Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Free radicals and antioxidants in normal physiological functions and human disease

Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269

Journal of Clinical Psychiatry

(2018) · Journal of Clinical Psychiatry · doi:10.5505/kpd · Cited by 13,703

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413

Nitric Oxide and Peroxynitrite in Health and Disease

Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390

Oxidative stress: oxidants and antioxidants

Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577

Neurodegenerative diseases and oxidative stress

Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683 · cited 1×

Oxidative stress and neurodegeneration: where are we now?

Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614

Vitamin E, antioxidant and nothing more

Traber, M. G., & Atkinson, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.024 · Cited by 1,547

Untreated Depression and Hippocampal Volume Loss

Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1516 · Cited by 1,180

Oxidative stress: the paradox of aerobic life

Davies, K. J. A. (1995) · Biochemical Society Symposia · doi:10.1042/bss0610001 · Cited by 1,150

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

Prabakaran, S., SWATTON, J. E., Ryan, M. M., Huffaker, S. J., Huang, J.-J., Griffin, J. L., Wayland, M. T., Freeman, T., Dudbridge, F., Lilley, K. S., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001511 · Cited by 985

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., & Neubrander, J. A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1611 · Cited by 955

The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia

GOFF, D. C., & Coyle, J. T. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.9.1367 · Cited by 926

The Chinese Medical Journal

Young, T. K. (1973) · New England Journal of Medicine · doi:10.1056/nejm197307122890231 · Cited by 903

Journal of Affective Disorders

Flint, A. J., & Rifat, S. L. (1996) · Journal of Affective Disorders · doi:10.1016/0165-0327(96)00074-2 · Cited by 864

Oxidative Stress, Antioxidant Defenses, and Damage Removal, Repair, and Replacement Systems

Davies, K. J. A. (2000) · IUBMB Life · doi:10.1080/713803728 · Cited by 774

N-Acetylcysteine—a safe antidote for cysteine/glutathione deficiency

Atkuri, K. R., Mantovani, J. J., Herzenberg, L. A., & Herzenberg, L. A. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.04.005 · Cited by 721

Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments

Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718

Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism

James, S. J., Melnyk, S., Jernigan, S., Cleves, M. A., Halsted, C. H., Wong, D. H., Cutler, P., Bock, K., Boris, M., Bradstreet, J., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30366 · Cited by 618

Oxidative Stress, Antioxidant Defenses, and Damage Removal, Repair, and Replacement Systems

Davies, K. J. A. (2000) · IUBMB Life · doi:10.1080/15216540051081010 · Cited by 608

Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention

Tansey, M. G., McCoy, M. K., & Frank-Cannon, T. C. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.07.004 · Cited by 587

Depletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients

Peet, M., Murphy, B., Shay, J., & Horrobin, D. F. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00206-0 · Cited by 585

Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo

Do, K. Q., Trabesinger, A. H., Kirsten‐Krüger, M., Lauer, C. J., Dydak, U., Hell, D., Holsboer, F., Boesiger, P., & Cuénod, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00229.x · Cited by 540

The International Journal of Neuropsychopharmacology

Lerer, B., Frazer, A., Stahl, S. M., Farde, L., & Lesch, K. (1998) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145798009018 · Cited by 500

Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice

Hovatta, I., Tennant, R. S., Helton, R., Marr, R. A., Singer, O., Redwine, J. M., Ellison, J. A., Schadt, E. E., Verma, I. M., Lockhart, D. J., et al. (2005) · Nature · doi:10.1038/nature04250 · Cited by 498

The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS

Chen, G., Zeng, W., YUAN, P., Huang, L., Jiang, Y., Zhao, Z., & Manji, H. K. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.720879.x · Cited by 490

Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems

Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E., & Kirli, S. (2007) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.829 · Cited by 486

THE BRITISH JOURNAL OF NUTRITION

(1948) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1948.tb97074.x · Cited by 480

Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors

Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A., & Palasodkar, R. (2003) · Redox Report · doi:10.1179/135100003225003393 · Cited by 458

Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin—the antioxidant proteins

Chauhan, A., Chauhan, V., Brown, W. T., & Cohen, I. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.038 · Cited by 424

Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients

Ranjekar, P. K., Hinge, A. S., Hegde, M. V., Ghate, M. R., Kale, A. A., Sitasawad, S. L., Wagh, U. V., Debsikdar, V. B., & Mahadik, S. P. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(03)00220-8 · Cited by 398

Molecular mechanism of α-tocopherol action

Azzi, A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.013 · Cited by 387

Non-Antioxidant Activities of Vitamin E

Zingg, J.-M. A., & Azzi, A. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043365332 · Cited by 377

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

Prabakaran, S., SWATTON, J. E., Ryan, M. M., Huffaker, S. J., Huang, J. T.-J., Griffin, J. L., Wayland, M. T., Freeman, T., Dudbridge, F., Lilley, K. S., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001532 · Cited by 375

Glutathione Precursor, N-Acetyl-Cysteine, Improves Mismatch Negativity in Schizophrenia Patients

Lavoie, S., Murray, M. M., Deppen, P., Knyazeva, M. G., Berk, M., Boulat, O., Bovet, P., Bush, A. I., Conus, P., Copolov, D., et al. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301624 · Cited by 371

Antioxidant enzyme activities and oxidative stress in affective disorders

Erkan Ozcan, M., Gulec, M., Ozerol, E., Polat, R., & Akyol, O. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200403000-00006 · Cited by 368

The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity

Hayley, S., Poulter, M. O., Merali, Z., & Anisman, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.051 · Cited by 324

Adenosine Deaminase, Nitric Oxide, Superoxide Dismutase, and Xanthine Oxidase in Patients with Major Depression: Impact of Antidepressant Treatment

Herken, H., Gurel, A., Selek, S., Armutcu, F., Ozen, M. E., Bulut, M., Kap, O., Yumru, M., Savas, H. A., & Akyol, O. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.10.005 · Cited by 322

Altered glutathione redox state in schizophrenia.

