The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index; 6 of the 21 sources its claims cite were checked for support.
Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages
Open accessAbstract
The effects of different polyphenol-containing beverages on Fe absorption from a bread meal were estimated in adult human subjects from the erythrocyte incorporation of radio-Fe. The test beverages contained different polyphenol structures and were rich in either phenolic acids (chlorogenic acid in coffee), monomeric flavonoids (herb teas, camomile ( Matricaria recutita L.)), vervain ( Verbena officinalis L.), lime flower ( Tilia cordata Mill.), pennyroyal ( Mentha pulegium L.) and peppermint ( Mentha piperita L.), or complex polyphenol polymerization products (black tea and cocoa). All beverages were potent inhibitors of Fe absorption and reduced absorption in a dose-dependent fashion depending on the content of total polyphenols. Compared with a water control meal, beverages containing 20–50 mg total polyphenols/serving reduced Fe absorption from the bread meal by 50–70 %, whereas beverages containing 100–400 mg total polyphenols/serving reduced Fe absorption by 60–90 %. Inhibition by black tea was 79–94 %, peppermint tea 84 %, pennyroyal 73 %, cocoa 71 %, vervain 59 %, lime flower 52 % and camomile 47 %. At an identical concentration of total polyphenols, black tea was more inhibitory than cocoa, and more inhibitory than herb teas camomile, vervain, lime flower and pennyroyal, but was of equal inhibition to peppermint tea. Adding milk to coffee and tea had little or no influence on their inhibitory nature. Our findings demonstrate that herb teas, as well as black tea, coffee and cocoa can be potent inhibitors of Fe absorption. This property should be considered when giving dietary advice in relation to Fe nutrition.
Overview
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Written from the paper’s full text.
TL;DR
In adult volunteers, polyphenol-containing beverages—black tea, herb teas, coffee and cocoa—strongly inhibited non-haem iron absorption from a bread meal in a dose-dependent manner. Black tea was generally most inhibitory, and adding milk had little or no effect.
Key findings
- All test beverages inhibited Fe absorption dose-dependently: beverages with 20–50 mg total polyphenols/serving reduced absorption by 50–70%, while those with 100–400 mg/serving reduced absorption by 60–90%.
- Compared with water control meals, absorption ratios were black tea 0.06–0.21, peppermint 0.16, pennyroyal 0.27, cocoa 0.29, vervain 0.41, lime flower 0.48 and camomile 0.53; corresponding inhibition was black tea 79–94%, peppermint 84%, pennyroyal 73%, cocoa 71%, vervain 59%, lime flower 52% and camomile 47%.
- At identical total polyphenol concentrations, black tea was more inhibitory than cocoa and the herb teas camomile, vervain, lime flower and pennyroyal, but equal to peppermint tea. Even 5% black tea, containing only 20 mg polyphenol/serving, reduced Fe absorption by almost 70% (absorption ratio 0.34).
- Adding milk had little or no influence: milk slightly increased Fe absorption from tea (0.71% to 0.96%; ratio 1.36, P<0.05) but had no effect on coffee (ratio 1.04, P>0.05). Coffee was less inhibitory than tea (2.81% vs 0.71% in study 6).
Methods
- Eight separate Fe absorption studies were performed in 77 volunteers (23 males, 54 females, aged 19–40 years), with 8–10 subjects per study; all were healthy and non-anaemic, serum ferritin ranged from 9 to 193 g/l, and five female subjects were Fe-deficient (serum ferritin ≤12 g/l).
- Fe absorption was measured by the extrinsic tag radio-Fe technique using 55Fe and 59Fe, with test meals of Fe-fortified bread rolls plus beverages or water, and absorption estimated from erythrocyte incorporation at 2 weeks; four measurements were made per subject.
- Total polyphenols in tea, herb teas and cocoa were measured by the Folin-Ciocalteau method with catechin as standard; coffee was analysed for chlorogenic acid by the AOAC method; Fe was determined by atomic absorption spectroscopy. Statistical analysis used log-transformed absorption values and paired tests.
