Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS
Abstract
The 22q11.2 deletion syndrome (22q11.2DS) is the most common hemizygous deletion syndrome in humans. In addition to a wide range of physical abnormalities 22q11.2DS subjects show high prevalence of several psychiatric disorders. In our previous study we showed that the low-activity allele (158Met) of the COMT gene is a risk factor for attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) in 22q11.2DS individuals. In the present study we have genotyped fifty-five 22q11.2DS individuals and 95 of their parents for eight SNPs in and around the COMT gene. A haplotype composed of three SNPs [rs2097603; rs4680 (158Val/Met); rs165599] representing the major linkage disequilibrium blocks in COMT and previously implicated in functional variation, was found to be associated with ADHD and OCD in 22q11.2DS individuals. A common risk haplotype (G-A-A) was significantly associated with both ADHD (OR 3.13, chi2=4.38, p=0.036) and OCD (OR 4.00, chi2=6.41, p=0.011) in 22q11.2DS individuals. Interestingly, the same haplotype was recently found to be associated with efficient prefrontal performance in the general population. The risk haplotype was not found to be associated with IQ scores in our 22q11.2DS sample. Parental origin of the deletion did not affect the susceptibility to ADHD and OCD in the 22q11.2DS subjects. This study demonstrated the association of a particular COMT haplotype with susceptibility to both ADHD and OCD in 22q11.2DS and supports the hypothesis that COMT gene variations contribute to genetic predisposition to psychiatric disorders in the general population.
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Met has been associated with ADHD inattention and hyperactivity-impulsivity symptoms in adult community samples.
“Moreover, Met has been associated with ADHD inattention and hyperactivity-impulsivity symptoms in adult community samples (Ettinger et al, 2006; Gothelf et al, 2007; Michaelovsky et al, 2008; Reuter et al, 2006).”
From DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls (2010) · cites this paper as Michaelovsky et al, 2008
Cites
Arlequin (version 3.0): An integrated software package for population genetics data analysis
Excoffier, L., Laval, G., & Schneider, S. (2005) · Evolutionary Bioinformatics · doi:10.1177/117693430500100003 · Cited by 14,194 · see citing works
Journal of Clinical Psychiatry
(2018) · Journal of Clinical Psychiatry · doi:10.5505/kpd · Cited by 13,703 · see citing works
The American Journal of Human Genetics
S., J. (1950) · Population · doi:10.2307/1523704 · Cited by 5,124 · see citing works
Performing the Exact Test of Hardy-Weinberg Proportion for Multiple Alleles
Guo, S., & Thompson, E. A. (1992) · Biometrics · doi:10.2307/2532296 · Cited by 4,854 · see citing works
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,374 · see citing works
International Journal of Molecular Medicine
(2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm · Cited by 2,247 · see citing works
McDonald-McGinn, D. M., Sullivan, K. E., Marino, B., Philip, N., Swillen, A., Vorstman, J. A. S., Zackai, E. H., Emanuel, B. S., Vermeesch, J. R., Morrow, B. E., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.71 · Cited by 2,236 · see citing works
Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y.-M., Szumlanski, C. L., & Weinshilboum, R. M. (1996) · Pharmacogenetics · doi:10.1097/00008571-199606000-00007 · Cited by 1,788 · see citing works
Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Kolachana, B. S., Hyde, T. M., Herman, M. M., Apud, J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/425589 · Cited by 1,675 · see citing works
Attention-deficit hyperactivity disorder
Biederman, J., & Faraone, S. V. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66915-2 · Cited by 1,463 · see citing works
High rates of schizophrenia in adults with velo-cardio-facial syndrome
Murphy, K. C., Jones, L. A., & Owen, M. J. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.10.940 · Cited by 1,024 · see citing works
