Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Free radicals and antioxidants in normal physiological functions and human disease

Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269

Journal of Clinical Psychiatry

(2018) · Journal of Clinical Psychiatry · doi:10.5505/kpd · Cited by 13,703

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413

Nitric Oxide and Peroxynitrite in Health and Disease

Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390

Oxidative stress: oxidants and antioxidants

Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577

Neurodegenerative diseases and oxidative stress

Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683 · cited 1×

Oxidative stress and neurodegeneration: where are we now?

Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614

Vitamin E, antioxidant and nothing more

Traber, M. G., & Atkinson, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.024 · Cited by 1,547

Untreated Depression and Hippocampal Volume Loss

Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1516 · Cited by 1,180

Oxidative stress: the paradox of aerobic life

Davies, K. J. A. (1995) · Biochemical Society Symposia · doi:10.1042/bss0610001 · Cited by 1,150

Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia

Madireddy, S., & Madireddy, S. (2020) · Brain Sciences · doi:10.3390/brainsci10100742 · Cited by 56

Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder

Henje Blom, E., Han, L. K. M., Connolly, C. G., Ho, T. C., Lin, J., LeWinn, K. Z., Simmons, A. N., Sacchet, M. D., Mobayed, N., Luna, M. E., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.172 · Cited by 51

Autistic spectrum disorder (ASD) – Gene, molecular and pathway signatures linking systemic inflammation, mitochondrial dysfunction, transsynaptic signalling, and neurodevelopment

Gevezova, M., Sbirkov, Y., Sarafian, V. S., Plaimas, K., Suratanee, A., & Maes, M. H. J. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100646 · Cited by 54

Lipid status, anti-oxidant enzyme defence and haemoglobin content in the blood of long-term clozapine-treated schizophrenic patients

Miljević, Č., Nikolic, M. R., Nikolić‐Kokić, A., Jones, D. R., Niketić, V., Lečić‐Toševski, D., & Spasić, M. B. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.11.024 · Cited by 53

Glutathione peroxidase-1 and neuromodulation: Novel potentials of an old enzyme

Sharma, G., Shin, E., Sharma, N., Nah, S.-Y., Nhu, H., Nguyen, B. T., Jeong, J. H., Lei, X. G., & Kim, H. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111945 · Cited by 53

Association of depressive symptoms with ambient PM2.5 in middle-aged and elderly Chinese adults: A cross-sectional study from the China health and Retirement Longitudinal Study wave 4

Yao, Y., Lu, T., Liu, Y., Qin, Q., Jiang, J., & Xiang, H. (2021) · Environmental Research · doi:10.1016/j.envres.2021.111889 · Cited by 53

Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies

Вячеславовна, Г. А., Svirin, E. P., Pavlov, D., Cespuglio, R., Proshin, A. T., Schroeter, C. A., Lesch, K., & Strekalova, T. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020915 · Cited by 54

Depression-Like Effect of Prenatal Buprenorphine Exposure in Rats

Hung, C.-J., Wu, C.-C., Chen, W., Chang, C.-Y., Kuan, Y., Pan, H.-C., Liao, S., & Chen, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082262 · Cited by 51

Doxycycline prevents and reverses schizophrenic-like behaviors induced by ketamine in mice via modulation of oxidative, nitrergic and cholinergic pathways

Ben‐Azu, B., Omogbiya, I. A., Aderibigbe, A. O., Umukoro, S., Ajayi, A. M., & Iwalewa, E. O. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.02.007 · Cited by 52

Improvement of cognitive function in schizophrenia withN-acetylcysteine: A theoretical review

Yolland, C. O. B., Phillipou, A., Castle, D. J., Neill, E., Hughes, M. E., Galletly, C. A., Smith, Z. M., Francis, P. S., Dean, O. M., Sarris, J. J., et al. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1478766 · Cited by 52

The relationship of dietary diversity score with depression and anxiety among prenatal and post‐partum women

Jiang, W., Mo, M., Li, M., Wang, S., Muyiduli, X., Shao, B., Jiang, S. S., & Yu, Y. (2018) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.13728 · Cited by 55

The effect of antidepressant drugs on thioacetamide-induced oxidative stress.

