Ovarian hormones and binge eating: exploring associations in community samples
Open accessAbstract
Background: Significant associations between changes in ovarian hormones and binge eating are present across the menstrual cycle in women with bulimia nervosa. However, no study has examined these relationships in a non-clinical sample, despite the need for these data for designing risk-factor studies. Method: In study 1, we modified several continuous measures of binge eating and identified those that were most sensitive to menstrual-cycle fluctuations in a non-clinical sample of 10 women who completed measures for 35 days. In study 2, we explored associations between ovarian hormones and binge-eating scores in nine women who completed these same measures for 65 days and provided daily saliva samples for assays of estradiol and progesterone concentrations. Results: In study 1, the Emotional Eating subscale of the Dutch Eating Behavior Questionnaire exhibited superior reliability and was most sensitive to predicted menstrual-cycle changes in binge eating (i.e. increased scores in the mid-luteal/premenstrual compared with follicular/ovulatory phases). In study 2, this scale showed predicted inverse associations with estradiol and positive associations with progesterone across the menstrual cycle that could not be accounted for by changes in negative affect. Conclusion: Associations between ovarian hormones and binge eating are robust and present in clinical and non-clinical samples. Findings support the ability to examine the role of ovarian hormones as risk factors for binge eating in large-scale prospective studies and twin studies.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This work replicates antagonistic effects of estradiol and progesterone in externalizing disorders.
“Our work replicates antagonistic effects of E2 and P4 in externalizing disorders (Eisenlohr-Moul et al., 2015; Klump et al., 2008; 2013; Singh, Su, & Ng, 2013) and is the first to indicate an antagonistic relationship of E2 and T.”
From Reproductive steroids and ADHD symptoms across the menstrual cycle (2018) · cites this paper as Klump et al., 2008
Cites
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433 · see citing works
The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger
Stunkard, A. J., & Messick, S. (1985) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(85)90010-8 · Cited by 4,687 · see citing works
Essentials of Behavioral Research: Methods and Data Analysis
Rosenthal, R., & Rosnow, R. L. (1984) · Cited by 3,925 · see citing works
(2006) · Cited by 3,705 · see citing works
Modulation of appetite by gonadal steroid hormones
Asarian, L., & Geary, N. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1860 · Cited by 506 · see citing works
Large breasts and narrow waists indicate high reproductive potential in women
Grazyna Jasienska, A., Ziomkiewicz, A., Ellison, P. T., Lipson, S. F., & Thune, I. (2004) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2004.2712 · Cited by 436 · see citing works
Wardle, J. (1987) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(87)90072-9 · Cited by 324 · see citing works
Some effects of ovarian hormones on food intake and body weight in female rats.
Wade, G. N. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0076186 · Cited by 308 · see citing works
Estrogen Receptor Gene Expression in Relation to Neuropsychiatric Disorders
Östlund, H., Keller, É., & Hurd, Y. L. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1286.006 · Cited by 287 · see citing works
Loucks, A. B. (1994) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.78.4.910 · Cited by 174 · see citing works
Ovarian hormones and binge eating in bulimia nervosa
Schiller, C. E., Lipson, S. F., & Keel, P. K. (2006) · Psychological Medicine · doi:10.1017/s0033291706008956 · Cited by 172 · see citing works
Self-citationEnergy intakes are higher during the luteal phase of ovulatory menstrual cycles
Barr, S., Janelle, K., & Prior, J. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.1.39 · Cited by 162 · see citing works
Shirtcliff, E. A., Granger, D. A., Schwartz, E. B., Curran, M. J., Booth, A., & Overman, W. H. (2000) · Hormones and Behavior · doi:10.1006/hbeh.2000.1614 · Cited by 149 · see citing works
Use of urine biomarkers to evaluate menstrual function in healthy premenopausal women
Waller, K., Swan, S. H., Windham, G. C., Fenster, L., Elkin, E. P., & Lasley, B. L. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009401 · Cited by 144 · see citing works
The Influence of Dieting on the Menstrual Cycle of Healthy Young Women
Pirke, K. M., Schweiger, U., LEMME, W., Krieg, J. C., & Berger, T. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-6-1174 · Cited by 144 · see citing works
Changes in Genetic and Environmental Influences on Disordered Eating Across Adolescence
Klump, K. L., Burt, S. A., McGue, M. K., & Iacono, W. G. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.12.1409 · Cited by 133 · see citing works
Self-citationDifferential heritability of eating attitudes and behaviors in prepubertal versus pubertal twins
Klump, K. L., McGue, M. K., & Iacono, W. G. (2003) · International Journal of Eating Disorders · doi:10.1002/eat.10151 · Cited by 127 · see citing works
Self-citationKlump, K., & Burt, S. (2006) · Twin Research and Human Genetics · doi:10.1375/twin.9.6.971 · Cited by 126 · see citing works
Self-citationKlump, K. L., & Burt, S. A. (2006) · Twin Research and Human Genetics · doi:10.1375/183242706779462868 · Cited by 122 · see citing works