Limitations
- The authors state that their studies used a simple bread meal and may not extrapolate directly to more complex meals containing a wider range of Fe absorption inhibitors and enhancers; they also note that different herb tea concentrations contained different polyphenol types, which may explain the less clear polyphenol–absorption relationship for herb teas.
- The authors state that the important public-health question is whether regular consumption affects Fe status, but their single-meal studies cannot resolve this, and population evidence is mixed.
- Evident from the text: the findings are short-term absorption measurements rather than clinical iron-status outcomes, each study had only 8–10 subjects, and the wide serum ferritin range with five Fe-deficient women may influence absorption responses.
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Claims the paper makes
31 Own result · 7 No full text of the sources · 5 Own interpretation · 2 Supported · 2 Supported so far · 2 Partly supported · 2 Not checked yet · 2 Own method · 1 Sources not found · 1 No basis given · accuracy not yet measured
Every source the paper cites for this claim was checked and supports it.
In the paper
“Fe absorption from other vegetables rich in polyphenols, such as spinach and aubergine, has also been observed to be low and a significant negative correlation has been reported between the total polyphenol content of vegetable foods and absorption of their Fe content in man (Gillooly et al. 1983).”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Iron absorption: Polyphenols: Coffee: Tea
What the sources say
- Supportedcites Gillooly et al. 1983 source
The Discussion reports a strong inverse correlation between total polyphenol content and Fe absorption across the vegetables tested (r = −0.859, P < 0.001). It also identifies aubergine and spinach as vegetables with poor Fe absorption. This supports the attributed claim, with the correlation bounded to the vegetables studied. (LLM, conf=0.95)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“A major cause of Fe deficiency is the impaired absorption of non-haem Fe (Charlton & Bothwell, 1983) due to the presence of potent inhibitors of absorption such as phytic acid or polyphenol compounds in many plant foods (Fairweather-Tait & Hurrell, 1996).”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Iron absorption: Polyphenols: Coffee: Tea
What the sources say
- Not checked — no full text of the sourcecites Charlton & Bothwell, 1983 source
- Supportedcites Fairweather-Tait & Hurrell, 1996 source
The Phytic acid section identifies phytic acid in cereal grains and legumes as a major determinant of their low Fe bioavailability. The Polyphenols section identifies inhibitory phenolic compounds in plant foods, and the Conclusions state that both inhibit non-haem Fe absorption. The sentence cites Charlton & Bothwell, not this source, for the broader claim about a major cause of Fe deficiency. (LLM, conf=0.94)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“The added radio-Fe uniformly labels all the non-haem food Fe in the meal.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Absorption measurements
What the sources say
- Partly supportedcites Cook et al. 1972 sourceExperimental — accuracy not yet measured
The Introduction and Discussion (pages unavailable in our copy) say the extrinsic radioiron tag can assess absorption from a common pool of nonheme iron in a meal. They do not show that added radioiron uniformly labels all nonheme food iron; the Discussion reports that absorption of the extrinsic tag was about 10% greater than absorption of the intrinsic tag. (LLM, conf=0.87)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In studies 1-3 (Table 2) which compared peppermint teas, cocoa and black tea, the black tea had the greatest inhibitory effect on Fe absorption.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Results
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Compared with a water control meal, beverages containing 20-50 mg total polyphenols/serving reduced Fe absorption from the bread meal by 50-70 %, whereas beverages containing 100-400 mg total polyphenols/serving reduced Fe absorption by 60-90 %.”
