Cited by 295Child Abuse and TraumaChild and Adolescent Psychosocial and Emotional DevelopmentChild Welfare and Adoption

The DOI matches its Crossref record; 103 of the 104 references it cites were found in a registry or an index.

The theory of latent vulnerability: Reconceptualizing the link between childhood maltreatment and psychiatric disorder

Open access

McCrory, Eamon J., Viding, Essi·2015·Development and Psychopathology

Open this paper in CoChat — free account Open PDF

Abstract

Maltreatment in childhood is associated with a significantly increased likelihood of psychiatric disorder that endures across the life span. If disorders emerge they tend to be more severe and less responsive to treatment. We introduce the concept of latent vulnerability as a way of conceptualizing the nature of this psychiatric risk. We argue that vulnerability to mental health problems can be understood as changes in a suite of neurocognitive systems that reflect adaptation or altered calibration to early neglectful or maltreating environments. Altered threat processing is presented as one exemplar candidate system. Heightened neurocognitive vigilance to threat is argued to reflect a calibration to an early at-risk environment that becomes maladaptive (and instantiates vulnerability) in the longer term. Other neurocognitive domains, including reward and memory processing, represent equally promising candidates for indexing latent vulnerability and warrant future enquiry. We suggest that the operationalization of latent vulnerability has the potential to guide a preventative psychiatry approach. Intervention currently occurs at two stages when maltreatment is confirmed: first, by addressing issues of risk; and second, by providing clinical intervention if a child meets criteria for psychiatric disorder. We argue that indexing latent vulnerability represents a third intervention opportunity, with the potential to target an indicated prevention approach for the most vulnerable children, offsetting risk trajectories before psychiatric disorders emerge.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1017/s0954579415000115

Cites

103 of 103 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Research domain criteria (RDoC): toward a new classification framework for research on mental disorders
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067
Burden and consequences of child maltreatment in high-income countries
Gilbert, R., Widom, C. S., Browne, K., Fergusson, D., Webb, E., & Janson, S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61706-7 · Cited by 3,876
Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia
Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391 · cited 3×
“…to threat reflects only one component of a distributed processing network, encompassing the medial prefrontal cortex (and the anterior cingulate cortex in particular), as well as the insula (e.g., Etkin & Wager, 2007; Kerestes, Davey, Stephanou, Whittle, & Harrison, 2013; Shin & Liberzon, 2010).”
Background
Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis
Ozer, E. J., Best, S. R., Lipsey, T. L., & Weiss, D. S. (2003) · Psychological Bulletin · doi:10.1037/0033-2909.129.1.52 · Cited by 3,322
The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083 · cited 2×
“…to threat reflects only one component of a distributed processing network, encompassing the medial prefrontal cortex (and the anterior cingulate cortex in particular), as well as the insula (e.g., Etkin & Wager, 2007; Kerestes, Davey, Stephanou, Whittle, & Harrison, 2013; Shin & Liberzon, 2010).”
Background
Reducing Risks for Mental Disorders: Frontiers for Preventive Intervention Research
(1994) · doi:10.17226/2139 · Cited by 2,073
Principles of Preventive Psychiatry
(1965) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1965.tb72290.x · Cited by 1,999
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · cited 1×
“For example, the amygdala plays a critical role in fear extinction (where an individual ceases to regard a given stimulus as threatening) along with several other brain areas (in particular the ventromedial prefrontal cortex; Milad & Quirk, 2002).”
Background
A cognitive-motivational analysis of anxiety.
Mogg, K., & Bradley, B. P. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(98)00063-1 · Cited by 1,642

Show all 104 references

Research works printed but not linked: 2

Springer, 2007, The Institute of Medicine framework and its implication for the advancement of prevention policy, programs and practice (Prevention Policy Paper Series)
2013, Child maltreatment, 2012