Yao, J. K., Leonard, S., & Reddy, R. (2006) · Disease Markers · doi:10.1155/2006/248387 · Cited by 321

Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder

Kuloglu, M., Ustundag, B., Atmaca, M., Canatan, H., Tezcan, A. E., & Cinkilinc, N. (2002) · Cell Biochemistry and Function · doi:10.1002/cbf.940 · Cited by 321

Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: A possible role for lithium antioxidant effects

Machado‐Vieira, R., Andreazza, A. C., Viale, C. I., Zanatto, V. C., Ceresér, V. H., Vargas, R. D. S., Kapczinski, F. P., Portela, L. V., Souza, D. O., Salvador, M. M., et al. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.05.016 · Cited by 314

Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence

Gysin, R., Kraftsik, R., Sandell, J., Bovet, P., Chappuis, C., Conus, P., Deppen, P., Preisig, M., Ruiz, V., Steullet, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706778104 · Cited by 309

Increased Serum Levels of 8-Hydroxy-2′-Deoxyguanosine in Clinical Depression

Forlenza, M. J., & Miller, G. E. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000195780.37277.2a · Cited by 309

Serum S100B and antioxidant enzymes in bipolar patients

Andreazza, A. C., Cassini, C., Rosa, A. R., Leite, M. C., de Almeida, L. M. V., Nardin, P., da Cunha, A. B., Ceresér, K. M. M., Santin, A. M. P., Gottfried, C., et al. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.07.013 · Cited by 307

Reduced erythrocyte membrane essential fatty acids and increased lipid peroxides in schizophrenia at the never-medicated first-episode of psychosis and after years of treatment with antipsychotics

Khan, M. M. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00334-6 · Cited by 300

Supplementation with a combination of ω-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia

Arvindakshan, M. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00284-0 · Cited by 281

The indices of endogenous oxidative and antioxidative processes in plasma from schizophrenic patients

Akyol, Ö., Herken, H., Uz, E., Fadıllıoğlu, E., Ünal, S., Söğüt, S., Özyurt, H., & SAVAS, H. A. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00220-8 · Cited by 280

Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects

Bouayed, J., Rammal, H., Dıcko, A., Younos, C., & Soulimani, R. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.06.028 · Cited by 278

Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism

Söğüt, S., Zoroğlu, S. S., Özyurt, H., Yilmaz, H. R., Özuğurlu, F., Sivaslı, E., Yetkin, Ö., Yanık, M., Tutkun, H., SAVAS, H. A., et al. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(03)00119-0 · Cited by 275

Lower serum vitamin E concentrations in major depression

Maes, M. H. J., Vos, N. D., Pioli, R., Demedts, P., Wauters, A., Neels, H. M., & Christophe, A. B. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00121-4 · Cited by 274

Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics

Zhang, X., Tan, Y. L., Cao, L. Y., Wu, G. Y., Xu, Q., Shen, Y., & Zhou, D. F. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.10.011 · Cited by 262

Oxidative Stress Responses in Older Men during Endurance Training and Detraining

Fatouros, I. G., Jamurtas, A. Z., Villiotou, V., POULIOPOULOU, S., Foteinakis, P. F., Taxildaris, K., & Deliconstantinos, G. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000147632.17450.ff · Cited by 246

Neuropsychopharmacology

Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_3942 · Cited by 245

Effects of lithium and valproate on amphetamineinduced oxidative stress generation in an animal model of mania

Frey, B. N., Valvassori, S. S., Réus, G. Z., Martins, M. R., Petronilho, F. C., Bardini, K., Dal‐Pizzol, F., Kapczinski, F. P., & Quevedo, J. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0637 · Cited by 238

Evidence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation are increased in different forms of schizophrenia

Herken, H., Uz, E., Özyurt, H., Söğüt, S., Vırıt, O., & Akyol, Ö. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000789 · Cited by 238

Increased excretion of a lipid peroxidation biomarker in autism

Ming, X., Stein, T. P., Brimacombe, M., Johnson, W. G., Lambert, G. H., & Wagner, G. C. (2005) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.06.002 · Cited by 236

Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism

Zoroğlu, S. S., Armutçu, F., Özen, Ş., Gürel, A., Sivaslı, E., Yetkin, O., & Meram, İ. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0456-7 · Cited by 235

Protective Effects of Lamotrigine, Aripiprazole and Escitalopram on Depression-induced Oxidative Stress in Rat Brain

Eren, İ., Nazıroğlu, M., & Demirdaş, A. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9289-x · Cited by 234

Schizophrenia and Oxidative Stress: Glutamate Cysteine Ligase Modifier as a Susceptibility Gene

Tosic, M., Ott, J., Barral, S., Bovet, P., Deppen, P., Gheorghita, F., Matthey, M.-L., Parnas, J., Preisig, M., Saraga, M., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/507566 · Cited by 234

Essential polyunsaturated fatty acid and lipid peroxide levels in never-medicated and medicated schizophrenia patients

Arvindakshan, M., Sitasawad, S. L., Debsikdar, V. B., Ghate, M. R., Evans, D. R., Horrobin, D. F., Bennett, C. N., Ranjekar, P. K., & Mahadik, S. P. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01443-9 · Cited by 232

N-Acetylcysteine Reduces Extinction Responding and Induces Enduring Reductions in Cue- and Heroin-Induced Drug-Seeking

Zhou, W., & Kalivas, P. W. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.008 · Cited by 225

Differential effects of antipsychotics on expression of antioxidant enzymes and membrane lipid peroxidation in rat brain

Parikh, V., Khan, M. M., & Mahadik, S. P. (2002) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(02)00048-1 · Cited by 224

Chronic Treatment with Mood Stabilizers Lithium and Valproate Prevents Excitotoxicity by Inhibiting Oxidative Stress in Rat Cerebral Cortical Cells

Shao, L., Young, L. T., & Wang, J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.052 · Cited by 218

Is Cocaine Desire Reduced by N -Acetylcysteine?