Nackley, A. G., Shabalina, S. A., Tchivileva, I. E., Satterfield, K., Korchynskyi, O., Makarov, S. S., Maixner, W., & Diatchenko, L. (2006) · Science · doi:10.1126/science.1131262 · Cited by 848 · see citing works
D1 receptors in prefrontal cells and circuits
Goldman-Rakic, P. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00045-4 · Cited by 807 · see citing works
A Highly Significant Association between a COMT Haplotype and Schizophrenia
Shifman, S., Bronstein, M., Sternfeld, M., Pisanté, A., Lev-Lehman, E., Weizman, A., Reznik, I., Spivak, B., Grisaru, N., Karp, L., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/344514 · Cited by 691 · see citing works
Self-citationCatechol-o-Methyltransferase, Cognition, and Psychosis: Val158Met and Beyond
Tunbridge, E. M., Harrison, P. J., & Weinberger, D. R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.024 · Cited by 685 · see citing works
Schizophrenia: Diverse Approaches to a Complex Disease
Sawa, A., & Snyder, S. H. (2002) · Science · doi:10.1126/science.1070532 · Cited by 599 · see citing works
Testing for linkage disequilibrium in genotypic data using the Expectation-Maximization algorithm
Slatkin, M., & Excoffier, L. (1996) · Heredity · doi:10.1038/hdy.1996.55 · Cited by 567 · see citing works
The International Journal of Neuropsychopharmacology
Lerer, B., Frazer, A., Stahl, S. M., Farde, L., & Lesch, K. (1998) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145798009018 · Cited by 500 · see citing works
Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype
Meyer-Lindenberg, A., Kohn, P. D., Kolachana, B., Kippenhan, S., McInerney-Leo, A., Nussbaum, R., Weinberger, D. R., & Berman, K. F. (2005) · Nature Neuroscience · doi:10.1038/nn1438 · Cited by 428 · see citing works
Drabant, E. M., Hariri, A. R., Meyer‐Lindenberg, A., Muñoz, K. E., Mattay, V. S., Kolachana, B. S., Egan, M. F., & Weinberger, D. R. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.12.1396 · Cited by 382 · see citing works
Molecular Definition of 22q11 Deletions in 151 Velo-Cardio-Facial Syndrome Patients
Carlson, C., Sirotkin, H. I., PANDITA, R. K., Goldberg, R. B., McKie, J. M., Wadey, R., Patanjali, S. R., Weissman, S. M., Anyane‐Yeboa, K., Warburton, D., et al. (1997) · The American Journal of Human Genetics · doi:10.1086/515508 · Cited by 362 · see citing works
Linkage disequilibrium in growing and stable populations.
Slatkin, M. (1994) · Genetics · doi:10.1093/genetics/137.1.331 · Cited by 352 · see citing works
Stein, D. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09620-4 · Cited by 352 · see citing works
Glatt, S. J., Faraone, S. V., & Tsuang, M. T. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.469 · Cited by 343 · see citing works
Bray, N. J., Buckland, P. R., Williams, N. M., Williams, H. J., Norton, N., Owen, M. J., & O’Donovan, M. C. (2003) · The American Journal of Human Genetics · doi:10.1086/376578 · Cited by 335 · see citing works
Catechol- <i>O</i> -Methyltransferase Genotype and Dopamine Regulation in the Human Brain
Akil, M., Kolachana, B. S., Rothmond, D. A., Hyde, T. M., Weinberger, D. R., & Kleinman, J. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02008.2003 · Cited by 325 · see citing works
Impact of complex genetic variation in COMT on human brain function
Meyer‐Lindenberg, A., Nichols, T. E., Callicott, J. H., Ding, J., Kolachana, B. S., Buckholtz, J. W., Mattay, V. S., Egan, M. F., & Weinberger, D. R. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001860 · Cited by 321 · see citing works
COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome
Gothelf, D., D, S. E. M., Thompson, T., Hinard, C., Penniman, L. C., Feinstein, C., Kwon, H., Jin, S., Jo, B., Antonarakis, S. E., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1572 · Cited by 318 · see citing works
Self-citationSchizophrenia and velo-cardio-facial syndrome
Murphy, K. C. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07604-3 · Cited by 284 · see citing works
Beyond the serotonin hypothesis: a role for dopamine in some forms of obsessive compulsive disorder?
