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Cited by 141Treatment of Major DepressionCognitive Functions and MemoryAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Successful computer-assisted cognitive remediation therapy in patients with unipolar depression: a proof of principle study

ELGAMAL, SAFA, McKINNON, MARGARET C., RAMAKRISHNAN, KARUNA, JOFFE, RUSSELL T., MacQUEEN, GLENDA·2007·Psychological Medicine
DOI 10.1017/s0033291707001110
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Abstract

Background: Despite increasing awareness of the extent and severity of cognitive deficits in major depressive disorder (MDD), trials of cognitive remediation have not been conducted. We conducted a 10-week course of cognitive remediation in patients with long-term MDD to probe whether deficits in four targeted cognitive domains, (i) memory, (ii) attention, (iii) executive functioning and (iv) psychomotor speed, could be improved by this intervention. Method: We administered a computerized cognitive retraining package (PSSCogReHab) with demonstrated efficacy to 12 stable patients with recurrent MDD. Twelve matched patients with MDD and a group of healthy control participants were included for comparison; neither comparator group received the intervention that involved stimulation of cognitive functions through targeted, repetitive exercises in each domain. Results: Patients who received cognitive training improved on a range of neuropsychological tests targeting attention, verbal learning and memory, psychomotor speed and executive function. This improvement exceeded that observed over the same time period in a group of matched comparisons. There was no change in depressive symptom scores over the course of the trial, thus improvement in cognitive performance occurred independent of other illness variables. Conclusions: These results provide preliminary evidence that improvement of cognitive functions through targeted, repetitive exercises is a viable method of cognitive remediation in patients with recurrent MDD.

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Research works printed but not linked: 4

  1. First, 2001, Structured Clinical Interview for DSM-IV-TR Axis 1 Disorders – Patient Edition
  2. Bracy, 1994, PSSCogReHab Version 95: Technical Manual
  3. Ruff, 1996, Ruff 2and7 Selective Attention Test. Professional Manual
  4. Delis, 1987, California Verbal Learning Test: Research Edition, Adult Version

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Metadata

Authors
ELGAMAL, S., McKINNON, M. C., RAMAKRISHNAN, K., JOFFE, R. T., & MacQUEEN, G.
Affiliations
  • McMaster University (CA)
  • University of Medicine and Dentistry of New Jersey (US)
Corresponding author
MacQUEEN, GLENDA
ORCID
Venue
Psychological Medicine
Publisher
Cambridge University Press (CUP)
Published
2007-07-05
Volume
37
Issue
9
Pages
1229-1238
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
DOI
10.1017/s0033291707001110
OpenAlex
W2112005691
Cited by
141
References
39
Citations by year
2026: 3 · 2025: 3 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 15 · 2016: 13 · 2015: 23 · 2014: 11 · 2013: 9 · 2012: 8
FWCI
2.22
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
cognitive remediation, major depressive disorder, computerized cognitive training, cognitive impairment, memory, attention, executive function, psychomotor speed, verbal learning, recurrent depression, long-term depression
MeSH terms
Adult, Attention, Cognition Disorders, Major Depressive Disorder, Female, Humans, Male, Memory Disorders, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Practice, Psychological, Problem Solving, Reaction Time, Remedial Teaching, Retention, Psychology, Therapy, Computer-Assisted, Treatment Outcome

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