Sorted by citations

Annual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry – the contribution of functional brain imaging
McCrory, E. J., Gerin, M. I., & Viding, E. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12713 · Cited by 402
Hidden talents in harsh environments
Ellis, B. J., Abrams, L. S., Masten, A. S., Sternberg, R. J., Tottenham, N., & Frankenhuis, W. E. (2020) · Development and Psychopathology · doi:10.1017/s0954579420000887 · Cited by 298
The role of adverse childhood experiences in cardiovascular disease risk: a review with emphasis on plausible mechanisms
Su, S., Jimenez, M. P., Roberts, C. T. F., & Loucks, E. B. (2015) · Current Cardiology Reports · doi:10.1007/s11886-015-0645-1 · Cited by 242
Emotion regulation as mediator between childhood adversity and psychopathology: A meta-analysis
Miu, A. C., Szentágotai-Tătar, A., Balázsi, R., Nechita, D., Bunea, I., & Pollak, S. D. (2022) · Clinical Psychology Review · doi:10.1016/j.cpr.2022.102141 · Cited by 233
The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192
“Accordingly, identifying at-risk individuals and tailoring interventions to target the reward processing system could represent an effective strategy to prevent later psychopathology (McCrory and Viding, 2015).”
Background
Concurrent and Longitudinal Contribution of Exposure to Bullying in Childhood to Mental Health
Singham, T., Viding, E. M., Schoeler, T., Arseneault, L., Ronald, A., Cecil, C. A. M., McCrory, E. J. P., Rijsdijk, F. V., & Pingault, J. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.2678 · Cited by 223
Structural and Functional Brain Abnormalities Associated With Exposure to Different Childhood Trauma Subtypes: A Systematic Review of Neuroimaging Findings
Cassiers, L. L. M., Sabbe, B. G. C., Schmaal, L., Veltman, D. J., Penninx, B. W. J. H., & Van Den Eede, F. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00329 · Cited by 194
Child Abuse and Neglect
Zeanah, C. H., & Humphreys, K. L. (2018) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2018.06.007 · Cited by 190
Childhood maltreatment and DNA methylation: A systematic review
Cecil, C. A. M., Zhang, Y., & Nolte, T. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.019 · Cited by 186
Child abuse, neural structure, and adolescent psychopathology: a longitudinal study
Busso, D. S., McLaughlin, K. A., Brueck, S., Peverill, M., Gold, A. L., & Sheridan, M. A. (2017) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.01.013 · Cited by 164
The complex neurobiology of resilient functioning after childhood maltreatment
Ioannidis, K., Askelund, A. D., Kievit, R., & van Harmelen, A. (2020) · BMC Medicine · doi:10.1186/s12916-020-1490-7 · Cited by 175
Social thinning and stress generation after childhood maltreatment: a neurocognitive social transactional model of psychiatric vulnerability
McCrory, E. J. P., Foulkes, L., & Viding, E. M. (2022) · The Lancet Psychiatry · doi:10.1016/s2215-0366(22)00202-4 · Cited by 147
Reduced hippocampal and amygdala volume as a mechanism underlying stress sensitization to depression following childhood trauma
Weissman, D. G., Lambert, H. K., Rodman, A. M., Peverill, M., Sheridan, M. A., & McLaughlin, K. A. (2020) · Depression and Anxiety · doi:10.1002/da.23062 · Cited by 130
Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability
Cecil, C. A. M., Smith, R. G., Walton, E., Mill, J. S., McCrory, E. J. P., & Viding, E. M. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.09.010 · Cited by 135
Lower structural integrity of the uncinate fasciculus is associated with a history of child maltreatment and future psychological vulnerability to stress
Hanson, J. L., Knodt, A. R., Brigidi, B. D., & Hariri, A. R. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000978 · Cited by 123
Understanding the development of psychopathy: progress and challenges
Viding, E. M., & McCrory, E. J. P. (2017) · Psychological Medicine · doi:10.1017/s0033291717002847 · Cited by 128
Child Maltreatment, Peer Victimization, and Mental Health: Neurocognitive Perspectives on the Cycle of Victimization
Goemans, A., Viding, E. M., & McCrory, E. J. P. (2021) · Trauma Violence & Abuse · doi:10.1177/15248380211036393 · Cited by 122
Understanding Addiction as a Developmental Disorder: An Argument for a Developmentally Informed Multilevel Approach
McCrory, E. J. P., & Mayes, L. C. (2015) · Current Addiction Reports · doi:10.1007/s40429-015-0079-2 · Cited by 91