Goodman, W. K., McDougle, C. J., Price, L. H., Riddle, M. A., Pauls, D. L., & Leckman, J. F. (1990) · PubMed · Cited by 283 · see citing works
The neuropsychopharmacology of attention-deficit/hyperactivity disorder
Pliszka, S. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.026 · Cited by 276 · see citing works
Chromosomal microdeletions: dissecting del22q11 syndrome
Lindsay, E. A. (2001) · Nature Reviews Genetics · doi:10.1038/35098574 · Cited by 261 · see citing works
Molecular definition of the 22q11 deletions in velo-cardio-facial syndrome.
Morrow, B. E., Goldberg, R. B., Carlson, C., et al. (1995) · PubMed · Cited by 245 · see citing works
Risk Factors for the Emergence of Psychotic Disorders in Adolescents With 22q11.2 Deletion Syndrome
Gothelf, D., Feinstein, C., Thompson, T., Gu, E., Penniman, L. C., Stone, E. V., Kwon, H., D, S. E. M., & Reiss, A. L. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.4.663 · Cited by 240 · see citing works
Self-citationCraddock, N., Owen, M. J., & O'Donovan, M. C. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001808 · Cited by 216 · see citing works
Lambe, E. K., Krimer, L. S., & Goldman-Rakic, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08780.2000 · Cited by 204 · see citing works
Imprinting defects on human chromosome 15
Horsthemke, B., & Buiting, K. (2006) · Cytogenetic and Genome Research · doi:10.1159/000090844 · Cited by 195 · see citing works
Feinstein, C., Eliez, S., Blasey, C. M., & Reiss, A. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01231-8 · Cited by 181 · see citing works
Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome
Raux, G., Bumsel, E., Hecketsweiler, B., van Amelsvoort, T., Zinkstok, J., Manouvrier‐Hanu, S., Fantini‐Hauwel, C., Brèviere, G., Rosa, G. D., Pustorino, G., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl443 · Cited by 170 · see citing works
COMT: A common susceptibility gene in bipolar disorder and schizophrenia
Shifman, S., Bronstein, M., Sternfeld, M., Pisanté, A., Weizman, A., Reznik, I., Spivak, B., Grisaru, N., Karp, L., Schiffer, R., et al. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30032 · Cited by 163 · see citing works
Self-citationObsessive‐compulsive disorder in patients with velocardiofacial (22q11 deletion) syndrome
Gothelf, D., Presburger, G., Zohar, A. H., Burg, M., Nahmani, A., Frydman, M., Shohat, M., Inbar, D., Aviram‐Goldring, A., Yeshaya, J., et al. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20124 · Cited by 157 · see citing works
Self-citationCOMT Val108/158Met Modifies Mismatch Negativity and Cognitive Function in 22q11 Deletion Syndrome
Baker, K., Baldeweg, T., Sivagnanasundaram, S., Scambler, P. J., & Skuse, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.020 · Cited by 150 · see citing works
Heinz, A., & Smolka, M. N. (2006) · Reviews in the Neurosciences · doi:10.1515/revneuro.2006.17.3.359 · Cited by 148 · see citing works
Nicodemus, K. K., Kolachana, B. S., Vakkalanka, R., Straub, R. E., Giegling, I., Egan, M. F., Rujescu, D., & Weinberger, D. R. (2006) · Human Genetics · doi:10.1007/s00439-006-0257-3 · Cited by 143 · see citing works
Li, T., Ball, D., Zhao, J., Murray, R. M., Liu, X., Sham, P. C., & Collier, D. A. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000638 · Cited by 140 · see citing works
Chromosome 22q11.2 deletion syndrome (DiGeorge and velocardiofacial syndromes)
Pérez, E., & Sullivan, K. E. (2002) · Current Opinion in Pediatrics · doi:10.1097/00008480-200212000-00005 · Cited by 134 · see citing works
COMT genetic variation confers risk for psychotic and affective disorders: a case control study
Funke, B., Malhotra, A. K., Finn, C. T., Plocik, A. M., Lake, S. L., Lencz, T., DeRosse, P., Kane, J. M., & Kucherlapati, R. (2005) · Behavioral and Brain Functions · doi:10.1186/1744-9081-1-19 · Cited by 134 · see citing works
