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WNT Signals Are Required for the Initiation of Hair Follicle Development
Open accessAbstract
Hair follicle morphogenesis is initiated by a dermal signal that induces the development of placodes in the overlying epithelium. To determine whether WNT signals are required for initiation of follicular development, we ectopically expressed Dickkopf 1, a potent diffusible inhibitor of WNT action, in the skin of transgenic mice. This produced a complete failure of placode formation prior to morphological or molecular signs of differentiation, and blocked tooth and mammary gland development before the bud stage. This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation.
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“Wnt signaling is one of the fundamental mechanisms regulating embryonic development and is closely associated with hair follicle morphogenesis and differentiation (32–34).”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [33]
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Metadata
- Authors
- Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Millar, Sarah E.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 2
- Issue
- 5
- Pages
- 643-653
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2048252195
- Cited by
- 1,088
- References
- 49
- Citations by year
- 2026: 29 · 2025: 41 · 2024: 53 · 2023: 63 · 2022: 66 · 2021: 44 · 2020: 59 · 2019: 43 · 2018: 55 · 2017: 40 · 2016: 48 · 2015: 37 · 2014: 48 · 2013: 42 · 2012: 48
- FWCI
- 46.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 4095 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dermatology Foundation
- National Institutes of Health (AR47709)
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt signaling, hair follicle development, DKK1, ectopic expression, tooth development, mammary gland development, transgenic mice
- MeSH terms
- Epidermal Cells, Animals, Base Sequence, Cell Differentiation, Cell Division, Cytoskeletal Proteins, DNA-Binding Proteins, Female, Hair, Mammary Glands, Animal, Membrane Proteins, Mice, Inbred C57BL, Mice, Transgenic, Phenotype, Proteins, Proto-Oncogene Proteins, RNA, Messenger, Skin Physiological Phenomena, Tooth Abnormalities, Transcription Factors, Signal Transduction, Trans-Activators, Up-Regulation, Receptors, Tumor Necrosis Factor, Gene Expression Regulation, Developmental, Hair Follicle, Zebrafish Proteins, Intercellular Signaling Peptides and Proteins, Wnt Proteins, beta Catenin, Mice, Lymphoid Enhancer-Binding Factor 1, Receptors, Ectodysplasin, Edar Receptor, In Vitro Techniques
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