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Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
Open accessAbstract
Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage. This review aims to examine the current evidence for the role of oxidative stress in psychiatric disorders, and its academic and clinical implications. A literature search was conducted using the Medline, Pubmed, PsycINFO, CINAHL PLUS, BIOSIS Preview, and Cochrane databases, with a time-frame extending to September 2007. The broadest data for oxidative stress mechanisms have been derived from studies conducted in schizophrenia, where evidence is available from different areas of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid foundation for oxidative stress hypotheses has been provided by biochemical, genetic, pharmacological, preclinical therapeutic studies and one clinical trial. Oxidative pathophysiology in anxiety disorders is strongly supported by animal models, and also by human biochemical data. Pilot studies have suggested efficacy of N-acetylcysteine in cocaine dependence, while early evidence is accumulating for oxidative mechanisms in autism and attention deficit hyperactivity disorder. In conclusion, multi-dimensional data support the role of oxidative stress in diverse psychiatric disorders. These data not only suggest that oxidative mechanisms may form unifying common pathogenic pathways in psychiatric disorders, but also introduce new targets for the development of therapeutic interventions.
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“This model is consistent with the idea that stress related to psychopathology is associated with physiological and cellular alterations related to telomere length, such as elevated oxidative stress or inflammation.25”
From Telomere Length and Psychopathology: Specificity and Direction of Effects Within the Bucharest Early Intervention Project (2020) · cites this paper as [25]
In the citing paper
“Oxidative stress in psychiatric disorders could result from the overproduction of ROS, impairments in Keap1-Nrf2 signalling, or both due to causes related to psychological stress, physiological impairments, inflammation, and genetic polymorphisms of antioxidant enzymes that are beyond the scope of this review [126,127].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [126]
In the citing paper
“Importantly, antioxidants have shown promising therapeutic benefits in the treatment of psychiatric disorders and are subject to further investigation [126,127,140].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [126]
In the citing paper
“bipolar disorder (BD) [10–14]”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [13]
In the citing paper
“Coming back to NAC, which is a precursor of glutathione, it has been shown that it can significantly improve the standard therapy, as a double-blind randomized placebo-controlled clinical study performed by Ng et al. in 2008 demonstrated [13].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [13]
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Citations
Cites
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
Journal of Clinical Psychiatry
(2018) · Journal of Clinical Psychiatry · doi:10.5505/kpd · Cited by 13,703
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Oxidative stress: oxidants and antioxidants
Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577
Neurodegenerative diseases and oxidative stress
Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683 · cited 1×
“In a similar vein, oxidation biology is emerging as a promising avenue of investigation, and has been actively pursued in other areas of medicine (Barnham et al., 2004; Mehta et al., 2006; Tsukahara, 2007).”
BackgroundSelf-citationOxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614