Hamilton, S. P., Slager, S. L., Heiman, G. A., Deng, Z., Haghighi, F. G., Klein, D. F., Hodge, S. E., Weissman, M. M., Fyer, A. J., & Knowles, J. A. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01322-1 · Cited by 129 · see citing works
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_641 · Cited by 125 · see citing works
Qian, Q., Wang, Y., Zhou, R., Li, J., Wang, B., Glatt, S., & Faraone, S. V. (2003) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10064 · Cited by 113 · see citing works
Fallgatter, A. J., Ehlis, A.-C., Rösler, M., Strik, W. K., Blocher, D., & Herrmann, M. J. (2005) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2004.12.002 · Cited by 103 · see citing works
Bassett, A. S., Caluseriu, O., Weksberg, R., Young, D. A., & Chow, E. W. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.038 · Cited by 99 · see citing works
Language skills in children with velocardiofacial syndrome (deletion 22q11.2)
Glaser, B., Mumme, D. L., Blasey, C. M., Morris, M. A., Dahoun, S. P., Antonarakis, S. E., Reiss, A. L., & D, S. E. M. (2002) · The Journal of Pediatrics · doi:10.1067/mpd.2002.124774 · Cited by 94 · see citing works
Gothelf, D., Presburger, G., Levy, D., Nahmani, A., Burg, M., Berant, M., Blieden, L. C., Finkelstein, Y., Frisch, A., Apter, A. S., et al. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20144 · Cited by 90 · see citing works
Self-citationHandoko, H. Y., Nyholt, D. R., Hayward, N. K., Nertney, D. A., Hannah, D. E., Windus, L. C. E., McCormack, C., Smith, H. J., Filippich, C., James, M. R., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001606 · Cited by 85 · see citing works
Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome
Shashi, V., Keshavan, M., Howard, T., Berry, M., Basehore, M. J., Lewandowski, K. E., & Kwapil, T. R. (2006) · Clinical Genetics · doi:10.1111/j.1399-0004.2006.00569.x · Cited by 79 · see citing works
Kates, W. R., Antshel, K. M., AbdulSabur, N. Y., Colgan, D., Funke, B., Fremont, W. P., Higgins, A. M., Kucherlapati, R., & Shprintzen, R. J. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30284 · Cited by 79 · see citing works
Azzam, A., & Mathews, C. A. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20013 · Cited by 76 · see citing works
Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia
Sanders, A. R., Rusu, I., Duan, J., Molen, J. E. V., Hou, C., Schwab, S. G., Wildenauer, D. B., Martinez, M. M., & Gejman, P. V. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001586 · Cited by 74 · see citing works
Parental Origin of the Deletion 22q11.2 and Brain Development in Velocardiofacial Syndrome
D, S. E. M., Antonarakis, S. E., Morris, M. A., Dahoun, S. P., & Reiss, A. L. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.1.64 · Cited by 69 · see citing works
Demczuk, S., L�vy, A., Aubry, M., et al. (1995) · Human Genetics · doi:10.1007/bf00214179 · Cited by 68 · see citing works
(2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706006699 · Cited by 67 · see citing works
Self-citationFokstuen, S., Arbenz, U., Artan, S., Dutly, F., Bauersfeld, U., Brečević, L., Fasnacht, M. S., Rathlisberger, B., & Schinzel, A. (1998) · Clinical Genetics · doi:10.1034/j.1399-0004.1998.531530113.x · Cited by 66 · see citing works
Risk Factors for the Emergence of Psychotic Disorders in Adolescents With 22q11.2 Deletion Syndrome
Gothelf, D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.4.663 · Cited by 59 · see citing works
Self-citationAbnormal cortical activation during response inhibition in 22q11.2 deletion syndrome
Gothelf, D., Hoeft, F., Hinard, C., Hallmayer, J. F., Stoecker, J. V. D., Antonarakis, S. E., Morris, M. A., & Reiss, A. L. (2007) · Human Brain Mapping · doi:10.1002/hbm.20405 · Cited by 55 · see citing works
Self-citationGlaser, B., Debbané, M., Hinard, C., Morris, M. A., Dahoun, S. P., Antonarakis, S. E., & D, S. E. M. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.3.537 · Cited by 53 · see citing works