Abdel‐Salam, O. M. E., Mohammed, N. A., Sleem, A. A., & Farrag, A. (2013) · PubMed · Cited by 52

Effect of a novel 5-HT3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice

Gupta, D., Radhakrishnan, M., & Kurhe, Y. (2015) · Steroids · doi:10.1016/j.steroids.2015.01.021 · Cited by 54

(−)‐Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats

Kluknavský, M., Bališ, P., Púzserová, A., Radošinská, J., Berenyiová, A., Drobna, M., Lukac, S., Muchová, J., & Bernátová, I. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6949020 · Cited by 51

Innovative biomarkers in psychiatric disorders: a major clinical challenge in psychiatry

Lozupone, M., Seripa, D., Stella, E., Montagna, M. L., Solfrizzi, V., Quaranta, N. A. A., Veneziani, F., Cester, A., Sardone, R., Bonfiglio, C., et al. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1375857 · Cited by 52

Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design

Ribaudo, G., Bortoli, M., Pavan, C., Zagotto, G., & Orian, L. (2020) · Antioxidants · doi:10.3390/antiox9080714 · Cited by 51

Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice

Silva, M. C. C., de Sousa, C. N. S., Gomes, P. X. L., de Oliveira, G. V., de Araújo, F. Y. R., Ximenes, N. C., da Silva, J. C., Vasconcelos, G. S., Leal, L. K. A. M., Macêdo, D. S., et al. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.002 · Cited by 52

Telomerase activation as a possible mechanism of action for psychopharmacological interventions

Bersani, F. S., Lindqvist, D., Mellon, S. H., Penninx, B. W. J. H., Verhoeven, J. E., Révész, D., Reus, V. I., & Wolkowitz, O. M. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.06.016 · Cited by 50

Studies on the effects of aspartame on memory and oxidative stress in brain of mice.

Abdel‐Salam, O. M. E., Salem, N. A., El-Shamarka, M. E.-S., Hussein, J., Ahmed, N. A., & El-Nagar, M. E. S. (2012) · PubMed · Cited by 50

Increased Oxidative Parameters and Decreased Cytokine Levels in an Animal Model of Attention-Deficit/Hyperactivity Disorder

Leffa, D. T., Bellaver, B., de Oliveira, C., de Macedo, I. C., de Freitas, J. S., Grevet, E. H., Caumo, W., Rohde, L. A., Quincozes‐Santos, A., & Torres, I. L. D. S. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2341-6 · Cited by 49

Vaccinium bracteatum Leaf Extract Reverses Chronic Restraint Stress-Induced Depression-Like Behavior in Mice: Regulation of Hypothalamic-Pituitary-Adrenal Axis, Serotonin Turnover Systems, and ERK/Akt Phosphorylation

Oh, D.-R., Yoo, J.-S., Kim, Y., Kang, H., Lee, H., So, J., Choi, E.-J., Jung, M., Bae, D., Oh, K.-N., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00604 · Cited by 49

On the Neurobiological Role of Oxidative Stress in Alcohol-Induced Impulsive, Aggressive and Suicidal Behavior

Tobore, T. O. (2019) · Substance Use & Misuse · doi:10.1080/10826084.2019.1645179 · Cited by 50

Trends in big data analyses by multicenter collaborative translational research in psychiatry

Onitsuka, T., Hirano, Y., Nemoto, K., Hashimoto, N., Kushima, I., Koshiyama, D., Koeda, M., Takahashi, T., Noda, Y., Matsumoto, J., et al. (2021) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13311 · Cited by 53

Genetic susceptibility and lifestyle modify the association of long-term air pollution exposure on major depressive disorder: a prospective study in UK Biobank

Li, D., Xie, J., Wang, L., Sun, Y., Hu, Y., & Tian, Y. (2023) · BMC Medicine · doi:10.1186/s12916-023-02783-0 · Cited by 49

Erectile Dysfunction and Oxidative Stress: A Narrative Review

Zhu, D., Pham, Q. M., Wang, C., Colonnello, E., Yannas, D., Hoai, B. N., Zhang, Y., Jannini, E. A., & Sansone, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073073 · Cited by 53

Analysis of Oxidative Damage by Gene‐Specific Quantitative PCR

Kovalenko, O. A., & Santos, J. H. (2009) · Current Protocols in Human Genetics · doi:10.1002/0471142905.hg1901s62 · Cited by 49

N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats

Möller, M., du Preez, J. L., Viljoen, F. P., Berk, M., & Harvey, B. H. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9433-z · Cited by 48

Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase

Jiang, L., Wu, X., Wang, S., Chen, S., Zhou, H., Wilson, B. C., Jin, C., Lu, R., Xie, K., Wang, Q., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0573-z · Cited by 48

The impacts of air pollution on maternal stress during pregnancy

Lin, Y., Zhou, L., Xu, J., Luo, Z., Kan, H., Zhang, J., Yan, C., & Zhang, J. (2017) · Scientific Reports · doi:10.1038/srep40956 · Cited by 49

Enriched environment prevents oxidative stress in zebrafish submitted to unpredictable chronic stress

Marcon, M., Mocelin, R., Sachett, A., Siebel, A. M., Herrmann, A. P., & Piato, Â. (2018) · PeerJ · doi:10.7717/peerj.5136 · Cited by 50

Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice

Gao, W., Wang, W., Zhang, J., Deng, P., Hu, J., Yang, J. M., & Deng, Z. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00443-y · Cited by 52

The level of oxidative stress and the expression of genes involved in DNA-damage signaling pathways in depressive patients with colorectal carcinoma

Wei, Y., Zhou, F., He, D., Bai, J., Hui, L., Wang, X., & Nan, K. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.09.001 · Cited by 49

Childhood trauma and parental style: Relationship with markers of inflammation, oxidative stress, and aggression in healthy and personality disordered subjects

Fanning, J. R., Lee, R., Gozal, D., Coussons‐Read, M. E., & Coccaro, E. F. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.09.003 · Cited by 48

In vitro antioxidant activity and in vivo antidepressant-like effect of α-(phenylselanyl) acetophenone in mice

Gerzson, M. F. B., Victoria, F. N., Radatz, C. S., de Gomes, M. G., Boeira, S. P., Jacob, R. G., Alves, D. A. C., Jessé, C. R., & Savegnago, L. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.03.016 · Cited by 48

Decreased mRNA expression of uncoupling protein 2, a mitochondrial proton transporter, in post-mortem prefrontal cortex from patients with bipolar disorder and schizophrenia

Gigante, A. D., Andreazza, A. C., Lafer, B., Yatham, L. N., Beasley, C. L., & Young, L. T. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.09.064 · Cited by 48

Thiobarbituric Acid-Reactive Substances: Markers of an Acute Episode and a Late Stage of Bipolar Disorder

Siwek, M., Sowa-Kućma, M., Styczeń, K., Misztak, P., Szewczyk, B., Topór‐Mądry, R., Nowak, G., Dudek, D., & RYBAKOWSKI, J. K. (2016) · Neuropsychobiology · doi:10.1159/000444491 · Cited by 46

Role of Oxidative Stress and Ca2+ Signaling in Psychiatric Disorders

Nakao, A., Matsunaga, Y., Hayashida, K., & Takahashi, N. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.615569 · Cited by 51

Vitamin A deficiency: An oxidative stress marker in sodium fluoride (NaF) induced oxidative damage in developing rat brain

Banala, R. R., & Karnati, P. R. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.08.010 · Cited by 47

Oxidative Stress in a Model of Toxic Demyelination in Rat Brain: The Effect of Piracetam and Vinpocetine

Abdel‐Salam, O. M. E., Khadrawy, Y. A., Salem, N. A., & Sleem, A. A. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0450-1 · Cited by 47

Relationship between matrix metalloproteinase-9 and oxidative stress in drug-free male schizophrenia: a case control study

Devanarayanan, S., Nandeesha, H., Kattimani, S., & Sarkar, S. (2015) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2015-0212 · Cited by 47

Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects

Kim, Y., McGee, S. L., Czeczor, J. K., Walker, A. J., Kale, R. P., Kouzani, A. Z., Walder, K. R., Berk, M., & Tye, S. J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.84 · Cited by 47

Thiamine and benfotiamine counteract ultrasound-induced aggression, normalize AMPA receptor expression and plasticity markers, and reduce oxidative stress in mice

Вячеславовна, Г. А., Pavlov, D., Anthony, D. C., Ponomarev, E. D., Sambon, M., Proshin, A. T., Shafarevich, I., Babaevskaya, D., Lesch, K., Bettendorff, L., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.025 · Cited by 47

Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview

Vismara, M. E. M., Girone, N., Cirnigliaro, G., Fasciana, F., Vanzetto, S., Ferrara, L., Priori, A., D’Addario, C., Viganò, C. A., & Dell’Osso, B. M. (2020) · Brain Sciences · doi:10.3390/brainsci10080564 · Cited by 48

8-Hydroxy-2’-Deoxyguanosine and Reactive Oxygen Species as Biomarkers of Oxidative Stress in Mental Illnesses: A Meta-Analysis

Goh, X. X., Tang, P. Y., & Tee, S. F. (2021) · Psychiatry Investigation · doi:10.30773/pi.2020.0417 · Cited by 48

Association of two DRD2 gene polymorphisms with acute and tardive antipsychotic-induced movement disorders in young Caucasian patients

Genetic Risk and Outcome in Psychosis (GROUP) investigators, Koning, J., Vehof, J., Burger, H., Wilffert, B., Hadithy, A. A., Alizadeh, B. Z., van Harten, P. N., & Snieder, H. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2394-1 · Cited by 46

Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet

Guimarães, L. R., Jacka, F. N., Gama, C. S., Berk, M., Leitão-Azevedo, C. L., de Abreu, M. G. B., Lobato, M. I. R., Andreazza, A. C., Ceresér, K. M. M., Kapczinski, F. P., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.06.004 · Cited by 46

Associations between dietary patterns and psychological factors: a cross-sectional study among Chinese postmenopausal women

Liu, Z., Ho, S. C., Xie, Y. J., Chen, Y., Chen, Y., Chen, B., Wong, S. Y. S., Chan, D. C.-C., Wong, C. K. M., He, Q., et al. (2016) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000701 · Cited by 48

Free radicals: what they are and what they do

Tvrdá, E., & Benko, F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815972-9.00001-9 · Cited by 46

Molecular correlates of mitochondrial dysfunctions in major depression: Evidence from clinical and rodent studies

Rappeneau, V., Wilmes, L., & Touma, C. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103555 · Cited by 47

Potential mechanisms of formononetin against inflammation and oxidative stress: a review

Ding, M., Bao, Y., Liang, H., Zhang, X., Li, B., Yang, R., & Zeng, N. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1368765 · Cited by 47

Basal low antioxidant capacity correlates with cognitive deficits in early onset psychosis. A 2-year follow-up study

Martínez‐Cengotitabengoa, M., Micó, J. A., Arango, C., Castro‐Fornieles, J., Graell, M., Payá, B., Leza, J. C., Zorrilla, E. P., Parellada, M., López, M. P., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.025 · Cited by 45

Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats

Nagasawa, M., Ogino, Y., Kurata, K., Otsuka, T., Yoshida, J., Tomonaga, S., & Furuse, M. (2012) · Amino Acids · doi:10.1007/s00726-012-1294-y · Cited by 45

Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse

Güldenpfennig, M., Wolmarans, D. W., du Preez, J. L., Stein, D. J., & Harvey, B. H. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.008 · Cited by 45

Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report

Szmulewicz, A., Valerio, M. P., & Smith, J. M. (2015) · International Journal of Bipolar Disorders · doi:10.1186/s40345-014-0020-y · Cited by 45

The VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention (VITAL-DEP): Rationale and design of a large-scale ancillary study evaluating vitamin D and marine omega-3 fatty acid supplements for prevention of late-life depression

Okereke, O. I., Reynolds, C. F., Mischoulon, D., Chang, G., Cook, N. R., Copeland, T., Friedenberg, G., Buring, J. E., & Manson, J. E. (2018) · Contemporary Clinical Trials · doi:10.1016/j.cct.2018.02.017 · Cited by 45

Dietary total antioxidant capacity in relation to depression and anxiety in Iranian adults

Milajerdi, A., Keshteli, A. H., Afshar, H., Esmaillzadeh, A., & Adibi, P. (2018) · Nutrition · doi:10.1016/j.nut.2018.11.017 · Cited by 47

Role of Quercetin in Depressive-Like Behaviors: Findings from Animal Models

Silvestro, S., Bramanti, P., & Mazzon, E. (2021) · Applied Sciences · doi:10.3390/app11157116 · Cited by 49

Prepregnancy Healthy Dietary Pattern Is Inversely Associated with Depressive Symptoms among Pregnant Brazilian Women

Vilela, A. A. F., Farias, D. R., Eshriqui, I., Vaz, J. D. S., Franco‐Sena, A. B., de Castro, M. B. T., Olinto, M. T. A., Machado, S. P., da Sílva, A. A. M., & Kac, G. (2014) · Journal of Nutrition · doi:10.3945/jn.114.190488 · Cited by 46

Inflammatory cytokine network in schizophrenia

Zakharyan, R., & Boyajyan, A. S. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.830774 · Cited by 45

Silymarin and silymarin nanoparticles guard against chronic unpredictable mild stress induced depressive-like behavior in mice: involvement of neurogenesis and NLRP3 inflammasome

Ashraf, A., Mahmoud, P. A., Reda, H., Mansour, S., Helal, M. H., Michel, H. E., & Nasr, M. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119836221 · Cited by 45

The therapeutic potential of exercise for neuropsychiatric diseases: A review

Swenson, S., Blum, K., McLaughlin, T., Gold, M. S., & Thanos, P. K. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116763 · Cited by 42

Expression Profiling of a Genetic Animal Model of Depression Reveals Novel Molecular Pathways Underlying Depressive-Like Behaviours

Blaveri, E., Kelly, F., Mallei, A., Harris, K., Taylor, A. R., Reid, J. L., Razzoli, M., Carboni, L., Piubelli, C., Musazzi, L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012596 · Cited by 44

Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project

Wade, M., Fox, N. A., Zeanah, C. H., Nelson, C. A., & Drury, S. S. (2020) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2019.02.013 · Cited by 43

Chronic variable stress induces oxidative stress and decreases butyrylcholinesterase activity in blood of rats

Tagliari, B., dos Santos, T. M., da Cunha, A. A., de Lima, D. D., Delwing, D., Sitta, Â., Vargas, C. R., Dalmaz, C., & Wyse, Â. T. D. S. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0445-0 · Cited by 43

State‐related alterations of gene expression in bipolar disorder: a systematic review

Munkholm, K., Vinberg, M., Berk, M., & Kessing, L. V. (2012) · Bipolar Disorders · doi:10.1111/bdi.12005 · Cited by 43

Kinins and microglial responses in bipolar disorder: a neuroinflammation hypothesis

Naaldijk, Y., Bittencourt, M. C., Sack, U., & Ulrich, H. (2016) · Biological Chemistry · doi:10.1515/hsz-2015-0257 · Cited by 44

Potential therapeutic antipsychotic effects of Naringin against ketamine-induced deficits in rats: Involvement of Akt/GSK-3β and Wnt/β-catenin signaling pathways

George, M. Y., Menze, E. T., Esmat, A., Tadros, M. G., & El‐Demerdash, E. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117535 · Cited by 43

Investigation of the protective effects of lutein on memory and learning using behavioral methods in a male rat model of Alzheimer's disease

Nazari, L., Komaki, S., Salehi, I., Raoufi, S., Golipoor, Z., Kourosh‐Arami, M., & Komaki‬, A. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105319 · Cited by 48

Towards stage specific treatments: Effects of duration of illness on therapeutic response to adjunctive treatment with N-acetyl cysteine in schizophrenia

Rapado‐Castro, M., Berk, M., Venugopal, K., Bush, A. I., Dodd, S., & Dean, O. M. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.10.002 · Cited by 43

Curcumin as a putative antidepressant

Seo, H., Wang, S., Han, C., Lee, S.-J., Patkar, A. A., Masand, P. S., & Pae, C. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1008457 · Cited by 42

Missense polymorphisms in three oxidative‐stress enzymes (GSTP1, SOD2, and GPX1) and dyskinesias in Russian psychiatric inpatients from Siberia

Hadithy, A. F. Y. A., Ivanova, S. А., Pechlivanoglou, P., Wilffert, B., Semke, A. V., Fedorenko, O. Y., Kornetova, E. G., Ryadovaya, L. A., Brouwers, J. R. B. J., & LOONEN, A. J. M. (2009) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1087 · Cited by 42

Di-(n-butyl)-phthalate-induced oxidative stress and depression-like behavior in mice with or without ovalbumin immunization.

Zuo, H. X., Li, J. Q., Han, B., Ke, C. J., Liu, X. D., Zhang, Y. C., Li, L., & Yang, X. (2014) · PubMed · doi:10.3967/bes2014.001 · Cited by 42

DeepGAMI: deep biologically guided auxiliary learning for multimodal integration and imputation to improve genotype-phenotype prediction

Chandrashekar, P. B., Alatkar, S., Wang, J., Hoffman, G. E., He, C., Jin, T., Khullar, S., Bendl, J., Fullard, J. F., Roussos, P., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01248-6 · Cited by 37

Air pollution and mental health: Evidence from China Health and Nutrition Survey

Chen, F., Zhang, X., & Chen, Z. (2023) · Journal of Asian Economics · doi:10.1016/j.asieco.2023.101611 · Cited by 43

Protective Effects of Tualang Honey against Oxidative Stress and Anxiety-Like Behaviour in Stressed Ovariectomized Rats

Al-Rahbi, B. S., Zakaria, R., Othman, Z., Hassan, A., & Ahmad, A. H. (2014) · International Scholarly Research Notices · doi:10.1155/2014/521065 · Cited by 40

The Chinese herbal formula Free and Easy Wanderer ameliorates oxidative stress through KEAP1-NRF2/HO-1 pathway

Hong, C., Cao, J., Wu, C., Kadioglu, O., Schüffler, A., Kauhl, U., Klauck, S. M., Opatz, T., Thines, E., Paul, N. W., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10443-6 · Cited by 41

Antidepressant, anti-inflammatory, and antioxidant effects of electroacupuncture through sonic hedgehog–signaling pathway in a rat model of poststroke depression

Cai, W., Ma, W., Wang, G., Li, Y., & Shen, W.-D. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s205033 · Cited by 43

Co-exposure with titanium dioxide nanoparticles exacerbates MCLR-induced brain injury in zebrafish

Wu, Q., Yan, W., Liu, C., Hung, T., & Li, G. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.07.346 · Cited by 40

The Role of Inflammation in the Pathophysiology of Depression and Suicidal Behavior

Serafini, G., Costanza, A., Aguglia, A., Amerio, A., Trabucco, A., Escelsior, A., Sher, L., & Amore, M. (2022) · Medical Clinics of North America · doi:10.1016/j.mcna.2022.09.001 · Cited by 48

The association between serum ferritin levels and post-stroke depression

Zhu, L., Han, B., Wang, L., Chang, Y., Ren, W., Gu, Y., Yan, M., Wu, C., Zhang, X., & He, J. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.09.074 · Cited by 42

Glutathione Deficit Affects the Integrity and Function of the Fimbria/Fornix and Anterior Commissure in Mice: Relevance for Schizophrenia

Corcoba, A., Steullet, P., Duarte, J. M. N., van de Looij, Y., Monin, A., Cuénod, M., Rolf Gruetter, A., & Kim, Q. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv110 · Cited by 40

Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice

Muramatsu, H., Katsuoka, F., Toide, K., Shimizu, Y. I., Furusako, S., & Yamamoto, M. P. (2013) · Genes to Cells · doi:10.1111/gtc.12083 · Cited by 40

N -Acetylcysteine for Nonsuicidal Self-Injurious Behavior in Adolescents: An Open-Label Pilot Study

Cullen, K. R., Klimes‐Dougan, B., Schreiner, M. W., Carstedt, P. A., Marka, N. A., Nelson, K. J., Miller, M. J., Reigstad, K. M., Westervelt, A., Gunlicks‐Stoessel, M., et al. (2017) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2017.0032 · Cited by 40

Neuroprotective Effects of Heat-Killed Lactobacillus plantarum 200655 Isolated from Kimchi Against Oxidative Stress

Cheon, M.-J., Lee, N., & Paik, H. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-020-09740-w · Cited by 40

Expression of oxidative stress-response genes is not activated in the prefrontal cortex of patients with depressive disorder

Teyssier, J.-R., Ragot, S., Chauvet-Gélinier, J.-C., Trojak, B., & Bonin, B. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2010.07.030 · Cited by 39

Effects of N‐acetylcysteine on oxidative stress biomarkers, depression, and anxiety symptoms in patients with multiple sclerosis

Mohseni, G. K., Hosseini, S. A., Majdinasab, N., & Cheraghian, B. (2023) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12360 · Cited by 40

Protective Effect of Nerolidol Against Pentylenetetrazol-Induced Kindling, Oxidative Stress and Associated Behavioral Comorbidities in Mice

Kaur, D., Pahwa, P., & Goel, R. K. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2001-2 · Cited by 39

The role of apitoxin in alleviating propionic acid-induced neurobehavioral impairments in rat pups: The expression pattern of Reelin gene

Daghestani, M. H., Selim, M. E., Abd‐Elhakim, Y. M., Said, E. N., El-Hameed, N. E. A., Khalil, S. R., & El-Tawil, O. S. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.034 · Cited by 38

Drug Screening and Drug Repositioning as Promising Therapeutic Approaches for Spinal Muscular Atrophy Treatment

Menduti, G., Rasà, D. M., Stanga, S., & Boido, M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.592234 · Cited by 40

Clinical Staging for Youth Mental Disorders: Progress in Reforming Diagnosis and Clinical Care

McGorry, P. D., & Mei, C. (2021) · Annual Review of Developmental Psychology · doi:10.1146/annurev-devpsych-050620-030405 · Cited by 38

Restraint stress exacerbates cardiac and adipose tissue pathology via β-adrenergic signaling in rats with metabolic syndrome

Matsuura, N., Nagasawa, K., Minagawa, Y., Ito, S., Sano, Y., Yamada, Y., Hattori, T., Watanabe, S., Murohara, T., & Nagata, K. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00906.2014 · Cited by 40

Naringin Reverses Neurobehavioral and Biochemical Alterations in Intracerebroventricular Collagenase-Induced Intracerebral Hemorrhage in Rats

Singh, N., Bansal, Y., Bhandari, R., Marwaha, L., Singh, R., Chopra, K., & Kuhad, A. (2017) · Pharmacology · doi:10.1159/000453580 · Cited by 40

The Diagnostic Value of Malondialdehyde, Superoxide Dismutase and Catalase Activity in Drug Naïve, First Episode, Non-Smoker Generalized Anxiety Disorder Patients

Fındıklı, E., Camkurt, M. A., İzci, F., Karaaslan, M. F., Fındıklı, H. A., Sümer, P., & Kurutaş, E. B. (2018) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2018.16.1.88 · Cited by 38

Acupuncture Relieves Stress-Induced Depressive Behavior by Reducing Oxidative Stress and Neuroapoptosis in Rats

Cheng, W., Li, P., Huang, W., Huang, Y., Chen, W., Chen, Y.-P., Shen, J., Chen, J., Long, N.-S., & Meng, X. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.783056 · Cited by 37

Increased plasma levels of thioredoxin-1 in patients with first episode psychosis and long-term schizophrenia

Owe‐Larsson, B., Ekdahl, K., Edbom, T., Ösby, U., Karlsson, H., Lundberg, C., & Lundberg, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.03.012 · Cited by 38

Chronic Social Isolation Compromises the Activity of Both Glutathione Peroxidase and Catalase in Hippocampus of Male Wistar Rats

Djordjevic, J., Djordjevic, A. D., Adžić, M., & Radojcic, M. B. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9493-0 · Cited by 38

Circadian preferences, oxidative stress and inflammatory cytokines in bipolar disorder: A community study

Mondin, T. C., Cardoso, T. D. A., Moreira, F. P., Wiener, C. D., Oses, J. P., Souza, L. D. D. M., Jansen, K., Magalhães, P. V. D. S., Kapczinski, F. P., & da Silva, R. A. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.10.012 · Cited by 38

The Role of Water-Soluble Vitamins and Vitamin D in Prevention and Treatment of Depression and Seasonal Affective Disorder in Adults

Jahan-Mihan, A., Stevens, P., Medero-Alfonso, S., Brace, G., Overby, L. K., Berg, K., & Labyak, C. A. (2024) · Nutrients · doi:10.3390/nu16121902 · Cited by 40

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga, I., Niedzielska, E., Gawlik, M., Moniczewski, A., Krzek, J., Przegaliński, E., Pera, J., & Filip, M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.015 · Cited by 252

Studies on Psychiatric Disorders

(2015) · Thammasat University Digital Collections

Editorial: Neurobiological Consequences of Oxidative Stress.

Alkadhi, K. A., & Salim, S. (2014) · Current Neuropharmacology · doi:10.2174/1570159x1202140307122223

Oxidative Stress is a New Avenue for Treatment of Neuropsychiatric Disorders: Hype of Hope?

Negah, S. S., & Forouzanfar, F. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230904150907 · Cited by 7

Association of Oxidative Stress with Psychiatric Disorders

Hassan, W., Noreen, H., Gomes, V. D. C., Mohammadzai, I., da Rocha, J. B. T., & Landeira-Fernández, J. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160307145931 · Cited by 76