Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218

ras oncogenes in human cancer: a review.

Bos, J. L. (1989) · PubMed · Cited by 5,061

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-rasPreprint

Jackson, E. L., Willis, N. A., Mercer, K. L., Bronson, R. T., Crowley, D. G., Montoya, R., Jacks, T., & Tuveson, D. A. (2001) · Genes & Development · doi:10.1101/gad.943001 · Cited by 1,927

RAS oncogenes: the first 30 years

Malumbres, M., & Barbacid, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1097 · Cited by 1,902

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Zhang, Y., Xiong, Y., & Yarbrough, W. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81401-4 · Cited by 1,626

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

Serrano, M., Lee, H.-W., Chin, L., Cordon-Cardo, C., Beach, D., & DePinho, R. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81079-x · Cited by 1,585

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80452-3 · Cited by 1,566

Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma

Stopczynski, R. E., Normolle, D. P., Hartman, D. J., Ying, H., DeBerry, J. J., Bielefeldt, K., Rhim, A. D., DePinho, R. A., Albers, K. M., & Davis, B. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2050 · Cited by 216

A Phosphatase Holoenzyme Comprised of Shoc2/Sur8 and the Catalytic Subunit of PP1 Functions as an M-Ras Effector to Modulate Raf Activity

Rodriguez-Viciana, P., Oses-Prieto, J., Burlingame, A., Fried, M., & McCormick, F. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.027 · Cited by 215

K-Ras Promotes Growth Transformation and Invasion of Immortalized Human Pancreatic Cells by Raf and Phosphatidylinositol 3-Kinase Signaling

Campbell, P. M., Groehler, A. L., Lee, K. M., Ouellette, M. M., Khazak, V., & Der, C. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3752 · Cited by 220

Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma

Burd, C. E., Liu, W., Huynh, M. V., Waqas, M. A., Gillahan, J. E., Clark, K. S., Fu, K., Martin, B. L., Jeck, W. R., Souroullas, G. P., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0729 · Cited by 214

ERKs in cancer: friends or foes?

Deschênes-Simard, X., Kottakis, F., Meloche, S., & Ferbeyre, G. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2381 · Cited by 186

RHOJ controls EMT-associated resistance to chemotherapy

Debaugnies, M., Rodríguez‐Acebes, S., Blondeau, J., Parent, M.-A., Zocco, M., Song, Y., Maertelaer, V. D., Moers, V., Latil, M., Dubois, C., et al. (2023) · Nature · doi:10.1038/s41586-023-05838-7 · Cited by 221

Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

Gabitova-Cornell, L., Surumbayeva, A., Peri, S., Franco‐Barraza, J., Restifo, D., Weitz, N., Ogier, C., Goldman, A. R., Hartman, T. R., Francescone, R., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.08.015 · Cited by 206

Different Levels of Twist1 Regulate Skin Tumor Initiation, Stemness, and Progression

Beck, B., Lapouge, G., Rorive, S., Drogat, B., Desaedelaere, K., Delafaille, S., Dubois, C., Salmon, I. J., Willekens, K., Marine, J., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2014.12.002 · Cited by 210

Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans

Ochi, A., Graffeo, C. S., Zambirinis, C. P., Rehman, A. U., Hackman, M., Fallon, N. C., Barilla, R., Henning, J. R., Jamal, M., Rao, R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63606 · Cited by 205

Tissue-Specific Oncogenic Activity of KRASA146T

Poulin, E. J., Bera, A. K., Lu, J., Lin, Y.-J., Strasser, S. D., Paulo, J. A., Huang, T. Q., Morales, C., Yan, W., Cook, J., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1220 · Cited by 197

Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

Latil, M., Nassar, D., Beck, B., Boumahdi, S., Wang, L., Brisebarre, A., Dubois, C., Nkusi, E., Lenglez, S., Chęcińska, A., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.10.018 · Cited by 201