GELLER, D. A., Petty, C. R., Vivas, F., Johnson, J., Pauls, D. L., & Biederman, J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.026 · Cited by 50 · see citing works
Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome
Meechan, D. W., Maynard, T. M., Wu, Y., Gopalakrishna, D., Lieberman, J. A., & LaMantia, A. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.09.001 · Cited by 48 · see citing works
Weinshilboum, R. M., & Dunnette, J. H. (1981) · Clinical Genetics · doi:10.1111/j.1399-0004.1981.tb00740.x · Cited by 46 · see citing works
Turic, D., Williams, H. J., Langley, K., Owen, M. J., Thapar, A., & O’Donovan, M. C. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30123 · Cited by 30 · see citing works
Prevalence and Parental Origin in Tetralogy of Fallot Associated With Chromosome 22q11 Microdeletion
Lu, J., Chung, M., Hwang, B., et al. (1999) · PEDIATRICS · doi:10.1542/peds.104.1.87 · Cited by 26 · see citing works
Haplotype analysis of the COMT‐ARVCF gene region in Israeli anorexia nervosa family trios
Michaelovsky, E., Frisch, A., Leor, S., Stein, D. J., Danziger, Y., Carel, C. A., Fennig, S., Mimouni, M., Klauck, S. M., Benner, A., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30230 · Cited by 23 · see citing works
Self-citationVittorini, S., Sacchelli, M., Iascone, M. R., et al. (2001) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2001.201 · Cited by 18 · see citing works
Fallgatter, A. J., & Lesch, K. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706006985 · Cited by 15 · see citing works
Haplotype analysis and identification of genes for a complex trait: examples from schizophrenia
Hennah, W., Varilo, T., Paunio, T., & Peltonen, L. (2004) · Annals of Medicine · doi:10.1080/07853890410029824 · Cited by 14 · see citing works
Chung, M., Lu, J., Chien, H.-P., et al. (2001) · International Journal of Molecular Medicine · doi:10.3892/ijmm.7.5.501 · Cited by 8 · see citing works
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Paloyelis, Y., Asherson, P., Mehta, M. A., Faraone, S. V., & Kuntsi, J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.124 · Cited by 180 · see citing works
Pálmason, H., Moser, D., Sigmund, J., Vogler, C., Hänig, S., Schneider, A., Seitz, C., Marcus, A., Meyer, J., & Freitag, C. M. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-009-0338-2 · Cited by 44 · see citing works
Gomez-Sanchez, C. I., Carballo, J. J., Riveiro-Alvarez, R., Soto-Insuga, V., Rodrigo, M., Mahillo-Fernandez, I., Abad-Santos, F., Dal-Ré, R., & Ayuso, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-10912-y · Cited by 24 · see citing works
- Authors
- Michaelovsky, E., Gothelf, D., Korostishevsky, M., Frisch, A., Burg, M., Carmel, M., Steinberg, T., Inbar, D., Apter, A., & Weizman, A.
- Affiliations
- Tel Aviv University (IL)
- Corresponding author
- Frisch, Amos
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-10-22
- Volume
- 11
- Issue
- 03
- Pages
- 351-63
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2127479476
- Cited by
- 53
- References
- 77
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 7 · 2012: 4
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Keywords
- 22q11.2 deletion syndrome, COMT gene, attention deficit hyperactivity disorder, obsessive-compulsive disorder, mental illness, linkage disequilibrium, single nucleotide polymorphisms, genetic susceptibility, parental origin, IQ
- MeSH terms
- Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Catechol O-Methyltransferase, Child, Child, Preschool, Chromosome Aberrations, Chromosomes, Human, Pair 22, Female, Gene Frequency, Genotype, Humans, Male, Methionine, Obsessive-Compulsive Disorder, Valine, Polymorphism, Single-Stranded Conformational, Genetic Predisposition to Disease
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