Functional Magnetic Resonance Imaging Studies in Bipolar Disorder
Abstract
Abnormalities in brain activation using functional magnetic resonance imaging (fMRI) during cognitive and emotional tasks have been identified in bipolar disorder patients, in frontal, subcortical and limbic regions. Several studies also indicate that mood state may be differentiated by lateralization of brain activation in fronto-limbic regions. The interpretation of fMRI studies in bipolar disorder is limited by the choice of regions of interest, medication effects, comorbidity, and task performance. These studies suggest that there is a complex alteration in regions important for neural networks underlying cognition and emotional processing in bipolar disorder. However, measuring changes in specific brain regions does not identify how these neural networks are affected. New analytical techniques of fMRI data are needed in order to resolve some of these issues and identify how changes in neural networks relate to cognitive and emotional processing in bipolar disorder.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Evidence for abnormalities in reward-related neural network function in mania is scarce.
“Although functional MRI studies have identified prefrontal dysfunction in bipolar disorder and manic psychosis, evidence for abnormalities in reward-related neural network function in mania is scarce [271-275].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [275]
Cites
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693 · see citing works
Frontal-subcortical circuits and human behavior
Cummings, J. L. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540080076020 · Cited by 2,262 · see citing works
Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585 · see citing works
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works
Cognitive deficits in depression: Possible implications for functional neuropathology
Austin, M.-P., Mitchell, P., & Goodwin, G. M. (2001) · British Journal of Psychiatry · doi:10.1192/bjp.178.3.200 · Cited by 1,154 · see citing works
The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings
Strakowski, S. M., DelBello, M. P., & Adler, C. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001585 · Cited by 818 · see citing works
Physiological Dysfunction of the Dorsolateral Prefrontal Cortex in Schizophrenia Revisited
Callicott, J. H. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.11.1078 · Cited by 810 · see citing works
Hornak, J., Rolls, E. T., & Wade, D. (1996) · Neuropsychologia · doi:10.1016/0028-3932(95)00106-9 · Cited by 735 · see citing works
Manoach, D. S. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00294-3 · Cited by 681 · see citing works
Emotional bias and inhibitory control processes in mania and depression
MURPHY, F. C., SAHAKIAN, B. J., RUBINSZTEIN, J. S., MICHAEL, A., ROGERS, R. D., ROBBINS, T. W., & PAYKEL, E. S. (1999) · Psychological Medicine · doi:10.1017/s0033291799001233 · Cited by 659 · see citing works
Davidson, R. J. (1998) · Psychophysiology · doi:10.1017/s0048577298000134 · Cited by 646 · see citing works
Selective Deficits in Prefrontal Cortex Function in Medication-Naive Patients With Schizophrenia
Barch, D. M., Carter, C. S., Braver, T. S., Sabb, F. W., MacDonald, A. W., Noll, D. C., & Cohen, J. D. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.3.280 · Cited by 615 · see citing works
Rajkowska, G., Halaris, A. E., & Selemon, L. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01080-0 · Cited by 572 · see citing works
Lawrence, N. S., Williams, A. M., Surguladze, S., Giampietro, V., Brammer, M. J., Andrew, C., Frangou, S., Ecker, C., & Phillips, M. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.017 · Cited by 548 · see citing works
Cognitive control and brain resources in major depression: An fMRI study using the n-back task
Harvey, P.-O., Fossati, P., Pochon, J.-B., Levy, R., LeBastard, G., Lehéricy, S., Allilaire, J.-F., & Dubois, B. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.048 · Cited by 534 · see citing works
A Functional Magnetic Resonance Imaging Study of Bipolar Disorder
Blumberg, H. P., Leung, H., Skudlarski, P., Lacadie, C., Fredericks, C. A., Harris, B. C., Charney, D. S., Gore, J. C., Krystal, J. H., & Peterson, B. S. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.601 · Cited by 475 · see citing works
The Neural Basis of Mood-Congruent Processing Biases in Depression
Elliott, R., Rubinsztein, J. S., Sahakian, B. J., & Dolan, R. J. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.7.597 · Cited by 440 · see citing works
fMRI during affect discrimination in bipolar affective disorder
Yurgelun‐Todd, D. A., Gruber, S. A., Kanayama, G., Killgore, W. D., Baird, A. A., & Young, A. D. (2000) · Bipolar Disorders · doi:10.1034/j.1399-5618.2000.20304.x · Cited by 359 · see citing works
