Cited by 109Gut microbiota and healthNutritional Studies and DietFood composition and properties

Association of dietary fibre intake and gut microbiota in adults

Open access
Lin, Daniel, Peters, Brandilyn A., Friedlander, Charles, Freiman, Hal J., Goedert, James J., Sinha, Rashmi, Miller, George, Bernstein, Mitchell A. +2 more·2018·British Journal of Nutrition

Abstract

Increasing evidence indicates that gut microbiota may influence colorectal cancer risk. Diet, particularly fibre intake, may modify gut microbiota composition, which may affect cancer risk. We investigated the relationship between dietary fibre intake and gut microbiota in adults. Using 16S rRNA gene sequencing, we assessed gut microbiota in faecal samples from 151 adults in two independent study populations: National Cancer Institute (NCI),n 75, and New York University (NYU),n 76. We calculated energy-adjusted fibre intake based on FFQ. For each study population with adjustment for age, sex, race, BMI and smoking, we evaluated the relationship between fibre intake and gut microbiota community composition and taxon abundance. Total fibre intake was significantly associated with overall microbial community composition in NYU (P=0·008) but not in NCI (P=0·81). In a meta-analysis of both study populations, higher fibre intake tended to be associated with genera of class Clostridia, including higher abundance of SMB53(fold change (FC)=1·04,P=0·04),Lachnospira(FC=1·03,P=0·05) and Faecalibacterium(FC=1·03,P=0·06), and lower abundance of Actinomyces(FC=0·95,P=0·002),Odoribacter(FC=0·95,P=0·03) and Oscillospira(FC=0·96,P=0·06). A species-level meta-analysis showed that higher fibre intake was marginally associated with greater abundance of Faecalibacterium prausnitzii(FC=1·03,P=0·07) and lower abundance of Eubacterium dolichum(FC=0·96,P=0·04) and Bacteroides uniformis(FC=0·97,P=0·05). Thus, dietary fibre intake may impact gut microbiota composition, particularly class Clostridia, and may favour putatively beneficial bacteria such as F. prausnitzii. These findings warrant further understanding of diet–microbiota relationships for future development of colorectal cancer prevention strategies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1017/s0007114518002465

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Lachnospira has been positively associated with high dietary fiber consumption in a human prospective study.

    “Lachnospira has been positively associated with high dietary fiber consumption in a human prospective study (Lin et al., 2018).”

    From Gut-microbiota-targeted diets modulate human immune status (2021) · cites this paper as Lin et al., 2018

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lin, D., Peters, B. A., Friedlander, C., Freiman, H. J., Goedert, J. J., Sinha, R., Miller, G., Bernstein, M. A., Hayes, R. B., & Ahn, J.
Affiliations
  • NYU Langone Health (US)
  • New York University (US)
  • National Institutes of Health (US)
Venue
British Journal of Nutrition
Published
2018-10-24
Volume
120
Issue
9
Pages
1014-1022
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
OpenAlex
W2898610897
Cited by
109
References
51
Citations by year
2026: 12 · 2025: 17 · 2024: 18 · 2023: 14 · 2022: 12 · 2021: 17 · 2020: 16 · 2019: 3
FWCI
3.20
Type
journal article
Language
en
Open access
Locations
  • British Journal Of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Veterans Affairs
  • National Institutes of Health
  • National Cancer Institute (P20CA252728, R01CA159036, R21CA183887, R03CA159414, U01CA182370, R01CA164964, P30CA016087)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Keywords
dietary fiber intake, gut microbiota, colorectal cancer risk, Faecalibacterium prausnitzii, Clostridia, Faecalibacterium, Lachnospira, Oscillospira, Bacteroides uniformis, microbial community composition
MeSH terms
Eubacteriales, Gastrointestinal Microbiome, Bacteria, Bacteroides, Energy Intake, Diet, Dietary Fiber, Eubacterium, Feces, Female, Fermentation, Humans, Male, Middle Aged, RNA, Ribosomal, 16S, Reproducibility of Results, Lactobacillales

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review