Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218

ras oncogenes in human cancer: a review.

Bos, J. L. (1989) · PubMed · Cited by 5,061

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-rasPreprint

Jackson, E. L., Willis, N. A., Mercer, K. L., Bronson, R. T., Crowley, D. G., Montoya, R., Jacks, T., & Tuveson, D. A. (2001) · Genes & Development · doi:10.1101/gad.943001 · Cited by 1,927

RAS oncogenes: the first 30 years

Malumbres, M., & Barbacid, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1097 · Cited by 1,902

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Zhang, Y., Xiong, Y., & Yarbrough, W. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81401-4 · Cited by 1,626

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

Serrano, M., Lee, H.-W., Chin, L., Cordon-Cardo, C., Beach, D., & DePinho, R. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81079-x · Cited by 1,585

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80452-3 · Cited by 1,566

The correlation between KRAS and TP53 gene mutations and early growth of pulmonary nodules

Zhao, B., Li, B., Guo, H., Zhao, Q., Zhang, X., Zhao, H., Xue, W., Li, W. S., Duan, G., & Xu, S. (2024) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-024-02927-0 · Cited by 1

ABL kinases regulate FGF signaling independent of CRK phosphorylation to prevent Peters anomaly type II

Wu, H., Mao, Y., Wang, Q., Yu, H., Bouaziz, M., Makrides, N., Wang, E., Ding, Z., Koleske, A. J., Radice, G. L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72489-3 · Cited by 1

Tumor Antigens Revealed by Exome Seqeuncing Drive Editing of Tumor Immunogenicity

Vesely, M. D. (2013) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7c8278n · Cited by 1

Relationship Between Chronic Inflammation and Cancer: Interleukin-1β Overexpression Induces Pancreatic Ductal Adenocarcinoma in Oncogenic Kras Mice

Macchini, M. (2016) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/7316 · Cited by 1

A new mouse model to study the role of ectopic Nanos3 expression in cancer

Andries, V., Keuckelaere, E. D., Staes, K., Hochepied, T., Taminau, J., Lemeire, K., Birembaut, P. L., Berx, G., & Roy, F. M. V. (2019) · BMC Cancer · doi:10.1186/s12885-019-5807-x · Cited by 1

Mesenchymal tumor cells drive adaptive resistance of Trp53−/− breast tumor cells to inactivated mutant Kras

van Weele, L. J., Djomehri, S. I., Cai, S., Antony, J., Sikandar, S. S., Qian, D., Ho, W. H. D., West, R. B., Scheeren, F. A., & Clarke, M. F. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13220 · Cited by 1

Oncogenes and Tumor Suppressor Genes in Therapeutic Resistance

Rak, J. W., Coomber, B. L., & Yu, J. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-035-5_4 · Cited by 1

Thyroid Targeted Kras G12D / Pten −/− Mice and Their Cell Lines: New Tools to Study Thyroid Cancer Biology

Schweppe, R. E., & Haugen, B. R. (2011) · Thyroid · doi:10.1089/thy.2011.2109.ed · Cited by 1

La sénescence prématurée : chimère, ange salvateur ou Dr Jekyll et Mr Hyde ?

Puisieux, A., & Ansieau, S. (2009) · médecine/sciences · doi:10.1051/medsci/2009252115 · Cited by 1

Pediatric malignancies: update on sarcomas and leukemia development in children

Braun, B. S., & Lessnick, S. L. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.12.005 · Cited by 1

Mouse Models of Human Cancer: Role in Preclinical Testing and Personalized Medicine

Berger, A. H., & Pandolfi, P. P. (2011) · Springer eBooks · doi:10.1007/978-0-387-69805-2_27 · Cited by 1

Pancreas-specific miR-216a regulates proliferation and endocrine and exocrine cell function in vivoPreprint

Erener, S., Ellis, C. E., Ramzy, A., Glavas, M. M., O’Dwyer, S. M., Pereira, S., Wang, T., Pang, J., Bruin, J. E., Riedel, M. J., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/792655 · Cited by 1

Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathwayPreprint

Gillies, T. E., Pargett, M., Silva, J. M., Teragawa, C., McCormick, F., & Albeck, J. G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.17.952093 · Cited by 1

Contribution of transforming growth factor-β signaling to intestinal cancer development

Muñoz, N. M. (2006) · Cited by 1

CK2 signaling from TOLLIP-dependent perinuclear endosomes is an essential feature of KRAS and NRAS mutant cancersPreprint