LaRowe, S. D., Myrick, H., Hedden, S. L., Mardikian, P. N., Saladin, M. E., McRae‐Clark, A. L., Brady, K. T., Kalivas, P. W., & Malcolm, R. J. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.7.1115 · Cited by 217

Neurotoxicity associated with neuroleptic-induced oral dyskinesias in rats

Andreassen, O. A., & Jørgensen, H. A. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00064-7 · Cited by 211

Proteomic analysis of protein changes developing in rat hippocampus after chronic antidepressant treatment: Implications for depressive disorders and future therapies

Khawaja, X. Z., Xu, J., Liang, J., & Barrett, J. E. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.10869 · Cited by 209

Investigation of antioxidant enzymes in children with autistic disorder

Yorbık, Ö., Sayal, A., Akay, C., Akbiyik, D. I., & Söhmen, T. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2002.0439 · Cited by 207

Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: Focus on vasopressin and glyoxalase-I

Landgraf, R., Kessler, M. S., Bunck, M., Murgatroyd, C., Spengler, D., Zimbelmann, M., Nußbaumer, M., Czibere, L., Turck, C. W., Singewald, N., et al. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.07.003 · Cited by 201

Reduced plasma antioxidants in first-episode patients with schizophrenia

Reddy, R. D. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00407-3 · Cited by 194

The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia

Benes, F. M., Matzilevich, D., Burke, R. E., & Walsh, J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001758 · Cited by 183

Safety and Tolerability of N‐Acetylcysteine in Cocaine‐Dependent Individuals

LaRowe, S. D., Mardikian, P. N., Malcolm, R. J., Myrick, H., Kalivas, P. W., McFarland, K., Saladin, M. E., McRae‐Clark, A. L., & Brady, K. T. (2006) · American Journal on Addictions · doi:10.1080/10550490500419169 · Cited by 181

Antioxidant Enzyme Activities and Malondialdehyde Levels in Patients with Obsessive-Compulsive Disorder

Kuloğlu, M., Atmaca, M., Tezcan, E., Geçici, Ö., Tunckol, H., & Üstündağ, B. (2002) · Neuropsychobiology · doi:10.1159/000063573 · Cited by 178

Vitamin C and Vitamin E for Alzheimer's Disease

Boothby, L. A., & Doering, P. L. (2005) · Annals of Pharmacotherapy · doi:10.1345/aph.1e495 · Cited by 176

The course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episode

Selek, S., Savas, H. A., Gergerlioglu, H. S., Bulbul, F., Uz, E., & Yumru, M. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.08.006 · Cited by 172

Oxidative stress in diabetes: A mechanistic overview of its effects on atherogenesis and myocardial dysfunction

Mehta, J. L., Rasouli, N., Sinha, A. K., & Molavi, B. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.12.008 · Cited by 169

Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic-depressive patients.

Abdalla, D. S. P., Monteiro, H., Oliveira, J., & Bechara, E. J. H. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.5.805 · Cited by 168

Acute or repeated cocaine administration generates reactive oxygen species and induces antioxidant enzyme activity in dopaminergic rat brain structures

Dietrich, J.-B., Mangeol, A., Revel, M.-O., Burgun, C., Aunis, D., & Zwiller, J. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.018 · Cited by 168 · cited 1×

Anxiolytic properties of green tea polyphenol (−)-epigallocatechin gallate (EGCG)

Vignes, M., Maurice, T., Lanté, F., Nedjar, M., Thethi, K., Guiramand, J., & Récasens, M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.062 · Cited by 167

Red blood cell membrane essential fatty acid metabolism in early psychotic patients following antipsychotic drug treatment

Evans, D. R., Parikh, V., Khan, M. M., Coussons, C., Buckley, P. F., & Mahadik, S. P. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.08.010 · Cited by 164

Elevated Plasma Lipid Peroxides at the Onset of Nonaffective Psychosis

Mahadik, S. P., Mukherjee, S., Scheffer, R. E., Correnti, E. E., & Mahadik, J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00282-5 · Cited by 163

Reduced status of plasma total antioxidant capacity in schizophrenia

Yao, J. K., Reddy, R. D., McElhinny, L. G., & van Kammen, D. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00030-9 · Cited by 161

Venlafaxine Modulates Depression-Induced Oxidative Stress in Brain and Medulla of Rat

Eren, İ., Nazıroğlu, M., Demirdaş, A., Çelik, Ö., Uğuz, A. C., Altunbaşak, A., Özmen, İ., & Uz, E. (2007) · Neurochemical Research · doi:10.1007/s11064-006-9258-9 · Cited by 161

Role of glutathione in neuroprotective effects of mood stabilizing drugs lithium and valproate

Cui, J., Shao, L., Young, L. T., & Wang, J.-F. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.010 · Cited by 160

Long-term antipsychotic treatments and crossover studies in rats: Differential effects of typical and atypical agents on the expression of antioxidant enzymes and membrane lipid peroxidation in rat brain

Pillai, A., Parikh, V., Terry, A. V., & Mahadik, S. P. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.01.011 · Cited by 153

N‐Acetyl Cysteine‐Induced Blockade of Cocaine‐Induced Reinstatement

Baker, D. L., McFarland, K., LAKE, R. W., Shen, H., Toda, S., & Kalivas, P. W. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.023 · Cited by 148

Oxidative Stress Produced by Marijuana Smoke: An Adverse Effect Enhanced by Cannabinoids

Sarafian, T. A., Marques-Magallanes, J. A., Shau, H., Tashkin, D. P., & Roth, M. D. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.6.3424 · Cited by 147

Hippocampal Volumes in Schizophrenic Twins

van Erp, T. G. M., Saleh, P. A., HUTTUNEN, M. O., Lönnqvist, J. K., Kaprio, J. A., Salonen, O. L. M., Valanne, L. K., Poutanen, V.-P., Standertskjöld-Nordenstam, C.-G., & Cannon, T. D. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.4.346 · Cited by 147

Increased Nitric Oxide Radicals in Postmortem Brain From Patients With Schizophrenia

YAO, J. K., Leonard, S. S., & Reddy, R. D. (2004) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007142 · Cited by 146

Elevated serum nitric oxide and superoxide dismutase in euthymic bipolar patients: Impact of past episodes

SAVAS, H. A., Gergerlioğlu, H. S., Armutçu, F., Herken, H., Yılmaz, H. R., Koçoğlu, E., Selek, S., Tutkun, H., Zoroğlu, S. S., & Akyol, Ö. (2006) · The World Journal of Biological Psychiatry · doi:10.1080/15622970510029993 · Cited by 143

Increased (E)-4-hydroxy-2-nonenal and asymmetric dimethylarginine concentrations and decreased nitric oxide concentrations in the plasma of patients with major depression

Selley, M. L. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(03)00135-6 · Cited by 139

Antioxidant Enzyme and Malondialdehyde Levels in Patients with Panic Disorder

Kuloğlu, M., Atmaca, M., Tezcan, E., Üstündağ, B., & Bulut, S. (2002) · Neuropsychobiology · doi:10.1159/000067810 · Cited by 137

Effect of antioxidant N-acetyl-l-cysteine on behavioral changes and neurotoxicity in rats after administration of methamphetamine

Fukami, G., Hashimoto, K., Koike, K., Okamura, N., Shimizu, E., & Iyo, M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.04.072 · Cited by 137

Biomarkers for Oxidative Stress: Clinical Application in Pediatric Medicine

Tsukahara, H. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707779941177 · Cited by 135

Abnormal age-related changes of plasma antioxidant proteins in schizophrenia

Yao, J. K., Reddy, R. D., & van Kammen, D. P. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00230-4 · Cited by 133

Erythrocyte Superoxide Dismutase and Glutathione Peroxidase Activities, and Malondialdehyde and Reduced Glutathione Levels in Schizophrenic Patients

Altuntaş, İ., Aksoy, H., Coşkun, İ., Çayköylü, A., & Akçay, F. (2000) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2000.201 · Cited by 131

Supplementation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophrenia

Dakhale, G. N., Khanzode, S. D., Khanzode, S. S., & Saoji, A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0117-1 · Cited by 131

Altered Vascular Phenotype in Autism

Yao, Y., Walsh, W. J., McGinnis, W. R., & Praticò, D. (2006) · Archives of Neurology · doi:10.1001/archneur.63.8.1161 · Cited by 131

Oxidative stress in the hippocampus, anxiety-like behavior and decreased locomotory and exploratory activity of adult rats: Effects of sub acute vitamin A supplementation at therapeutic doses

DEOLIVEIRA, M., SILVESTRIN, R., MELLOESOUZA, T., & MOREIRA, J. (2007) · NeuroToxicology · doi:10.1016/j.neuro.2007.07.008 · Cited by 130

Olanzapine protects PC12 cells from oxidative stress induced by hydrogen peroxide

Wei, Z., Bai, O., Richardson, J. S., Mousseau, D. D., & Li, X. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10668 · Cited by 129

The relationship between potency of oxidative stress and severity of depression

Yanık, M., Erel, Ö., & Katı, M. (2004) · Acta Neuropsychiatrica · doi:10.1111/j.0924-2708.2004.00090.x · Cited by 126

Biological Psychiatry

Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_641 · Cited by 125

Clinical pharmacology and therapeutic use of antioxidant vitamins

Rodrigo, R., Guichard, C., & Charles, R. (2007) · Fundamental & Clinical Pharmacology · doi:10.1111/j.1472-8206.2006.00466.x · Cited by 124

Progress in neuro-psychopharmacology and biological psychiatry Re.: omega-3 fatty acids and sudden unexpected death in epilepsy: what does the evidence tell us?

Scorza, F., Cysneiros, R., Cavalheiro, E., Arida, R., & de Albuquerque, M. (2007) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.02.001 · Cited by 122

Cytoprotection by lithium and valproate varies between cell types and cellular stresses

Lai, J. S., Zhao, C., Warsh, J. J., & Li, P. P. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.03.076 · Cited by 122

Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice.

Desrumaux, C., Risold, P.-Y., Schroeder, H., Deckert, V., Masson, D., Athias, A., Laplanche, H., Le Guern, N., Blache, D., Jiang, X.-C., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2400fje · Cited by 122

Reduced level of plasma antioxidant uric acid in schizophrenia

Yao, J. K., Reddy, R. D., & van Kammen, D. P. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00051-1 · Cited by 121

Increased oxidative stress and DNA damage in bipolar disorder: A twin-case report

Frey, B. N., Andreazza, A. C., Kunz, M., Gomes, F. A., Quevedo, J., Salvador, M., Gonçalves, C. A., & Kapczinski, F. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.011 · Cited by 120

Treatment of ADHD with French maritime pine bark extract, Pycnogenol®

Trebatická, J., Kopasová, S., Hradečná, Z., Činovský, K., Škodáček, I., Šuba, J., Muchová, J., Žitňanová, I., Waczulı́ková, I., Rohdewald, P. J., et al. (2006) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-006-0538-3 · Cited by 119

Oxidative Damage and Schizophrenia: The Potential Benefit by Atypical Antipsychotics

Dakhale, G. N., Khanzode, S. D., Khanzode, S. S., Saoji, A., Khobragade, L., & Turankar, A. V. (2004) · Neuropsychobiology · doi:10.1159/000077368 · Cited by 118

Vitamin E Treatment for Tardive Dyskinesia

Adler, L. A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.9.836 · Cited by 118

Altered antioxidant defense system in clinically stable patients with schizophrenia and their unaffected siblings

Othmen, L. B., Mechri, A., Fendri, C., Bost, M., Chazot, G., Gaha, L., & Kerkeni, A. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.003 · Cited by 117

Oxidative Stress During Treatment With First- and Second-Generation Antipsychotics

Kropp, S., Kern, V., Lange, K., Degner, D., Hajak, G., Kornhuber, J., Rüther, E., Emrich, H. M., Schneider, U., & Bleich, S. (2005) · Journal of Neuropsychiatry · doi:10.1176/jnp.17.2.227 · Cited by 117

Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: A study of patients treated with haloperidol or clozapine

Gama, C. S., Salvador, M. M., Andreazza, A. C., Kapczinski, F. P., & Belmonte-de-Abreu, P. S. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.11.009 · Cited by 116

Mitochondrial Dysfunction as the Molecular Basis of Bipolar Disorder

Kato, T. (2007) · CNS Drugs · doi:10.2165/00023210-200721010-00001 · Cited by 114

Positive correlation between peripheral blood granulocyte oxidative status and level of anxiety in mice

Bouayed, J., Rammal, H., Younos, C., & Soulimani, R. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.02.055 · Cited by 114

Evidence for Oxidative DNA Damage in the Hippocampus of Elderly Patients With Chronic Schizophrenia

Nishioka, N., & Arnold, S. E. (2004) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200403000-00008 · Cited by 114

Contribution of Cystine–Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine

Baker, D. L., Madayag, A., Kristiansen, L. V., Meador‐Woodruff, J. H., Haroutunian, V. H., & Raju, I. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301532 · Cited by 113

Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12

Penugonda, S., Mare, S., Goldstein, G. A., Banks, W. A., & Nuran Ercal, A. (2005) · Brain Research · doi:10.1016/j.brainres.2005.07.032 · Cited by 113

Changes in nitric oxide level and superoxide dismutase activity during antimanic treatment

Gergerlioğlu, H. S., SAVAS, H. A., Bülbül, F., Selek, S., Uz, E., & Yumru, M. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.020 · Cited by 111

Unifying mechanism for toxicity and addiction by abused drugs: electron transfer and reactive oxygen species

Kovacic, P., & Cooksy, A. L. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.07.021 · Cited by 110

Increased oxidative stress after repeated amphetamine exposure: possible relevance as a model of mania

Frey, B. N., Martins, M. R., Petronilho, F. C., Dal‐Pizzol, F., Quevedo, J., & Kapczinski, F. P. (2006) · Bipolar Disorders · doi:10.1111/j.1399-5618.2006.00318.x · Cited by 109

Impairment of several immune functions in anxious women

Arranz, L., Guayerbas, N., & la Fuente, M. D. (2006) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.07.030 · Cited by 107

Valproate inhibits oxidative damage to lipid and protein in primary cultured rat cerebrocortical cells

Wang, J., Azzam, J. E., & Young, L. T. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00655-3 · Cited by 107

Low plasma vitamin E levels in major depression: diet or disease?

Owen, A. J., Batterham, M. J., Probst, Y., Grenyer, B. F. S., & Tapsell, L. C. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602072 · Cited by 105

A double-blind placebo-controlled study of vitamin E treatment of tardive dyskinesia.

Lohr, J. B., & Caligiuri, M. P. (1996) · PubMed · Cited by 105

Orally administered N-acetylcysteine may improve general well-being in patients with mild chronic bronchitis

Hansen, N. C. G., Skriver, A., Brorson-Riis, L., Balsløv, S., Evald, T., Maltbæk, N., Gunnersen, G., Garsdal, P., Sander, P., Pedersen, J., et al. (1994) · Respiratory Medicine · doi:10.1016/s0954-6111(05)80337-3 · Cited by 104

The impact of ω-3 fatty acids, vitamins E and C supplementation on treatment outcome and side effects in schizophrenia patients treated with haloperidol: An open-label pilot study

Sivrioglu, E. Y., Kirli, S., Sipahioglu, D., Gursoy, B., & Sarandöl, E. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.07.004 · Cited by 102

Effect of polyphenolic extract, Pycnogenol®, on the level of 8-oxoguanine in children suffering from attention deficit/hyperactivity disorder

Chovanová, Z., Muchová, J., Sivoňová, M. K., Dvořáková, M., Žitňanová, I., Waczulı́ková, I., Trebatická, J., Škodáček, I., & Ďuračková, Z. (2006) · Free Radical Research · doi:10.1080/10715760600824902 · Cited by 101

Association between Ala–9Val polymorphism of Mn-SOD gene and schizophrenia

Akyol, Ö., Yanık, M., Elyas, H., Namlı, M. N., Canatan, H., Akın, H., Yüce, H., Yilmaz, H. R., Tutkun, H., Söğüt, S., et al. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.10.014 · Cited by 99

Nitrite content and antioxidant enzyme levels in the blood of schizophrenia patients

Srivastava, N., Barthwal, M. K., Dalal, P., Agarwal, A. K., Nag, D., Srimal, R. C., Seth, P. K., & Dikshit, M. (2001) · Psychopharmacology · doi:10.1007/s002130100860 · Cited by 99

Changes in Antioxidant Defense Enzymes after d-amphetamine Exposure: Implications as an Animal Model of Mania

Frey, B. N., Valvassori, S. S., Réus, G. Z., Martins, M. R., Petronilho, F. C., Bardini, K., Dal‐Pizzol, F., Kapczinski, F. P., & Quevedo, J. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9070-6 · Cited by 98

N-Acetyl Cysteine in the Treatment of Grooming Disorders

Odlaug, B. L., & Grant, J. E. (2007) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000264976.86990.00 · Cited by 94

Fine mapping of a susceptibility locus for bipolar and genetically related unipolar affective disorders, to a region containing the C21ORF29 and TRPM2 genes on chromosome 21q22.3

McQuillin, A., Bass, N. J., Kalsi, G., Lawrence, J., Puri, V., Choudhury, K., Detera‐Wadleigh, S. D., Curtis, D., & Gurling, H. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001759 · Cited by 93

A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress

Marchbanks, R. M., Ryan, M., Day, I. N. M., Owen, M., McGuffin, P., & Whatley, S. A. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00011-2 · Cited by 93

Olanzapine and quetiapine protect PC12 cells from β-amyloid peptide25-35-induced oxidative stress and the ensuing apoptosis

Wang, H., Xu, H., Dyck, L. E., & Li, X. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20570 · Cited by 93

Oxidative–antioxidative systems and their relation with serum S100 B levels in patients with schizophrenia: Effects of short term antipsychotic treatment