Conduct problems in youth and the RDoC approach: A developmental, evolutionary-based view
Fonagy, P., & Luyten, P. (2017) · Clinical Psychology Review · doi:10.1016/j.cpr.2017.08.010 · Cited by 94
The neural correlates of Childhood Trauma Questionnaire scores in adults: A meta-analysis and review of functional magnetic resonance imaging studies
Heany, S. J., Groenewold, N. A., Uhlmann, A., Dalvie, S., Stein, D. J., & Brooks, S. J. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001717 · Cited by 87
Mentalizing Family Violence Part 1: Conceptual Framework
Asen, E., & Fonagy, P. (2016) · Family Process · doi:10.1111/famp.12261 · Cited by 85
The Association Between Child Maltreatment and Loneliness Across the Lifespan: A Systematic Review and Multilevel Meta-Analysis
de Heer, C., Bi, S., Finkenauer, C., Alink, L. R. A., & Maes, M. (2022) · Child Maltreatment · doi:10.1177/10775595221103420 · Cited by 83
The mediating role of attachment and mentalising in the relationship between childhood maltreatment, self-harm and suicidality
Stagaki, M., Nolte, T., Feigenbaum, J., King‐Casas, B., Lohrenz, T. M., Fonagy, P., & Montague, P. R. (2022) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2022.105576 · Cited by 91
Impact of early life adversities on human brain functioning: A coordinate-based meta-analysis
Kraaijenvanger, E. J., Pollok, T. M., Monninger, M., Kaiser, A., Brandeis, D., Banaschewski, T., & Holz, N. E. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.03.008 · Cited by 83
Dynamic stress-related epigenetic regulation of the glucocorticoid receptor gene promoter during early development: The role of child maltreatment
Parent, J., Parade, S. H., Laumann, L. E., Ridout, K. K., Yang, B.-Z., Marsit, C. J., Seifer, R., & Tyrka, A. R. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001298 · Cited by 72
Attachment, Mentalizing and Trauma: Then (1992) and Now (2022)
Fonagy, P., Campbell, C., & Luyten, P. (2023) · Brain Sciences · doi:10.3390/brainsci13030459 · Cited by 104
Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder
Holz, N. E., Boecker-Schlier, R., Buchmann, A. F., Blomeyer, D., Jennen-Steinmetz, C., Baumeister, S., Plichta, M. M., Cattrell, A., Schumann, G., Esser, G., et al. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw120 · Cited by 70
Investigating patterns of neural response associated with childhood abuse v. childhood neglect
Puetz, V. B., Viding, E. M., Gerin, M. I., Pingault, J., Sethi, A., Knodt, A. R., Radtke, S. R., Brigidi, B. D., Hariri, A. R., & McCrory, E. J. P. (2019) · Psychological Medicine · doi:10.1017/s003329171900134x · Cited by 76
A transdiagnostic neuroanatomical signature of psychiatric illness
Gong, Q., Scarpazza, C., Dai, J., He, M., Xu, X., Shi, Y., Zhou, B., Vieira, S., McCrory, E. J. P., Ai, Y., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0175-9 · Cited by 68
Migration‐related trauma and mental health among migrant children emigrating from Mexico and Central America to the United States: Effects on developmental neurobiology and implications for policy
Cohodes, E. M., Kribakaran, S., Odriozola, P., Bakirci, S., McCauley, S., Hodges, H. R., Sisk, L. M., Zacharek, S. J., & Gee, D. G. (2021) · Developmental Psychobiology · doi:10.1002/dev.22158 · Cited by 85
A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children
Gerin, M. I., Puetz, V. B., Blair, J., White, S. F., Sethi, A., Hoffmann, F., Palmer, A. L., Viding, E. M., & McCrory, E. J. P. (2017) · Development and Psychopathology · doi:10.1017/s095457941700133x · Cited by 76
Separating the Signal from the Noise: How Psychiatric Diagnoses Can Help Discern Food Addiction from Dietary Restraint
Wiss, D., & Brewerton, T. (2020) · Nutrients · doi:10.3390/nu12102937 · Cited by 63
A stable and replicable neural signature of lifespan adversity in the adult brain
Holz, N. E., Zabihi, M., Kia, S. M., Monninger, M., Aggensteiner, P.-M., Siehl, S., Floris, D. L., Bokde, A. L. W., Desrivières, S., Flor, H., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01410-8 · Cited by 70
Altered neural response to rejection‐related words in children exposed to maltreatment
Puetz, V. B., Viding, E., Palmer, A., Kelly, P. A., Lickley, R., Koutoufa, I., Sebastian, C. L., & McCrory, E. J. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12595 · Cited by 61
Childhood maltreatment and attention deficit hyperactivity disorder symptoms in adults: a large twin study