Basu, S., Luke, B. T., Karim, B. O., Martín, N. C. R., Lockett, S., Das, S., Andrésson, Þ., Saylor, K. L., Kozlov, S. V., Bassel, L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.05.487175 · Cited by 1

Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens developmentPreprint

Wang, Q., Li, H., Mao, Y., Garg, A., Park, E. S., Wu, Y., Chow, A., Peregrin, J., & Zhang, X. (2024) · eLife · doi:10.7554/elife.103615 · Cited by 1

Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens developmentPreprint

Wang, Q., Li, H., Mao, Y., Garg, A., Park, E. S., Wu, Y., Chow, A., Peregrin, J., & Zhang, X. (2024) · eLife · doi:10.7554/elife.103615.1 · Cited by 1

Transcriptional Dosage of Oncogenic KRAS Drives Lung Adenocarcinoma Cell States, Progression and MetastasisPreprint

Serresi, M., Çetin, A. O., Dramaretska, Y., Kertalli, S., Schmitt, M. J., Naumann, H., Zschummel, M., Asselin-Labat, M.-L., Maciel, L. F., Declercq, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.29.630643 · Cited by 1

Effectors of Ras-Mediated Oncogenesis

Chenette, E. J., Repasky, G. A., & Der, C. J. (2006) · Springer eBooks · doi:10.1007/1-4020-4708-8_6

Ras

Cox, A. D., & DeCristo, M. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139046947.022

The role of KRAS mutations signalling in autophagy control in Colorectal Carcinomas

Castro, P. J. T. D. (2012) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Investigação das quinases Aurora A e Aurora B como potenciais alvos terapêuticos no câncer de pulmão induzido pelo oncogene KRAS

dos Santos, E. O. (2013) · doi:10.11606/d.46.2013.tde-15012014-143156

Animal Models for Noonan Syndrome and Related Disorders

Araki, T., & Neel, B. G. (2008) · Monographs in human genetics · doi:10.1159/000164850

THE MECHANISM OF TUMORIGENESIS IN THE IMMORTALIZED HUMAN PANCREATIC CELL LINES: CELL CULTURE MODELS OF HUMAN PANCREATIC CANCER

Chang, Z. (2011) · Digital Commons-TMC (Texas Medical Center)

LOSS OF GPRC5A ENHANCES SURVIVAL IN NORMAL AND MALIGNANT LUNG EPITHELIAL CELLS BY ELICITING PERSISTENT STAT3 ACTIVATION INDUCED BY AUTOCRINE LIF

Chen, Y. (2010) · Digital Commons-TMC (Texas Medical Center)

Defining RCE1 and ICMT as Therapeutic Targets in K-RAS-induced Cancer

Wahlstrom, A. M. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Neuroplastic changes in a mouse model of pancreatic ductal adenocarcinoma

Stopczynski, R. E. (2013) · D-Scholarship@Pitt (University of Pittsburgh)

Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells

Avdulov, S. V., Gómez-García, J. R., Bitterman, P. B., & Polunovsky, V. A. (2014) · Springer eBooks · doi:10.1007/978-94-017-9078-9_18

Neurofibromin and IL-4 as Regulators of T Cell Development, Function, and Homeostasis

Oliver, J. A. (2012) · Deep Blue (University of Michigan)

Molecular Pathology and Diagnostics of Non-small Cell Lung Carcinoma

Quigley, B., Ducker, S., & Khalil, F. K. (2013) · Springer eBooks · doi:10.1007/978-94-007-7192-5_4

Examining the Role of Hedgehog Signaling in the Pancreatic Tumor Microenvironment.

Dosch, J. S. (2011) · Deep Blue (University of Michigan)

Inhibition of activated K-ras gene by sirna expression cassettes in human pancreatic carcinoma cell line MIAPaCa-2

Wang, W., Wang, C., Dong, J.-H., Chen, X., Zhang, M., & Zhao, G. (2005) · Chinese Journal of Cancer Research · doi:10.1007/s11670-005-0050-1

Skeletal Muscle Stem Cells and Progenitors as Cells of Origin in Sarcoma

Blum, J. M. (2013) · DukeSpace (Duke University)

Bases moleculares del cáncer y factores de riesgo: el caso del cáncer de páncreas

Pérez-Díaz, I. (2010) · Revista Portuguesa de Pneumologia

METHOD Open Access

Maretty, L., Sibbesen, J. A., & Krogh, A. (2014)