Sarandöl, A., Kırlı, S., Akkaya, C., Altın, A., Demirci, M., & Sarandöl, E. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.03.008 · Cited by 92

Redox Control of Apoptosis: An Update

Filomeni, G., & Ciriolo, M. R. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2187 · Cited by 92

A Double-Blind, Placebo-Controlled Trial of Extract of Ginkgo biloba Added to Haloperidol in Treatment-Resistant Patients With Schizophrenia

Zhang, X. Y., Zhou, D. F., Zhang, P. Y., Wu, G. Y., Su, J. M., & Cao, L. Y. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n1107 · Cited by 90

Cu, Zn- and Mn-superoxide dismutase levels in brains of patients with schizophrenic psychosis

Michel, T. M., Thome, J., Martin, D., Keinosuke, N. A. R. A., Zwerina, S., Tatschner, T., Weijers, H. ‐., & Koutsilieri, E. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0160-9 · Cited by 90

Examination of free radical metabolism and antioxidant defence system elements in patients with obsessive–compulsive disorder

Erşan, S., Bakır, S., Erşan, E. E., & Doğan, O. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.034 · Cited by 90

Magnetic Resonance Imaging of the Thalamus and Adhesio Interthalamica in Twins With Schizophrenia

Ettinger, U., Picchioni, M., Landau, S., Matsumoto, K., van Haren, N. E. M., Marshall, N., Hall, M., Schulze, K., Toulopoulou, T., Davies, N., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.4.401 · Cited by 85

Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells

Shao, L., Sun, X., Xu, L., Young, L. T., & Wang, J. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.07.007 · Cited by 85

The effect of polyphenolic extract from pine bark, Pycnogenol®on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD)

Dvořáková, M., Sivoňová, M. K., Trebatická, J., Škodáček, I., Waczulı́ková, I., Muchová, J., & Ďuračková, Z. (2006) · Redox Report · doi:10.1179/135100006x116664 · Cited by 84

Oxidative stress in blood platelets from schizophrenic patients

Dietrich‐Muszalska, A., Olas, B., & Rabe‐Jabłońska, J. (2005) · Platelets · doi:10.1080/09537100500128872 · Cited by 84

Long-term treatment effects of vitamin E for tardive dyskinesia

Adler, L. A., Edson, R., Lavori, P. W., Peselow, E. D., Duncan, E., Rosenthal, M., & Rotrosen, J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00027-9 · Cited by 83

Increased oxidative stress in submitochondrial particles after chronic amphetamine exposure

Frey, B. N., Valvassori, S. S., Gomes, K. M., Martins, M. R., Dal‐Pizzol, F., Kapczinski, F. P., & Quevedo, J. (2006) · Brain Research · doi:10.1016/j.brainres.2006.04.076 · Cited by 82

Elevated Nitric Oxide/Peroxynitrite Mechanism for the Common Etiology of Multiple Chemical Sensitivity, Chronic Fatigue Syndrome, and Posttraumatic Stress Disorder

Pall, M. L., & Satterlee, J. D. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05836.x · Cited by 81

Effect of Chronic N-Acetyl Cysteine Administration on Oxidative Status in the Presence and Absence of Induced Oxidative Stress in Rat Striatum

Harvey, B. H., Joubert, C., du Preez, J. L., & Berk, M. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9466-y · Cited by 81

Is the Arginine-Nitric Oxide Pathway Involved in the Pathogenesis of Schizophrenia?

Yanık, M., Vural, H., Koçyiğit, A., Tutkun, H., Zoroğlu, S. S., Herken, H., SAVAS, H. A., Köylü, A., & Akyol, Ö. (2003) · Neuropsychobiology · doi:10.1159/000070010 · Cited by 81

A study on nitric oxide, β-adrenergic receptors and antioxidant status in the polymorphonuclear leukocytes from the patients of depression

Srivastava, N., Barthwal, M. K., Dalal, P., Agarwal, A., Nag, D., Seth, P. K., Srimal, R. C., & Dikshit, M. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00421-9 · Cited by 80

γ‐Glutamylglutamine and Taurine Concentrations Are Decreased in the Cerebrospinal Fluid of Drug‐Naive Patients with Schizophrenic Disorders

Do, K. Q., Lauer, C. J., Schreiber, W., Zollinger, M., Gutteck‐Amsler, U., Cuénod, M., & Holsboer, F. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65062652.x · Cited by 79

Low concentration of nitrite and nitrate in the cerebrospinal fluid from schizophrenic patients: a pilot study

Ramírez‐Bermúdez, J. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00070-7 · Cited by 77

Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment

Atmaca, M., Tezcan, E., Kuloglu, M., Ustundag, B., & Tunckol, H. (2004) · European Archives of Psychiatry and Clinical Neurosciences · doi:10.1007/s00406-004-0484-3 · Cited by 75

The role of the arginine-nitric oxide pathway in the pathogenesis of bipolar affective disorder

Yanık, M., Vural, H., Tutkun, H., Zoroğlu, S. S., SAVAS, H. A., Herken, H., Ko�yigit, A., Keles, H., & Akyol, �. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0453-x · Cited by 75

The World Journal of Biological Psychiatry

Kasper, S. F. (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970903416878 · Cited by 74

Free radicals in patients with post-traumatic stress disorder

Tezcan, E., Atmaca, M., Kuloğlu, M., & Üstündağ, B. (2003) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-003-0413-x · Cited by 72

The Effect of Extract of Ginkgo Biloba Added to Haloperidol on Superoxide Dismutase in Inpatients With Chronic Schizophrenia

Zhang, X., Zhou, D. F., Su, J. M., & Zhang, P. Y. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200102000-00015 · Cited by 70

Glutathione peroxidase and CT scan abnormalities in schizophrenia

Buckman, T. D., Kling, A. S., Eiduson, S., Sutphin, M. S., & Steinberg, A. M. (1987) · Biological Psychiatry · doi:10.1016/0006-3223(87)90069-2 · Cited by 68

Chronic valproate treatment increases expression of endoplasmic reticulum stress proteins in the rat cerebral cortex and hippocampus

