Unit Mass Baseline Resolution for an Intact 148 kDa Therapeutic Monoclonal Antibody by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Electrospray Ionization for Mass Spectrometry of Large Biomolecules

Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634 · see citing works

Mass spectrometry-based proteomics

Aebersold, R., & Mann, M. (2003) · Nature · doi:10.1038/nature01511 · Cited by 6,955 · see citing works

Fourier transform ion cyclotron resonance mass spectrometry: A primer

Marshall, A. G., Hendrickson, C. L., & Jackson, G. S. (1998) · Mass Spectrometry Reviews · doi:10.1002/(sici)1098-2787(1998)17:1 · Cited by 1,992 · see citing works

Micro-electrospray mass spectrometry: Ultra-high-sensitivity analysis of peptides and proteins

Emmett, M. R., & Caprioli, R. M. (1994) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(94)85001-1 · Cited by 512 · see citing works

Space charge effects in Fourier transform mass spectrometry. II. Mass calibration

Ledford, E. B., Rempel, D. L., & Gross, M. L. (1984) · Analytical Chemistry · doi:10.1021/ac00278a027 · Cited by 469 · see citing works

Determination of monoisotopic masses and ion populations for large biomolecules from resolved isotopic distributions

Senko, M. W., Beu, S. C., & McLaffertycor, F. W. (1995) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(95)00017-8 · Cited by 451 · see citing works

Precision proteomics: The case for high resolution and high mass accuracy

Mann, M., & Kelleher, N. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800788105 · Cited by 450 · see citing works

Proteomics by FTICR mass spectrometry: Top down and bottom up

Bogdanov, B., & Smith, R. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20015 · Cited by 447 · see citing works

Peer Reviewed: Top-Down Proteomics

Kelleher, N. (2004) · Analytical Chemistry · doi:10.1021/ac0415657 · Cited by 386 · see citing works

Top Down Characterization of Larger Proteins (45 kDa) by Electron Capture Dissociation Mass Spectrometry

Ge, Y., Lawhorn, B. G., ElNaggar, M., Strauss, E., Park, J.-H., Begley, T. P., & McLafferty, F. W. (2002) · Journal of the American Chemical Society · doi:10.1021/ja011335z · Cited by 356 · see citing works

Fourier Transform Mass Spectrometry

Amster, I. J. (1996) · Journal of Mass Spectrometry · doi:10.1002/(sici)1096-9888(199612)31:12 · Cited by 350 · see citing works

External accumulation of ions for enhanced electrospray ionization fourier transform ion cyclotron resonance mass spectrometry

Senko, M., Hendrickson, C., Emmett, M., Shi, S. D., & Marshall, A. (1997) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(97)00126-8 · Cited by 344 · see citing works

Mechanism of Charging and Supercharging Molecules in Electrospray Ionization

Iavarone, A. T., & Williams, E. R. (2003) · Journal of the American Chemical Society · doi:10.1021/ja021202t · Cited by 324 · see citing works

Top Down Proteomics

Yates, J. R., & Kelleher, N. L. (2013) · Analytical Chemistry · doi:10.1021/ac401484r · Cited by 324 · see citing works

Predator data station: A fast data acquisition system for advanced FT-ICR MS experiments

Blakney, G. T., Hendrickson, C. L., & Marshall, A. G. (2011) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2011.03.009 · Cited by 264 · see citing works

A High-performance Modular Data System for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Senko, M. W., Canterbury, J. D., Guan, S., & Marshall, A. G. (1996) · Rapid Communications in Mass Spectrometry · doi:10.1002/(sici)1097-0231(199611)10:14 · Cited by 256 · see citing works

Parts-Per-Billion Fourier Transform Ion Cyclotron Resonance Mass Measurement Accuracy with a “Walking” Calibration Equation

Savory, J., Kaiser, N. K., Mckenna, A. M., Xian, F., Blakney, G. T., Rodgers, R. P., Hendrickson, C. L., & Marshall, A. G. (2011) · Analytical Chemistry · doi:10.1021/ac102943z · Cited by 255 · see citing works

Trends in Glycosylation, Glycoanalysis and Glycoengineering of Therapeutic Antibodies and Fc-Fusion Proteins

Beck, A., Wagner‐Rousset, E., Bussat, M., Lokteff, M., Klinguer, C., Haeuw, J., Goetsch, L., Wurch, T., DORSSELAER, A. V., & Corvaı̈a, N. (2008) · Current Pharmaceutical Biotechnology · doi:10.2174/138920108786786411 · Cited by 246 · see citing works

Determination of N-Glycosylation Sites and Site Heterogeneity in Glycoproteins

An, H. J., Peavy, T. R., Hedrick, J. L., & Lebrilla, C. B. (2003) · Analytical Chemistry · doi:10.1021/ac034414x · Cited by 242 · see citing works

A Novel 9.4 Tesla FTICR Mass Spectrometer with Improved Sensitivity, Mass Resolution, and Mass Range

Kaiser, N. K., Quinn, J. P., Blakney, G. T., Hendrickson, C. L., & Marshall, A. G. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-011-0141-9 · Cited by 225 · see citing works

