10.1111/j.1365-3164.2006.00544.x · Cited by 52
Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment
Wansbury, O., Mackay, A. G., Kogata, N., Mitsopoulos, C., Kendrick, H. D., Davidson, K., Ruhrberg, C., Reis-Filho, J. S., Smalley, M. J., Zvelebil, M., et al. (2011) · Breast Cancer Research · doi:10.1186/bcr2928 · Cited by 52
The Vitamin D Receptor Is Required for Activation of cWnt and Hedgehog Signaling in Keratinocytes
Lisse, T. S., Saini, V., Zhao, H., Luderer, H. F., Gori, F., & Demay, M. B. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1043 · Cited by 51
Tissue interactions in the regulation of axon pathfinding during tooth morphogenesis
Luukko, K., Kvinnsland, I. H., & Kettunen, P. J. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20586 · Cited by 52
Inhibition of Wnt/β‐catenin pathway promotes regenerative repair of cutaneous and cartilage injury
Bastakoty, D., Saraswati, S., Cates, J., Lee, E. N., Nanney, L. B., & Young, P. P. (2015) · The FASEB Journal · doi:10.1096/fj.15-275941 · Cited by 54
FGF signals specifically regulate the structure of hair shaft medulla via IGF-binding protein 5
Schlake, T. (2005) · Development · doi:10.1242/dev.01873 · Cited by 51
Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding
Wier, E. M., & Garza, L. A. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.10.002 · Cited by 51
Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls
Abreu, C. M., & Marques, A. P. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10235 · Cited by 50
Functional role of rho‐kinase in ameloblast differentiation
Otsu, K., Kishigami, R., Fujiwara, N., Ishizeki, K., & Harada, H. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22597 · Cited by 51
Activation of Wnt/β‐catenin/Tcf signaling in mouse skin carcinogenesis
Bhatia, N., & Spiegelman, V. S. (2005) · Molecular Carcinogenesis · doi:10.1002/mc.20077 · Cited by 51
Identifying and targeting tumor-initiating cells in the treatment of breast cancer
Wei, W., & Lewis, M. T. (2015) · Endocrine Related Cancer · doi:10.1530/erc-14-0447 · Cited by 52
Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing ΔNp63α
Romano, R., Smalley, K., Liu, S., & Sinha, S. (2010) · Development · doi:10.1242/dev.045427 · Cited by 51
Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment
Pećina‐Šlaus, N., Aničić, S., Bukovac, A., & Kafka, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076733 · Cited by 53
Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences
Yamaguchi, H. L., Yamaguchi, Y., & Peeva, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084409 · Cited by 50
Scientific foundations and current state of trace evidence—A review
Trejos, T., Koch, S. L., & Mehltretter, A. H. (2020) · Forensic Chemistry · doi:10.1016/j.forc.2020.100223 · Cited by 60
Genetic Signatures of Selection for Cashmere Traits in Chinese Goats
Jin, M., Lu, J., Fei, X., Lu, Z., Quan, K., Liu, Y., Chu, M., Di, R., Wang, H., & Wei, C. (2020) · Animals · doi:10.3390/ani10101905 · Cited by 51
Characterization of Hair Follicle Development in Engineered Skin Substitutes
Sriwiriyanont, P., Lynch, K. A., McFarland, K. L., Supp, D. M., & Boyce, S. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065664 · Cited by 49
Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration
Qiu, W., Lei, M., Zhou, L., Bai, X., Lai, X., Yu, Y., Yang, T., & Lian, X. (2017) · Histochemistry and Cell Biology · doi:10.1007/s00418-017-1540-1 · Cited by 49
Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit (Oryctolagus cuniculus) Hair Follicle Cycle by RNA Sequencing
Zhao, B., Chen, Y., Hu, S., Yang, N., Wang, M., Liu, M., Li, J., Xiao, Y., & Wu, X. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00407 · Cited by 49
miR-29a/b1 Inhibits Hair Follicle Stem Cell Lineage Progression by Spatiotemporally Suppressing WNT and BMP Signaling
Ge, M., Liu, C., Li, L., Lan, M., Yu, Y., Gu, L., Su, Y., Zhang, K., Zhang, Y., Wang, T., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.062 · Cited by 51
Embryonic mammary gland development
Spina, E., & Cowin, P. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.12.012 · Cited by 49
The Roles of WNT Signaling Pathways in Skin Development and Mechanical-Stretch-Induced Skin Regeneration
Bai, R., Guo, Y., Liu, W., Song, Y., Yu, Z., & Ma, X. (2023) · Biomolecules · doi:10.3390/biom13121702 · Cited by 53
An investigation of crosstalk between Wnt/β-catenin and transforming growth factor-β signaling in androgenetic alopecia
Lu, G. Y., Wu, Z.-B., Chu, X.-Y., Bi, Z., & Fan, W. (2016) · Medicine · doi:10.1097/md.0000000000004297 · Cited by 48
From skin to nerve: flies, vertebrates and the first helix
Quan, X., & Hassan, B. A. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5124-1 · Cited by 48
Dkk4 and Eda Regulate Distinctive Developmental Mechanisms for Subtypes of Mouse Hair
Cui, C., Kunisada, M., Piao, Y., Childress, V., Ko, M. S. H., & Schlessinger, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010009 · Cited by 46
LHX2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth
Tomann, P., Paus, R., Millar, S. E., Scheidereit, C., & Schmidt‐Ullrich, R. (2016) · Development · doi:10.1242/dev.130898 · Cited by 46
Self-citation
Androgenetic alopecia
Kabir, Y., & Goh, C. (2013) · Journal of the Egyptian Womenʼs Dermatologic Society · doi:10.1097/01.ewx.0000432183.50644.f6 · Cited by 48
Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice
Xing, F., Yi, W., Fang, M., Su, M., & Lei, T. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3391 · Cited by 47
Lack of Collagen VI Promotes Wound-Induced Hair Growth
Chen, P., Cescon, M., & Bonaldo, P. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.187 · Cited by 46
Fgfr2b mediated epithelial–mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning
Kettunen, P. J., Spencer‐Dene, B., Furmanek, T., Kvinnsland, I. H., Dickson, C., Thesleff, I., & Luukko, K. (2007) · Mechanisms of Development · doi:10.1016/j.mod.2007.09.003 · Cited by 46
Activated WNT signaling in postnatal SOX2-positive dental stem cells can drive odontoma formation
Xavier, G. M., Patist, A. L., Healy, C., Pagrut, A., Carreno, G., Sharpe, P. T., Martı́nez-Barberá, J. P., Thavaraj, S., Cobourne, M. T., & Andoniadou, C. L. (2015) · Scientific Reports · doi:10.1038/srep14479 · Cited by 46
Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma
Noubissi, F. K., Yedjou, C. G., Spiegelman, V. S., & Tchounwou, P. B. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15071442 · Cited by 47
Use of human intra-tissue stem/progenitor cells and induced pluripotent stem cells for hair follicle regeneration
Ohyama, M. (2019) · Inflammation and Regeneration · doi:10.1186/s41232-019-0093-1 · Cited by 46
Wnt10b promotes hair follicles growth and dermal papilla cells proliferation via Wnt/β-Catenin signaling pathway in Rex rabbits
Wu, Z., Zhu, Y., Liu, H., Liu, G., & Li, F. (2020) · Bioscience Reports · doi:10.1042/bsr20191248 · Cited by 46
Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy
Papukashvili, D., Rcheulishvili, N., Liu, C., Xie, F., Tyagi, D., He, Y., & Wang, P. G. (2021) · Cells · doi:10.3390/cells10112957 · Cited by 51
FZD6encoding the Wnt receptor frizzled 6 is mutated in autosomal‐recessive nail dysplasia
Naz, G., Pasternack, S. M., Perrin, C., Mattheisen, M., Refke, M., Khan, S., Gul, A., Simons, M., Ahmad, W., & Betz, R. C. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10800.x · Cited by 45
Local Dkk1 Crosstalk from Breeding Ornaments Impedes Regeneration of Injured Male Zebrafish Fins
Kang, J., Nachtrab, G. T., & Poss, K. D. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.08.015 · Cited by 46