Self-citationCulbert, K. M., Breedlove, S., Burt, S. A., & Klump, K. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.47 · Cited by 122 · see citing works
Self-citationPuberty moderates genetic influences on disordered eating
Klump, K., Perkins, P. S., Burt, S. A., McGue, M., & Iacono, W. (2007) · Psychological Medicine · doi:10.1017/s0033291707000189 · Cited by 103 · see citing works
Self-citationKassam, A., Overstreet, J. W., Snow-Harter, C., Souza, M. J. D., Gold, E. B., & Lasley, B. L. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.96104408 · Cited by 90 · see citing works
Premenstrual exacerbation of binge eating in bulimia
Gladis, M., & Walsh, B. T. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.12.1592 · Cited by 84 · see citing works
Symptom fluctuation in bulimia nervosa: relation to menstrual-cycle phase and cortisol levels
Lester, N. A., Keel, P. K., & Lipson, S. (2002) · Psychological Medicine · doi:10.1017/s0033291702006815 · Cited by 82 · see citing works
Self-citationVARMA, M., Chai, J., Meguid, M., Laviano, A., Gleason, J. R., YANG, Z., & Blaha, V. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00152-3 · Cited by 75 · see citing works
Molecular Genetic Studies of Eating Disorders
Klump, K. L., & Culbert, K. M. (2007) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2007.00471.x · Cited by 42 · see citing works
Self-citationOvereating induced by progesterone in the ovariectomized, adrenalectomized rat*1
ROBERTS, S. (1972) · Hormones and Behavior · doi:10.1016/0018-506x(72)90040-2 · Cited by 37 · see citing works
Premenstrual exacerbation of bulimia
Price, W. A., Torem, M. S., & Dimarzio, L. R. (1987) · Psychosomatics · doi:10.1016/s0033-3182(87)72511-0 · Cited by 34 · see citing works
Assessment of eating disorders: interview or self-report questionnaire
Fairburn, C. G., & Beglin, S. J. (1994) · International Journal of Eating Disorders · doi:10.1002/1098-108x(199412)16:4
van Strien (1986) · doi:10.1002/1098-108x(198602)5:2
Garner (1983) · doi:10.1002/1098-108x(198321)2:2
Flagged first, then by citations
Cited by
Sorted by citations
Culbert, K. M., Racine, S. E., & Klump, K. L. (2015) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12441 · Cited by 642 · see citing works
Self-citationSex differences in the physiology of eating
Asarian, L., & Geary, N. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2012 · Cited by 513 · see citing works
Klump, K. L., Keel, P. K., Racine, S. E., Burt, S. A., Neale, M., Sisk, C. L., Boker, S., & Hu, J. Y. (2013) · Journal of Abnormal Psychology · doi:10.1037/a0029524 · Cited by 195 · see citing works
Self-citationPsychiatric Symptoms Across the Menstrual Cycle in Adult Women: A Comprehensive Review
Handy, A. B., Greenfield, S. F., Yonkers, K. A., & Payne, L. A. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000329 · Cited by 153 · see citing works
A narrative review of sex differences in eating disorders: Is there a biological basis?
Culbert, K. M., Sisk, C. L., & Klump, K. L. (2021) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.12.003 · Cited by 142 · see citing works
Self-citationReproductive steroids and ADHD symptoms across the menstrual cycle
Roberts, B., Eisenlohr-Moul, T., & Martel, M. M. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.11.015 · Cited by 77 · see citing works
Eisenlohr-Moul, T. A., DeWall, C. N., Girdler, S. S., & Segerstrom, S. C. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.03.016 · Cited by 57 · see citing works
Gonadal hormone contributions to individual differences in eating disorder risk
Mikhail, M. E., Culbert, K. M., Sisk, C. L., & Klump, K. L. (2019) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000543 · Cited by 26 · see citing works
Premenstrual symptoms as a marker of ovarian hormone sensitivity in eating disorders
Hardin, S. L., Thornton, L. M., Munn‐Chernoff, M. A., & Baker, J. H. (2020) · International Journal of Eating Disorders · doi:10.1002/eat.23213 · Cited by 22 · see citing works
de Jong, M., Wynchank, D. S. M. R., Michielsen, M., Beekman, A. T. F., & Kooij, J. J. S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13072106 · Cited by 11 · see citing works
ADHD in Females Across the Lifespan and the Role of Estrogen
Littman, E., Dean, J. M., Wagenberg, B., & Wasserstein, J. (2021) · The ADHD Report · doi:10.1521/adhd.2021.29.5.1 · Cited by 10 · see citing works
- Authors
- Klump, K. L., Keel, P. K., Culbert, K. M., & Edler, C.
- Affiliations
- Michigan State University (US)
- University of Iowa (US)
- Corresponding author
- Klump, K. L.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008-02-29
- Volume
- 38
- Issue
- 12
- Pages
- 1749-1757
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC2885896
- OpenAlex
- W2096285866
- Cited by
- 157
- References
- 31
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 11 · 2019: 13 · 2018: 2 · 2017: 14 · 2016: 10 · 2015: 11 · 2014: 8 · 2013: 11 · 2012: 14
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (T32MH070343)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- binge eating, ovarian hormones, menstrual cycle, estradiol, progesterone, emotional eating, risk factors, luteal phase, negative affect
- MeSH terms
- Adolescent, Adult, Affect, Bulimia, Community Health Services, Estrogens, Female, Humans, Menstrual Cycle, Middle Aged, Ovary, Progesterone, Prospective Studies, Surveys and Questionnaires, Severity of Illness Index, Body Mass Index
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