Capusan, A., Kuja-Halkola, R., Bendtsen, P., Viding, E., McCrory, E., Marteinsdóttir, Í., & Larsson, H. (2016) · Psychological Medicine · doi:10.1017/s0033291716001021 · Cited by 56
A meta-analysis of childhood maltreatment in relation to psychopathic traits
de Ruiter, C., Burghart, M., Silva, R. D., García, S., Mian, U., Walshe, E., & Zouharova, V. (2022) · PLoS ONE · doi:10.1371/journal.pone.0272704 · Cited by 67
Human amygdala engagement moderated by early life stress exposure is a biobehavioral target for predicting recovery on antidepressants
Goldstein‐Piekarski, A. N., Korgaonkar, M. S., Green, E., Suppes, T. M., Schatzberg, A. F., Hastie, T. J., Nemeroff, C. B., & Williams, L. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606671113 · Cited by 63
Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: A multilevel investigation
Kelly, P. A., Viding, E. M., Puetz, V. B., Palmer, A. L., Mechelli, A., Pingault, J., Samuel, S., & McCrory, E. J. P. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000966 · Cited by 64
Autobiographical memory: A candidate latent vulnerability mechanism for psychiatric disorder following childhood maltreatment
McCrory, E. J. P., Puetz, V. B., Maguire, E. A., Mechelli, A., Palmer, A. L., Gerin, M. I., Kelly, P. A., Koutoufa, I., & Viding, E. M. (2017) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.117.201798 · Cited by 61
Aggressive Behavior Among Persons With Schizophrenia and Those Who Are Developing Schizophrenia: Attempting to Understand the Limited Evidence on Causality
Hodgins, S. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx079 · Cited by 60
A systematic review of childhood maltreatment and resting state functional connectivity
Gerin, M. I., Viding, E. M., Herringa, R. J., Russell, J. D., & McCrory, E. J. P. (2023) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2023.101322 · Cited by 65
The Role of Epistemic Trust in Mentalization-Based Treatment of Borderline Psychopathology
Nolte, T., Hutsebaut, J., Sharp, C., Campbell, C., Fonagy, P., & BATEMAN, A. W. (2023) · Journal of Personality Disorders · doi:10.1521/pedi.2023.37.5.633 · Cited by 62
Resting state coupling between the amygdala and ventromedial prefrontal cortex is related to household income in childhood and indexes future psychological vulnerability to stress
Hanson, J. L., Albert, D., Skinner, A. T., Shen, S., Dodge, K. A., & Lansford, J. E. (2019) · Development and Psychopathology · doi:10.1017/s0954579419000592 · Cited by 56
Retrospectively reported childhood physical abuse, systemic inflammation, and resting corticolimbic connectivity in midlife adults
Kraynak, T. E., Marsland, A. L., Hanson, J. L., & Gianaros, P. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.186 · Cited by 54
Trauma-informed care for adult survivors of developmental trauma with psychotic and dissociative symptoms: a systematic review of intervention studies
Bloomfield, M., Yusuf, F. N. I. B., Srinivasan, R., Kelleher, I., Bell, V., & Pitman, A. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30041-9 · Cited by 61
Childhood adversity and impaired reward processing: A meta-analysis
Oltean, L.-E., Șoflău, R., Miu, A. C., & Szentágotai-Tătar, A. (2022) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2022.105596 · Cited by 50
The emotional and behavioural symptom trajectories of children in long-term out-of-home care in an English local authority
Hiller, R. M., & Clair, M. S. (2018) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2018.04.017 · Cited by 51
Child maltreatment and the risk of antisocial behaviour: A population-based cohort study spanning 50 years
Esposti, M. D., Pereira, S. M. P., Humphreys, D. K., Sale, R. D., & Bowes, L. (2019) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2019.104281 · Cited by 62
Attentional avoidance of fearful facial expressions following early life stress is associated with impaired social functioning
Humphreys, K. L., Kircanski, K., Colich, N. L., & Gotlib, I. H. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12607 · Cited by 47
Environmental and neurodevelopmental contributors to youth mental illness
Whittle, S., Zhang, L., & Rakesh, D. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01926-y · Cited by 49
Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors
Fava, N. M., Trucco, E. M., Martz, M. E., Cope, L. M., Jester, J. M., Zucker, R. A., & Heitzeg, M. M. (2018) · Development and Psychopathology · doi:10.1017/s0954579418001025 · Cited by 44