Self-citationDecreased regional cortical gray matter volume in schizophrenia
Schlaepfer, T. E., Harris, G. J., Tien, A. Y., Peng, L. W., Lee, S., Federman, E. B., Chase, G. A., Barta, P. E., & Pearlson, G. D. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.6.842 · Cited by 354 · see citing works
ELLIOTT, R., BAKER, S. C., ROGERS, R. D., O'LEARY, D. A., PAYKEL, E. S., FRITH, C. D., DOLAN, R. J., & SAHAKIAN, B. J. (1997) · Psychological Medicine · doi:10.1017/s0033291797005187 · Cited by 307 · see citing works
Cognitive impairment in the euthymic phase of affective disorder
Kessing, L. V. (1998) · Psychological Medicine · doi:10.1017/s0033291798006862 · Cited by 292 · see citing works
Anomalous Prefrontal-Subcortical Activation in Familial Pediatric BipolarDisorder
Chang, K., Adleman, N. E., Dienes, K., Simeonova, D. I., Menon, V., & Reiss, A. L. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.781 · Cited by 286 · see citing works
Wagner, G., Sinsel, E., Sobanski, T., Köhler, S., Marinou, V., Mentzel, H.-J., Sauer, H., & Schlösser, R. G. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.025 · Cited by 278 · see citing works
Increased anterior cingulate and caudate activity in bipolar mania
Blumberg, H. P., Stern, E. R., Martínez, D., Ricketts, S., de Asis, J. M., White, T. G., Epstein, J., McBride, P., Eidelberg, D., Kocsis, J. H., et al. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00962-8 · Cited by 276 · see citing works
Basal ganglia volumes and white matter hyperintensities in patients with bipolar disorder
Aylward, E., Roberts-Twillie, J. V., Barta, P. E., Kumar, A. J., Harris, G. J., Geer, M. J., Peyser, C. E., & Pearlson, G. D. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.5.687 · Cited by 273 · see citing works
George, M. S., Ketter, T. A., Parekh, P. I., Rosinsky, N., RING, H. A., Pazzaglia, P. J., Marangell, L. B., Callahan, A. M., & Post, R. M. (1997) · Journal of Neuropsychiatry · doi:10.1176/jnp.9.1.55 · Cited by 253 · see citing works
Attenuated Frontal Activation During a Verbal Fluency Task in Patients With Schizophrenia
Curtis, V. A., Bullmore, E. T., Brammer, M. J., Wright, I. C., Williams, S., Morris, R. G., Sharma, T. S., Murray, R. M., & McGuire, P. K. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.8.1056 · Cited by 249 · see citing works
Cognitive impairment and cerebral structure by MRI in bipolar disorder
Coffman, J. A., Bornstein, R. A., Olson, S. C., Schwarzkopf, S. B., & Nasrallah, H. A. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90416-y · Cited by 244 · see citing works
Yurgelun-Todd, D. A., WATERNAUX, C. M., Cohen, B. M., Gruber, S. A., English, C. D., & Renshaw, P. F. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.2.200 · Cited by 242 · see citing works
Self-citationA Preliminary fMRI Study of Sustained Attention in Euthymic, Unmedicated Bipolar Disorder
Strakowski, S. M., Adler, C. M., Holland, S. K., Mills, N., & DelBello, M. P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300492 · Cited by 242 · see citing works
Chen, C.-H., Lennox, B., Jacob, R., Calder, A., Lupson, V., Bisbrown-Chippendale, R., Suckling, J., & Bullmore, E. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.008 · Cited by 235 · see citing works
Blumberg, H. P., Martin, A., Kaufman, J., Leung, H.-C., Skudlarski, P., Lacadie, C., Fulbright, R. K., Gore, J. C., Charney, D. S., Krystal, J. H., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.7.1345 · Cited by 235 · see citing works
Clinical and Psychosocial Origins of Chronic Depressive Episodes
Brown, G. W., & Moran, P. M. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.165.4.447 · Cited by 233 · see citing works
Ll, A., Curran, J. G., Hauser, P., Mintz, J., Denicoff, K. D., & Post, R. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.8.1139 · Cited by 229 · see citing works
Elliott, R., Ogilvie, A. D., Rubinsztein, J. S., Calderon, G., Dolan, R. J., & Sahakian, B. J. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.007 · Cited by 221 · see citing works
Subcortical Abnormalities Detected in Bipolar Affective Disorder Using Magnetic Resonance Imaging
Dupont, R. M. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810130057008 · Cited by 218 · see citing works
Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study
Adler, C. M., Holland, S. K., Schmithorst, V. J., Wilke, M., Weiss, K. L., Pan, H., & Strakowski, S. M. (2004) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00108.x · Cited by 211 · see citing works
Strakowski, S. M., Adler, C. M., Holland, S. K., Mills, N. P., DelBello, M. P., & Eliassen, J. C. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.9.1697 · Cited by 209 · see citing works
Structural brain abnormalities in first-episode mania
Strakowski, S. M., Wilson, D. R., Tohen, M. F., Woods, B. T., Douglass, A. W., & Stoll, A. L. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90098-x · Cited by 204 · see citing works
