Charting the landscape of priority problems in psychiatry, part 2: pathogenesis and aetiology
Abstract
This is the second of two companion papers proposing priority problems for research on mental disorders. Whereas the first paper focuses on questions of nosology and diagnosis, this Personal View concerns pathogenesis and aetiology of psychiatric diseases. We hope that this (non-exhaustive and subjective) list of problems, nominated by scientists and clinicians from different fields and institutions, provides guidance and perspectives for choosing future directions in psychiatric science.
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These quantities span a three-dimensional space where different pathologies could be located.
“These quantities span a three-dimensional space where different pathologies could be located (86).”
From Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice? (2016) · cites this paper as [86]
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- Authors
- Stephan, K. E., Binder, E. B., Breakspear, M., Dayan, P., Johnstone, E. C., Meyer-Lindenberg, A., Schnyder, U., Wang, X.-J., Bach, D. R., Fletcher, P. C., Flint, J., Frank, M. J., Heinz, A., Huys, Q. J. M., Montague, P. R., Owen, M. J., & Friston, K. J.
- Affiliations
- Wellcome Centre for Human Neuroimaging (GB)
- Emory University (US)
- QIMR Berghofer Medical Research Institute (AU)
- Gatsby Computational Neuroscience Unit (GB)
- University of Edinburgh (GB)
- University of Zurich (CH)
- New York University Shanghai (CN)
- University of Cambridge (GB)
- Brown University (US)
- Humboldt-Universität zu Berlin (DE)
- Cardiff University (GB)
- Corresponding author
- Stephan, Klaas E
- ORCID
- Venue
- The Lancet Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 3
- Issue
- 1
- Pages
- 84-90
- ISSN
- 2215-0366 (ISSN-L)
- OpenAlex
- W2100222965
- Cited by
- 64
- References
- 93
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 8 · 2020: 10 · 2019: 9 · 2018: 4 · 2017: 8 · 2016: 8 · 2015: 1
- FWCI
- 21.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Max Planck Digital Library (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Wellcome Trust (091593, 503147, 091188, 095692, 093875)
- Medical Research Council (MR/L010305/1)
- National Institute of Mental Health (R01MH062349)
- Topics
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Clinical Psychology › Psychology and Mental Health
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- pathogenesis, etiology, mental illness, psychiatric classification, psychiatric diagnosis, research agenda
- MeSH terms
- Mental Disorders, Humans, Psychiatry, Research
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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