Neurocognitive Adaptation and Mental Health Vulnerability Following Maltreatment: The Role of Social Functioning
McCrory, E. J. P., Ogle, J. R., Gerin, M. I., & Viding, E. M. (2019) · Child Maltreatment · doi:10.1177/1077559519830524 · Cited by 46
Evidence for Depressogenic Spontaneous Thoughts and Altered Resting-State Connectivity in Adolescents With a Maltreatment History
Hoffmann, F., Viding, E. M., Puetz, V. B., Gerin, M. I., Sethi, A., Rankin, G., & McCrory, E. J. P. (2018) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2018.05.020 · Cited by 44
The association between latent trauma and brain structure in children
Jeong, H. J., Durham, E. L., Moore, T. M., Dupont, R. M., McDowell, M. G., Cardenas‐Iniguez, C., Micciche, E. T., Berman, M. G., Lahey, B. B., & Kaczkurkin, A. N. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01357-z · Cited by 48
Childhood maltreatment and emotion regulation in everyday life: an experience sampling study
(2023) · doi:10.1038/s41598-023-34302-9 · Cited by 42
A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health
Wiss, D. A. (2019) · Frontiers in Public Health · doi:10.3389/fpubh.2019.00193 · Cited by 41
Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment
Gerin, M. I., Viding, E. M., Pingault, J., Puetz, V. B., Knodt, A. R., Radtke, S. R., Brigidi, B. D., Swartz, J. R., Hariri, A. R., & McCrory, E. J. P. (2019) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13041 · Cited by 46
Trust and childhood maltreatment: evidence of bias in appraisal of unfamiliar faces
Neil, L., Viding, E. M., Armbruster‐Genc, D., Lisi, M., Mareschal, I., Rankin, G., Sharp, M. L., Phillips, H., Rapley, J. M., Martin, P., et al. (2021) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13503 · Cited by 48
Exploring the Relationship Between Childhood Maltreatment and Addiction: A Review of the Neurocognitive Evidence
Puetz, V. B., & McCrory, E. J. P. (2015) · Current Addiction Reports · doi:10.1007/s40429-015-0073-8 · Cited by 45
Relational and affective neuroscience: a quiet revolution in psychiatric and psychotherapeutic practice
Mizen, C. S., & Hook, J. (2020) · BJPsych Advances · doi:10.1192/bja.2020.63 · Cited by 38
The roles of early-life adversity and rumination in neural response to emotional faces amongst anxious and depressed adults
Peters, A. T., Burkhouse, K. L., Kinney, K. L., & Phan, K. L. (2018) · Psychological Medicine · doi:10.1017/s0033291718003203 · Cited by 41
Effects of childhood adversity on the volumes of the amygdala subnuclei and hippocampal subfields in individuals with major depressive disorder
Aghamohammadi‐Sereshki, A., Coupland, N. J., Silverstone, P. H., Huang, Y., Hegadoren, K., Carter, R., Seres, P., & Malykhin, N. V. (2021) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.200034 · Cited by 37
A review of childhood maltreatment, latent vulnerability and the brain: implications for clinical practice and prevention
Gerin, M. I., Hanson, E., Viding, E. M., & McCrory, E. J. P. (2019) · Adoption & Fostering · doi:10.1177/0308575919865356 · Cited by 43
Disruptive Behavior Disorders: The Challenge of Delineating Mechanisms in the Face of Heterogeneity
Viding, E. M., & McCrory, E. J. P. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20070998 · Cited by 37
How Does COVID-19 Affect the Neurobiology of Suicide?
Conejero, I., Nobile, B., Olié, É., & Courtet, P. (2021) · Current Psychiatry Reports · doi:10.1007/s11920-021-01227-x · Cited by 86
Adverse childhood experiences, adult trauma, and depressive symptom trajectories
Wilson-Genderson, M., Heid, A. R., Cartwright, F. P., & Pruchno, R. A. (2021) · Aging & Mental Health · doi:10.1080/13607863.2021.1978926 · Cited by 34
Salivary oxytocin concentration changes during a group drumming intervention for maltreated school children
Yuhi, T., Kyuta, H., Mori, H.-A., Murakami, C., Furuhara, K., Okuno, M., Takahashi, M., Fuji, D., & Higashida, H. (2017) · Brain Sciences · doi:10.3390/brainsci7110152 · Cited by 32
Social cognitive performance in posttraumatic stress disorder: A meta-analysis
Janssen, P. G. J., van Est, L. A. C., Hilbink, M., Gubbels, L., Egger, J. I. M., Cillessen, A. H. N., & van Ee, E. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.09.082 · Cited by 36
Childhood Maltreatment and Longitudinal Epigenetic Aging