Haznedar, M. M., Roversi, F., Pallanti, S., Rossi, N. B., Schnur, D. B., LiCalzi, E. M., Tang, C. Y., Hof, P. R., Hollander, E., & Buchsbaum, M. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.002 · Cited by 204 · see citing works
Adler, C. M., Holland, S. K., Schmithorst, V. J., Tuchfarber, M. J., & Strakowski, S. M. (2004) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00117.x · Cited by 194 · see citing works
Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania
LENNOX, B. R., JACOB, R., CALDER, A. J., LUPSON, V., & BULLMORE, E. T. (2004) · Psychological Medicine · doi:10.1017/s0033291704002557 · Cited by 192 · see citing works
Neuropsychology of bipolar disorder
Murphy, F. C., & Sahakian, B. J. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.41.s120 · Cited by 180 · see citing works
Attenuated Left Prefrontal Activation during a Verbal Fluency Task in Patients with Depression
Okada, G., Okamoto, Y., Morinobu, S., Yamawaki, S., & Yokota, N. (2003) · Neuropsychobiology · doi:10.1159/000068871 · Cited by 178 · see citing works
Monks, P. J., Thompson, J. M., Bullmore, E. T., John Suckling, A., Brammer, M. J., Williams, S., Simmons, A., Giles, N., Lloyd, A. J., Harrison, C. L., et al. (2004) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00147.x · Cited by 174 · see citing works
Cognitive generation of affect in bipolar depression: an fMRI study
Malhi, G. S., Lagopoulos, J., Ward, P. B., Kumari, V., Mitchell, P. B., Parker, G. B., Ivanovski, B., & Sachdev, P. S. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2003.03159.x · Cited by 165 · see citing works
Decreased activation of the anterior cingulate in bipolar patients: an fMRI study
Gruber, S. A., Rogowska, J., & Yurgelun-Todd, D. A. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2003.10.010 · Cited by 164 · see citing works
Self-citationHugdahl, K., Rund, B. R., Lund, A., Asbjørnsen, A. E., Egeland, J., Ersland, L., Landrø, N. I., Roness, A., Stordal, K. I., Sundet, K. S., et al. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.286 · Cited by 162 · see citing works
Cortical White Matter Microstructural Abnormalities in Bipolar Disorder
Beyer, J. L., Taylor, W. D., MacFall, J. R., Kuchibhatla, M. N., Payne, M. E., Provenzale, J. M., Cassidy, F., & Krishnan, K. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300802 · Cited by 155 · see citing works
Haldane, M., & Frangou, S. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.05.040 · Cited by 138 · see citing works
Volz, H., Christian Gaser, B., Häger, F., Rzanny, R., Pönisch, J., Mentzel, H., Kaiser, W. A., & Sauer, H. (1999) · European Psychiatry · doi:10.1016/s0924-9338(99)80711-1 · Cited by 136 · see citing works
Joseph, R. (1999) · Psychiatry · doi:10.1080/00332747.1999.11024862 · Cited by 133 · see citing works
Corpus callosum signal intensity in patients with bipolar and unipolar disorder.
(2004) · PubMed Central · Cited by 131 · see citing works
Caligiuri, M. P., Brown, G. G., Meloy, M. J., Eberson, S., Kindermann, S. S., Frank, L. R., Zorrilla, L. T. E., & Lohr, J. B. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00075-1 · Cited by 130 · see citing works
Neural response to emotional prosody in schizophrenia and in bipolar affective disorder
Mitchell, R. L. C., Elliott, R., Barry, M., Cruttenden, A., & Woodruff, P. W. R. (2004) · British Journal of Psychiatry · doi:10.1192/bjp.184.3.223 · Cited by 128 · see citing works
Reduced left hemispheric white matter volume in twins with bipolar I disorder
Kieseppä, T., van Erp, T. G. M., Haukka, J. K., Partonen, T., Cannon, T. D., Poutanen, V.-P., Kaprio, J. A., & Lönnqvist, J. K. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00373-1 · Cited by 115 · see citing works
Differential frontal activation in schizophrenia and bipolar illness during verbal fluency
Curtis, V. A., Dixon, T., Morris, R. G., Bullmore, E. T., Brammer, M. J., Williams, S., Sharma, T., Murray, R. M., & McGuire, P. K. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00240-8 · Cited by 114 · see citing works
Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorder
Brambilla, P., Nicoletti, M., Sassi, R. B., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00070-2 · Cited by 113 · see citing works
Cognitive generation of affect in hypomania: an fMRI study
Malhi, G. S., Lagopoulos, J., Sachdev, P. S., Mitchell, P. B., Ivanovski, B., & Parker, G. B. (2004) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00123.x · Cited by 105 · see citing works
Zipursky, R. B., Seeman, M. V., Bury, A. S., Langevin, R., Wortzman, G., & Katz, R. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00042-x · Cited by 103 · see citing works
Bipolar disorder: Are repeated episodes associated with neuroanatomic and cognitive changes?