Isotopic distributions in mass spectra of large molecules

Yergey, J. A., Heller, D. N., Hansen, G., Cotter, R. J., & Fenselau, C. (1983) · Analytical Chemistry · doi:10.1021/ac00253a037 · Cited by 202 · see citing works

Automated Broadband Phase Correction of Fourier Transform Ion Cyclotron Resonance Mass Spectra

Xian, F., Hendrickson, C. L., Blakney, G. T., Beu, S. C., & Marshall, A. G. (2010) · Analytical Chemistry · doi:10.1021/ac101091w · Cited by 189 · see citing works

Comparison and interconversion of the two most common frequency-to-mass calibration functions for Fourier transform ion cyclotron resonance mass spectrometry

Shi, S. D. ‐., Drader, J. J., Freitas, M. A., Hendrickson, C. L., & Marshall, A. G. (2000) · International Journal of Mass Spectrometry · doi:10.1016/s1387-3806(99)00226-2 · Cited by 181 · see citing works

High-performance mass spectrometry: Fourier transform ion cyclotron resonance at 14.5 Tesla.

Schaub, T. M., Hendrickson, C., Horning, S., Quinn, J. P., Senko, M., & Marshall, A. (2008) · Analytical Chemistry · doi:10.1021/ac800386h · Cited by 178 · see citing works

Initial Experimental Characterization of a New Ultra-High Resolution FTICR Cell with Dynamic Harmonization

Николаев, Е. Н., Boldin, I. A., Jertz, R., & Baykut, G. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-011-0125-9 · Cited by 165 · see citing works

Relaxation and spectral line shape in Fourier transform ion resonance spectroscopy

Marshall, A. G., Comisarow, M. B., & Parisod, G. (1979) · The Journal of Chemical Physics · doi:10.1063/1.438196 · Cited by 165 · see citing works

New reagents for increasing ESI multiple charging of proteins and protein complexes

Lomeli, S. H., Peng, I. X., Yin, S., Loo, R. R. O., & Loo, J. A. (2009) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2009.09.014 · Cited by 162 · see citing works

Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state

Ge, Y., Rybakova, I. N., Xu, Q., & Moss, R. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813369106 · Cited by 154 · see citing works

Counting individual sulfur atoms in a protein by ultrahighresolution Fourier transform ion cyclotron resonance mass spectrometry: Experimental resolution of isotopic fine structure in proteins

Shi, S. D. ‐., Hendrickson, C. L., & Marshall, A. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11532 · Cited by 147 · see citing works

Increasing charge while preserving noncovalent protein complexes for ESI-MS

Lomeli, S. H., Yin, S., Loo, R. R. O., & Loo, J. A. (2008) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2008.11.013 · Cited by 144 · see citing works

Fourier transform ion cyclotron resonance cell with dynamic harmonization of the electric field in the whole volume by shaping of the excitation and detection electrode assembly

Boldin, I. A., & Николаев, Е. Н. (2010) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4838 · Cited by 129 · see citing works

Unit resolution mass spectra of 112 kDa molecules with 3 Da accuracy

Kelleher, N. L., Senko, M. W., Siegel, M. M., & McLafferty, F. W. (1997) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(97)00060-3 · Cited by 122 · see citing works

Native electrospray and electron-capture dissociation in FTICR mass spectrometry provide top-down sequencing of a protein component in an intact protein assembly

Zhang, H., Cui, W., Wen, J., Blankenship, R. E., & Gross, M. L. (2010) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2010.08.006 · Cited by 121 · see citing works

Peer Reviewed: Scaling MS Plateaus with High-Resolution FT-ICRMS

Marshall, A. G., Hendrickson, C. L., & Shi, S. D. ‐. (2002) · Analytical Chemistry · doi:10.1021/ac022010j · Cited by 115 · see citing works

Protein Molecular Mass to 1 Da by 13C, 15N Double-Depletion and FT-ICR Mass Spectrometry

Marshall, A. G., Senko, M. W., Li, W., Li, M., Dillon, S. R., Guan, S., & Logan, T. M. (1997) · Journal of the American Chemical Society · doi:10.1021/ja9630046 · Cited by 110 · see citing works

Electrically Compensated Fourier Transform Ion Cyclotron Resonance Cell for Complex Mixture Mass Analysis

Kaiser, N. K., Savory, J., Mckenna, A. M., Quinn, J. P., Hendrickson, C. L., & Marshall, A. G. (2011) · Analytical Chemistry · doi:10.1021/ac201546d · Cited by 109 · see citing works

Trapped-ion cell with improved dc potential harmonicity for FT-ICR MS

Tolmachev, A. V., Robinson, E. W., Wu, S., Kang, H., Lourette, N. M., Paša‐Tolić, L., & Smith, R. D. (2008) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2008.01.006 · Cited by 108 · see citing works

High-resolution tandem mass spectrometry of large biomolecules.

