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Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?
Abstract
The first studies carried out on the mechanisms by which peripheral immune stimuli signal the brain to induce fever, activation of the hypothalamic-pituitary-adrenal axis and sickness behavior emphasized the importance of fenestrated parts of the blood-brain barrier known as circumventricular organs for allowing blood-borne proinflammatory cytokines to act on brain functions. The discovery in the mid-1990s that subdiaphragmatic section of the vagus nerves attenuates the brain effects of systemic cytokines, together with the demonstration of an inducible brain cytokine compartment shifted the attention from circumventricular organs to neural pathways in the transmission of the immune message to the brain. Since then, neuroanatomical studies have confirmed the existence of a fast route of communication from the immune system to the brain via the vagus nerves. This neural pathway is complemented by a humoral pathway that involves cytokines produced at the level of the circumventricular organs and the choroid plexus and at the origin of a second wave of cytokines produced in the brain parenchyma. Depending on their source, these locally produced cytokines can either activate neurons that project to specific brain areas or diffuse by volume transmission into the brain parenchyma to reach their targets. Activation of neurons by cytokines can be direct or indirect, via prostaglandins. The way the neural pathway of transmission interacts with the humoral pathway remains to be elucidated.
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“Animal and human studies suggest that pro-inflammatory cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α play a pivotal role in mediating sickness-related behavior and cognitive impairments by communicating peripheral inflammation to the brain [1], [3], [15], [16], [17].”
From Dose-dependent effects of endotoxin on neurobehavioral functions in humans (2011) · cites this paper as [15]
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Metadata
- Authors
- Dantzer, R., Konsman, J.-P., Bluthé, R.-M., & Kelley, K. W.
- Affiliations
- Inserm (FR)
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Dantzer, Robert
- Venue
- Autonomic Neuroscience
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 85
- Issue
- 1-3
- Pages
- 60-65
- ISSN
- 1566-0702 (ISSN-L)
- OpenAlex
- W2011871032
- Cited by
- 400
- References
- 65
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 18 · 2023: 20 · 2022: 18 · 2021: 19 · 2020: 19 · 2019: 19 · 2018: 14 · 2017: 16 · 2016: 14 · 2015: 18 · 2014: 17 · 2013: 17 · 2012: 17
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autonomic Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- National Institutes of Health (5k08mh001258-05)
- National Institute of Mental Health (R01MH051569, MH-1258, MH51569)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuroimmune interactions, vagus nerve, cytokine signaling, circumventricular organs, choroid plexus, fever, sickness behavior, hypothalamic-pituitary-adrenal axis, inflammatory cytokines, volume transmission, prostaglandins, brain cytokines
- MeSH terms
- Animals, Antibody Formation, Brain, Neural Pathways, Vagus Nerve, Neuroimmunomodulation
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