Role and regulation of the p53-homolog p73 in the transformation of normal human fibroblasts

Hofmann, L. (2007)

Pancreatic cancer

Liau, S., & Tuveson, D. A. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139046947.049

The interaction between Hedgehog/Patched and Ras signaling in Rhabdomyosarcoma

Cuvelier, N. (2016) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5564

Doctor of Philosophy in Molecular and Medical Pharmacology

Angeles, L. (2012)

Molecular Pathogenesis of Pancreatic Adenocarcinoma

Shroff, R. T., & Abbruzzese, J. L. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4066-6.00035-4

Regulation and Function of the Cancer Stem Cell Transcription Factors GLI1 and Kruppel-like Factor 4

Vanderbilt, D. B. (2015) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.6863

Cell surface proteoglycans control astrocyte migration and retinal angiogenesis by regulating basement membrane assembly

Tao, C. (2015) · IUScholarWorks (Indiana University) · doi:10.7912/c2/2064

The role of adaptor proteins Crk and CrkL in lens development

Collins, T. N. (2016) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1970

Alterations in Tgf-β Signaling Mediate the Biologic Behaviour of Osteosarcoma Cell Lines

Deheshi, B. M. (2010) · TSpace (University of Toronto)

The effect of macrophages on fibroblast activity and lesion development in mouse models of endometriosis.

Johan, M. Z. (2014) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)

The Role of Semaphorin 5A in Pancreatic Cancer Progression and Metastasis

Saxena, S. (2017) · DigitalCommons@UNMC

RhoA as a Potential Target in Lung Cancer

Zandvakili, I. (2015) · OhioLink ETD Center (Ohio Library and Information Network)

O papel da quinase Aurora A na biologia das células iniciadoras de turmor pulmonares com mutação em KRAS

Scalabrini, L. C. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.46.2017.tde-11042017-082202

Investigação das quinases Aurora A e Aurora B na tumorigenicidade mediada pelo oncogene KRAS

dos Santos, E. O. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2017.tde-21062017-103949

Metastatic Pancreatic Cancer

Martinelli, P., & Lonardo, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804003-4.00007-4

In Vitro Modeling of Pancreatic Duct Cell Carcinogenesis

Leung, L. (2014) · TSpace (University of Toronto)

Supplemental Figure Legends

Satler, J. D., Carstens, B. C., & Hedin, M. C. (2015) · DRYAD · doi:10.5061/dryad.68s40.2/3.2

Using High-Precision Signaling Activity Imaging to Personalize Ras Pathway Inhibition Strategies in Neurofibromatosis

Albeck, J. G., Gillies, T. E., Blizard, H., & Pargett, M. (2017)

Role of RAS signaling in Hedgehog-associated embryonal rhabdomyosarcoma

Bauer, J. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7239

Mesenchymal expression of activated K-ras yields Noonan Syndrome-like bone defects that are rescued by mid-gestational MEK inhibitionPreprint

Nedelcu, S., Kobayashi, T., Stanciu, M., Kronenberg, H. M., & Lees, J. A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/634840

Foxm1 Transcription Factor Regulates Lung Adenocarcinoma Development

Liang, S., Chao, S.-Y., Li, C., Ip, K.-U., Lin, Y.-K., Hsu, C.-C., Hsu, P.-C., & Wang, I. (2019) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/276/1/012003

Regulation of the kRAS Promoter in Pancreatic Cancer by Proteins and Small Molecules

Batra, H. (2017) · ProQuest Demo Repository

Investigação da quinase IKKβ como um alvo terapêutico anti-metastático em câncer de pulmão associado à ativação do oncogene KRAS

Miranda, V. S. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.46.2019.tde-01082019-085027

Molecular Pathogenesis of Pancreatic Adenocarcinoma

Xiong, H. Q., & Abbruzzese, J. L. (2008) · Elsevier eBooks · doi:10.1016/b978-141603703-3.10035-4

The Role of Nuclear Factor Kappa B in Myeloid Cells During Lung Carcinogenesis

Perry, A. G. (2016)

MAPK-induced miR-29 targets MAFG and suppresses melanoma developmentPreprint

Vera, O., Bok, I., Jasani, N., Nakamura, K., Xu, X., Mecozzi, N., Angarita, A., Wang, K., Tsai, K. Y., & Karreth, F. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.27.922153

