Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation
Open accessAbstract
Dermal fibroblasts are required for structural integrity of the skin and for hair follicle development. Uniform Wnt signaling activity is present in dermal fibroblast precursors preceding hair follicle initiation, but the functional requirement of dermal Wnt signaling at early stages of skin differentiation and patterning remains largely uncharacterized. We show in mice that epidermal Wnt ligands are required for uniform dermal Wnt signaling/β-catenin activity and regulate fibroblast cell proliferation and initiation of hair follicle placodes. In the absence of dermal Wnt signaling/β-catenin activity, patterned upregulation of epidermal β-catenin activity and Edar expression are absent. Conversely, forced activation of β-catenin signaling leads to the formation of thickened dermis, enlarged epidermal placodes and dermal condensates that result in prematurely differentiated enlarged hair follicles. These data reveal functional roles for dermal Wnt signaling/β-catenin in fibroblast proliferation and in the epidermal hair follicle initiation program.
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Some crucial mechanisms of EMIs, including the effect of Wnt signaling on hair follicle morphogenesis, have been elucidated using animal models.
“Over the past several decades, some crucial mechanisms of EMIs, including the effect of Wnt signaling on hair follicle morphogenesis (9), have been elucidated using animal models.”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [9]
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- Authors
- Chen, D., Jarrell, A., Guo, C., Lang, R., & Atit, R.
- Affiliations
- Case Western Reserve University (US)
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Atit, Radhika
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2012-04-15
- Volume
- 139
- Issue
- 8
- Pages
- 1522-1533
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- PMC
- PMC3308184
- OpenAlex
- W2061008214
- Cited by
- 260
- References
- 66
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 32 · 2023: 23 · 2022: 17 · 2021: 13 · 2020: 28 · 2019: 11 · 2018: 18 · 2017: 24 · 2016: 21 · 2015: 9 · 2014: 9 · 2013: 20 · 2012: 8
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R01 DE01870, R01DE018470)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt signaling, dermal fibroblasts, fibroblast proliferation, EDAR, hair follicle development
- MeSH terms
- Animals, Cell Survival, Fibroblasts, Ligands, Skin, Stem Cells, Time Factors, Signal Transduction, Protein Structure, Tertiary, Gene Expression Regulation, Developmental, Hair Follicle, Cell Proliferation, Wnt Proteins, beta Catenin, Mice
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