Loo, J., Quinn, J. P., Ryu, S. I., Henry, K. D., Senko, M., & McLafferty, F. (1992) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.89.1.286 · Cited by 105 · see citing works

Selective-phase Ion Cyclotron Resonance Spectroscopy

Comisarow, M. B., & Marshall, A. G. (1974) · Canadian Journal of Chemistry · doi:10.1139/v74-288 · Cited by 105 · see citing works

Origin of supercharging in electrospray ionization of noncovalent complexes from aqueous solution

Sterling, H. J., & Williams, E. R. (2009) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2009.06.012 · Cited by 105 · see citing works

Baseline Mass Resolution of Peptide Isobars: A Record for Molecular Mass Resolution

He, F., Hendrickson, C. L., & Marshall, A. G. (2000) · Analytical Chemistry · doi:10.1021/ac000973h · Cited by 102 · see citing works

Sensitive and Specific Identification of Wild Type and Variant Proteins from 8 to 669 kDa Using Top-down Mass Spectrometry

Karabacak, M., Li, L., Tiwari, A., Hayward, L. J., Hong, P., Easterling, M. L., & Agar, J. N. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800099-mcp200 · Cited by 95 · see citing works

High‐resolution tandem mass spectra of 37‐67 kDa proteins

Speir, J. P., Senko, M. W., Little, D. P., Loo, J. A., & McLafferty, F. W. (1995) · Journal of Mass Spectrometry · doi:10.1002/jms.1190300108 · Cited by 86 · see citing works

Detecting Deamidation Products in Proteins by Electron Capture Dissociation

Cournoyer, J. J., Lin, C. T., & O’Connor, P. B. (2005) · Analytical Chemistry · doi:10.1021/ac051691q · Cited by 82 · see citing works

New Reagents for Enhanced Liquid Chromatographic Separation and Charging of Intact Protein Ions for Electrospray Ionization Mass Spectrometry

Valeja, S. G., Tipton, J. D., Emmett, M. R., & Marshall, A. G. (2010) · Analytical Chemistry · doi:10.1021/ac1016858 · Cited by 76 · see citing works

Theoretical and Experimental Prospects for Protein Identification Based Solely on Accurate Mass Measurement

He, F., Emmett, M. R., Håkansson, K., Hendrickson, C. L., & Marshall, A. G. (2003) · Journal of Proteome Research · doi:10.1021/pr034058z · Cited by 75 · see citing works

Baseline Resolution of Isobaric Phosphorylated and Sulfated Peptides and Nucleotides by Electrospray Ionization FTICR MS: Another Step toward Mass Spectrometry-Based Proteomics

Bossio, R. E., & Marshall, A. G. (2002) · Analytical Chemistry · doi:10.1021/ac0108461 · Cited by 74 · see citing works

Method for Lipidomic Analysis: p53 Expression Modulation of Sulfatide, Ganglioside, and Phospholipid Composition of U87 MG Glioblastoma Cells

He, H., Conrad, C. A., Nilsson, C. L., Ji, Y., Schaub, T. M., Marshall, A. G., & Emmett, M. R. (2007) · Analytical Chemistry · doi:10.1021/ac071413m · Cited by 73 · see citing works

Phase Correction of Fourier Transform Ion Cyclotron Resonance Mass Spectra Using MatLab

Qi, Y., Thompson, C. J., Orden, S. L. V., & O’Connor, P. B. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-010-0006-7 · Cited by 62 · see citing works

Isotopic beat patterns in Fourier transform ion cyclotron resonance mass spectrometry: implications for high resolution mass measurements of large biopolymers

Hofstadler, S. A., Bruce, J. E., Rockwood, A. L., Anderson, G., Winger, B. E., & Smith, R. D. (1994) · International Journal of Mass Spectrometry and Ion Processes · doi:10.1016/0168-1176(94)85020-8 · Cited by 55 · see citing works

The role of conformational flexibility on protein supercharging in native electrospray ionization

Sterling, H. J., Cassou, C. A., Trnka, M. J., Burlingame, A. L., Krantz, B. A., & Williams, E. R. (2011) · Physical Chemistry Chemical Physics · doi:10.1039/c1cp20277d · Cited by 55 · see citing works

Approaches and Limits for Accurate Mass Characterization of Large Biomolecules

Zubarev, R. A., Demirev, P. A., Håkansson, P., & Sundqvist, B. (1995) · Analytical Chemistry · doi:10.1021/ac00116a028 · Cited by 55 · see citing works

Prediction of a Space Charge Induced Upper Molecular Mass Limit Towards Achieving Unit Mass Resolution in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Mitchell, D. W., & Smith, R. (1996) · Journal of Mass Spectrometry · doi:10.1002/(sici)1096-9888(199607)31:7 · Cited by 54 · see citing works

Elimination of frequency drift from Fourier transform ion cyclotron resonance mass spectra by digital quadrature heterodyning: ultrahigh mass resolving power for laser-desorbed molecules

Guan, S., Wahl, M. C., & Marshall, A. G. (1993) · Analytical Chemistry · doi:10.1021/ac00072a019 · Cited by 53 · see citing works

Nano-electrospray tandem mass spectrometry for the analysis of neurosteroid sulphates†