Chang, O. D., Meier, H. C. S., Maguire‐Jack, K., Davis-Kean, P. E., & Mitchell, C. M. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.21877 · Cited by 34
Childhood maltreatment is associated with increased neural response to ambiguous threatening facial expressions in adulthood: Evidence from the late positive potential
Sandre, A., Ethridge, P., Kim, I., & Weinberg, A. (2018) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-017-0559-z · Cited by 33
What evidence is there that parenting interventions reduce child abuse and neglect among maltreating families? A systematic review
Whitcombe‐Dobbs, S., & Tarren‐Sweeney, M. (2019) · Developmental Child Welfare · doi:10.1177/2516103219893383 · Cited by 32
Foster Parents’ Parenting and the Social-Emotional Development and Adaptive Functioning of Children in Foster Care: A PRISMA-Guided Literature Review and Meta-Analysis
Chodura, S., Lohaus, A., Symanzik, T., Heinrichs, N., & Konrad, K. (2021) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-020-00336-y · Cited by 41
Childhood maltreatment influences adult brain structure through its effects on immune, metabolic, and psychosocial factors
Orellana, S. C., Bethlehem, R. A. I., Simpson-Kent, I. L., van Harmelen, A., Vértes, P. E., & Bullmore, E. T. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2304704121 · Cited by 33
Compounding Stress: Childhood Adversity as a Risk Factor for Adulthood Trauma Exposure in the Health and Retirement Study
Bürgin, D., Boonmann, C., Schmeck, K., Schmid, M., Tripp, P., Nishimi, K. M., & O’Donovan, A. (2020) · Journal of Traumatic Stress · doi:10.1002/jts.22617 · Cited by 30
A Functional Magnetic Resonance Imaging Meta-Analysis of Childhood Trauma
Ireton, R., Hughes, A. E., & Klabunde, M. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.01.009 · Cited by 36
Adverse childhood experiences and fronto-subcortical structures in the developing brain
Buimer, E. E. L., Brouwer, R. M., Mandl, R. C. W., Pas, P., Schnack, H. G., & Hulshoff Pol, H. E. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.955871 · Cited by 29
The Development of Young Peoples’ Internalising and Externalising Difficulties Over the First Three-Years in the Public Care System
Hiller, R. M., Fraser, A., Denne, M., Bauer, A., & Halligan, S. L. (2022) · Child Maltreatment · doi:10.1177/10775595211070765 · Cited by 27
Cumulative Childhood Trauma and Couple Satisfaction: Examining the Mediating Role of Mindfulness
Godbout, N., Harvey, F. M., Cyr, G., & Bélanger, C. (2020) · Mindfulness · doi:10.1007/s12671-020-01390-x · Cited by 40
The Hidden Talents Framework
Ellis, B. J., Abrams, L. S., Masten, A. S., Sternberg, R. J., Tottenham, N., & Frankenhuis, W. E. (2023) · Cambridge University Press eBooks · doi:10.1017/9781009350051 · Cited by 33
Clinical management of common presentations of patients diagnosed with BPD during the COVID-19 pandemic: the contribution of the MBT framework
Wurman, T. V., Lee, T., BATEMAN, A. W., Fonagy, P., & Nolte, T. (2020) · Counselling Psychology Quarterly · doi:10.1080/09515070.2020.1814694 · Cited by 26
Risk-taking, peer-influence and child maltreatment: a neurocognitive investigation
Hoffmann, F., Puetz, V. B., Viding, E. M., Sethi, A., Palmer, A. L., & McCrory, E. J. P. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx124 · Cited by 29
Chronic Pelvic Pain in Endometriosis: Cross-Sectional Associations with Mental Disorders, Sexual Dysfunctions and Childhood Maltreatment
Netzl, J., Gusy, B., Voigt, B., Sehouli, J., & Mechsner, S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11133714 · Cited by 24
Limitations of the protective measure theory in explaining the role of childhood sexual abuse in eating disorders, addictions, and obesity: an updated model with emphasis on biological embedding
Wiss, D. A., Brewerton, T. D., & Tomiyama, A. J. (2021) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-021-01293-3 · Cited by 27
The sexually dimorphic impact of maltreatment on cortical thickness, surface area and gyrification
Kelly, P. A., Viding, E. M., Puetz, V. B., Palmer, A. L., Samuel, S., & McCrory, E. J. P. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1523-8 · Cited by 26
Do dimensions of childhood adversity differ in their direct associations with youth psychopathology? A meta-analysis
Lee, A. H., Kitagawa, Y., Mirhashem, R., Rodriguez, M., Hilerio, R., & Bernard, K. (2024) · Development and Psychopathology · doi:10.1017/s0954579424000737 · Cited by 26