Vitamin E, antioxidant and nothing more
Traber, M. G., & Atkinson, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.024 · Cited by 1,547
Untreated Depression and Hippocampal Volume Loss
Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1516 · Cited by 1,180
Oxidative stress: the paradox of aerobic life
Davies, K. J. A. (1995) · Biochemical Society Symposia · doi:10.1042/bss0610001 · Cited by 1,150
Research works printed but not linked: 9
- Li, 2006, Journal of Zhejiang University. Science B, 7, 1981
- 10.1002/(SICI)1099-0801(199809/10)12:53.0.CO;2-# · DOI
- Frey, 2006, Journal of Psychiatry and Neurosciences, 31, 326
- Zhou, 2007, Biological Psychiatry, none, none
- Zhou, 1999, Chinese Medical Journal, 112, 1093
- Berk, 2007, Bipolar Disorders, 9, 3
- Ben Othmen, 2007, Progress in Neuropsychopharmacology and Biological Psychiatry, none, none
- Young, 2007, Journal of Psychiatry and Neurosciences, 32, 160
- Baker, 2007, Neuropsychopharmacology, none, none
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Items 101–200 of 1,000
Nutritional and dietary influences on attention deficit hyperactivity disorder
Parletta, N. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00107.x · Cited by 141
Role of the intestinal microbiome, intestinal barrier and psychobiotics in depression
Trzeciak, P., & Herbet, M. (2021) · Nutrients · doi:10.3390/nu13030927 · Cited by 139
Papakostas, G. I., Shelton, R. C., Zajecka, J., Bottiglieri, T., Roffman, J. L., Cassiello-Robbins, C. F., Stahl, S. M., & D, M. F. M. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08947 · Cited by 139
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Ee, C., Lake, J., Firth, J., Hargraves, F., de Manincor, M., Meade, T., Marx, W., & Sarris, J. J. (2020) · International Journal of Mental Health Systems · doi:10.1186/s13033-020-00410-6 · Cited by 173
Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment
Xu, Y., Wang, C., Klabnik, J., & Donnell, J. O. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120231448 · Cited by 141
Lehmann, M. L., Weigel, T. K., Poffenberger, C. N., & Herkenham, M. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0184-19.2019 · Cited by 138
Physical Exercise for Treatment of Mood Disorders: A Critical Review
Hearing, C. M., Chang, W. C., Szuhany, K. L., Deckersbach, T., Nierenberg, A. A., & Sylvia, L. G. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0089-y · Cited by 137
de la Torre‐Carbot, K., Chávez‐Servín, J. L., Jáuregui, O., Castellote, A. I., Lamuela-Raventós, R. M., Nurmi, T., Poulsen, H. E., Gaddi, A. V., Kaikkonen, J., Zunft, H.-F., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.109.112912 · Cited by 132
Minocycline: Therapeutic Potential in Psychiatry
Dean, O. M., Data-Franco, J., Giorlando, F., & Berk, M. (2012) · CNS Drugs · doi:10.2165/11632000-000000000-00000 · Cited by 131
Self-citationAssies, J., Mocking, R. J. T., Lok, A., Ruhé, H. G., Pouwer, F., & Schene, A. H. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12265 · Cited by 134
Tobore, T. O. (2019) · Journal of Adolescence · doi:10.1016/j.adolescence.2019.09.004 · Cited by 143
Liu, Q., Wang, W., Gu, X., Deng, F., Wang, X., Lin, H., Guo, X., & Wu, S. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-12357-3 · Cited by 134
Evidence and implications for early intervention in bipolar disorder
Berk, M., Hallam, K. T., Malhi, G. S., Henry, L. P., Hasty, M. K., Macneil, C. A., Yücel, M., Pantelis, C., Murphy, B., Vieta, E., et al. (2010) · Journal of Mental Health · doi:10.3109/09638230903469111 · Cited by 135
Self-citationNeurobiology of Schizophrenia Spectrum Disorders: The Role of Oxidative Stress
Wood, S. J., Yücel, M., Pantelis, C., & Berk, M. (2009) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v38n5p396 · Cited by 127