- Also stated in: § Influence of polyphenols on iron absorption · hedged
“Despite these differences, our results would indicate that any beverage providing 20-50 mg total polyphenols would reduce Fe absorption from a bread meal by 50-70 %, whereas beverages containing 100-400 mg total polyphenols would reduce Fe absorption by 60-90 %.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Influence of polyphenols on iron absorption · hedged
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Percentage Fe absorption from black tea with bread (0⋅83 %) (study 7, Table 2) was slightly but not significantly (P Ͼ 0⋅05) lower than from black tea alone (1⋅00 %).”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Iron absorption from beverages alone
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Inhibition by black tea was 79-94 %, peppermint tea 84 %, pennyroyal 73 %, cocoa 71 %, vervain 59 %, lime flower 52 % and camomile 47 %.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, even a 5 % concentration of the original black tea, containing only 20 mg polyphenol/ serving, still reduced Fe absorption by almost 70 % (absorption ratio compared with the water meal 0⋅34), demonstrating the potent inhibitory effect of black tea polyphenols on Fe absorption.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Results
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At low polyphenol concentrations (about 50 mg/serving) black tea was more inhibitory to Fe absorption than the herb teas, camomile and lime flower, however, at higher polyphenol concentrations (about 200 mg/serving), black tea and peppermint tea were equally inhibitory.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Results
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At low polyphenol concentrations (about 50 mg/serving) black tea was more inhibitory to Fe absorption than the herb teas, camomile and lime flower, however, at higher polyphenol concentrations (about 200 mg/serving), black tea and peppermint tea were equally inhibitory.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Results
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- It may state two separate claims as one. 9
- Probably not a substantial claim. 5
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“The consumption of black tea and coffee has been shown to strongly inhibit Fe absorption from composite meals (Disler et al. 1975;Hallberg & Rossander, 1982;Morck et al. 1983), with coffee having about half the inhibitory effect of tea.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Iron absorption: Polyphenols: Coffee: Tea
What the sources say
- Partly supportedcites Disler et al. 1975 sourceExperimental — accuracy not yet measured
The Abstract and the section on non-haem food iron report that tea inhibited iron absorption from bread and a rice meal with potato and onion soup. The Discussion mentions only unpublished preliminary observations that coffee has a similar effect; it does not establish coffee’s effect on composite meals or say it is half as inhibitory as tea. (LLM, conf=0.88)
- Not checked — no full text of the sourcecites Hallberg & Rossander, 1982
- Not checked — no full text of the sourcecites Morck et al. 1983 source
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Fe absorption was measured using the extrinsic tag radio-Fe technique with 55 Fe and 59 Fe (Cook et al. 1972).”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Absorption measurements
What the sources say
- Supportedcites Cook et al. 1972 source
The Methods section describes radioiron-labeled foods and an extrinsic radioiron tag, and the Discussion reports dual-isotope measurements of absorption from the same test meal. The isotope superscripts are garbled in our copy, but the described intrinsic and extrinsic labels support the cited technique using 55Fe and 59Fe. Page numbers are unavailable in our copy. (LLM, conf=0.90)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Other beverages such as red wine (Bezwoda et al. 1985;Cook et al. 1995) and cocoa (Gillooly et al. 1984), as well as various vegetables with a high polyphenol content (Gillooly et al. 1983;Tuntawiroon et al. 1991), have also been reported to inhibit Fe absorption.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Iron absorption: Polyphenols: Coffee: Tea
What the sources say
- Not checked — no full text of the sourcecites Bezwoda et al. 1985 source
- Not checked — no full text of the sourcecites Cook et al. 1995 source
- Supportedcites Gillooly et al. 1984 source
Gillooly et al. (1984) is cited for cocoa, not for red wine or vegetables. The Abstract reports that adding cocoa to milk significantly reduced iron absorption, and the Discussion describes the same finding. (LLM, conf=0.94)
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Compared with the water control meal, the absorption ratios were: peppermint 0⋅16, pennyroyal 0⋅27, cocoa 0⋅29, vervain 0⋅41, lime flower 0⋅48 and camomile 0⋅53.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Results
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“This is much higher than the 20-25 % inhibition reported for red wine in our previous study (Cook et al. 1995) but indicates that a polyphenol-Fe complex was formed in the intestinal lumen and that Fe within the complex was unavailable for absorption.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Iron absorption from beverages alone
What the sources say
- Not checked — no full text of the sourcecites Cook et al. 1995 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Polyphenols from the different beverages inhibited Fe absorption in a dose-dependent fashion and relative Fe absorption from different concentrations of polyphenols fitted best onto the curve following a potential law (relative Fe absorption ¼ 2 × (mg polyphenol/serving) -0⋅5 ).”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Results
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“In the absence of the bread roll, Fe absorption from black tea, peppermint and cocoa was still far lower than from water alone, the absorption ratios being 0⋅03 for black tea, 0⋅16 for peppermint and 0⋅06 for cocoa (study 8).”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Results
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The inhibitory phenolic compounds would appear to include phenolic acids, such as chlorogenic acid from coffee, monomeric flavonoids such as found in herb teas, and the complex polymerization products found in black tea and cocoa.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Influence of polyphenols on iron absorption
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Paired tests were used to compare absorption from selected test meals within each study by determining whether the mean log absorption ratios differed significantly from zero.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Statistical methods
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Fe was determined by atomic absorption spectroscopy after dry ashing.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Test beverages
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Tea-drinking by infants in Israel (Merhav et al. 1985) and coffee-drinking by pregnant women in Costa Rica (Munoz et al. 1988) have been shown to have a negative effect on Fe status.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Influence of polyphenolic-containing beverages on iron status
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Coffee was analysed for chlorogenic acid by the AOAC method (Association of Official Analytical Chemists, 1990).”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Test beverages
What the sources say
- Not matchedcites Association of Official Analytical Chemists, 1990
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
In the paper
“Total polyphenols were measured in the tea, herb teas and cocoa beverages using the Folin-Ciocalteau method (Singleton & Rossi, 1965) with catechin as a standard.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Test beverages
What the sources say
- Not checked — no full text of the sourcecites Singleton & Rossi, 1965 source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This is much higher than the 20-25 % inhibition reported for red wine in our previous study (Cook et al. 1995) but indicates that a polyphenol-Fe complex was formed in the intestinal lumen and that Fe within the complex was unavailable for absorption.”
§ Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages > Iron absorption from beverages alone
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Polyphenol compounds can complex with Fe in the intestinal lumen, making Fe unavailable for absorption.
The paper relies on this without support.
Polyphenol compounds can complex with Fe in the intestinal lumen, making Fe unavailable for absorption.
“The phenolic compounds are released from the food or beverage during digestion, and can complex with Fe in the intestinal lumen making it unavailable for absorption.”
Citations
Cites
Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents
Singleton, V. L., & Rossi, J. A. (1965) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1965.16.3.144 · Cited by 24,852
Clark, L. C. (1996) · JAMA · doi:10.1001/jama.1996.03540240035027 · Cited by 3,283
Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin
Clark, L. (1996) · JAMA · doi:10.1001/jama.276.24.1957 · Cited by 2,988
The Flavonoids Advances in Research Since 1986
(2017) · Routledge eBooks · doi:10.1201/9780203736692 · Cited by 1,580
Phenolics in Food and Nutraceuticals
Shahidi, F., & Naczk, M. (2003) · CRC Press eBooks · doi:10.1201/9780203508732 · Cited by 1,501
The Flavonoids. A Class of Semi-Essential Food Components: Their Role in Human Nutrition
K�hnau, J. (2015) · World review of nutrition and dietetics · doi:10.1159/000399407 · Cited by 1,492
The Flavonoids: Advances in Research.
Richardson, P. M., Harborne, J. B., & Mabry, T. J. (1984) · Brittonia · doi:10.2307/2806301 · Cited by 1,429
The specificity of proanthocyanidin-protein interactions.