Whole-Exome Sequencing Reveals Somatic Mutations in HRAS and KRAS, which Cause Nevus Sebaceus

Sun, B. K., Saggini, A., Sarin, K. Y., Kim, J., Benjamin, L., LeBoit, P. E., & Khavari, P. A. (2010)

La uniformidad de la aplicación del agua en la parcela: efectos sobre el diseño y manejo del agua bajo el riego por aspersión

Picornell, M. R., de Juan, J. A., Martín‐Benito, J. M. T., Ortega, F., & Domínguez, A. (2011) · Riegos y drenajes XXI

Einfluss verschiedener KRAS-Mutationen auf das Ansprechen von kolorektalen Zellen auf eine 5-Fluorouracil-basierende Radiochemotherapie in Anwesenheit von Rezeptortyrosinkinase-Inhibitoren

Wiedmann, S. (2022) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-43

Exploring the role of LZTR1 in an autosomal recessive form of Noonan Syndrome by genome-edited induced pluripotent stem cells

Hindmarsh, R. (2021) · doi:10.53846/goediss-8838

Faculty Opinions recommendation of Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer.

Leslie, N. R., & Porcza, L. M. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737998700.793575573

Data from Glioma Formation in Neurofibromatosis 1 Reflects Preferential Activation of K-RAS in Astrocytes

Dasgupta, B., Li, W., Perry, A., & Gutmann, D. H. (2023) · doi:10.1158/0008-5472.c.6492989

The role of atypical ubiquitin chains in intestinal homeostasis and colorectal cancer

Liu, J. (2024) · doi:10.69622/26003371

Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens developmentPreprint

Wang, Q., Li, H., Mao, Y., Garg, A., Park, E. S., Wu, Y., Chow, A., Peregrin, J., & Zhang, X. (2025) · eLife · doi:10.7554/elife.103615.3

eLife Assessment: Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development

Reboutier, D. (2025) · eLife · doi:10.7554/elife.103615.4.sa0

Cooperativity between Ras pathway mutations in colonic tumorigenesisPreprint

Johnson, C. W., Idelevich, A., Shui, B., Tisdale, A. W., O’Donoghue, E., Cook, J., Hull, S., Yang, M. H., Sheth, S., Terrell, E. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.05.673994

Pathophysiological impact of targeting the ROS-p53 axis

Sayin, V. I. (2014) · Gothenburg University Publications Electronic Archive (Gothenburg University)

The Role of Redox-dependent Reactions with Kras Cysteine 118 in Tumorigenesis

Huang, L. (2015) · DukeSpace (Duke University)

Molecular Regulators of Stem Cell Fate and Tumor Development in the Cerebellum

Brun, S. N. (2014) · DukeSpace (Duke University)

Additional file 4 of Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells

Lin, H.-T., Takagi, M., Kubara, K., Yamazaki, K., Michikawa, F., Okumura, T., Naruto, T., Morio, T., Miyazaki, K., Taniguchi, H., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26707643

Additional file 2 of Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells

Lin, H.-T., Takagi, M., Kubara, K., Yamazaki, K., Michikawa, F., Okumura, T., Naruto, T., Morio, T., Miyazaki, K., Taniguchi, H., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25622082

Additional file 1 of Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells

Lin, H.-T., Takagi, M., Kubara, K., Yamazaki, K., Michikawa, F., Okumura, T., Naruto, T., Morio, T., Miyazaki, K., Taniguchi, H., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25621892

Additional file 3 of Monoallelic KRAS (G13C) mutation triggers dysregulated expansion in induced pluripotent stem cell-derived hematopoietic progenitor cells

Lin, H.-T., Takagi, M., Kubara, K., Yamazaki, K., Michikawa, F., Okumura, T., Naruto, T., Morio, T., Miyazaki, K., Taniguchi, H., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26707640

Additional file 1 of The correlation between KRAS and TP53 gene mutations and early growth of pulmonary nodules

Zhao, B., Li, B., Guo, H., Zhao, Q., Zhang, X., Zhao, H., Xue, W., Li, W., Duan, G., & Xu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26739270

TMPO promotes cellular dissemination and metastasis in circulating tumor cellsPreprint

Giacobbe, A., Obradović, A., Lu, J., Park, S., Pedraz‐Valdunciel, C., Fanelli, G. N., Zheng, A., Kim, J. Y., Dixon, M. S., Nam, J. S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.27.696673

