Cited by 1,088Hair Growth and DisordersWnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

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WNT Signals Are Required for the Initiation of Hair Follicle Development

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Andl, Thomas, Reddy, Seshamma T., Gaddapara, Trivikram, Millar, Sarah E.·2002·Developmental Cell

DOI 10.1016/s1534-5807(02)00167-3

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Abstract

Hair follicle morphogenesis is initiated by a dermal signal that induces the development of placodes in the overlying epithelium. To determine whether WNT signals are required for initiation of follicular development, we ectopically expressed Dickkopf 1, a potent diffusible inhibitor of WNT action, in the skin of transgenic mice. This produced a complete failure of placode formation prior to morphological or molecular signs of differentiation, and blocked tooth and mammary gland development before the bud stage. This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation.

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MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,030
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352
Reiterative signaling and patterning during mammalian tooth morphogenesis
Jernvall, J., & Thesleff, I. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00322-6 · Cited by 1,101
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,042
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
DasGupta, R., & Fuchs, E. V. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 995
Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.Preprint
van Genderen, C., Okamura, R. M., Fariñas, I., Quo, R. G., Parslow, T. G., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 972
Molecular Mechanisms Regulating Hair Follicle Development
Millar, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01670.x · Cited by 967
Self-citation
The secret life of the hair follicle
Hardy, M. H. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90350-d · Cited by 931

Show all 49 references

Research works printed but not linked: 1

Wang, 1996, Murine Wnt10a and Wnt10b, Oncogene, 13, 1537

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Zhang, Y., Andl, T., Yang, S. H., Teta, M., Liu, F., Seykora, J. T., Tobias, J. W., Piccolo, S., Schmidt‐Ullrich, R., Nagy, A., et al. (2008) · Development · doi:10.1242/dev.017459 · Cited by 198
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Watt, F. M., & Jensen, K. B. (2009) · EMBO Molecular Medicine · doi:10.1002/emmm.200900033 · Cited by 193
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Self-citation
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Farago, M., Dominguez, I. M., Landesman‐Bollag, E., Xu, X., Rosner, A., Cardiff, R. D., & Seldin, D. C. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1021 · Cited by 151
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Jamora, C., Lee, P., Kocieniewski, P., Azhar, M., Hosokawa, R., Chai, Y., & Fuchs, E. V. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0030011 · Cited by 145
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Saxena, N., Mok, K., & Rendl, M. (2019) · Experimental Dermatology · doi:10.1111/exd.13913 · Cited by 146
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Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium
Mukhopadhyay, M., Gorivodsky, M., Shtrom, S., Grinberg, A., Niehrs, C., Morasso, M. I., & Westphal, H. (2006) · Development · doi:10.1242/dev.02381 · Cited by 144
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Sekine, S., Sato, S., Takata, T., Fukuda, Y., Ishida, T., Kishino, M., Shibata, T., Kanai, Y., & Hirohashi, S. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63528-6 · Cited by 144
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Hwang, J., Mehrani, T., Millar, S. E., & Morasso, M. I. (2008) · Development · doi:10.1242/dev.022202 · Cited by 143
Self-citation
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Genetic prediction of male pattern baldness
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A new scenario for the evolutionary origin of hair, feather, and avian scales
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Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing
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Self-citation
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Bayle, J., Fitch, J. L., Jacobsen, K. A., Kumar, R., Lafyatis, R., & Lemaire, R. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701101 · Cited by 135
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Nemoto, E., 越川, 洋., Kanaya, S., Tsuchiya, M., Tamura, M., Somerman, M. J., & Shimauchi, H. (2009) · Bone · doi:10.1016/j.bone.2008.12.029 · Cited by 136
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Plikus, M. V., Wang, W. P., Liu, J., Wang, X., Jiang, T., & Chuong, C. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63197-5 · Cited by 134
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Pendás-Franco, N., Aguilera, O., Pereira, F., González‐Sancho, J. M., & Múñoz, A. (2008) · PubMed · Cited by 134
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Majidinia, M., Javad, A., Jahanban‐Esfahlan, R., & Yousefi, B. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26265 · Cited by 132
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Lindvall, C. J., Diegel, C. R., Evans, N. C., West, R. A., Dykema, K. J., Furge, K. A., & Williams, B. O. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005813 · Cited by 136
Sustained epithelial β-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation
Närhi, K. M., Järvinen, E., Birchmeier, W., Taketo, M. M., Mikkola, M. L., & Thesleff, I. (2008) · Development · doi:10.1242/dev.016550 · Cited by 132
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Suomalainen, M., & Thesleff, I. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22106 · Cited by 133
Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation
Youssef, K. K., Lapouge, G., Bouvrée, K., Rorive, S., Brohée, S., Appelstein, O., Larsimont, J., Sukumaran, V., de Sande, B. V., Pucci, D., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2628 · Cited by 130
PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration
Chen, Y., Fan, Z., Wang, X., Mo, M., Zeng, S. B., Xu, R.-H., Wang, X., & Wu, Y. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01650-6 · Cited by 130
Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland
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Authors: Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E.
Affiliations: University of Pennsylvania (US)
Corresponding author: Millar, Sarah E.
ORCID: Andl, Thomas
Millar, Sarah E.
Venue: Developmental Cell
Publisher: Elsevier BV
Published: 2002-05
Volume: 2
Issue: 5
Pages: 643-653
ISSN: 1534-5807 (ISSN-L)
DOI: 10.1016/s1534-5807(02)00167-3
OpenAlex: W2048252195
Cited by: 1,088
References: 49
Citations by year: 2026: 29 · 2025: 41 · 2024: 53 · 2023: 63 · 2022: 66 · 2021: 44 · 2020: 59 · 2019: 43 · 2018: 55 · 2017: 40 · 2016: 48 · 2015: 37 · 2014: 48 · 2013: 42 · 2012: 48
FWCI: 46.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4095 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Developmental Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Dermatology Foundation
National Institutes of Health (AR47709)
Topics: Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: Wnt signaling, hair follicle development, DKK1, ectopic expression, tooth development, mammary gland development, transgenic mice
MeSH terms: Epidermal Cells, Animals, Base Sequence, Cell Differentiation, Cell Division, Cytoskeletal Proteins, DNA-Binding Proteins, Female, Hair, Mammary Glands, Animal, Membrane Proteins, Mice, Inbred C57BL, Mice, Transgenic, Phenotype, Proteins, Proto-Oncogene Proteins, RNA, Messenger, Skin Physiological Phenomena, Tooth Abnormalities, Transcription Factors, Signal Transduction, Trans-Activators, Up-Regulation, Receptors, Tumor Necrosis Factor, Gene Expression Regulation, Developmental, Hair Follicle, Zebrafish Proteins, Intercellular Signaling Peptides and Proteins, Wnt Proteins, beta Catenin, Mice, Lymphoid Enhancer-Binding Factor 1, Receptors, Ectodysplasin, Edar Receptor, In Vitro Techniques

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WNT Signals Are Required for the Initiation of Hair Follicle Development

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