Hagerman, A. E., & Butler, L. G. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69462-7 · Cited by 1,005
Handbook of Nutritionally Essential Mineral Elements
(1997) · CRC Press eBooks · doi:10.1201/9781482273106 · Cited by 644
Tannins: their adverse role in ruminant nutrition
Kumar, R., & Singh, M. (1984) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00123a006 · Cited by 541
Research works printed but not linked: 1
- 1989, Recommended Dietary Allowances
Cited by
Sorted by citations
Items 401–489 of 489
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Phytotherapy-Induced Hepatocytotoxicity: A Case Report
Malnick, S. D. H., Abdullah, A. R., Maor, Y., & Neuman, M. G. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46070448 · Cited by 1
Luo, Y., & Li, J. (2016) · Legume Research - An International Journal · doi:10.18805/lr.v0iof.9391 · Cited by 1
Martínez, I., Garcia, A. I., Rodeiro, I., & Morón, F. (2015) · Journal of Pharmacy & Pharmacognosy Research · doi:10.56499/jppres15.055_3.2.37 · Cited by 1
Emiri, U. N., & Enaregha, E. B. (2020) · Brazilian Journal of Biological Sciences · doi:10.21472/bjbs(2020)071502 · Cited by 1
Delimont, N. M., & Nickel, S. (2020) · Nutrients · doi:10.3390/nu12071911 · Cited by 1
A Critical Review of the Association between Nutrition and Health in Modern Chinese Diet
Sun, S., Li, H., Liu, G., & Zhang, J. (2020) · Journal of Food and Nutrition Research · doi:10.12691/jfnr-8-7-5 · Cited by 1
Iron Status in Preschool Children with Normal Hemoglobin, Egypt
El-Asheer, O. M., Naeem, M. S., Aal, F. H. A. E., Abdou, M. A. A., & Mohamed, K. A. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.6735 · Cited by 1
Measures of Iron Metabolism and Applications to Dietary Patterns
Chang, J., Tinkov, A. A., Lundy, D. J., & Skalny, A. V. (2022) · Biomarkers in disease · doi:10.1007/978-3-031-07389-2_14 · Cited by 1
Muller, L. (2005) · Cited by 1
Wu, J., & Aarts, M. G. M. (2008) · CRC Press eBooks · doi:10.1201/9781420060065.ch14 · Cited by 1
Fisher, L. R. (2011) · SUNScholar (Stellenbosch University) · Cited by 1
Sifelani, J. B. (2016) · UpSpace Institutional Repository (University of Pretoria) · Cited by 1
Investigation of the antioxidant properties of five aromatic plants in model food systems
Azman, N. A. M. (2015) · doi:10.5821/dissertation-2117-96043 · Cited by 1
Johnson, N. F. (2014) · MOspace Institutional Repository (University of Missouri) · Cited by 1
Abizari, A. (2013) · doi:10.18174/257457 · Cited by 1
Peña‐Neira, Á. (2017) · doi:10.1002/9781119158042.ch51 · Cited by 1
(2013) · Elsevier eBooks · doi:10.1016/b978-0-443-06992-5.00010-4 · Cited by 2
Sun, Y. (2010) · NORA - Norwegian Open Research Archives · Cited by 1
The Role of Hypoxia-Inducible Factors in the Regulation of Systemic Iron Homeostasis.
Anderson, E. R. (2013) · Deep Blue (University of Michigan)
Putative hepatoprotective effects of coffee: authors' reply
Cadden, I. S., & Yoshida, E. M. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03554.x
Biodisponibilidad mineral de menús escolares
Martos, F. C. (2006) · Dialnet (Universidad de la Rioja)
Green Tea Consumption Prevented Iron Overload: A Case Report of Thalassemia Intermedia
Jetsrisuparb, A., Komwilaisak, P., & Wiangnon, S. (2014) · Journal of Hematology and Transfusion Medicine (วารสารโลหิตวิทยาและเวชศาสตร์บริการโลหิต)
Pepparmyntans bioaktiva ämnen - hur påverkar de människors hälsa?