K-Ras promotes tumorigenicity through suppression of non-canonical Wnt signaling

Wang, M.-T., Holderfield, M., Galeas, J., Delrosario, R., To, M. D., Balmain, A., & McCormick, F. (2015) · Cell · doi:10.1016/j.cell.2015.10.041 · Cited by 196

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

Kümper, S., Mardakheh, F. K., McCarthy, A., Yeo, M., Stamp, G., Paul, A., Worboys, J. D., Sadok, A., Jørgensen, C., Guichard, S., et al. (2016) · eLife · doi:10.7554/elife.12203 · Cited by 201

Assessing cell and organ senescence biomarkers

de Jesus, B. B., & Blasco, M. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.247866 · Cited by 187

Defining the origins of Ras/p53-mediated squamous cell carcinoma

White, A. C., Tran, K. V., Khuu, J., Dang, C., Cui, Y., Binder, S. W., & Lowry, W. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012670108 · Cited by 189

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K- ras oncogene in vivo

Sansom, O. J., Méniel, V. S., Wilkins, J. A., Cole, A. M., Oien, K. A., Marsh, V. L., Jamieson, T. J., Guerra, C. E., Ashton, G. H. S., Barbacid, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604130103 · Cited by 195

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

Burgess, M. R., Hwang, E., Mroue, R., Bielski, C. M., Wandler, A. M., Huang, B. J., Firestone, A. J., Young, A., Lacap, J. A., Crocker, L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.01.020 · Cited by 183

Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish

Le, X., Langenau, D. M., Keefe, M. D., Kutok, J. L., Neuberg, D. S., & Zon, L. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611302104 · Cited by 186

RalGDS is required for tumor formation in a model of skin carcinogenesis

González-Garcı́a, A., Pritchard, C. A., Paterson, H. F., Mavria, G., Stamp, G., & Marshall, C. J. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.01.029 · Cited by 181

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

Schoppy, D. W., Ragland, R. L., Gilad, O., Shastri, N., Peters, A. A., Murga, M., Fernández-Capetillo, Ó., Diehl, J. A., & Brown, E. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58928 · Cited by 182

Harnessing metabolic dependencies in pancreatic cancers

Encarnación-Rosado, J., & Kimmelman, A. C. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00431-7 · Cited by 190

Non-germline genetically engineered mouse models for translational cancer research

Heyer, J., Kwong, L. N., Lowe, S. W., & Chin, L. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2877 · Cited by 181

CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion

Mou, H., Smith, J. L., Peng, L., Yin, H., Moore, J. E., Zhang, X.-O., Song, C., Sheel, A., Wu, Q., Özata, D. M., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1237-8 · Cited by 190

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer

Vallejo, A., Perurena, N., Guruceaga, E., Mazur, P. K., Martínez-Canarias, S., Zandueta, C., Valencia, K., Arricibita, A., Gwinn, D. M., Sayles, L. C., et al. (2017) · Nature Communications · doi:10.1038/ncomms14294 · Cited by 179

Expression of Endogenous Oncogenic V600EB-raf Induces Proliferation and Developmental Defects in Mice and Transformation of Primary Fibroblasts

Mercer, K., Giblett, S. M., Green, S. A., Lloyd, D. J., Dias, S. D. R., Plumb, M., Marais, R., & Pritchard, C. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2211 · Cited by 176

Platelet-derived Growth Factor and Reactive Oxygen Species (ROS) Regulate Ras Protein Levels in Primary Human Fibroblasts via ERK1/2

Svegliati, S., Cancello, R., Sambo, P., Luchetti, M. M., Paroncini, P., Orlandini, G., Discepoli, G., Paternò, R., Santillo, M., Cuozzo, C., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502851200 · Cited by 173

Preclinical Murine Models for Lung Cancer: Clinical Trial Applications

Kellar, A., Egan, C., & Morris, D. G. (2015) · BioMed Research International · doi:10.1155/2015/621324 · Cited by 179

