Cited by 260Hair Growth and DisordersWnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation

Open access
Chen, Demeng, Jarrell, Andrew, Guo, Canting, Lang, Richard, Atit, Radhika·2012·Development

Abstract

Dermal fibroblasts are required for structural integrity of the skin and for hair follicle development. Uniform Wnt signaling activity is present in dermal fibroblast precursors preceding hair follicle initiation, but the functional requirement of dermal Wnt signaling at early stages of skin differentiation and patterning remains largely uncharacterized. We show in mice that epidermal Wnt ligands are required for uniform dermal Wnt signaling/β-catenin activity and regulate fibroblast cell proliferation and initiation of hair follicle placodes. In the absence of dermal Wnt signaling/β-catenin activity, patterned upregulation of epidermal β-catenin activity and Edar expression are absent. Conversely, forced activation of β-catenin signaling leads to the formation of thickened dermis, enlarged epidermal placodes and dermal condensates that result in prematurely differentiated enlarged hair follicles. These data reveal functional roles for dermal Wnt signaling/β-catenin in fibroblast proliferation and in the epidermal hair follicle initiation program.

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Registry

Crossref · 10.1242/dev.076463

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64 of 64 references verified0 citation errors · 0 not checkable

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  • Some crucial mechanisms of EMIs, including the effect of Wnt signaling on hair follicle morphogenesis, have been elucidated using animal models.

    “Over the past several decades, some crucial mechanisms of EMIs, including the effect of Wnt signaling on hair follicle morphogenesis (9), have been elucidated using animal models.”

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Authors
Chen, D., Jarrell, A., Guo, C., Lang, R., & Atit, R.
Affiliations
  • Case Western Reserve University (US)
  • Cincinnati Children's Hospital Medical Center (US)
Corresponding author
Atit, Radhika
Venue
Development
Published
2012-04-15
Volume
139
Issue
8
Pages
1522-1533
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W2061008214
Cited by
260
References
66
Citations by year
2026: 12 · 2025: 14 · 2024: 32 · 2023: 23 · 2022: 17 · 2021: 13 · 2020: 28 · 2019: 11 · 2018: 18 · 2017: 24 · 2016: 21 · 2015: 9 · 2014: 9 · 2013: 20 · 2012: 8
FWCI
16.93
Type
journal article
Language
en
Open access
Locations
  • Development (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Dental and Craniofacial Research (R01 DE01870, R01DE018470)
Topics
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
Wnt signaling, dermal fibroblasts, fibroblast proliferation, EDAR, hair follicle development
MeSH terms
Animals, Cell Survival, Fibroblasts, Ligands, Skin, Stem Cells, Time Factors, Signal Transduction, Protein Structure, Tertiary, Gene Expression Regulation, Developmental, Hair Follicle, Cell Proliferation, Wnt Proteins, beta Catenin, Mice

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