Pallin, A. (2010) · Epsilon Archive for Student Projects (University of Southampton)
Effect of white tea consumption on the heart of type 2 diabetic rats
Teixeira, N. F. (2013)
Dietary factors influencing non-heme iron absorption
Bonsmann, S. S. G. (2007) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-005332658
Carrasco, R., & del Carmen, J. (2014) · Americanae (AECID Library)
Abizari, A., Moretti, D., Schuth, S., Zimmermann, M. B., Armar‐Klemesu, M., & Brouwer, I. D. (2012)
UNIVERSIDADE FEDERAL DE SANTA CATARINA PROGRAMA DE PÓS-GRADUAÇÃO EM QUÍMICA
Costa, T. G. (2012)
Hubungan Status Gizi (TB/U) dengan Status Kesehatan dan Prestasi Akademik Anak Usia Sekolah
Aziz, D. B. A. F. (2015)
Dietary-nutritional intervention in the prevention of iron deficiency.
Otegui, A. U., Sanz, J. M. M., & González-Muniesa, P. (2010) · Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria
REVIEW ON IRON AND ITS IMPORTANCE FOR HUMAN HEALTH (REVIEW ARTICLE)
Abbaspour, N., Hurrell, R. F., & Kelishadi, R. (2014)
Self-citationRooibos: Effect on Iron Status of South African Adults at Risk for Coronary Heart Disease
Marnewick, J. L., Venter, I., Rautenbach, F., Neethling, H., & Kotze, M. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.340
Mossanda, K. S., & Asare, G. A. (2014) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb2014.13629
Ghanem, K. Z., El-Deen, A. F. H. N., ramadan, M. M., Farrag, A.-R. H., Fadel, H. H. M., & Ahdallah, N. M. (2011) · Medical Research Journal · doi:10.1097/01.mjx.0000397211.31669.ed
Berger, P., Greffeuille, V., Dijkhuizen, M. A., & Wieringa, F. T. (2013)
Dietary Intake of Spices and Herbs in Habitual Northeast
Diets, T., Tantipopipat, S., Boonpraderm, A., & Charoenkiatkul, S. (2010)
A Review Of Recommended Foods In The Prevention Of Cancer
Mogoş, T., Dondoi, C., Chelan, C.-V., & Iacobini, A. E. (2015) · Romanian Journal of Diabetes Nutrition and Metabolic Diseases · doi:10.1515/rjdnmd-2015-0024
Cardiovascular/haematological systems
Galvin, K., & Bishop, M. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7295-3955-5.10007-1
Towards redesigning indigenous mung bean foods
Dahiya, P. K. (2013) · doi:10.18174/255443
Alvarenga, I. C. (2016) · K-State Research Exchange (Kansas State University)
Sanchís, L. P. (2017) · España | Enciclopedia Jurídica Online
Hassan, M., Datta, S., Rahman, S., Islam, O., Hossain, M. D., Hossain, I., & Rahman, M. (2018) · Bangladesh Journal of Animal Science · doi:10.3329/bjas.v46i4.36968
Шубина, В. С., Kozina, V. I., & Шаталин, Ю. В. (2017) · Биоорганическая химия · doi:10.7868/s0132342317030186
Asl, D. H., Rahmani, B., Farivar, T. N., Manouchehri, F. H., & Peymani, A. (2018) · The Journal of Qazvin University of Medical Sciences · doi:10.29252/qums.22.5.36
Undernutrition Interventions in Egypt: Status, Gaps, and Opportunities
Ashour, F. S., Ljungqvist, B. G., & Robinson, M. (2019) · World Bank, Washington, DC eBooks · doi:10.1596/978-1-4648-1467-9_ch3
Disposición hereditaria en la paresia recidivante del motor ocular común
Curtius, F., de Decker, J. F., & Zabaleta, H. O. (1931) · Archivos de Oftalmología Hispano-Americanos
Nutrientes e elementos tóxicos em alface (Lactuca sativa)
da Silva, E. D. N. (2016) · doi:10.47749/t/unicamp.2016.976935
Sanford, A. M. (2022) · Wiley eBooks · doi:10.1002/9781119484288.ch22