Mouse models of colorectal cancer: Past, present and future perspectives

Bürtin, F., Mullins, C. S., & Linnebacher, M. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i13.1394 · Cited by 183

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewalPreprint

Zhao, Z., Zuber, J. A., Díaz-Flores, E., Lintault, L., Kogan, S. C., Shannon, K., & Lowe, S. W. (2010) · Genes & Development · doi:10.1101/gad.1940710 · Cited by 175

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma

Lytle, N. K., Ferguson, L. P., Rajbhandari, N., Gilroy, K. L., Fox, R. G., Deshpande, A. J., Schürch, C. M., Hamilton, M., Robertson, N., Lin, W., et al. (2019) · Cell · doi:10.1016/j.cell.2019.03.010 · Cited by 166

Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells

Dost, A. F. M., Moye, A. L., Vedaie, M., Tran, L. M., Fung, E., Heinze, D. M., Villacorta-Martín, C., Huang, J., Hekman, R. M., Kwan, J., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.07.022 · Cited by 166

Mutant KRAS Conversion of Conventional T Cells into Regulatory T Cells

Zdanov, S., Mandapathil, M., Eid, R. A., Adamson-Fadeyi, S., Wilson, W., Qian, J., Carnie, A., Tarasova, N. I., Mkrtichyan, M., Berzofsky, J. A., et al. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0241 · Cited by 157

KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis

Wei, D., Wang, L., Yan, Y., Jia, Z., Gagea, M., Li, Z., Zuo, X., Kong, X., Huang, S., & Xie, K. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.02.005 · Cited by 156

Molecular definition of a metastatic lung cancer state reveals a targetable CD109–Janus kinase–Stat axis

Chuang, C.-H., Greenside, P., Rogers, Z. N., Brady Jennifer, J., Yang, D., Ma, R. K., Caswell, D. R., Chiou, S., Winters, A. F., Grüner, B. M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4285 · Cited by 153

The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance

Biancur, D. E., & Kimmelman, A. C. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.04.011 · Cited by 152

Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation

Fan, H., Shimada, M., Liu, Z., Cahill, N., Noma, N., Wu, Y., Gossen, J. A., & Richards, J. S. (2008) · Development · doi:10.1242/dev.020560 · Cited by 155

Senescence comes of age

Narita, M., & Lowe, S. W. (2005) · Nature Medicine · doi:10.1038/nm0905-920 · Cited by 153

Inhibition of Mammalian Target of Rapamycin Reverses Alveolar Epithelial Neoplasia Induced by Oncogenic K-ras

Wislez, M., Spencer, L., Izzo, J. G., Juroske, D. M., Balhara, K. S., CODY, D. D., Price, R. E., Hittelman, W. N., Wistuba, I. I., & Kurie, J. M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4420 · Cited by 150

C-Raf Is Required for the Initiation of Lung Cancer by K-RasG12D

Karreth, F. A., Frese, K. K., DeNicola, G. M., Baccarini, M., & Tuveson, D. A. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-10-0044 · Cited by 149

C/EBPβ cooperates with RB:E2F to implement RasV12‐induced cellular senescence

Sebastian, T. B., Malı́k, R., Thomas, S., Sage, J., & Johnson, P. F. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600789 · Cited by 151

Pharmacological targeting of netrin-1 inhibits EMT in cancer

Lengrand, J., Pastushenko, I., Vanuytven, S., Song, Y., Venet, D., Sarate, R. M., Bellina, M., Moers, V., Boinet, A., Sifrim, A., et al. (2023) · Nature · doi:10.1038/s41586-023-06372-2 · Cited by 163

Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma

Walter, D. M., Venancio, O. S., Buza, E. L., Tobias, J. W., Deshpande, C. G., Gudiel, A. A., Kim-Kiselak, C., Cicchini, M., Yates, T. J., & Feldser, D. M. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2159 · Cited by 148

Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance

Morkel, M., Riemer, P., Bläker, H., & Sers, C. (2015) · Oncotarget · doi:10.18632/oncotarget.4750 · Cited by 146

