Preserved spatial memory after hippocampal lesions: effects of extensive experience in a complex environment
Abstract
Damage to the hippocampus typically impairs spatial learning and memory in animals, but humans with hippocampal lesions retain spatial memories of premorbidly familiar environments. We showed that, like humans, normal rats reared in a complex environment and then given hippocampal lesions retained allocentric spatial memory for that environment. These results, which ruled out dependency on single cues, landmarks or specific routes, suggest that extensive premorbid experience leads to spatial representations that are independent of the hippocampus.
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Rats with HPC lesions but extensive experience with the village maze acquired associations as quickly as controls, whereas inexperienced HPC-lesioned rats took much longer.
“Rats with HPC lesions but extensive experience with the village acquired those associations as quickly as controls did, whereas inexperienced HPC-lesioned rats took much longer.”
From From cognitive maps to spatial schemas (2023) · cites this paper as [70]
Schematized spatial memories primarily include geometric properties rather than surface properties.
“Schematized spatial memories primarily include geometric properties [G], rather than surface properties [G] 27,70,80,83 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [70]
The village maze provided converging evidence that semantic-like spatial representations or spatial schemas exist independently of the HPC.
“It provided converging evidence that semantic-like spatial representations or spatial schemas exist independently of the HPC 70 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [70]
In rats with pre-lesion experience in the complex village maze, allocentric navigation abilities are preserved after HPC lesions.
“As described above, in rats with pre-lesion experience in the complex village maze, allocentric navigation abilities are preserved after HPC lesions 70 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [70]
Navigation ability in these animals was impaired after manipulating distal cues, indicating that stable room geometry determined success.
“Navigation ability in these animals was impaired after manipulating distal cues (for example, pictures on walls surrounding the maze), however, indicating that stable room geometry determined success.”
From From cognitive maps to spatial schemas (2023) · cites this paper as [70]
Rodents with HPC lesions and extensive pre-lesion experience in an environment are able to use the overall layout of the learned environment, or its spatial gist.
“This ditinction is similar to that found in rodents with HPC lesions and extensive pre-lesion experience in an environment: they are able to use the overall layout of the learned environment, or its spatial gist, and take detours to reach goal locations, although often not the most optimal ones 70,125,126 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [70]
Rodents with HPC lesions and extensive pre-lesion experience take detours to reach goal locations, although often not the most optimal ones.
“they are able to use the overall layout of the learned environment, or its spatial gist, and take detours to reach goal locations, although often not the most optimal ones 70,125,126 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [70]
Geometric cues, rather than surface properties, seem to facilitate allocentric navigation in a highly familiar environment, despite HPC lesions.
“Therefore, geometric cues, rather than surface properties, seem to facilitate allocentric navigation in a highly familiar environment, despite HPC lesions 70 .”
From From cognitive maps to spatial schemas (2023) · cites this paper as [70]
HPC-lesioned rats used stable room geometry rather than distal or surface cues to navigate to correct goal locations.
“These findings indicate that HPC-lesioned rats used stable room geometry rather than distal or surface cues to navigate to correct goal locations.”
From From cognitive maps to spatial schemas (2023) · cites this paper as [70]
HPC-lesioned rats were severely impaired in room change and village rotation conditions, but performed well in the cue distortion condition.
“HPC-lesioned rats were severely impaired in room change and village rotation conditions, but performed well in the cue distortion condition.”
From From cognitive maps to spatial schemas (2023) · cites this paper as [70]
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Self-citation
- Authors
- Winocur, G., Moscovitch, M., Fogel, S., Rosenbaum, R. S., & Sekeres, M.
- Affiliations
- University of Toronto (CA)
- Trent University (CA)
- Baycrest Hospital (CA)
- Corresponding author
- Winocur, Gordon
- Venue
- Nature Neuroscience
- Published
- 2005-02-20
- Volume
- 8
- Issue
- 3
- Pages
- 273-275
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2075785331
- Cited by
- 161
- References
- 16
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 24 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 6
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Update notices
- erratum (2005-04-01)
- Open access
- closed
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Trent University
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampal lesions, spatial memory, spatial learning, complex environments, rats, hippocampal-dependent memory
- MeSH terms
- Animals, Behavior, Animal, Cues, Discrimination Learning, Environment, Hippocampus, Male, Memory, Memory Disorders, Reaction Time, Space Perception, Time Factors, Maze Learning, Rats, Long-Evans, Rats
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