Chen, B., Wang, J. F., & Young, L. T. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00878-7 · Cited by 68

The possible pathophysiological role of plasma nitric oxide and adrenomedullin in schizophrenia

Zoroğlu, S. S., Herken, H., Yürekli, M., Uz, E., Tutkun, H., SAVAS, H. A., Bağcı, C., Özen, M. E., Cengiz, B., Çakmak, E. A., et al. (2002) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(02)00014-6 · Cited by 67

Chronic Stimulation of D1 Dopamine Receptors in Human SK-N-MC Neuroblastoma Cells Induces Nitric-oxide Synthase Activation and Cytotoxicity

Chen, J., Wersinger, C., & Sidhu, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303094200 · Cited by 67

Unifying mechanism for addiction and toxicity of abused drugs with application to dopamine and glutamate mediators: Electron transfer and reactive oxygen species

Kovacic, P. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.01.031 · Cited by 67

Biomarkers of oxidative stress in schizophrenic and control subjects

Young, J. A., McKinney, S. B., Ross, B. M., Wahle, K. W. J., & Boyle, S. P. (2007) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.11.003 · Cited by 66

Oxidation of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in major depressive disorder

Sarandöl, A., Sarandöl, E., Eker, S. S., Karaagac, E. U., Hizli, B., Dirican, M., & Kırlı, S. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.04.012 · Cited by 64

Chronic Lithium Treatment has Antioxidant Properties but does not Prevent Oxidative Damage Induced by Chronic Variate Stress

de Vasconcellos, A. P. S., Nieto, F., Crema, L. M., Diehl, L. A., de Almeida, L. M., Prediger, M. E., da Rocha, E. R., & Dalmaz, C. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9139-2 · Cited by 63

Imbalanced free radicals and antioxidant defense systems in schizophrenia: A comparative study

Li, H.-C., Chen, Q., Ma, Y., & Zhou, J.-F. (2006) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.2006.b0981 · Cited by 62

The Effect of Risperidone Treatment on Superoxide Dismutase in Schizophrenia

Zhang, X., Zhou, D. F., Cao, L. Y., Zhang, P. Y., Wu, G. Y., & Shen, Y. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200304000-00004 · Cited by 61

Genetic polymorphism of glutathione S-transferase T1: A candidate genetic modifier of individual susceptibility to schizophrenia

Saadat, M., Mobayen, F., & Farrashbandi, H. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.03.024 · Cited by 60

Isoprostenes as indicators of oxidative stress in schizophrenia

Dietrich‐Muszalska, A., & Olas, B. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701361263 · Cited by 59

Lower total serum protein, albumin, and beta- and gamma-globulin in major and treatment-resistant depression: Effects of antidepressant treatments

Hunsel, F. V., Wauters, A., Vandoolaeghe, E., Neels, H. M., Demedts, P., & Maes, M. H. J. (1996) · Psychiatry Research · doi:10.1016/s0165-1781(96)03010-7 · Cited by 58

An experimental comparison of Pycnogenol® and methylphenidate in adults with Attention-Deficit/ Hyperactivity Disorder (ADHD)

Tenenbaum, S., Paull, J. C., Sparrow, E. P., Dodd, D., & GREEN, L. (2002) · Journal of Attention Disorders · doi:10.1177/108705470200600201 · Cited by 57

Oxidative stress in heroin administered mice and natural antioxidants protection

Pan, J., Zhang, Q., Zhang, Y., Ouyang, Z., Zheng, Q., & Zheng, R. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.12.025 · Cited by 57

Serum nitric oxide metabolite levels and the effect of antipsychotic therapy in schizophrenia

Taneli, F., Pırıldar, Ş., Akdeniz, F., Uyanık, B. S., & Arı, Z. (2004) · Archives of Medical Research · doi:10.1016/j.arcmed.2004.06.002 · Cited by 56

Glutathione as a cerebral substrate in depressive behavior

Pal, S. N., & Dandiya, P. C. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90191-0 · Cited by 54

The Role of Mitochondrial Dysfunction in Bipolar Disorder

Kato, T. (2006) · Drug News & Perspectives · doi:10.1358/dnp.2006.19.10.1068006 · Cited by 52

THE LACTIC ACID AND GLUTATHIONE CONTENT OF THE BLOOD OF SCHIZOPHRENIC PATIENTS 1

Looney, J. M., & Childs, H. M. (1934) · Journal of Clinical Investigation · doi:10.1172/jci100639 · Cited by 52

Neurochemical Research

(2013) · Neurochemical Research · doi:10.1007/11064.1573-6903 · Cited by 52

The effect of extract of ginkgo biloba addition to olanzapine on therapeutic effect and antioxidant enzyme levels in patients with schizophrenia

Atmaca, M., Tezcan, E., Kuloğlu, M., Üstündağ, B., & KIRTAS, O. (2005) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2005.01432.x · Cited by 50

β-Carotene and canthaxanthin alter the pro-oxidation and antioxidation balance in rats fed a high-cholesterol and high-fat diet

Shih, C., Chang, J.-H., Yang, S., Chou, T.-W., & Cheng, H.-H. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507781497 · Cited by 50

Is bipolar disorder a mitochondrial disease?

Young, L. T. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0715 · Cited by 50

Oxidative Status in Patients with Alcohol Dependence: A Clinical Study in Taiwan

Peng, F.-C., Tang, S. W., Huang, M.-C., Chen, C.-C., Kuo, T., & Yin, S. (2005) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390590967432 · Cited by 48

A functional glutathioneS‐transferase P1 gene polymorphism is associated with methamphetamine‐induced psychosis in Japanese population

Hashimoto, T., Hashimoto, K., Matsuzawa, D., Shimizu, E., Sekine, Y., Inada, T., Ozaki, N., Iwata, N., Harano, M., Komiyama, T., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30164 · Cited by 47

Are we on the threshold of a new theory of disease? Toxicant-induced loss of tolerance and its relationship to addiction and abdiction

Miller, C. S. (1999) · Toxicology and Industrial Health · doi:10.1177/074823379901500302 · Cited by 46

The platelet intracellular calcium response to serotonin is augmented in bipolar manic and depressed patients

Berk, M., Bodemer, W., Oudenhove, T. V., & Butkow, N. (1995) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.470100304 · Cited by 44

Is Cocaine Desire Reduced by N -Acetylcysteine?

LaRowe, S. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.7.1115 · Cited by 41

DNA damage and repair efficiency in lymphocytes from schizophrenic patients

Psimadas, D., Messini‐Nikolaki, N., Zafiropoulou, M., Fortos, A., Tsilimigaki, S., & Piperakis, S. M. (2003) · Cancer Letters · doi:10.1016/j.canlet.2003.09.022 · Cited by 39

Methodological considerations of measuring disability in bipolar disorder: validity of the Multidimensional Scale of Independent Functioning

Berns, S. M., Uzelac, S., González, C. M., & Jaeger, J. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00305.x · Cited by 38

Ligand binding to a human serum albumin stationary phase: use of same-drug competition to discriminate pharmacologically relevant interactions

Ascoli, G. A., Bertucci, C., & Salvadori, P. A. (1998) · Biomedical Chromatography · doi:10.1002/(sici)1099-0801(199809/10)12:5 · Cited by 37

Antioxidant Effect of Phenelzine on MPP+-Induced Cell Viability Loss in Differentiated PC12 Cells

Lee, C. S., Han, E. S., & Lee, W. B. (2003) · Neurochemical Research · doi:10.1023/a:1026119708124 · Cited by 32

Effect of the extract of Ginkgo biloba (EGb 761) on the circulating and cellular profiles of polyunsaturated fatty acids: correlation with the anti-oxidant properties of the extract

Drieu, K., Vranckx, R., Benassayad, C., Haourigi, M., Hassid, J., Yoa, R. G., Rapin, J. R., & Nunez, E. A. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0217 · Cited by 30

Polysomnographic Effects of Adjuvant Ginkgo Biloba Therapy in Patients with Major Depression Medicated with Trimipramine1

Hemmeter, U., Annen, B., Bischof, R., Brüderlin, U., Hatzinger, M., Rose, U., & Holsboer‐Trachsler, E. (2001) · Pharmacopsychiatry · doi:10.1055/s-2001-15182 · Cited by 28

Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress

Chan, A. S. L., Ng, L. W. C., Poon, L. S. W., Chan, W. W. Y., & Wong, Y. H. (2006) · APOPTOSIS · doi:10.1007/s10495-006-0524-8 · Cited by 28

The effects of Ginkgo biloba extract added to haloperidol on peripheral T cell subsets in drug-free schizophrenia: a double-blind, placebo-controlled trial

Zhang, X. Y., Zhou, D. F., Cao, L. Y., & Wu, G. Y. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0476-2 · Cited by 25

Thiobarbituric acid reactive substances in the cerebrospinal fluid in schizophrenia

Skinner, A. O., Mahadik, S. P., & Garver, D. L. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.10.010 · Cited by 23

The effects of classic antipsychotic haloperidol plus the extract of ginkgo biloba on superoxide dismutase in patients with chronic refractory schizophrenia.

Zhou, D., Zhang, X., Su, J., Nan, Z., Cui, Y., Liu, J., Guan, Z., Zhang, P., & Shen, Y. (1999) · PubMed · Cited by 19

Lithium Blocks 45Ca2+ Uptake into Platelets in Bipolar Affective Disorder and Controls

Berk, M., Kirchmann, N. H., & Butkow, N. (1996) · Clinical Neuropharmacology · doi:10.1097/00002826-199619010-00002 · Cited by 17

Opposite effects of antioxidants on anxiety in Wistar and OXYS rats

Kolosova, N. G., Trofimova, N. A., & Фурсова, А. Ж. (2006) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-006-0266-1 · Cited by 16

Effects of nicotine replacement therapy on markers of oxidative stress in cigarette smokers enrolled in a smoking cessation program

Petruzzelli, S., Tavanti, L. M., Pulerà, N., Fornai, E., Puntoni, R., Celi, A., & Giuntini, C. (2000) · Nicotine & Tobacco Research · doi:10.1080/713688155 · Cited by 16

Immediate Effects of Shock Therapies, Epinephrine and ACTH on Blood Glutathione Level of Psychotic Patients

HENNEMAN, D. H., & Altschule, M. D. (1951) · Journal of Applied Physiology · doi:10.1152/jappl.1951.3.7.411 · Cited by 15

Does ascorbate/l-cys/l-met mixture protect different parts of the rat brain against chronic alcohol toxicity?

Amanvermez, R., & Ağar, E. (2006) · Advances in Therapy · doi:10.1007/bf02850310 · Cited by 14

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638

Oxidative Stress and the Central Nervous System

Salim, S. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237503 · Cited by 1,268

Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors

Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.001 · Cited by 1,178

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130

Clinical Relevance of Biomarkers of Oxidative Stress

Frijhoff, J., Winyard, P. G., Žarković, N., Davies, S. S., Stocker, R., Cheng, D., Knight, A. R., Taylor, E., Oettrich, J., Ruskovska, T., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6317 · Cited by 918

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga, I., Niedzielska, E., Gawlik, M., Moniczewski, A., Krzek, J., Przegaliński, E., Pera, J., & Filip, M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.015 · Cited by 252

Studies on Psychiatric Disorders

(2015) · Thammasat University Digital Collections

Editorial: Neurobiological Consequences of Oxidative Stress.

Alkadhi, K. A., & Salim, S. (2014) · Current Neuropharmacology · doi:10.2174/1570159x1202140307122223

Oxidative Stress is a New Avenue for Treatment of Neuropsychiatric Disorders: Hype of Hope?

Negah, S. S., & Forouzanfar, F. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230904150907 · Cited by 7

Association of Oxidative Stress with Psychiatric Disorders

Hassan, W., Noreen, H., Gomes, V. D. C., Mohammadzai, I., da Rocha, J. B. T., & Landeira-Fernández, J. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160307145931 · Cited by 76