An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations

Caulı́n, C., Nguyen, T., Lang, G. A., Goepfert, T. M., Brinkley, B. R., Cai, W., Lozano, G., & Roop, D. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31721 · Cited by 141

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma

Fox, R. G., Lytle, N. K., Jaquish, D. V., Park, F. D., Ito, T., Bajaj, J., Koechlein, C. S., Zimdahl, B., Yano, M., Kopp, J. L., et al. (2016) · Nature · doi:10.1038/nature17988 · Cited by 142

An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants

Zafra, M. P., Parsons, M. J., Kim, J., Alonso-Curbelo, D., Goswami, S., Schatoff, E. M., Han, T., Katti, A., Fernandez, M. T. C., Wilkinson, J. E., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0442 · Cited by 139

Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma

Lee, A. Y. L., Dubois, C. L., Sarai, K., Zarei, S., Schaeffer, D. F., Sander, M., & Kopp, J. L. (2019) · Gut · doi:10.1136/gutjnl-2017-314426 · Cited by 139

Endogenous expression of Hras G12V induces developmental defects and neoplasms with copy number imbalances of the oncogene

Chen, X., Mitsutake, N., LaPerle, K., Akeno, N., ZANZONICO, P. B., Longo, V. A., Mitsutake, S., Kimura, E. T., Geiger, H., Santos, E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900343106 · Cited by 144

A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment

Zhao, X., Liu, L., Lang, J., Cheng, K., Wang, Y., Li, X., Shi, J. Y., Wang, Y., & Nie, G. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.042 · Cited by 139

Krüppel-Like Factor 5 Mediates Cellular Transformation During Oncogenic KRAS-Induced Intestinal Tumorigenesis

Nandan, M. O., McConnell, B. B., Ghaleb, A. M., Bialkowska, A. B., Sheng, H., Shao, J., Babbin, B. A., Robine, S., & Yang, V. W. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.023 · Cited by 136

Mist1-KrasG12D Knock-In Mice Develop Mixed Differentiation Metastatic Exocrine Pancreatic Carcinoma and Hepatocellular Carcinoma

Tuveson, D. A., Zhu, L., Gopinathan, A., Willis, N. A., Kachatrian, L., Mishuris, R. G., Pin, C. L., Mitin, N., Taparowsky, E. J., Gimotty, P. A., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2305 · Cited by 136

ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer

Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M. A., Deswaerte, V., Tang, K., Jardé, T., Smith, J. A., Prodanovic, Z., et al. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809976 · Cited by 137

Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells

Lee, K. E., & Bar‐Sagi, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.020 · Cited by 138

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

Shaw, A. T., Meissner, A., Dowdle, J. A., Crowley, D., Magendantz, M., Ouyang, C., Parisi, T., Rajagopal, J., Blank, L. J., Bronson, R. T., et al. (2007) · Genes & Development · doi:10.1101/gad.1526207 · Cited by 131

The atypical PKCs in inflammation: NF‐κB and beyond

Díaz-Meco, M. T., & Moscat, J. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01093.x · Cited by 132

Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models

Vicent, S., Ron, C., Sayles, L. C., Lin, C., Walker, R. G., Gillespie, A. K., Subramanian, A., Hinkle, G., Yang, X., Saif, S., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44165 · Cited by 131

Response and Resistance to NF-κB Inhibitors in Mouse Models of Lung Adenocarcinoma

Xue, W., Meylan, E., Oliver, T. G., Feldser, D. M., Winslow, M. M., Bronson, R. T., & Jacks, T. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0073 · Cited by 131

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

Johnson, T. M., Hammond, E. M., Giaccia, A. J., & Attardi, L. D. (2005) · Nature Genetics · doi:10.1038/ng1498 · Cited by 134

Classification of KRAS -Activating Mutations and the Implications for Therapeutic Intervention