Externalizing Behaviors and Callous-Unemotional Traits: Different Associations With Sleep Quality
Denis, D., Akhtar, R., Holding, B. C., Murray, C., Panatti, J., CLARIDGE, G. S., Sadeh, A., Barclay, N. L., O’Leary, R., Maughan, B., et al. (2017) · SLEEP · doi:10.1093/sleep/zsx070 · Cited by 22
Overlapping Neurobiological Substrates for Early-Life Stress and Resilience to Psychosis
DeRosse, P., & Barber, A. D. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.09.003 · Cited by 25
Chronic harsh parenting and anxiety associations with fear circuitry function in healthy adolescents: A preliminary study
Buissonnière-Ariza, V. L., Séguin, J. R., Nassim, M., Boivin, M., Pine, D. S., Leporé, F., Tremblay, R. E., & Maheu, F. S. (2019) · Biological Psychology · doi:10.1016/j.biopsycho.2019.03.019 · Cited by 22
Developing a novel co‐produced methodology to understand ‘real‐world’ help‐seeking in online peer–peer communities by young people experiencing emotional abuse and neglect
Bennett, V., Gill, C., Miller, P., Lewis, P., NeurOX, Y. P. A. G., Hamilton-Giachritsis, C. E., & Lavi, I. (2022) · Health Expectations · doi:10.1111/hex.13621 · Cited by 20
Psychological maltreatment, meaning-centered coping, psychological flexibility, and suicide cognitions: A moderated mediation model
Türk, N., Arslan, G., Kaya, A., Güç, E., & Turan, M. E. (2024) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2024.106735 · Cited by 20
A narrative review of stability and change in the mental health of children who grow up in family-based out-of-home care
Tarren‐Sweeney, M., & Goemans, A. (2019) · Developmental Child Welfare · doi:10.1177/2516103219874810 · Cited by 20
Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability
Armbruster‐Genc, D., Valton, V., Neil, L., Vuong, V., Freeman, Z., Packer, K. C., Kiffin, M. J., Roiser, J. P., Viding, E. M., & McCrory, E. J. P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01284-7 · Cited by 19
A longitudinal study of childhood maltreatment, subcortical development, and subcortico-cortical structural maturational coupling from early to late adolescence
Rakesh, D., Elzeiny, R. E., Vijayakumar, N., & Whittle, S. (2023) · Psychological Medicine · doi:10.1017/s0033291723001253 · Cited by 21
A Scoping Review of Factors Associated With the Mental Health of Young People Who Have “Aged Out” of the Child Welfare System
Phillips, A., Halligan, S. L., Lavi, I., Macleod, J., Robinson, S., Wilkins, D., & Hiller, R. M. (2023) · Trauma Violence & Abuse · doi:10.1177/15248380231196107 · Cited by 21
Disentangling the mental health impact of childhood abuse and neglect: A replication and extension study in a Brazilian sample of high-risk youth
de Oliveira, I. R., Matos-Ragazzo, A. C. S., Zhang, Y., de Vasconcelos, N. S. S. M., Velasquez, M. L., Reis, D. M. L., Ribeiro, M. G., da Rocha, M. M., do Rosário, M. C., Stallard, P. N., et al. (2018) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2018.03.021 · Cited by 19
Mood and neural responses to social rejection do not seem to be altered in resilient adolescents with a history of adversity
Fritz, J., Stretton, J., Askelund, A. D., Schweizer, S., Walsh, N. D., Elzinga, B. M., Goodyer, I. M., Wilkinson, P. O., & van Harmelen, A.-L. (2020) · Development and Psychopathology · doi:10.1017/s0954579419000178 · Cited by 18
Childhood abuse and neglect and profiles of adult emotion dynamics
Myroniuk, S., Reitsema, A. M., de Jonge, P., & Jeronimus, B. F. (2024) · Development and Psychopathology · doi:10.1017/s0954579423001530 · Cited by 24
Facial Expression Processing Across the Autism–Psychosis Spectra: A Review of Neural Findings and Associations With Adverse Childhood Events
Samaey, C., der Donck, S. V., van Winkel, R., & Boets, B. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.592937 · Cited by 17
Associations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study
Bailey, M., Fairchild, G. F., Hammerton, G., Bauer, A., Carpena, M. X., Murray, J., Santos, I. S., Barros, A. J. D., Tovo‐Rodrigues, L., Danese, A., et al. (2025) · The Lancet Global Health · doi:10.1016/s2214-109x(24)00452-2 · Cited by 21
The influence of childhood maltreatment on trait depression in patients with major depressive disorder: A moderated mediation model of rumination and mindful attention awareness
Mao, L., Wu, Y., Xin, H., Li, P., Yuan, X., & Hu, M. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.03.052 · Cited by 18

Authors: McCrory, E. J., & Viding, E.
Affiliations: University College London (GB)
Corresponding author: McCrory, Eamon J.
ORCID: McCrory, Eamon J.
Viding, Essi
Venue: Development and Psychopathology
Publisher: Cambridge University Press (CUP)
Published: 2015-05
Volume: 27
Issue: 2
Pages: 493-505
ISSN: 0954-5794 (ISSN-L)
1469-2198
DOI: 10.1017/s0954579415000115
OpenAlex: W2099527079
Cited by: 295
References: 104
Citations by year: 2026: 43 · 2025: 35 · 2024: 31 · 2023: 32 · 2022: 29 · 2021: 23 · 2020: 29 · 2019: 18 · 2018: 16 · 2017: 22 · 2016: 12 · 2015: 5
FWCI: 2.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 5 d)
Locations: Development and Psychopathology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Economic and Social Research Council (ES/K005723/1, ES/H007059/1)
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Sociology and Political Science › Child Welfare and Adoption
Keywords: child abuse, mental illness, threat processing, threat vigilance, reward processing, memory processes, mental health prevention, indicated prevention, risk trajectories
MeSH terms: Attention, Mental Disorders, Child, Child Abuse, Humans, Risk Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The theory of latent vulnerability: Reconceptualizing the link between childhood maltreatment and psychiatric disorder

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks