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Cited by 487Neural and Behavioral Psychology StudiesTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Attention and executive functions in remitted major depression patients

Paelecke-Habermann, Yvonne, Pohl, Johannes, Leplow, Bernd·2005·Journal of Affective Disorders
DOI 10.1016/j.jad.2005.09.006
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Abstract

Background Although deficits in attention and executive functions in patients with Major Depressive Disorder (MDD) are well confirmed [Veiel, H.O.F., 1997. A preliminary profile of neuropsychological deficits associated with major depression. Journal of Clinical and Experimental Neuropsychology 19, 587-603.]. The database regarding the relationship between impairments and the duration of disease or the number of episodes is inconsistent. Furthermore, the role of long-term cognitive impairments in MDD during remitted state is not well understood [Elliott, R., 2002. The neuropsychological profile in primary depression. Taylor and Francis, London, pp. 273-293.]. There is consequently a lack of studies accounting for different courses of illness in the euthymic state and considering the influence of possible attentional deficits on executive performance.Methods 40 euthymic patients with MDD diagnosis according to DSM-IV (20 patients with 1-2 episodes and 20 severe depressives with at least three episodes) as well as 20 healthy controls matched for education and age were administered three tests for attention (attentional shift, Stroop task, sustained attention) and three for executive functions (BADS, word fluency, memory span). The methods selected were theory based with regard to an involvement of frontal-subcortical networks in MDD, attention, and executive functions, respectively.Results Euthymic patients with MDD showed deficits in all tests related to attentional and executive functions compared to healthy controls. The patient groups did not differ with regard to attentional performance. Executive functions in severe depressives were more impaired than in mild depressives.Limitations Differing performances of the patient groups in the subtests of the executive test battery (BADS) can only be interpreted to a limited extent.Conclusions The results support the assumption that deficits in attention and executive functions in MDD show an increase in trait character and executive function during chronic course. Implications for differential diagnosis and cognitive psychotherapy are discussed.

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Authors
Paelecke-Habermann, Y., Pohl, J., & Leplow, B.
Affiliations
Martin Luther University Halle-Wittenberg (DE)
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2005-12
Volume
89
Issue
1-3
Pages
125-135
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2005.09.006
OpenAlex
W2060710107
Cited by
487
References
56
Citations by year
2026: 5 · 2025: 13 · 2024: 13 · 2023: 15 · 2022: 15 · 2021: 33 · 2020: 16 · 2019: 23 · 2018: 30 · 2017: 26 · 2016: 28 · 2015: 36 · 2014: 37 · 2013: 30 · 2012: 39
FWCI
5.77
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
major depressive disorder, remitted depression, attention deficits, executive function, number of depressive episodes, disease duration, Stroop task, attentional shift, sustained attention, verbal fluency, memory span, cognitive therapy
MeSH terms
Adult, Antidepressive Agents, Attention, Brain, Cognition Disorders, Major Depressive Disorder, Diagnosis, Differential, Female, Follow-Up Studies, Frontal Lobe, Humans, Male, Memory, Short-Term, Middle Aged, Nerve Net, Neuropsychological Tests, Problem Solving, Psychometrics, Reference Values, Cognitive Behavioral Therapy, Treatment Outcome

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