Frontostriatal Abnormalities in Adolescents With Bipolar Disorder: Preliminary Observations From Functional MRI
Abstract
OBJECTIVE: This study investigated whether the functional abnormalities in prefrontal systems observed in adult bipolar disorder are manifested in adolescents with this illness. METHOD: Ten adolescents with bipolar disorder and 10 healthy comparison subjects participated in a color-naming Stroop task during event-related functional magnetic resonance imaging. RESULTS: Signal increases in the left putamen and thalamus were significantly greater in the bipolar disorder group than in the healthy group. Age correlated positively with signal increases in the bilateral rostroventral prefrontal cortex and the striatum in the healthy group but not in the bipolar disorder group. In the bipolar disorder subjects, depressive symptoms correlated positively with signal increases in the ventral striatum. CONCLUSIONS: These findings suggest the presence of dysfunction in the subcortical portions of the frontostriatal circuits in adolescents with bipolar disorder. The absence of the prefrontal abnormalities that were observed previously in adults and the absence of the age-related increases in prefrontal activity observed in normal comparison subjects suggest that a developmental disturbance in prefrontal function may emerge in bipolar disorder over the course of adolescence.
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Evidence for abnormalities in reward-related neural network function in mania is scarce.
“Although functional MRI studies have identified prefrontal dysfunction in bipolar disorder and manic psychosis, evidence for abnormalities in reward-related neural network function in mania is scarce [271-275].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [271]
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Self-citation
- Authors
- Blumberg, H. P., Martin, A., Kaufman, J., Leung, H.-C., Skudlarski, P., Lacadie, C., Fulbright, R. K., Gore, J. C., Charney, D. S., Krystal, J. H., & Peterson, B. S.
- Affiliations
- Yale University (US)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2003-07-01
- Volume
- 160
- Issue
- 7
- Pages
- 1345-1347
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2111705033
- Cited by
- 235
- References
- 12
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 13 · 2012: 17
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k01mh001792-05)
- National Institute on Alcohol Abuse and Alcoholism (AA-00261-01)
- National Institute of Mental Health (MH01792, MH59139, R01MH059139, MH-01232, K08MH001232)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- bipolar disorder, adolescents, frontostriatal circuits, prefrontal cortex, ventral striatum, putamen, thalamus, Stroop task, depressive symptoms, age-related brain development, subcortical dysfunction
- MeSH terms
- Adolescent, Age Factors, Basal Ganglia, Bipolar Disorder, Child, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Prefrontal Cortex
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