Cited by 1,088Hair Growth and DisordersWnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

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WNT Signals Are Required for the Initiation of Hair Follicle Development

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Andl, Thomas, Reddy, Seshamma T., Gaddapara, Trivikram, Millar, Sarah E.·2002·Developmental Cell

DOI 10.1016/s1534-5807(02)00167-3

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Abstract

Hair follicle morphogenesis is initiated by a dermal signal that induces the development of placodes in the overlying epithelium. To determine whether WNT signals are required for initiation of follicular development, we ectopically expressed Dickkopf 1, a potent diffusible inhibitor of WNT action, in the skin of transgenic mice. This produced a complete failure of placode formation prior to morphological or molecular signs of differentiation, and blocked tooth and mammary gland development before the bud stage. This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation.

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Authors: Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E.
Affiliations: University of Pennsylvania (US)
Corresponding author: Millar, Sarah E.
ORCID: Andl, Thomas
Millar, Sarah E.
Venue: Developmental Cell
Publisher: Elsevier BV
Published: 2002-05
Volume: 2
Issue: 5
Pages: 643-653
ISSN: 1534-5807 (ISSN-L)
DOI: 10.1016/s1534-5807(02)00167-3
OpenAlex: W2048252195
Cited by: 1,088
References: 49
Citations by year: 2026: 29 · 2025: 41 · 2024: 53 · 2023: 63 · 2022: 66 · 2021: 44 · 2020: 59 · 2019: 43 · 2018: 55 · 2017: 40 · 2016: 48 · 2015: 37 · 2014: 48 · 2013: 42 · 2012: 48
FWCI: 46.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4095 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Developmental Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Dermatology Foundation
National Institutes of Health (AR47709)
Topics: Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: Wnt signaling, hair follicle development, DKK1, ectopic expression, tooth development, mammary gland development, transgenic mice
MeSH terms: Epidermal Cells, Animals, Base Sequence, Cell Differentiation, Cell Division, Cytoskeletal Proteins, DNA-Binding Proteins, Female, Hair, Mammary Glands, Animal, Membrane Proteins, Mice, Inbred C57BL, Mice, Transgenic, Phenotype, Proteins, Proto-Oncogene Proteins, RNA, Messenger, Skin Physiological Phenomena, Tooth Abnormalities, Transcription Factors, Signal Transduction, Trans-Activators, Up-Regulation, Receptors, Tumor Necrosis Factor, Gene Expression Regulation, Developmental, Hair Follicle, Zebrafish Proteins, Intercellular Signaling Peptides and Proteins, Wnt Proteins, beta Catenin, Mice, Lymphoid Enhancer-Binding Factor 1, Receptors, Ectodysplasin, Edar Receptor, In Vitro Techniques

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WNT Signals Are Required for the Initiation of Hair Follicle Development

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