Association of dietary fibre intake and gut microbiota in adults
Open accessAbstract
Increasing evidence indicates that gut microbiota may influence colorectal cancer risk. Diet, particularly fibre intake, may modify gut microbiota composition, which may affect cancer risk. We investigated the relationship between dietary fibre intake and gut microbiota in adults. Using 16S rRNA gene sequencing, we assessed gut microbiota in faecal samples from 151 adults in two independent study populations: National Cancer Institute (NCI),n 75, and New York University (NYU),n 76. We calculated energy-adjusted fibre intake based on FFQ. For each study population with adjustment for age, sex, race, BMI and smoking, we evaluated the relationship between fibre intake and gut microbiota community composition and taxon abundance. Total fibre intake was significantly associated with overall microbial community composition in NYU (P=0·008) but not in NCI (P=0·81). In a meta-analysis of both study populations, higher fibre intake tended to be associated with genera of class Clostridia, including higher abundance of SMB53(fold change (FC)=1·04,P=0·04),Lachnospira(FC=1·03,P=0·05) and Faecalibacterium(FC=1·03,P=0·06), and lower abundance of Actinomyces(FC=0·95,P=0·002),Odoribacter(FC=0·95,P=0·03) and Oscillospira(FC=0·96,P=0·06). A species-level meta-analysis showed that higher fibre intake was marginally associated with greater abundance of Faecalibacterium prausnitzii(FC=1·03,P=0·07) and lower abundance of Eubacterium dolichum(FC=0·96,P=0·04) and Bacteroides uniformis(FC=0·97,P=0·05). Thus, dietary fibre intake may impact gut microbiota composition, particularly class Clostridia, and may favour putatively beneficial bacteria such as F. prausnitzii. These findings warrant further understanding of diet–microbiota relationships for future development of colorectal cancer prevention strategies.
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Lachnospira has been positively associated with high dietary fiber consumption in a human prospective study.
“Lachnospira has been positively associated with high dietary fiber consumption in a human prospective study (Lin et al., 2018).”
From Gut-microbiota-targeted diets modulate human immune status (2021) · cites this paper as Lin et al., 2018
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Gut-microbiota-targeted diets modulate human immune status
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- Authors
- Lin, D., Peters, B. A., Friedlander, C., Freiman, H. J., Goedert, J. J., Sinha, R., Miller, G., Bernstein, M. A., Hayes, R. B., & Ahn, J.
- Affiliations
- NYU Langone Health (US)
- New York University (US)
- National Institutes of Health (US)
- ORCID
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2018-10-24
- Volume
- 120
- Issue
- 9
- Pages
- 1014-1022
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- PMC
- PMC8451428
- OpenAlex
- W2898610897
- Cited by
- 109
- References
- 51
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 18 · 2023: 14 · 2022: 12 · 2021: 17 · 2020: 16 · 2019: 3
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Cancer Institute (P20CA252728, R01CA159036, R21CA183887, R03CA159414, U01CA182370, R01CA164964, P30CA016087)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- dietary fiber intake, gut microbiota, colorectal cancer risk, Faecalibacterium prausnitzii, Clostridia, Faecalibacterium, Lachnospira, Oscillospira, Bacteroides uniformis, microbial community composition
- MeSH terms
- Eubacteriales, Gastrointestinal Microbiome, Bacteria, Bacteroides, Energy Intake, Diet, Dietary Fiber, Eubacterium, Feces, Female, Fermentation, Humans, Male, Middle Aged, RNA, Ribosomal, 16S, Reproducibility of Results, Lactobacillales
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