The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Successful computer-assisted cognitive remediation therapy in patients with unipolar depression: a proof of principle study
Abstract
Background: Despite increasing awareness of the extent and severity of cognitive deficits in major depressive disorder (MDD), trials of cognitive remediation have not been conducted. We conducted a 10-week course of cognitive remediation in patients with long-term MDD to probe whether deficits in four targeted cognitive domains, (i) memory, (ii) attention, (iii) executive functioning and (iv) psychomotor speed, could be improved by this intervention. Method: We administered a computerized cognitive retraining package (PSSCogReHab) with demonstrated efficacy to 12 stable patients with recurrent MDD. Twelve matched patients with MDD and a group of healthy control participants were included for comparison; neither comparator group received the intervention that involved stimulation of cognitive functions through targeted, repetitive exercises in each domain. Results: Patients who received cognitive training improved on a range of neuropsychological tests targeting attention, verbal learning and memory, psychomotor speed and executive function. This improvement exceeded that observed over the same time period in a group of matched comparisons. There was no change in depressive symptom scores over the course of the trial, thus improvement in cognitive performance occurred independent of other illness variables. Conclusions: These results provide preliminary evidence that improvement of cognitive functions through targeted, repetitive exercises is a viable method of cognitive remediation in patients with recurrent MDD.
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“cognitive remediation therapies that have proven effective in other psychiatric populations (Bowie et al., 2013;Deckersbach et al., 2010;Elgamal et al., 2007;Kurtz, 2012;Wykes et al., 2011)”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Elgamal et al., 2007
In the citing paper
“For example, data from studies evaluating the impact of cognitive remediation therapy on cognitive performance in MDD indicate a positive effect on neuropsychological tasks of attention, verbal learning and memory, psychomotor speed, and executive function [189, 190].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [189]
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Metadata
- Authors
- ELGAMAL, S., McKINNON, M. C., RAMAKRISHNAN, K., JOFFE, R. T., & MacQUEEN, G.
- Affiliations
- McMaster University (CA)
- University of Medicine and Dentistry of New Jersey (US)
- Corresponding author
- MacQUEEN, GLENDA
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-07-05
- Volume
- 37
- Issue
- 9
- Pages
- 1229-1238
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2112005691
- Cited by
- 141
- References
- 39
- Citations by year
- 2026: 3 · 2025: 3 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 15 · 2016: 13 · 2015: 23 · 2014: 11 · 2013: 9 · 2012: 8
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- cognitive remediation, major depressive disorder, computerized cognitive training, cognitive impairment, memory, attention, executive function, psychomotor speed, verbal learning, recurrent depression, long-term depression
- MeSH terms
- Adult, Attention, Cognition Disorders, Major Depressive Disorder, Female, Humans, Male, Memory Disorders, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Practice, Psychological, Problem Solving, Reaction Time, Remedial Teaching, Retention, Psychology, Therapy, Computer-Assisted, Treatment Outcome
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