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Cited by 306

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Quantitative Profiling of Phospholipids by Multiple Precursor Ion Scanning on a Hybrid Quadrupole Time-of-Flight Mass Spectrometer

Ekroos, Kim, Chernushevich, Igor V., Simons, Kai, Shevchenko, Andrej·2002·Analytical Chemistry
DOI 10.1021/ac015655c
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Abstract

A hybrid quadrupole time-of-flight mass spectrometer featured with ion trapping capabilities was employed for quantitative profiling of total extracts of endogenous phospholipids. Simultaneous acquisition of precursor ion spectra of multiple fragment ions allowed detection of major classes of phospholipids in a single experiment. Relative changes in their concentration were monitored using a mixture of isotopically labeled endogenous lipids as a comprehensive internal standard. Precursor ion scanning spectra were acquired simultaneously for acyl anions of major fatty acids in negative ion mode and identified the fatty acid moieties and their relative position at the glycerol backbone in individual lipid species. Taken together, a combination of multiple precursor ion scans allowed quantitative monitoring of major perturbation in phospholipid composition and elucidating of molecular heterogeneity of individual lipid species.

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Metadata

Authors
Ekroos, K., Chernushevich, I. V., Simons, K., & Shevchenko, A.
Venue
Analytical Chemistry
Publisher
American Chemical Society (ACS)
Published
2002-02-02
Volume
74
Issue
5
Pages
941-949
ISSN
  • 0003-2700 (ISSN-L)
  • 1520-6882
DOI
10.1021/ac015655c
OpenAlex
W2017109633
Cited by
306
References
18
FWCI
3.56
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.