Dietary Genistein Prevents Denervation-Induced Muscle Atrophy in Male Rodents Via Effects on Estrogen Receptor-α
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Background Genistein has high estrogenic activity. Previous studies have shown beneficial effects of estrogen or hormone replacement therapy on muscle mass and muscle atrophy.Objective We investigated the preventive effects and underlying mechanisms of genistein on muscle atrophy.Methods In Expt. 1, male Wistar rats were fed a diet containing no genistein [control (CON)] or 0.05% genistein (GEN; wt:wt diet) for 24 d. On day 14, the sciatic nerve in the left hind leg was severed, and the right hind leg was sham-treated. In Expt. 2, male C57BL6J mice were subcutaneously administered a vehicle (Veh group) or the estrogen receptor (ER) antagonist ICI 182,780 (ICI group) via an osmotic pump for 27 d, and each group was subsequently fed CON or GEN diets from day 3 to day 27. Muscle atrophy was induced on day 17 as in Expt. 1. In Expt. 3, male C57BL6J mice were subcutaneously administered vehicle or a selective ER agonist-ER-α [4,4',4'-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT)] or ER-β [2,3-bis(4-hydroxyphenyl)-propionitrile (DPN)]-or genistein (GEN-sc-i) via an osmotic pump for 13 d, and muscle atrophy was induced on day 3 as in Expt. 1. The ratio of denervated soleus muscle weight to sham-operated soleus muscle weight (d/s ratio) was used as the index of muscle atrophy.Results Expt. 1: The d/s ratio in the GEN group was 20% higher than that in the CON group (P < 0.05). Expt. 2: The d/s ratio in the Veh-GEN group was 14% higher than that in the Veh-CON group (P < 0.05), although there was no significant difference between ICI-CON and ICI-GEN groups (P = 0.69). Expt. 3: The d/s ratio in the PPT-treated group was 20% greater than that in the Veh group (P < 0.05), but DPN and GEN-sc-i had no effect on the d/s ratio (P ≥ 0.05 compared with vehicle).Conclusion Genistein intake mitigated denervation-induced soleus muscle atrophy. ER-α was related to the preventive effect of genistein on muscle atrophy.
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Dietary genistein supplementation attenuates denervation-induced muscle atrophy in male C57BL/6J mice.
“Whereafter, Aoyama et al. found that dietary genistein supplementation attenuates denervation-induced muscle atrophy in male C57BL/6J mice [115].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [115]
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- Authors
- Aoyama, S., Jia, H., Nakazawa, K., Yamamura, J., Saito, K., & Kato, H.
- Affiliations
- The University of Tokyo (JP)
- Corresponding author
- Kato, Hisanori
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 146
- Issue
- 6
- Pages
- 1147-1154
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2347034027
- Cited by
- 23
- References
- 37
- Citations by year
- 2023: 2 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Agriculture, Forestry, and Fisheries
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- genistein, muscle atrophy, denervation, sciatic nerve transection, estrogen receptor alpha, estrogen receptor beta, soleus muscle, fulvestrant, selective estrogen receptor agonists, dietary supplementation, muscle mass, mice, phytoestrogens, sex differences, insulin-like growth factor I
- MeSH terms
- Forkhead Box Protein O1, Fulvestrant, Animals, Diet, Estradiol, Male, Mice, Inbred C57BL, Muscle Denervation, Muscular Atrophy, Nerve Tissue Proteins, Nitriles, Phenols, Propionates, Pyrazoles, Rats, Wistar, Muscle, Skeletal, Genistein, Estrogen Receptor alpha, Estrogen Receptor beta, Mice, Rats, Estrogen Receptor Antagonists
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