Self-citationKim, H. K., Andreazza, A. C., Elmi, N., Chen, W., & Young, L. T. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.10.015 · Cited by 128
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Moritz, B., Schmitz, A. E., Rodrigues, A. L. S., Dafré, A. L., & Cunha, M. P. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108459 · Cited by 138
Nutritional Factors Affecting Mental Health
Lim, S. Y., Kim, E. J., Kim, A., Lee, H. J., Choi, H. J., & Yang, S. J. (2016) · Clinical Nutrition Research · doi:10.7762/cnr.2016.5.3.143 · Cited by 135
Neuroprogression and illness trajectories in bipolar disorder
Kapczinski, N. S., Mwangi, B., Cassidy, R. M., Librenza‐Garcia, D., Bermúdez, M. B., Kauer‐Sant’Anna, M., Kapczinski, F. P., & Passos, I. C. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1240615 · Cited by 132
Assies, J., Pouwer, F., Lok, A., Mocking, R. J. T., Bockting, C., Visser, I., Abeling, N. G. G. M., Durán, M., & Schene, A. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010635 · Cited by 128
Gonzalez-Liencres, C., Taş, C., Brown, E. C., Erdin, S., Onur, E., Çubukcoǧlu, Z., Aydemır, Ö., Esen-Danacı, A., & Brüne, M. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0268-x · Cited by 118
Improvement of Negative and Positive Symptoms in Treatment-Refractory Schizophrenia
de Lucena, D. F., Fernandes, B. S., Berk, M., Dodd, S., Medeiros, D. W., Pedrini, M., Kunz, M., Gomes, F. A., Giglio, L. M. F., Lobato, M. I. R., et al. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04935gry · Cited by 118
Self-citationN-acetylcysteine in the treatment of psychiatric disorders: current status and future prospects
Minarini, A., Ferrari, S., Galletti, M., Giambalvo, N., Perrone, D., Rioli, G., & Galeazzi, G. M. (2016) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2017.1251580 · Cited by 126
Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males
Sayeed, M. S. B., Shams, T., Hossain, S. F., Rahman, M. R., Mostofa, A., Kadir, M. F., Mahmood, S., & Asaduzzaman, M. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.12.050 · Cited by 119
Oxidative imbalance in child and adolescent patients with attention-deficit/hyperactivity disorder
Ceylan, M. F., Şener, Ş., Bayraktar, A. Ç., & Kavutçu, M. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.08.010 · Cited by 115
Reduced antioxidant defense in early onset first-episode psychosis: a case-control study
Micó, J. A., Rojas-Corrales, M. O., Gibert‐Rahola, J., Parellada, M., Moreno, D. M., Fraguas, D., Graell, M., Gil, J., Irazusta, J., Castro‐Fornieles, J., et al. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-26 · Cited by 114
Speech deficits in serious mental illness: A cognitive resource issue?
Cohen, A. S., McGovern, J. E., Dinzeo, T. J., & Covington, M. A. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.10.032 · Cited by 117
Different sub-anesthetic doses of ketamine increase oxidative stress in the brain of rats
de Oliveira, L., dos Santos, C. M. S., Bortolin, T., Canever, L., Petronilho, F. C., Mina, F., Dal‐Pizzol, F., Quevedo, J., & Zugno, A. I. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.05.010 · Cited by 113
Dietary selenium and major depression: a nested case-control study
Pasco, J. A., Jacka, F. N., Williams, L. J., Evans-Cleverdon, M., Brennan-Olsen, S. L., Kotowicz, M. A., Nicholson, G. C., Ball, M. J., & Berk, M. (2012) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2011.12.008 · Cited by 112
Self-citationPolyphenols: A Potential New Strategy for the Prevention and Treatment of Anxiety and Depression
Bouayed, J. (2010) · Current Nutrition & Food Science · doi:10.2174/157340110790909608 · Cited by 110
Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus
Réus, G. Z., Stringari, R. B., de Souza, B., Petronilho, F., Dal-Pizzol, F., Hallak, J. E., Zuardi, A. W., Crippa, J. A., & Quevedo, J. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.5.13109 · Cited by 110
Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine
Caiaffo, V., de Oliveira, B. D. R., de Sá, F. B., & Evêncio‐Neto, J. (2016) · Pharmacology Research & Perspectives · doi:10.1002/prp2.231 · Cited by 112
On the central role of mitochondria dysfunction and oxidative stress in Alzheimer’s disease
Tobore, T. O. (2019) · Neurological Sciences · doi:10.1007/s10072-019-03863-x · Cited by 112
Liao, D., Lv, C., Cao, L., Yao, D., Wu, Y. P., Long, M., Liu, N., & Jiang, P. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9268083 · Cited by 112
Prediabetes Is Associated With Structural Brain Abnormalities: The Maastricht Study
van Agtmaal, M. J. M., Houben, A. J. H. M., de Wit‐Verheggen, V. H. W., Henry, R. M. A., Schaper, N. C., Dagnelie, P. C., Kallen, C., Koster, A., Sep, S. J. S., Kroon, A. A., et al. (2018) · Diabetes Care · doi:10.2337/dc18-1132 · Cited by 112
Kempf, L., Nicodemus, K. K., Kolachana, B. S., Vakkalanka, R., Verchinski, B. A., Egan, M. F., Straub, R. E., Mattay, V. S., Callicott, J. H., Weinberger, D. R., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000252 · Cited by 108
Min, J., & Min, K. (2016) · Environment International · doi:10.1016/j.envint.2016.11.022 · Cited by 107
Neurobiology of vitamin C: Expanding the focus from antioxidant to endogenous neuromodulator
Ballaz, S., & Rebec, G. V. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104321 · Cited by 106
Nakamichi, N., Nakayama, K., Ishimoto, T., Masuo, Y., Wakayama, T., Sekiguchi, H., Sutoh, K., Usumi, K., Iseki, S., & Kato, Y. (2016) · Brain and Behavior · doi:10.1002/brb3.477 · Cited by 107
Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms
Ilgın, S., Can, Ö. D., Atlı, Ö., Üçel, U. İ., Şener, E., & Guven, I. (2015) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2015.1026008 · Cited by 105
Oudin, A., Bråbäck, L., Åström, D. O., Strömgren, M., & Forsberg, B. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010004 · Cited by 111
Yolton, K. A., Khoury, J. C., Burkle, J. W., LeMasters, G. K., Cecil, K. M., & Ryan, P. (2019) · Environmental Research · doi:10.1016/j.envres.2019.03.005 · Cited by 107
Medial temporal lobe glutathione concentration in first episode psychosis: A 1H-MRS investigation
Wood, S. J., Berger, G. E., Wellard, R. M., Proffitt, T., McConchie, M., Berk, M., McGorry, P. D., & Pantelis, C. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.11.018 · Cited by 105
Self-citationWang, R., Liu, Y., Xue, D.-S., Yao, Y., Liu, P.-H., & Helbich, M. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.02.007 · Cited by 92
Potential contribution of oxidative stress and inflammation to anxiety and hypertension
Salim, S., Asghar, M., Taneja, M., Hovatta, I., Chugh, G., Vollert, C. T., & Vu, A. (2011) · Brain Research · doi:10.1016/j.brainres.2011.06.024 · Cited by 104
Möller, M., du Preez, J. L., Emsley, R. A., & Harvey, B. H. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.09.006 · Cited by 103
Cognitive effects of adjunctive N-acetyl cysteine in psychosis
Rapado‐Castro, M., Dodd, S., Bush, A. I., Malhi, G. S., Skvarc, D., On, Z. X., Berk, M., & Dean, O. M. (2016) · Psychological Medicine · doi:10.1017/s0033291716002932 · Cited by 103
Self-citationBalmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103
“In this way, one of these aspects is oxidative stress status, which seems to be implicated in most of the different affective disorders, since it has been shown that increased oxidative damage occurs quite often in depression [7–9], anxiety [9, 10], bipolar disorder (BD) [10–14], panic disorder (PD) [15, 16], and also…”
BackgroundAntioxidant treatments for schizophrenia
Magalhães, P. V. D. S., Dean, O. M., Andreazza, A. C., Berk, M., & Kapczinski, F. P. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008919.pub2 · Cited by 106
Self-citationGao, W., Wang, W., Peng, Y., & Deng, Z. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-0389-5 · Cited by 103
N-acetylcysteine Pharmacology and Applications in Rare Diseases—Repurposing an Old Antioxidant
Sahasrabudhe, S. A., Terluk, M. R., & Kartha, R. V. (2023) · Antioxidants · doi:10.3390/antiox12071316 · Cited by 102
Oxidative stress in egyptian children with autism: Relation to autoimmunity
Mostafa, G. A., El-Hadidi, E. S., Hewedi, D. H., & Abdou, M. M. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.12.003 · Cited by 101
Magalhães, P. V. D. S., Dean, O. M., Bush, A. I., Copolov, D., Malhi, G. S., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson‐Hunt, M., & Berk, M. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.08.001 · Cited by 100
Self-citationAmr, M., El-Mogy, A., Shams, T., Vieira, K. F., & Lakhan, S. E. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-31 · Cited by 103
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Rasmus, P., & Kozłowska, E. (2023) · Antioxidants · doi:10.3390/antiox12030676 · Cited by 102
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Jacka, F. N., Pasco, J. A., Mykletun, A., Williams, L. J., Nicholson, G. C., Kotowicz, M. A., & Berk, M. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.09.004 · Cited by 100
Self-citationGawryluk, J. W., Wang, J.-F., Andreazza, A. C., Shao, L., Yatham, L. N., & Young, L. T. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000617 · Cited by 99
Asevedo, E. D. M., Gadelha, A., Noto, C. D. S., Mansur, R. B., Zugman, A., Belangero, S. I., Berberian, A. D. A., Scarpato, B. S., Leclerc, E., Teixeira, A. L., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.032 · Cited by 101
Increased oxidative stress in patients with depression and its relationship to treatment
Chung, C. P., Schmidt, D. E., Stein, C. M., Morrow, J. D., & Salomon, R. M. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.10.018 · Cited by 99
Nunes, M. E. M., Müller, T. E., Braga, M. M., Fontana, B. D., de Quadros, V. A., Marins, A. T., Rodrigues, C. C. R., de Menezes, C. C., Rosemberg, D. B., & Loro, V. L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9919-x · Cited by 101
Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice
da Silva, F. C. C., Citó, M. D. C. D. O., Silva, M. I. G., Moura, B. A., Neto, M. R. D. A., Feitosa, M. L., Chaves, R. D. C., Macêdo, D. S., Vasconcelos, S. M. M., Fonteles, M. M. D. F., et al. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.05.011 · Cited by 99
Effects of Chronic Social Isolation on Wistar Rat Behavior and Brain Plasticity Markers
Djordjevic, J., Djordjevic, A. D., Adžić, M., & Radojcic, M. B. (2012) · Neuropsychobiology · doi:10.1159/000338605 · Cited by 102
The interplay between BDNF and oxidative stress in chronic schizophrenia
Zhang, X. Y., Chen, D.-C., Tan, Y.-L., Tan, S.-P., Wang, Z.-R., Yang, F.-D., Okusaga, O. O., Zunta-Soares, G. B., & Soares, J. C. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.029 · Cited by 99
Oxidative Stress and Male Infertility: Evidence From a Research Perspective
Ayad, B. M., Omolaoye, T. S., Louw, N., Ramsunder, Y., Skosana, B. T., Oyeipo, P. I., & du Plessis, S. S. (2022) · Frontiers in Reproductive Health · doi:10.3389/frph.2022.822257 · Cited by 103
Aboul-Fotouh, S. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.027 · Cited by 97
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Berk, M., Conus, P., Kapczinski, F. P., Andreazza, A. C., Yücel, M., Wood, S. J., Pantelis, C., Malhi, G. S., Dodd, S., Bechdolf, A., et al. (2010) · PubMed · Cited by 96