Potential herb–drug interactions for commonly used herbs
(2013) · Elsevier eBooks · doi:10.1016/b978-0-443-06992-5.00073-6 · Cited by 1
Chavan, R. F., & Sakhale, B. K. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-030-45299-5_30-2
Chavan, R. F., & Sakhale, B. K. (2020) · Reference series in phytochemistry · doi:10.1007/978-3-030-45299-5_30-1
Galvin, K., & Bishop, M. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7295-3955-5.10004-6
Gardner, Z., McGuffin, M., Upton, R., Bear, S., Winston, D., Gagnon, D., Romm, A. J., Dog, T. L., Hardy, M. L., Craker, L. E., et al. (2013) · CRC Press eBooks · doi:10.1201/b14292-14
Gardner, Z., McGuffin, M., Upton, R., Bear, S., Winston, D., Gagnon, D., Romm, A. J., Dog, T. L., Hardy, M. L., Craker, L. E., et al. (2013) · CRC Press eBooks · doi:10.1201/b14292-21
Measures of Iron Metabolism and Applications to Dietary Patterns
Chang, J., Tinkov, A. A., Lundy, D. J., & Skalny, A. V. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-81304-8_14-1
A importância metabólica de compostos bioativos não nutrientes
Sgarbieri, V. C., Pacheco, M. T. B., Gibrim, N. F., de Oliveira, D. A. G., & Caetano‐Silva, M. E. (2021) · Editora da Unicamp eBooks · doi:10.7476/9788526815353.0004
Frequency of Tea Consumption among Iron Deficient Pregnant Women
Khairunnisa, K., Hameed, N., Khan, N. A., & Hameed, M. (2022) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs221610562
Café y cafeína y sus efectos sobre la salud
Vera-Ponce, V. J. (2021) · Revista Peruana de Medicina Integrativa · doi:10.26722/rpmi.2021.v6n4.33
Atrushi, A. M., Mohammed, B. I., Naqid, I. A., Mikail, D. S., & Atab, D. S. (2023) · The Journal of The University of Duhok · doi:10.26682/sjuod.2023.26.2.36
Regulating ferroptosis: Toward precision treatment of dysregulated cell death
Landis, H. E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-98808-7.00018-7
Physico-Chemical and Functional Modifications of Wheat Bran after Ozone TreatmentPreprint
Sztupecki, W., Dépeint, F., Aussenac, T., & Rhazi, L. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5177649
Iron Deficiency Prevention and Dietary Habits Among Elite Female University Athletes in Japan
Inaba, H., Hanawa, H., Hoshino, F., Edama, M., & Omori, G. (2025) · Sports · doi:10.3390/sports13070220 · Cited by 2
Coffee Interactions with Various Medications
Surma, S., & Okopień, B. (2025) · Springer eBooks · doi:10.1007/978-3-031-93459-9_10
Dutta, H. K., Barman, M. P., Gupta, P., Kotoky, M. J., Acharyya, B. K., Gogoi, J., Sarmah, P. P., Chowdhury, P., Sabhapondit, S., Vora, R. M., et al. (2025) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2025-001287
Sunuwar, D. R., Singh, D. R., Pradhan, P. M. S., Shrestha, V., Rai, P., Shah, S. K., & Adhikari, B. (2024) · Figshare · doi:10.6084/m9.figshare.26568889
Sunuwar, D. R., Singh, D. R., Pradhan, P. M. S., Shrestha, V., Rai, P., Shah, S. K., & Adhikari, B. (2024) · Figshare · doi:10.6084/m9.figshare.26568895
Sunuwar, D. R., Singh, D. R., Pradhan, P. M. S., Shrestha, V., Rai, P., Shah, S. K., & Adhikari, B. (2024) · Figshare · doi:10.6084/m9.figshare.26568892
Impact of tea consumption frequency on hemoglobin and ferritin levels: a comparative analysis