Authors: Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E.
Affiliations: University of Pennsylvania (US)
Corresponding author: Millar, Sarah E.
ORCID: Andl, Thomas
Millar, Sarah E.
Venue: Developmental Cell
Publisher: Elsevier BV
Published: 2002-05
Volume: 2
Issue: 5
Pages: 643-653
ISSN: 1534-5807 (ISSN-L)
DOI: 10.1016/s1534-5807(02)00167-3
OpenAlex: W2048252195
Cited by: 1,088
References: 49
Citations by year: 2026: 29 · 2025: 41 · 2024: 53 · 2023: 63 · 2022: 66 · 2021: 44 · 2020: 59 · 2019: 43 · 2018: 55 · 2017: 40 · 2016: 48 · 2015: 37 · 2014: 48 · 2013: 42 · 2012: 48
FWCI: 46.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4095 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Developmental Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Dermatology Foundation
National Institutes of Health (AR47709)
Topics: Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: Wnt signaling, hair follicle development, DKK1, ectopic expression, tooth development, mammary gland development, transgenic mice
MeSH terms: Epidermal Cells, Animals, Base Sequence, Cell Differentiation, Cell Division, Cytoskeletal Proteins, DNA-Binding Proteins, Female, Hair, Mammary Glands, Animal, Membrane Proteins, Mice, Inbred C57BL, Mice, Transgenic, Phenotype, Proteins, Proto-Oncogene Proteins, RNA, Messenger, Skin Physiological Phenomena, Tooth Abnormalities, Transcription Factors, Signal Transduction, Trans-Activators, Up-Regulation, Receptors, Tumor Necrosis Factor, Gene Expression Regulation, Developmental, Hair Follicle, Zebrafish Proteins, Intercellular Signaling Peptides and Proteins, Wnt Proteins, beta Catenin, Mice, Lymphoid Enhancer-Binding Factor 1, Receptors, Ectodysplasin, Edar Receptor, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

WNT Signals Are Required for the Initiation of Hair Follicle Development

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks