The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
WNT Signals Are Required for the Initiation of Hair Follicle Development
Open accessAbstract
Hair follicle morphogenesis is initiated by a dermal signal that induces the development of placodes in the overlying epithelium. To determine whether WNT signals are required for initiation of follicular development, we ectopically expressed Dickkopf 1, a potent diffusible inhibitor of WNT action, in the skin of transgenic mice. This produced a complete failure of placode formation prior to morphological or molecular signs of differentiation, and blocked tooth and mammary gland development before the bud stage. This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation.
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“Wnt signaling is one of the fundamental mechanisms regulating embryonic development and is closely associated with hair follicle morphogenesis and differentiation (32–34).”
From Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction (2022) · cites this paper as [33]
Citations
Cites
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,030
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352
Reiterative signaling and patterning during mammalian tooth morphogenesis
Jernvall, J., & Thesleff, I. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00322-6 · Cited by 1,101
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,042
DasGupta, R., & Fuchs, E. V. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 995
van Genderen, C., Okamura, R. M., Fariñas, I., Quo, R. G., Parslow, T. G., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 972
Molecular Mechanisms Regulating Hair Follicle Development
Millar, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01670.x · Cited by 967
Self-citationThe secret life of the hair follicle
Hardy, M. H. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90350-d · Cited by 931
Research works printed but not linked: 1
- Wang, 1996, Murine Wnt10a and Wnt10b, Oncogene, 13, 1537
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Wnt/β-catenin signaling and disease
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Nusse, R., & Clevers, H. (2017) · Cell · doi:10.1016/j.cell.2017.05.016 · Cited by 4,342
Defining the Epithelial Stem Cell Niche in Skin
Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031
Epidermal homeostasis: a balancing act of stem cells in the skin
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Metadata
- Authors
- Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Millar, Sarah E.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 2
- Issue
- 5
- Pages
- 643-653
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2048252195
- Cited by
- 1,088
- References
- 49
- Citations by year
- 2026: 29 · 2025: 41 · 2024: 53 · 2023: 63 · 2022: 66 · 2021: 44 · 2020: 59 · 2019: 43 · 2018: 55 · 2017: 40 · 2016: 48 · 2015: 37 · 2014: 48 · 2013: 42 · 2012: 48
- FWCI
- 46.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 4095 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dermatology Foundation
- National Institutes of Health (AR47709)
- Topics
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt signaling, hair follicle development, DKK1, ectopic expression, tooth development, mammary gland development, transgenic mice
- MeSH terms
- Epidermal Cells, Animals, Base Sequence, Cell Differentiation, Cell Division, Cytoskeletal Proteins, DNA-Binding Proteins, Female, Hair, Mammary Glands, Animal, Membrane Proteins, Mice, Inbred C57BL, Mice, Transgenic, Phenotype, Proteins, Proto-Oncogene Proteins, RNA, Messenger, Skin Physiological Phenomena, Tooth Abnormalities, Transcription Factors, Signal Transduction, Trans-Activators, Up-Regulation, Receptors, Tumor Necrosis Factor, Gene Expression Regulation, Developmental, Hair Follicle, Zebrafish Proteins, Intercellular Signaling Peptides and Proteins, Wnt Proteins, beta Catenin, Mice, Lymphoid Enhancer-Binding Factor 1, Receptors, Ectodysplasin, Edar Receptor, In Vitro Techniques
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