Detection of Cortisol in Saliva with a Flow-Filtered, Portable Surface Plasmon Resonance Biosensor System
Open accessAbstract
Saliva provides a useful and noninvasive alternative to blood for many biomedical diagnostic assays. The level of the hormone cortisol in blood and saliva is related to the level of stress. We present here the development of a portable surface plasmon resonance (SPR) biosensor system for detection of cortisol in saliva. Cortisol-specific monoclonal antibodies were used to develop a competition assay with a six-channel portable SPR biosensor designed in our laboratory. The detection limit of cortisol in laboratory buffers was 0.36 ng/mL (1.0 nM). An in-line filter based on diffusion through a hollow fiber hydrophilic membrane served to separate small molecules from the complex macromolecular matrix of saliva prior to introduction to the sensor surface. The filtering flow cell provided in-line separation of small molecules from salivary mucins and other large molecules with only a 29% reduction of signal compared with direct flow of the same concentration of analyte over the sensor surface. A standard curve for detection of cortisol in saliva was generated with a detection limit of 1.0 ng/mL (3.6 nM), sufficiently sensitive for clinical use. The system will also be useful for a wide range of applications where small molecular weight analytes are found in complex matrixes.
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Because saliva can be readily collected, it has been used in connection to in vitro diagnostic biosensors on strips or portable device platforms.
“Because saliva can be readily collected123-125, it has been used in connection to in vitro diagnostic biosensors on strips or portable device platforms,126-134.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [127]
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- Authors
- Stevens, R. C., Soelberg, S. D., Near, S., & Furlong, C. E.
- Affiliations
- University of Washington (US)
- Corresponding author
- Furlong, Clement E.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-26
- Volume
- 80
- Issue
- 17
- Pages
- 6747-6751
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- PMC
- PMC3056881
- OpenAlex
- W1977790675
- Cited by
- 179
- References
- 30
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 16 · 2023: 13 · 2022: 9 · 2021: 12 · 2020: 14 · 2019: 9 · 2018: 14 · 2017: 2 · 2016: 7 · 2015: 9 · 2014: 8 · 2013: 10 · 2012: 12
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- National Institutes of Health
- National Institute of Environmental Health Sciences (P50ES012762)
- National Institute of Dental and Craniofacial Research (1-UO1DE14971, U01DE014971)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Plasmonic and Surface Plasmon Research
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
- Keywords
- cortisol, saliva, surface plasmon resonance biosensor, portable biosensor, hollow fiber membranes, competitive immunoassay, monoclonal antibodies, salivary mucins, stress biomarkers
- MeSH terms
- Buffers, Humans, Hydrocortisone, Molecular Weight, Saliva, Surface Properties, Surface Plasmon Resonance
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