Altshuler, L. L. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90093-s · Cited by 92 · see citing works
A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorder
Caligiuri, M. P., Brown, G. G., Meloy, M. J., Eyler, L. T., Kindermann, S. S., Eberson, S., Frank, L. R., & Lohr, J. B. (2004) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00116.x · Cited by 92 · see citing works
Mediational factors underlying cognitive changes and laterality in affective illness
Sapin, L. R., Berrettini, W. H., Nürnberger, J. I., & Rothblat, L. A. (1987) · Biological Psychiatry · doi:10.1016/0006-3223(87)90007-2 · Cited by 90 · see citing works
The Maudsley Bipolar Disorder Project
Frangou, S. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.463005.x · Cited by 74 · see citing works
White matter hyperintensities in subjects with bipolar disorder
Ahn, K. H., Lyoo, I. K., Lee, H. K., Song, I. C., Oh, J. S., Hwang, J., Kwon, J.-Y., Kim, M. J., Kim, M.-J., & Renshaw, P. F. (2004) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2004.01294.x · Cited by 72 · see citing works
Davis, K. L. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.03.010 · Cited by 48 · see citing works
Age-related MRI abnormalities in bipolar illness: A clinical study
Woods, B. T., Yurgelun-Todd, D. A., Mikulis, D. J., & Pillay, S. S. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(95)00363-0 · Cited by 34 · see citing works
Self-citationInsights and treatment options for psychiatric disorders guided by functional MRI
Sharma, T. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19166 · Cited by 15 · see citing works
Calsyn, D. A., Roszell, D. K., & Chaney, E. F. (1989) · Journal of Clinical Psychology · doi:10.1002/1097-4679(198911)45:6 · Cited by 14 · see citing works
THE MANIC‐DEPRESSIVE PSYCHOSES
Farber, I. J. (1926) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1926.tb40643.x · Cited by 10 · see citing works
White, W. A. (1926) · Nervous and Mental Disease Publishing Co eBooks · doi:10.1037/13422-009 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Affective Neural Circuitry During Facial Emotion Processing in Pediatric Bipolar Disorder
Pavuluri, M. N., O‘Connor, M. M., Harral, E., & Sweeney, J. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.011 · Cited by 268 · see citing works
Abnormal Reward System Activation in Mania
Abler, B., Greenhouse, I., Ongur, D., Walter, H., & Heckers, S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301620 · Cited by 216 · see citing works
Potkin, S. G., Turner, J. A., Fallon, J. A., Lakatos, A., Keator, D. B., Guffanti, G., Macciardi, F., & FBIRN (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.127 · Cited by 97 · see citing works
Pharmacological Treatment of Cognitive Dysfunction in Neuropsychiatric Disorders
Venero, C. (2015) · Cognitive Enhancement · doi:10.1016/b978-0-12-417042-1.00010-3 · Cited by 4 · see citing works
- Authors
- Yurgelun-Todd, D. A., & Ross, A. J.
- Affiliations
- Harvard University (US)
- Venue
- CNS Spectrums
- Publisher
- Cambridge University Press (CUP)
- Published
- 2006-04
- Volume
- 11
- Issue
- 4
- Pages
- 287-297
- ISSN
- 1092-8529 (ISSN-L)
- 2165-6509
- OpenAlex
- W1878643816
- Cited by
- 44
- References
- 71
- Citations by year
- 2025: 1 · 2023: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2013: 2 · 2012: 6
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Spectrums (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, brain activation, mood states, laterality, subcortical structures, cognitive processes, emotional processing, artificial neural networks, medication effects, comorbidities
- MeSH terms
- Bipolar Disorder, Cognition Disorders, Dominance, Cerebral, Emotions, Frontal Lobe, Humans, Limbic System, Magnetic Resonance Imaging, Nerve Net
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