Self-citationMechanisms of Illness Progression in the Recurrent Affective Disorders
Post, R. M. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9182-2 · Cited by 99
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Lee, S., Lee, W., Kim, D., Kim, E., Myung, W., Kim, S., & Kim, H. (2019) · Environmental Research · doi:10.1016/j.envres.2019.01.036 · Cited by 96
Reddy, I. A., Pino, J. A., Weikop, P., Osses, N., Sørensen, G., Bering, T., Valle, C., Bluett, R. J., Erreger, K., Wortwein, G., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.86 · Cited by 96
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Raffa, M., Barhoumi, S., Atig, F., Fendri, C., Kerkeni, A., & Mechri, A. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.013 · Cited by 97
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Nucifora, L. G., Tanaka, T., Hayes, L. N., Kim, M., Lee, B. J., Matsuda, T., Nucifora, F. C., Sedlak, T. W., Mojtabai, R., Eaton, W. W., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.178 · Cited by 96
Dean, O. M., van den Buuse, M., Berk, M., Copolov, D., Mavros, C., & Bush, A. I. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.027 · Cited by 92
Self-citationProtective Effects of Ascorbic Acid on Behavior and Oxidative Status of Restraint-Stressed Mice
Moretti, M., Budni, J., Santos, D. B., Antunes, A. A., Daufenbach, J. F., Manosso, L. M., Farina, M., & Rodrigues, A. L. S. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9892-4 · Cited by 92
Rosa, A. R., Singh, N., Whitaker, E., de Brito, M., Lewis, A. M., Vieta, E., Churchill, G. C., Geddes, J. R., & Goodwin, G. M. (2014) · Psychological Medicine · doi:10.1017/s0033291714000014 · Cited by 90
Polyunsaturated Fatty Acid Deuteration against Neurodegeneration
Shchepinov, M. S. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.01.010 · Cited by 86
Oxidative/Nitroxidative Stress and Multiple Sclerosis
Tobore, T. O. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01672-y · Cited by 89
Mariani, N., Cattane, N., Pariante, C. M., & Cattaneo, A. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01469-6 · Cited by 96
Iyaswamy, A., & Sheeladevi, R. (2014) · Redox Biology · doi:10.1016/j.redox.2014.04.011 · Cited by 89
Cerebrovascular dysfunction with stress and depression
Chantler, P. D., Burrage, E. N., Marshall, K. L., & Santanam, N. (2018) · Brain Circulation · doi:10.4103/bc.bc_6_18 · Cited by 91
López-Vílchez, I., Díaz‐Ricart, M., Navarro, V., Torramadé‐Moix, S., Zamorano‐León, J. J., López-Farré, A. J., Galan, A. M., Gastó, C., & Escolar, G. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.156 · Cited by 90
Is Neurotoxicity of Metallic Nanoparticles the Cascades of Oxidative Stress?
Song, B., Zhang, Y., Liu, J., Feng, X., Zhou, T., & Shao, L. (2016) · Nanoscale Research Letters · doi:10.1186/s11671-016-1508-4 · Cited by 87
Proteomic and Metabolomic Profiling of a Trait Anxiety Mouse Model Implicate Affected Pathways
Zhang, Y., Filiou, M. D., Reckow, S., Gormanns, P., Maccarrone, G., Kessler, M. S., Frank, E., Hambsch, B., Holsboer, F., Landgraf, R., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.008110 · Cited by 88
Camkurt, M. A., Fındıklı, E., İzci, F., Kurutaş, E. B., & Tuman, T. C. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.01.075 · Cited by 86
Phyu, M. P., & Tangpong, J. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.04.035 · Cited by 87
Early intervention in bipolar disorders: Clinical, biochemical and neuroimaging imperatives
Berk, M., Malhi, G. S., Hallam, K. T., Gama, C. S., Dodd, S., Andreazza, A. C., Frey, B. N., & Kapczinski, F. P. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.08.011 · Cited by 81
Self-citationRole of Oxidative Stress in Male Reproductive Dysfunctions with Reference to Phthalate Compounds.