Spatial Transcriptomics Profiling of Small Intestine Adenocarcinoma and Adenoma in Humans and a Murine Model with KRASG12D and Loss of CDKN2a-p16

Seckar, T. D., Komissarova, E. V., Sun, J., Fevre, N. L., Ye, Z., Jordan, T. X., Babaei, A., Portillo, A. D., Sepulveda, J. L., & Sepulveda, A. R. (2026) · American Journal Of Pathology · doi:10.1016/j.ajpath.2026.01.013

Roles of the multifunctional protein E4F1 in cellular senescence

Maciejewska, Z. (2010) · theses.fr (ABES) · doi:10.70675/21f99f8bze775z413fza364z48dd293ca460

Crizotinib-Induced Immunogenic Cell Death in Non-Small Cell Lung Cancer

Liu, P. (2018) · theses.fr (ABES) · doi:10.70675/ed550df1z9febz41d6z9846z294a6695b865

Identification of pharmacological agents that induce HMGB1 release and inhibitors of conventional protein secretion

Zhao, L. (2019) · theses.fr (ABES) · doi:10.70675/8cfe2d2fzeddcz406az9affz9d6590219bd4

Analyse fonctionnelle du variant d’histone H2A.J impliqué dans le développement d’un phénotype pro-inflammatoire en sénescence induite par des dommages à l’ADN

Mangelinck, A. (2020) · theses.fr (ABES) · doi:10.70675/736aff1fzf132z4ce3z938cz6c3b7a9e9f75

Characterizing the role of epithelial cells at transition zones in normal and disease state

Mitoyan, L. (2021) · theses.fr (ABES) · doi:10.70675/ddf25abazea11z4dd1za773zea6476b58547

Innovative targeted therapies for mosaic RAS-related vascular malformations

Morin, G. (2024) · theses.fr (ABES) · doi:10.70675/88882e5fz1bf9z4dbezae13zba4200ee9598

IN VIVO HEMATOPOIETIC CELL ENGRAFTMENT IS MODULATED BY DPPIV/CD26 INHIBITION AND RHEB2 OVEREXPRESSION

Campbell, T. (2009) · doi:10.7912/c2/1687

KRAS mutations in gastrointestinal cancers: New insights from pathogenic mechanisms to therapeutic challenges

Yang, X., Tao, X., Qi, W., Luo, R., Lan, T., Xie, K., Cai, Y., Gao, F., Lv, Y., Liu, C., et al. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101718

FLIP is essential for oncogenic KRAS- driven lung cancerPreprint

Hamilton, C., Sharkey, S., Khawaja, H. A., Downs, M., McLaughlin, C., Brown, C. N., Doherty, D. F., Fox, J., Pettigrew, M., Butterworth, K. T., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.04.738686

TRAF7 mutations stabilize K/NRAS and hyperactivate MAPK signaling to cause CAFDADD neurodevelopmental defects

Xiao, M., Liu, Y., Song, X., Liu, J., Tang, X., Maosen, 窦. D., Yu, W., Zhang, H., Weng, W., Han, D., et al. (2026) · Science Advances · doi:10.1126/sciadv.adw8672

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Ashihara, T., Murakami, K., Takamatsu, S., Kanto, A., Mori, S., Otani, T., Sakai, K., Kotani, Y., Nishio, K., Abiko, K., et al. (2026) · Molecular Oncology · doi:10.1002/1878-0261.70347

Signaling by RasG12V requires EGFR function in vivo to trigger full downstream pathway activation

Vega-Cuesta, P., López‐Varea, A., Ruiz‐Gómez, A., & de Celis, J. F. (2026) · Nature Communications · doi:10.1038/s41467-026-78939-2

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

Guerra, C. E., Mijimolle, N., Dhawahir, A., Dubus, P. R., Barradas, M., Serrano, M., Campuzano, V., & Barbacid, M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00191-0 · Cited by 577

Mouse Tissues that Undergo Neoplastic Progression after K-Ras Activation Are Distinguished by Nuclear Translocation of phospho-Erk1/2 and Robust Tumor Suppressor Responses

Parikh, N., Shuck, R. L., Nguyen, T., Herron, A. J., & Donehower, L. A. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0089 · Cited by 21

Conditional Expression of K- ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis

Vitale-Cross, L. A., Amornphimoltham, P., Fisher, G. H., Molinolo, A., & Gutkind, J. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2623 · Cited by 133

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

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