Johnson, C. W., Burkhart, D. L., & Haigis, K. M. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0035 · Cited by 134

Cerebrospinal Fluid Proteomic Analysis Reveals Dysregulation of Methionine Aminopeptidase-2 Expression in Human and Mouse Neurofibromatosis 1–Associated Glioma

Dasgupta, B., Yi, Y., Hegedűs, B., Weber, J. D., & Gutmann, D. H. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1842 · Cited by 128

Conditional Expression of K- ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis

Vitale-Cross, L. A., Amornphimoltham, P., Fisher, G. H., Molinolo, A., & Gutkind, J. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2623 · Cited by 133

Oncogenic Kras Requires Simultaneous PI3K Signaling to Induce ERK Activation and Transform Thyroid Epithelial Cells In vivo

Miller, K. A., Yeager, N., Baker, K., Liao, X.-H., Refetoff, S., & Cristofano, A. D. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0024 · Cited by 128

The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis

Rajurkar, M., DeJesus-Monge, W. E., Driscoll, D. R., Appleman, V. A., Huang, H., Cotton, J. L., Klimstra, D., Zhu, L., Simin, K., Xu, L., et al. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1114168109 · Cited by 119

Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1genes

Gelsi‐Boyer, V., Trouplin, V., Adélaı̈de, J., Aceto, N., Rémy, V., Pinson, S., Houdayer, C., Arnoulet, C., Sainty, D., Bentires‐Alj, M., et al. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-299 · Cited by 135

Use of gene expression profiling to direct in vivo molecular imaging of lung cancer

Grimm, J., Kirsch, D. G., Windsor, S. D., Kim, C. F. B., Santiago, P. M., Ntziachristos, V., Jacks, T., & Weissleder, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503920102 · Cited by 129

Ras proteins: paradigms for compartmentalised and isoform-specific signalling

Omerović, J., Laude, A., & Prior, I. A. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7133-8 · Cited by 130

Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas

Vincent, D. F., Yan, K.-P., Treilleux, I., Gay, F., Arfi, V., Kaniewski, B., Marie, J. C., Lépinasse, F., Martel, S., Goddard‐Léon, S., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000575 · Cited by 122

β1 integrin–dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin

Sabra, H., Brunner, M., Mandati, V., Wehrle‐Haller, B., Lallemand, D., Ribba, A., Chevalier, G., Guardiola, P., Block, M. R., & Bouvard, D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.808063 · Cited by 121

Targeting the Complement Pathway as a Therapeutic Strategy in Lung Cancer

Kleczko, E. K., Kwak, J., Schenk, E. L., & Nemenoff, R. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00954 · Cited by 122

Ras-Raf-Arf Signaling Critically Depends on the Dmp1 Transcription Factor

Sreeramaneni, R., Chaudhry, A., McMahon, M., Sherr, C. J., & Inoue, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.220-232.2005 · Cited by 123

Heterogeneity and plasticity of epidermal stem cells

Schepeler, T., Page, M. E., & Jensen, K. B. (2014) · Development · doi:10.1242/dev.104588 · Cited by 125

Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation

Mills, L. D., Zhang, Y., Marler, R. J., Herreros‐Villanueva, M., Zhang, L., Almada, L. L., Couch, F. J., Wetmore, C., di Magliano, M. P., & Fernández-Zapico, M. E. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.438846 · Cited by 120

Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids

Huang, L., Desai, R., Conrad, D. N., Leite, N. C., Akshinthala, D., Lim, C. M., González, R. S., Muthuswamy, L. B., Gartner, Z. J., & Muthuswamy, S. K. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.03.022 · Cited by 119

Animal models of colorectal cancer

Johnson, R. L., & Fleet, J. C. (2012) · Cancer and Metastasis Reviews · doi:10.1007/s10555-012-9404-6 · Cited by 125

Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia

Wang, J., Liu, Y., Li, Z., Du, J., Ryu, M., Taylor, P. R., Fleming, M. D., Young, K. H., Pitot, H. C., & Zhang, J. (2010) · Blood · doi:10.1182/blood-2010-04-281527 · Cited by 118

IL17 Functions through the Novel REG3β–JAK2–STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer

Loncle, C., Bonjoch, L., Folch‐Puy, E., López‐Millán, B., Lac, S., Molejon, M. I., Chuluyán, E., Cordelier, P., Dubus, P. R., Lomberk, G. A., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0896 · Cited by 116

Deregulated Ras signaling in developmental disorders: new tricks for an old dog

Schubbert, S., Bollag, G. E., & Shannon, K. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.12.004 · Cited by 117

Pten Inactivation Accelerates Oncogenic K-ras –Initiated Tumorigenesis in a Mouse Model of Lung Cancer

Iwanaga, K., Yang, Y., Raso, M. G., Ma, L., Hanna, A. E., Thilaganathan, N., Moghaddam, S. J., Evans, C. M., Li, H., Cai, W., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3117 · Cited by 118

Keratinocytic epidermal nevi are associated with mosaic RAS mutations

Hafner, C. M., Toll, A., Gantner, S., Mauerer, A., Lurkin, I., Acquadro, F., Fernández-Casado, A., Zwarthoff, E. C., Dietmaier, W., Baselga, E., et al. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2011-100637 · Cited by 115

Ral GTPases: corrupting the exocyst in cancer cells

Camonis, J., & White, M. A. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.04.002 · Cited by 115

PTEN dosage is essential for neurofibroma development and malignant transformation

Gregorian, C., Nakashima, J. K., Dry, S., Nghiemphu, P. L., Smith, K. B., Ao, Y., Dang, J. H. T., Lawson, G. W., Mellinghoff, I. K., Mischel, P. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910398106 · Cited by 115

Inducible Activation of Oncogenic K- ras Results in Tumor Formation in the Oral Cavity

Caulı́n, C., Nguyen, T., Longley, M. A., Zhou, Z., Wang, X., & Roop, D. R. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1488 · Cited by 114

Precision cancer mouse models through genome editing with CRISPR-Cas9

Mou, H., Kennedy, Z., Anderson, D. G., Yin, H., & Xue, W. (2015) · Genome Medicine · doi:10.1186/s13073-015-0178-7 · Cited by 116

K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells

Meter, M. E. M. V., Díaz-Flores, E., Archard, J. A., Passegue, E. A., Irish, J. M., Kotecha, N., Nolan, G. P., Shannon, K., & Braun, B. S. (2006) · Blood · doi:10.1182/blood-2006-09-047530 · Cited by 114

Genetic reconstitution of tumorigenesis in primary intestinal cells

Onuma, K., Ochiai, M., Orihashi, K., Takahashi, M., Imai, T., Nakagama, H., & Hippo, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221926110 · Cited by 116

Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen

Poole, A. J., Karuppiah, V., Hartt, A., Haidar, J. N. S., Moureau, S., Dobrzycki, T., Hayes, C., Rowley, C. N., Dias, J. C., Harper, S. J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32811-1 · Cited by 115

Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I

Kudo, N. R., Anger, M., Peters, A. H. F. M., Stemmann, O., Theussl, H., Helmhart, W., Kudo, H., Heyting, C., & Nasmyth, K. (2009) · Journal of Cell Science · doi:10.1242/jcs.035287 · Cited by 112

RIT1 oncoproteins escape LZTR1-mediated proteolysis

Castel, P., Cheng, A. S., Cuevas-Navarro, A., Everman, D. B., Papageorge, A. G., Simanshu, D. K., Tankka, A. T., Galeas, J., Urisman, A., & McCormick, F. P. (2019) · Science · doi:10.1126/science.aav1444 · Cited by 114

Epithelial Tissues Have Varying Degrees of Susceptibility to KrasG12D-Initiated Tumorigenesis in a Mouse Model