Humaira, T., Mustafa, K. M., Sourabh, B., Kulsoom, B., & Andriyas Ekta, A. (2026) · International Journal of Community Medicine and Public Health · doi:10.18203/2394-6040.ijcmph20261039
Joshi, K., Bakshi, H., Kadri, A. M., Agarwal, A., Vala, A., Dholariya, S. J., Sonagra, A. D., Upadhyay, M., Anandani, G., Singh, G., et al. (2026) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2026.1793809
Pflanzenbasierte Ernährung im Kindes- und Jugendalter
Hünninghaus, K., & Naami, N. (2026) · Springer eBooks · doi:10.1007/978-3-662-71302-0_6
AKIŞ, R., TEMEL, S., Kulak, M., Keskin, B., Tohumcu, S. A., & Şeren, Z. N. (2026) · Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology · doi:10.1007/s44473-026-00233-2
Webb, B., Farrell, M., Montelius, C., & Önning, G. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1905459
Aguree, S., Turi, K. N., Handt, A., Kohut, M., & Reddy, M. B. (2026) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70575
Self-citationDietary Polyphenols in Type 2 Diabetes: A Metabolite-Centric Review of Human Evidence
Andrés, C. M. C., de la Lastra, J. M. P., Munguira, E. B., Andrés, C., & Lebeña, E. P. (2026) · Nutrients · doi:10.3390/nu18172856
Ezzahra, R. F., Mousadik, M. E., Halloumi, O., Lahlou, L., & Fares, S. (2026) · Cureus · doi:10.7759/cureus.116340
Alimentation végétarienne : conseils et complémentation en pratique
Begriche, K., Martineau, C., Cottet, V., Lecerf, J., & Lemale, J. (2026) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2026.08.104
7 of the weirdest things coffee does to your body
Beckett, E. (2026) · doi:10.64628/aa.w5wktagat
Baranowski, W. J. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.111011
Sete das coisas mais estranhas que o café faz ao seu corpo
Beckett, E. (2026) · doi:10.64628/ade.5uqvxauuj
Atla, S. R., Dussa, K. N., Veronica, J., Yasmeen, G., Zareen, Q., & Tanveer, S. (2026) · Health and population. Perspectives and issues · doi:10.5005/hppi-11041-0056
Faulks (2000) · doi:10.1002/(sici)1097-0010(20000515)80:7
Metadata
- Authors
- Hurrell, R. F., Reddy, M., & Cook, J. D.
- Affiliations
- ETH Zurich (CH)
- Iowa State University (US)
- University of Kansas Medical Center (US)
- Corresponding author
- Hurrell, Richard F.
- ORCID
- Hurrell, Richard F.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 1999-04
- Volume
- 81
- Issue
- 4
- Pages
- 289-295
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2148247285
- Semantic Scholar
- 23e567ba42e8321bbad2b334f344eea08d5fb6bc
- Cited by
- 490
- References
- 60
- Citations by year
- 2026: 23 · 2025: 15 · 2024: 17 · 2023: 16 · 2022: 19 · 2021: 23 · 2020: 20 · 2019: 19 · 2018: 18 · 2017: 20 · 2016: 16 · 2015: 22 · 2014: 22 · 2013: 35 · 2012: 21
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, other-oa)
- Iowa State University Digital Repository (Iowa State University) (submittedVersion)
- ETH Zürich Research Collection
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Keywords
- polyphenols, iron absorption inhibition, black tea, Theobroma cacao, coffee, peppermint tea, Mentha pulegium, Verbena officinalis, chamomile, flavonoids, phenolic acids, chlorogenic acid, dietary iron, milk
- MeSH terms
- Adult, Animals, Beverages, Bread, Coffee, Dose-Response Relationship, Drug, Erythrocytes, Female, Humans, Intestinal Absorption, Iron, Male, Milk, Phenols, Tea
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