Sedha, S., Kumar, S. L., & Shukla, S. (2015) · Urology journal./Urology jornal. · Cited by 84
Kim, S. Y., Bang, M., Wee, J. H., Min, C., Yoo, D. M., Han, S.-M., Kim, S., & Choi, H. G. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143960 · Cited by 83
Bouayed, J., Desor, F., Rammal, H., Kiemer, A. K., Tybl, E., Schroeder, H., Rychen, G., & Soulimani, R. (2009) · Toxicology · doi:10.1016/j.tox.2009.02.010 · Cited by 87
Zeni, A. L. B., Camargo, A., & Dalmagro, A. P. (2017) · Steroids · doi:10.1016/j.steroids.2017.07.006 · Cited by 83
Probable mechanisms involved in the antipsychotic-like activity of morin in mice
Ben‐Azu, B., Aderibigbe, A. O., Omogbiya, I. A., Ajayi, A. M., Owoeye, O., Olonode, E. T., & Iwalewa, E. O. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.057 · Cited by 79
Daneshzad, E., Keshavarz, S. A., Qorbani, M., Larijani, B. A., & Azadbakht, L. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.03.002 · Cited by 81
The dual hit hypothesis of schizophrenia: Evidence from animal models
Guerrin, C. G. J., Doorduin, J., Sommer, I. E., & de Vries, E. F. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.025 · Cited by 87
Réus, G. Z., Carlessi, A. S., Titus, S. E., Abelaira, H. M., Ignácio, Z. M., da Luz, J. R., Matias, B. I., Bruchchen, L., Florentino, D., Vieira, A. A. D. S., et al. (2015) · Developmental Neurobiology · doi:10.1002/dneu.22283 · Cited by 84
Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice
Dean, O. M., Bush, A. I., Berk, M., Copolov, D., & van den Buuse, M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.017 · Cited by 81
Self-citationParker, W., Hornik, C. D., Bilbo, S. D., Holzknecht, Z. E., Gentry, L., Rao, R., Lin, S. S., Herbert, M. R., & Nevison, C. D. (2017) · Journal of International Medical Research · doi:10.1177/0300060517693423 · Cited by 87
Martínez‐Gras, I., Perez‐Nievas, B. G., García‐Bueno, B., Madrigal, J. L. M., Andres, E. M., Rodríguez–Jiménez, R., Hoenicka, J., Palomo, T., Rubio, G., & Leza, J. C. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.01.018 · Cited by 80
Belpomme, D., Campagnac, C., & Irigaray, P. (2015) · Reviews on Environmental Health · doi:10.1515/reveh-2015-0027 · Cited by 82
The influence of shift work on cognitive functions and oxidative stress
Özdemir, P. G., Selvı, Y., Özkol, H., Aydın, A., Tülüce, Y., Boysan, M., & Beşiroğlu, L. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.09.022 · Cited by 80
The effects of exercise on oxidative stress (TBARS) and BDNF in severely depressed inpatients
Schuch, F. B., Vasconcelos-Moreno, M. P., Borowsky, C., Zimmermann, A. B., Wollenhaupt-Aguiar, B., Ferrari, P., & Fleck, M. P. D. A. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0489-5 · Cited by 94
Wang, H., Jin, M., Xie, M., Yang, Y., Xue, F., Li, W., Zhang, M., Li, Z., Li, X., Jia, N., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.11.072 · Cited by 80
Metadata
- Authors
- Ng, F., Berk, M., Dean, O., & Bush, A. I.
- Affiliations
- Barwon Health (AU)
- Mental Health Research Institute (AU)
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-01-21
- Volume
- 11
- Issue
- 06
- Pages
- 851-76
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W1986211748
- Cited by
- 1,069
- References
- 203
- Citations by year
- 2026: 23 · 2025: 52 · 2024: 49 · 2023: 60 · 2022: 52 · 2021: 81 · 2020: 73 · 2019: 69 · 2018: 74 · 2017: 42 · 2016: 84 · 2015: 71 · 2014: 74 · 2013: 68 · 2012: 50
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Deakin Research Online (Deakin University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxidative stress, mental illness, schizophrenia, bipolar disorder, depression, anxiety disorders, cocaine dependence, autism spectrum disorder, attention deficit hyperactivity disorder, antioxidants, N-acetylcysteine, oxidative stress biomarkers, psychopharmacology, common pathogenic mechanisms
- MeSH terms
- Antioxidants, Mental Disorders, Humans, Databases, Bibliographic, Oxidative Stress
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