Ray, K. C., Bell, K. M., Yan, J., Gu, G., Chung, C. H., Washington, M. K., & Means, A. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016786 · Cited by 113

CDK1 couples proliferation with protein synthesis

Haneke, K., Schott, J., Lindner, D., Hollensen, A. K., Damgaard, C. K., Mongis, C., Knop, M., Palm, W., Ruggieri, A., & Stoecklin, G. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.201906147 · Cited by 112

Epithelial and stromal co-evolution and complicity in pancreatic cancer

Hingorani, S. R. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00530-w · Cited by 108

BRAF vs RAS oncogenes: are mutations of the same pathway equal? differential signalling and therapeutic implications

Oikonomou, E., Koustas, E., Goulielmaki, M., & Pintzas, A. (2014) · Oncotarget · doi:10.18632/oncotarget.2555 · Cited by 113

Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer

McLoed, A. G., Sherrill, T. P., Cheng, D.-S., Han, W., Saxon, J. A., Gleaves, L. A., Wu, P., Polosukhin, V. V., Karin, M., Yull, F. E., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.085 · Cited by 107

MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice

Cogoi, S., Zorzet, S., Rapozzi, V., Géci, I., Pedersen, E. B., & Xodo, L. E. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt127 · Cited by 106

Role of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development

Chung, E., & Kondo, M. (2010) · Immunologic Research · doi:10.1007/s12026-010-8187-5 · Cited by 107

GLI1: A Therapeutic Target for Cancer

Avery, J. T., Zhang, R., & Boohaker, R. J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.673154 · Cited by 110

TGF-β Receptor Inactivation and Mutant Kras Induce Intestinal Neoplasms in Mice via a β-Catenin-Independent Pathway

Trobridge, P. A., Knoblaugh, S. E., Washington, M. K., Muñoz, N. M., Tsuchiya, K. D., Muñoz-Rojas, A. R., Song, X., Ulrich, C. M., Sasazuki, T., Shirasawa, S., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.066 · Cited by 103

Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation

Zhang, J., Wang, J., Liu, Y., Sidik, H., Young, K. H., Lodish, H. F., & Fleming, M. D. (2008) · Blood · doi:10.1182/blood-2008-01-134262 · Cited by 105

Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8+ T cell activation and limit responsiveness to immunotherapy in mice

Assouline, B., Kahn, R., Hodali, L., Condiotti, R., Engel, Y., Elyada, E., Mordechay‐Heyn, T., Pitarresi, J. R., Atias, D., Steinberg, E., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50441-7 · Cited by 105

Ras isoform abundance and signalling in human cancer cell lines

Omerović, J., Hammond, D. E., Clague, M. J., & Prior, I. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210925 · Cited by 101

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

Guerra, C. E., Mijimolle, N., Dhawahir, A., Dubus, P. R., Barradas, M., Serrano, M., Campuzano, V., & Barbacid, M. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00191-0 · Cited by 577

Mouse Tissues that Undergo Neoplastic Progression after K-Ras Activation Are Distinguished by Nuclear Translocation of phospho-Erk1/2 and Robust Tumor Suppressor Responses

Parikh, N., Shuck, R. L., Nguyen, T., Herron, A. J., & Donehower, L. A. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0089 · Cited by 21

Conditional Expression of K- ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis

Vitale-Cross, L. A., Amornphimoltham, P., Fisher, G. H., Molinolo, A., & Gutkind, J. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2623 · Cited by 133

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

Braun, B. S., Tuveson, D. A., Kong, N., Le, D. T., Kogan, S. C., Rozmus, J., Le Beau, M. M., Jacks, T. E., & Shannon, K. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307203101 · Cited by 299

Activating the Expression of Human K-rasG12D Stimulates Oncogenic Transformation in Transgenic Goat Fetal

Gong, J., Wang, Z., Polejaeva, I., Salgia, R., Kao, C., Chen, T., Cells, F., Gong, J., Polejaeva, I. A., Salgia, R., et al. (2016)