The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A systematic review of vitamin D status in populations worldwide
Open accessAbstract
Vitamin D deficiency is associated with osteoporosis and is thought to increase the risk of cancer and CVD. Despite these numerous potential health effects, data on vitamin D status at the population level and within key subgroups are limited. The aims of the present study were to examine patterns of 25-hydroxyvitamin D (25(OH)D) levels worldwide and to assess differences by age, sex and region. In a systematic literature review using the Medline and EMBASE databases, we identified 195 studies conducted in forty-four countries involving more than 168 000 participants. Mean population-level 25(OH)D values varied considerably across the studies (range 4·9–136·2 nmol/l), with 37·3 % of the studies reporting mean values below 50 nmol/l. The highest 25(OH)D values were observed in North America. Although age-related differences were observed in the Asia/Pacific and Middle East/Africa regions, they were not observed elsewhere and sex-related differences were not observed in any region. Substantial heterogeneity between the studies precluded drawing conclusions on overall vitamin D status at the population level. Exploratory analyses, however, suggested that newborns and institutionalised elderly from several regions worldwide appeared to be at a generally higher risk of exhibiting lower 25(OH)D values. Substantial details on worldwide patterns of vitamin D status at the population level and within key subgroups are needed to inform public health policy development to reduce risk for potential health consequences of an inadequate vitamin D status.
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Metadata
- Authors
- Hilger, J., Friedel, A., Herr, R., Rausch, T., Roos, F., Wahl, D. A., Pierroz, D. D., Weber, P., & Hoffmann, K.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-08-09
- Volume
- 111
- Issue
- 1
- Pages
- 23-45
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2068855200
- Cited by
- 832
- References
- 9
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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