Griffiths, W. J., Liu, S., Yang, Y., Purdy, R. H., & Sjövall, J. (1999) · Rapid Communications in Mass Spectrometry · doi:10.1002/(sici)1097-0231(19990815)13:15 · Cited by 50 · see citing works

FT-ICR MS optimization for the analysis of intact proteins

Tolmachev, A. V., Robinson, E. W., Wu, S., Paša‐Tolić, L., & Smith, R. D. (2008) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2008.10.010 · Cited by 48 · see citing works

Theory of peak coalescence in Fourier transform ion cyclotron resonance mass spectrometry

Boldin, I. A., & Николаев, Е. Н. (2009) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4231 · Cited by 43 · see citing works

Time‐base modulation for the correction of cyclotron frequency shifts observed in long‐lived transients from fourier‐transform ion‐cyclotron‐resonance mass spectrometry of electrosprayed biopolymers

Bruce, J. E., Anderson, G., Hofstadler, S. A., Winger, B. E., & Smith, R. D. (1993) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1290070803 · Cited by 39 · see citing works

Large Molecule Characterization Based upon Individual Ion Detection with Electrospray Ionization-FTICR Mass Spectrometry

Bruce, J. E., Anderson, G., Udseth, H. R., & Smith, R. D. (1998) · Analytical Chemistry · doi:10.1021/ac9711706 · Cited by 36 · see citing works

In-Trap Cleanup of Proteins from Electrospray Ionization Using Soft Sustained Off-Resonance Irradiation with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Tolić, L. P., Bruce, J. E., Lei, Q. P., Anderson, G., & Smith, R. D. (1998) · Analytical Chemistry · doi:10.1021/ac970828c · Cited by 35 · see citing works

Detection of four oxidation sites in viral prolyl‐4‐hydroxylase by top‐down mass spectrometry

Ge, Y., Lawhorn, B. G., ElNaggar, M., Sze, S. K., Begley, T. P., & McLafferty, F. W. (2003) · Protein Science · doi:10.1110/ps.03244403 · Cited by 34 · see citing works

Direct Sequence Data from Heterogeneous Creatine Kinase (43 kDa) by High-Resolution Tandem Mass Spectrometry

Wood, T. D., Chen, L. H., Kelleher, N. L., Little, D. P., Kenyon, G. L., & McLafferty, F. W. (1995) · Biochemistry · doi:10.1021/bi00050a004 · Cited by 33 · see citing works

Sub part-per-million mass accuracy by using stepwise-external calibration in fourier transform ion cyclotron resonance mass spectrometry

Wong, R. L., & Amster, I. J. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2006.07.019 · Cited by 32 · see citing works

Advantages of Thermococcus kodakaraenis (KOD) DNA Polymerase for PCR-mass spectrometry based analyses

Benson, L. M., Null, A. P., & Muddiman, D. C. (2003) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(03)00148-x · Cited by 27 · see citing works

Negative Ionization Micro Electrospray Mass Spectrometry of Oligonucleotides and their Complexes

Greig, M. J., Gaus, H. J., & Griffey, R. H. (1996) · Rapid Communications in Mass Spectrometry · doi:10.1002/(sici)1097-0231(19960115)10:1 · Cited by 27 · see citing works

Charge reduction lowers mass resolving power for isotopically resolved electrospray ionization Fourier transform ion cyclotron resonance mass spectra

Marshall, A. G., & Hendrickson, C. L. (2001) · Rapid Communications in Mass Spectrometry · doi:10.1002/1097-0231(20010215)15:3 · Cited by 27 · see citing works

Isotope depletion of large biomolecules: Implications for molecular mass measurements

Zubarev, R. A., & Demirev, P. A. (1998) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(97)00232-8 · Cited by 26 · see citing works

Advantages of Isotopic Depletion of Proteins for Hydrogen/Deuterium Exchange Experiments Monitored by Mass Spectrometry

Bou-Assaf, G. M., Chamoun, J. E., Emmett, M. R., Fajer, P. G., & Marshall, A. G. (2010) · Analytical Chemistry · doi:10.1021/ac100079z · Cited by 24 · see citing works

Electrospray ionization Fourier transform ion

Wunschel, D. S., Tolić, L. P., Feng, B., & Smith, R. D. (2000) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(99)00156-7 · Cited by 19 · see citing works

Competitive binding to the oligopeptide binding protein, OppA: In-trap cleanup in an fourier transform ion cyclotron resonance mass spectrometer

Freitas, M. A., Hendrickson, C. L., Marshall, A. G., Rostom, A. A., & Robinson, C. V. (2000) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(00)00180-x · Cited by 16 · see citing works

Utility of accurate monoisotopic mass measurements to confidently identify lambda exonuclease generated single-stranded amplicons containing 7-deaza analogs by electrospray ionization FT-ICR mass spectrometry

Frahm, J. L., Mason, C. J., & Muddiman, D. C. (2004) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2004.02.004 · Cited by 11 · see citing works

Characterization of Therapeutic Antibodies and Related Products

Beck, A., Wagner‐Rousset, E., Ayoub, D., DORSSELAER, A. V., & Cianférani, S. (2012) · Analytical Chemistry · doi:10.1021/ac3032355 · Cited by 588 · see citing works

High-Throughput Proteomics

Zhang, Z., Wu, S., Stenoien, D. L., & Paša‐Tolić, L. (2014) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-071213-020216 · Cited by 321 · see citing works

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

Hendrickson, C. L., Quinn, J. P., Kaiser, N. K., Smith, D. F., Blakney, G. T., Chen, T., Marshall, A. G., Weisbrod, C. R., & Beu, S. C. (2015) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-015-1182-2 · Cited by 278 · see citing works

High Resolution Mass Spectrometry

Xian, F., Hendrickson, C. L., & Marshall, A. G. (2012) · Analytical Chemistry · doi:10.1021/ac203191t · Cited by 281 · see citing works

Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry

Beck, A., Cianférani, S., & DORSSELAER, A. V. (2012) · Analytical Chemistry · doi:10.1021/ac3002885 · Cited by 249 · see citing works

Top‐down proteomics in health and disease: Challenges and opportunities

Gregorich, Z. R., & Ge, Y. (2014) · PROTEOMICS · doi:10.1002/pmic.201300432 · Cited by 217 · see citing works

Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs

Zhang, P., Woen, S., Wang, T., Liau, B., Zhao, S., Chen, C., Yang, Y., Song, Z., Wormald, M. R., Yu, C., et al. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.01.006 · Cited by 212 · see citing works

Analysis of Intact Monoclonal Antibody IgG1 by Electron Transfer Dissociation Orbitrap FTMS

Fornelli, L., Damoc, E., Thomas, P. M., Kelleher, N. L., Aizikov, K., Denisov, E. V., Makarov, A., & Tsybin, Y. O. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.019620 · Cited by 161 · see citing works

Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry

Rosati, S., Rose, R., Thompson, N., van Duijn, E., Damoc, E., Denisov, E. V., Makarov, A., & Heck, A. J. R. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201206745 · Cited by 153 · see citing works

Modern chromatographic and mass spectrometric techniques for protein biopharmaceutical characterization

Sandra, K., Vandenheede, I., & Sandra, P. J. F. (2013) · Journal of Chromatography A · doi:10.1016/j.chroma.2013.11.057 · Cited by 153 · see citing works

Top-down proteomics: challenges, innovations, and applications in basic and clinical research

Brown, K. A., Melby, J. A., Roberts, D. S., & Ge, Y. (2020) · Expert Review of Proteomics · doi:10.1080/14789450.2020.1855982 · Cited by 152 · see citing works

Boundaries of Mass Resolution in Native Mass Spectrometry

Lössl, P., Snijder, J., & Heck, A. J. R. (2014) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-014-0874-3 · Cited by 137 · see citing works

Integrated Microfluidic Capillary Electrophoresis-Electrospray Ionization Devices with Online MS Detection for the Separation and Characterization of Intact Monoclonal Antibody Variants

Redman, E. A., Batz, N. G., Mellors, J. S., & Ramsey, J. M. (2015) · Analytical Chemistry · doi:10.1021/ac503964j · Cited by 136 · see citing works

Top-Down Structural Analysis of an Intact Monoclonal Antibody by Electron Capture Dissociation-Fourier Transform Ion Cyclotron Resonance-Mass Spectrometry

Mao, Y., Valeja, S. G., Rouse, J. C., Hendrickson, C. L., & Marshall, A. G. (2013) · Analytical Chemistry · doi:10.1021/ac303525n · Cited by 129 · see citing works

Native Top-Down Electrospray Ionization-Mass Spectrometry of 158 kDa Protein Complex by High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Li, H., Wolff, J. J., Orden, S. L. V., & Loo, J. A. (2013) · Analytical Chemistry · doi:10.1021/ac4033214 · Cited by 119 · see citing works

Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry

Srzentič, K., Fornelli, L., Tsybin, Y. O., Loo, J., Seckler, H. S., Agar, J. N., Anderson, L. C., Bai, D.-N. L., Beck, A., Brodbelt, J., et al. (2020) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.0c00036 · Cited by 98 · see citing works

Top-down Proteomics: Technology Advancements and Applications to Heart Diseases

Cai, W., Tucholski, T. M., Gregorich, Z. R., & Ge, Y. (2016) · Expert Review of Proteomics · doi:10.1080/14789450.2016.1209414 · Cited by 99 · see citing works

Electrothermal Supercharging of Proteins in Native Electrospray Ionization

Sterling, H. J., Cassou, C. A., Susa, A. C., & Williams, E. R. (2012) · Analytical Chemistry · doi:10.1021/ac300468a · Cited by 85 · see citing works

Three Dimensional Liquid Chromatography Coupling Ion Exchange Chromatography/Hydrophobic Interaction Chromatography/Reverse Phase Chromatography for Effective Protein Separation in Top-Down Proteomics

Valeja, S. G., Xiu, L., Gregorich, Z. R., Güner, H., Jin, S., & Ge, Y. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00657 · Cited by 77 · see citing works

Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer

Fornelli, L., Ayoub, D., Aizikov, K., Liu, X., Damoc, E., Pevzner, P. A., Makarov, A., Beck, A., & Tsybin, Y. O. (2017) · Journal of Proteomics · doi:10.1016/j.jprot.2017.02.013 · Cited by 70 · see citing works

Comprehensive characterization of monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry

Jin, Y., Lin, Z., Xu, Q., Fu, C., Zhang, Z., Zhang, Q., Pritts, W. A., & Ge, Y. (2019) · mAbs · doi:10.1080/19420862.2018.1525253 · Cited by 68 · see citing works

Effective Protein Separation by Coupling Hydrophobic Interaction and Reverse Phase Chromatography for Top-down Proteomics

Xiu, L., Valeja, S. G., Alpert, A. J., Jin, S., & Ge, Y. (2014) · Analytical Chemistry · doi:10.1021/ac501836k · Cited by 68 · see citing works

Mass Resolution and Mass Accuracy: How Much Is Enough?

Marshall, A. G., Blakney, G. T., Chen, T., Kaiser, N. K., Mckenna, A. M., Rodgers, R. P., Ruddy, B. M., & Xian, F. (2013) · Mass Spectrometry · doi:10.5702/massspectrometry.s0009 · Cited by 66 · see citing works

Complementary MS Methods Assist Conformational Characterization of Antibodies with Altered S–S Bonding Networks

Jones, L. M., Zhang, H., Cui, W., Kumar, S., Sperry, J. B., Carroll, J. A., & Gross, M. L. (2013) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-013-0582-4 · Cited by 62 · see citing works

Two-dimensional mass spectrometry: new perspectives for tandem mass spectrometry

van Agthoven, M. A., Lam, Y. P. Y., O’Connor, P. B., Rolando, C. H., & Delsuc, M. (2019) · European Biophysics Journal · doi:10.1007/s00249-019-01348-5 · Cited by 60 · see citing works

The impact of mass spectrometry on the study of intact antibodies: from post-translational modifications to structural analysis

Thompson, N., Rosati, S., Rose, R., & Heck, A. J. R. (2012) · Chemical Communications · doi:10.1039/c2cc36755f · Cited by 59 · see citing works

High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry

Sawyer, W. S., Srikumar, N., Carver, J., Chu, P. Y., Shen, A., Xu, A., Williams, A. J., Spiess, C., Wu, C., Liu, Y., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1917383117 · Cited by 55 · see citing works

Top-Down Characterization of an Intact Monoclonal Antibody Using Activated Ion Electron Transfer Dissociation

Lodge, J. M., Schauer, K. L., Brademan, D. R., Riley, N. M., Shishkova, E., Westphall, M. S., & Coon, J. J. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c00705 · Cited by 49 · see citing works

Structural Analysis of an Intact Monoclonal Antibody by Online Electrochemical Reduction of Disulfide Bonds and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Nicolardi, S., Deelder, A. M., Palmblad, M., & van der Burgt, Y. E. M. (2014) · Analytical Chemistry · doi:10.1021/ac500383c · Cited by 49 · see citing works

Determination of the NISTmAb Primary Structure

Formolo, T., Ly, M., Levy, M. J., Kilpatrick, L. E., Lute, S. C., Phinney, K. W., Marzilli, L. A., Brorson, K., Boyne, M., Davis, D., et al. (2015) · ACS symposium series · doi:10.1021/bk-2015-1201.ch001 · Cited by 49 · see citing works

Structural Elucidation of Post-Translational Modifications in Monoclonal Antibodies

Li, W., Kerwin, J. L., Schiel, J. E., Formolo, T., Davis, D., Mahan, A. D., & Benchaar, S. A. (2015) · ACS symposium series · doi:10.1021/bk-2015-1201.ch003 · Cited by 47 · see citing works

Developing top down proteomics to maximize proteome and sequence coverage from cells and tissues

Ahlf, D. R., Thomas, P. M., & Kelleher, N. L. (2013) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2013.07.028 · Cited by 45 · see citing works

Quantification of an intact monoclonal antibody, rituximab, by (RP)HPLC/DAD in compliance with ICH guidelines

Navas, N., Herrera, A., Martínez-Ortega, A., Salmerón‐García, A., Barrera, J. C., & Cuadros-Rodrı́guez, L. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-013-7368-1 · Cited by 44 · see citing works

Towards analytically useful two-dimensional Fourier transform ion cyclotron resonance mass spectrometry

van Agthoven, M. A., Delsuc, M., Bodenhausen, G., & Rolando, C. H. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6422-8 · Cited by 44 · see citing works

Nano-LC FTICR Tandem Mass Spectrometry for Top-Down Proteomics: Routine Baseline Unit Mass Resolution of Whole Cell Lysate Proteins up to 72 kDa

Tipton, J. D., Tran, J. C., Catherman, A. D., Ahlf, D. R., Durbin, K. R., Lee, J. E., Kellie, J. F., Kelleher, N. L., Hendrickson, C. L., & Marshall, A. G. (2012) · Analytical Chemistry · doi:10.1021/ac202651v · Cited by 40 · see citing works

Twelve Million Resolving Power on 4.7 T Fourier Transform Ion Cyclotron Resonance Instrument with Dynamically Harmonized Cell—Observation of Fine Structure in Peptide Mass Spectra

Popov, I. A., Nagornov, K. O., Vladimirov, G., Kostyukevich, Y., & Николаев, Е. Н. (2014) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-014-0846-7 · Cited by 40 · see citing works

Current landscape of protein glycosylation analysis and recent progress toward a novel paradigm of glycoscience research

Yamamoto, S., Kinoshita, M., & Suzuki, S. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.07.015 · Cited by 36 · see citing works

Top-Down Mass Spectrometry: Proteomics to Proteoforms

Patrie, S. M. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-41448-5_8 · Cited by 34 · see citing works

The isotope distribution: A rose with thorns

Claesen, J., Rockwood, A. L., Gorshkov, M. V., & Valkenborg, D. (2023) · Mass Spectrometry Reviews · doi:10.1002/mas.21820 · Cited by 32 · see citing works

Structural mass spectrometry in biologics discovery: advances and future trends

Mo, J., Tymiak, A. A., & Chen, G. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.07.006 · Cited by 30 · see citing works

Transient-Mediated Simulations of FTMS Isotopic Distributions and Mass Spectra to Guide Experiment Design and Data Analysis

Nagornov, K. O., Kozhinov, A. N., Gasilova, N., Menin, L., & Tsybin, Y. O. (2020) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.0c00190 · Cited by 29 · see citing works

Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry for Characterizing Proteoforms

Tucholski, T., & Ge, Y. (2020) · Mass spectrometry reviews (Print) · doi:10.1002/mas.21653 · Cited by 18 · see citing works

Extending the Isotopically Resolved Mass Range of Orbitrap Mass Spectrometers

Shaw, J. B., & Brodbelt, J. S. (2013) · Analytical Chemistry · doi:10.1021/ac401634b · Cited by 28 · see citing works

Native MS and ECD Characterization of a Fab–Antigen Complex May Facilitate Crystallization for X-ray Diffraction

Zhang, Y., Cui, W., Wecksler, A. T., Zhang, H., Molina, P., Deperalta, G., & Gross, M. L. (2016) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-016-1398-9 · Cited by 27 · see citing works

Surface Induced Dissociation Coupled with High Resolution Mass Spectrometry Unveils Heterogeneity of a 211 kDa Multicopper Oxidase Protein Complex

Zhou, M., Yan, J. R., Romano, C. A., Tebo, B. M., Wysocki, V. H., & Paša‐Tolić, L. (2018) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-017-1882-x · Cited by 27 · see citing works

Top-Down Mass Spectrometry on Tissue Extracts and Biofluids with Isoelectric Focusing and Superficially Porous Silica Liquid Chromatography

Zhang, J., Roth, M. J., Chang, A. N., Plymire, D. A., Corbett, J. R., Greenberg, B. M., & Patrie, S. M. (2013) · Analytical Chemistry · doi:10.1021/ac402394w · Cited by 22 · see citing works

To 200,000 m / z and Beyond: Native Electron Capture Charge Reduction Mass Spectrometry Deconvolves Heterogeneous Signals in Large Biopharmaceutical Analytes

Huray, K. I. P. L., Wörner, T. P., Moreira, T., Dembek, M., Reinhardt-Szyba, M., Devine, P. W. A., Bond, N. J., Fort, K. L., Makarov, A., & Sobott, F. (2024) · ACS Central Science · doi:10.1021/acscentsci.4c00462 · Cited by 23 · see citing works

Tackling the increasing complexity of therapeutic monoclonal antibodies with mass spectrometry

Rosati, S., Thompson, N., & Heck, A. J. R. (2013) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2013.02.013 · Cited by 19 · see citing works

LC-MS characterization of antibody-based therapeutics

Robotham, A. C., & Kelly, J. F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-103019-6.00001-1 · Cited by 17 · see citing works

Data processing and automation in Fourier transform mass spectrometry

Kanawati, B., Wanczek, K. P., & Schmitt‐Kopplin, P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814013-0.00006-5 · Cited by 17 · see citing works

Proteomics as a tool to gain next level insights into photo-crosslinkable biopolymer modifications

Pien, N., Bray, F., Gheysens, T., Tytgat, L., Rolando, C. H., Mantovani, D., Dubruel, P., & Vlierberghe, S. V. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.01.023 · Cited by 14 · see citing works

Characterization of the Time-Domain Isotopic Beat Patterns of Monoclonal Antibodies in Fourier Transform Mass Spectrometry

Nagornov, K. O., Kozhinov, A. N., Gasilova, N., Menin, L., & Tsybin, Y. O. (2022) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.1c00336 · Cited by 6 · see citing works

Mass spectrometric analysis of protein species of biologics

Richter, V., Kwiatkowski, M., Omidi, M., Omidi, A., Robertson, W. D., & Schlüter, H. (2013) · Pharmaceutical Bioprocessing · doi:10.4155/pbp.13.39 · Cited by 6 · see citing works

