Cited by 1,069Antioxidant Activity and Oxidative StressTryptophan and brain disordersRedox biology and oxidative stress

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Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

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Ng, Felicity, Berk, Michael, Dean, Olivia, Bush, Ashley I.·2008·The International Journal of Neuropsychopharmacology

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Abstract

Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage. This review aims to examine the current evidence for the role of oxidative stress in psychiatric disorders, and its academic and clinical implications. A literature search was conducted using the Medline, Pubmed, PsycINFO, CINAHL PLUS, BIOSIS Preview, and Cochrane databases, with a time-frame extending to September 2007. The broadest data for oxidative stress mechanisms have been derived from studies conducted in schizophrenia, where evidence is available from different areas of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid foundation for oxidative stress hypotheses has been provided by biochemical, genetic, pharmacological, preclinical therapeutic studies and one clinical trial. Oxidative pathophysiology in anxiety disorders is strongly supported by animal models, and also by human biochemical data. Pilot studies have suggested efficacy of N-acetylcysteine in cocaine dependence, while early evidence is accumulating for oxidative mechanisms in autism and attention deficit hyperactivity disorder. In conclusion, multi-dimensional data support the role of oxidative stress in diverse psychiatric disorders. These data not only suggest that oxidative mechanisms may form unifying common pathogenic pathways in psychiatric disorders, but also introduce new targets for the development of therapeutic interventions.

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Authors: Ng, F., Berk, M., Dean, O., & Bush, A. I.
Affiliations: Barwon Health (AU)
Mental Health Research Institute (AU)
ORCID: Ng, Felicity
Dean, Olivia
Bush, Ashley I.
Venue: The International Journal of Neuropsychopharmacology
Publisher: Oxford University Press (OUP)
Published: 2008-01-21
Volume: 11
Issue: 06
Pages: 851-76
ISSN: 1461-1457 (ISSN-L)
1469-5111
DOI: 10.1017/s1461145707008401
OpenAlex: W1986211748
Cited by: 1,069
References: 203
Citations by year: 2026: 23 · 2025: 52 · 2024: 49 · 2023: 60 · 2022: 52 · 2021: 81 · 2020: 73 · 2019: 69 · 2018: 74 · 2017: 42 · 2016: 84 · 2015: 71 · 2014: 74 · 2013: 68 · 2012: 50
FWCI: 4.26
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The International Journal of Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Deakin Research Online (Deakin University) (submittedVersion)
Figshare (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: oxidative stress, mental illness, schizophrenia, bipolar disorder, depression, anxiety disorders, cocaine dependence, autism spectrum disorder, attention deficit hyperactivity disorder, antioxidants, N-acetylcysteine, oxidative stress biomarkers, psychopharmacology, common pathogenic mechanisms
MeSH terms: Antioxidants, Mental Disorders, Humans, Databases, Bibliographic, Oxidative Stress

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Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

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