Cited by 141Antioxidant Activity and Oxidative StressNutritional Studies and DietPhytochemicals and Antioxidant Activities

Plasma concentrations of carotenoids and vitamin C are better correlated with dietary intake in normal weight than overweight and obese elderly subjects

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Vioque, Jesús, Weinbrenner, Tanja, Asensio, Laura, Castelló, Adela, Young, Ian S., Fletcher, Astrid·2007·British Journal Of Nutrition

Abstract

Carotenoid and vitamin C intakes, assessed by FFQ, have been positively associated with plasma concentrations in different populations. However, the influence of BMI on these associations has not been explored in detail. We explored in a cross-sectional study the relation between dietary carotenoid and vitamin C intakes, using a 135-item FFQ, with their plasma concentrations by BMI categories in 252 men and 293 women, 65 years and older. For men and women combined, significant (P < 0.05) Pearson correlations were observed between energy-adjusted dietary intakes and plasma concentrations (carotenoids adjusted for cholesterol) for: alpha-carotene 0.21, beta-carotene 0.19, lycopene 0.18, beta-cryptoxanthin 0.20 and vitamin C 0.36. Multiple linear regression analyses showed that the intake of carotenoids and vitamin C were significant predictors of their respective plasma concentration (P<0.01), and that BMI was inversely associated with plasma concentration of carotenoids (P< or =0.01) but not with plasma vitamin C. In addition, we observed significant interactions between BMI and the intakes of alpha-carotene and lutein + zeaxanthin, and to a lower extent beta-carotene, suggesting that these intakes in subjects with high BMI were not good predictors of their plasma concentration. The present data suggest that plasma carotenoids and vitamin C may be good markers of dietary intake in elderly subjects, but not so for alpha-carotene, beta-carotene and lutein + zeaxanthin in obese subjects.

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  • Dietary biomarker concentrations can be altered by genetic factors, physiologic or health status, dietary factors, and lifestyle factors.

    “They may be altered because of possible interactions with genetic factors, physiologic or health status (ie, age or obesity) (30), dietary factors such as fats for lipophilic biomarkers (31), and lifestyle factors such as alcohol intake or smoking (32).”

    From The food metabolome: a window over dietary exposure (2014) · cites this paper as [30]

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  1. Hunter D (1998) Biochemical indicators of dietary intake. In Nutri- tional Epidemiology, pp. 174-243 [
  2. Vioque J (1995) Validez de la evaluacio ´n de la ingesta diete ´tica [in Spanish]. In Nutricio ´n y Salud Pu ´blica. Me ´todos, Bases Cientı ´ficas y Aplicaciones, pp. 132-136 [

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Authors
Vioque, J., Weinbrenner, T., Asensio, L., Castelló, A., Young, I. S., & Fletcher, A.
Affiliations
  • Universitat de Miguel Hernández d'Elx (ES)
  • Queen's University Belfast (GB)
  • London School of Hygiene & Tropical Medicine (GB)
Venue
British Journal Of Nutrition
Published
2007-05
Volume
97
Issue
5
Pages
977-986
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
OpenAlex
W2136305782
Cited by
141
References
53
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 11 · 2019: 9 · 2018: 12 · 2017: 9 · 2016: 13 · 2015: 12 · 2014: 11 · 2013: 9 · 2012: 7
FWCI
3.60
Type
journal article
Language
en
Open access
Locations
  • British Journal Of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
Funders
  • European Commission
  • Generalitat Valenciana (G 03/136)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
carotenoids, vitamin C, plasma carotenoid concentrations, dietary intake, body mass index, obesity, overweight, older adults, alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, lutein/zeaxanthin, dietary biomarkers, dietary assessment
MeSH terms
Lycopene, Aged, Antioxidants, Ascorbic Acid, Energy Intake, Carotenoids, Cholesterol, Cross-Sectional Studies, Diet, Female, Humans, Male, Obesity, Spain, Vitamins, Body Mass Index, Prevalence, beta Carotene, Xanthophylls, Overweight, Cryptoxanthins

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