Structural Analysis of Complex Molecular Systems by High‐Resolution and Tandem Mass Spectrometry

Tsybin, Y. O. (2014) · Wiley eBooks · doi:10.1002/9783527673223.ch3 · Cited by 4 · see citing works

Evolving bioanalytical strategies in the wake of pioneering biotherapeutics

Sirtori, F. R., Ianni, A. D., Crosasso, C., Bertotti, E., Molinaro, F., Salve, I. D., Barbero, L. M., & Cowan, K. J. (2025) · Bioanalysis · doi:10.1080/17576180.2025.2546775 · Cited by 4 · see citing works

Mass Spectrometry‐Based Strategies for Therapeutic Antibodies Extensive Characterization and Optimization (OptimAbs)

Bœuf, A., Debaene, F., Ayoub, D., Diemer, H., Ehkirch, A., Wagner‐Rousset, E., DORSSELAER, A. V., Cianférani, S., & Beck, A. (2020) · doi:10.1002/9781118681121.ch21 · Cited by 3 · see citing works

Etablierung eines Orbitrap‐Analysators zur Charakterisierung von intakten Antikörpern mittels nativer Massenspektrometrie

Rosati, S., Rose, R., Thompson, N., van Duijn, E., Damoc, E., Denisov, E. V., Makarov, A., & Heck, A. J. R. (2012) · Angewandte Chemie · doi:10.1002/ange.201206745 · Cited by 2 · see citing works

Top-Down Mass Spectrometry for Protein Molecular Diagnostics and Biomarker Discovery

Patrie, S. M., Roth, M. J., & Zhang, J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394446-7.00020-0 · Cited by 1 · see citing works

Artifacts Induced by Selective Blanking of Time-Domain Data in Fourier Transform Mass Spectrometry

Xian, F., Valeja, S. G., Beu, S. C., Hendrickson, C. L., & Marshall, A. G. (2013) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-013-0735-5 · Cited by 1 · see citing works

An Open-Source Framework for Mass Calculation of Antibody-Based Therapeutic Molecules

Harkins, T., Cao, L., & Khatri, K. (2023) · Journal of Visualized Experiments · doi:10.3791/65298 · Cited by 1 · see citing works

Anion-Peptide Adduct Formation and Decomposition As Studied by Fourier Transform Ion Cyclotron Resonance (FT-ICR) Mass Spectrometry

Liu, X. (2013) · ScholarWorks @ The University of New Orleans (The University of New Orleans)

Development of tandem mass spectrometric methods for proteome analysis utilizing photodissociation and ion/ion reactions

Shaw, J. (2013) · Texas ScholarWorks (Texas Digital Library)

Advanced applications of high performance Fourier transform ion cyclotron resonance mass spectrometry

Wei, J. (2026) · Warwick Research Archive Portal (University of Warwick) · doi:10.82444/warw.33685840

Applications of mass spectrometry imaging and top-down proteomic techniques for clinical and biomedical research

Rawlins (2018) · doi:10.17760/d20292916

Characterization of critical quality attributes (CQAs) for bispecific antigen- binding biotherapeutic (BABB) through comprehensive analysis using separation techniques and footprinting approaches coupled with mass spectrometry

Shah, A. (2023) · doi:10.17760/d20537505

Mass Spectrometry in Measuring Masses of Atoms, Molecules, and Their Complexes: Brief Review of Progress

Milman, B. L., & Журкович, И. К. (2023) · Journal of Analytical Chemistry · doi:10.1134/s1061934823130099

Identity Testing of Biopharmaceuticals using Nano-Differential-Scanning-Fluorimetry

Fakler, E., Kiessig, S., Mahler, H., & Allmendinger, A. (2026) · Pharmaceutical Research · doi:10.1007/s11095-026-04220-2

High Speed Intact Protein Characterization Using 4X Frequency Multiplication, Ion Trap Harmonization, and 21 Tesla FTICR-MS

Shaw, J., Gorshkov, M. V., Wu, Q., & Paša‐Tolić, L. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04606 · Cited by 26 · see citing works

FTICR (Fourier-transformed ion cyclotron resonance mass spectrometer)

(2008) · Springer eBooks · doi:10.1007/978-1-4020-6754-9_6278

High Mass Analysis with a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: From Inorganic Salt Clusters to Antibody Conjugates and Beyond

Campuzano, I. D. G., Nshanian, M., Spahr, C. S., Lantz, C., Netirojjanakul, C., Li, H., Wongkongkathep, P., Wolff, J. J., & Loo, J. A. (2020) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.0c00030 · Cited by 21 · see citing works

FT-ICR MS optimization for the analysis of intact proteins

Tolmachev, A. V., Robinson, E. W., Wu, S., Paša‐Tolić, L., & Smith, R. D. (2008) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2008.10.010 · Cited by 48 · see citing works

Application of FTICR-MS to the Proteomics Era

Yamada, N. (2002) · Journal of the Mass Spectrometry Society of Japan · doi:10.5702/massspec.50.142 · Cited by 2 · see citing works