The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine
Open accessAbstract
The emergence of the aggregation-induced emission (AIE) concept significantly changes the cognition of the scientific community toward classic photophysical phenomena. More importantly, the AIE phenomenon has brought huge opportunities for the analysis of bioactive species, the monitoring of complicated biological processes, and the elucidation of key physiological and pathological behaviors. As a class of promising luminescent materials, AIE luminogens (AIEgens) are weakly or non-emissive in the form of isolated molecular species but emit particularly strong fluorescence in the aggregated and solid states. Motivated by the prominent advantages such as high brightness, large Stokes shift, excellent photostability, and good biocompatibility, AIEgen-based bioprobes have been widely explored in the field of biomedicine. This review aims to provide a systematic summary of the developmental history and an in-depth perspective of the current landscape of AIE in the biomedical field, with an emphasis on the discussions of major working principles. The milestones of the historical development of AIE in the biomedical field are first reviewed. A total of four major research directions are then extracted, including biomacromolecule sensing (at the molecular level), in vitro cell imaging (at the cellular level), in vivo imaging (at the animal level), and cancer theranostics (at the cellular and animal levels), together with clear-cut tables showing comprehensive cases for further study. Lastly, this review is concluded by the discussions of several perspectives on future directions. It is believed that AIEgen-based bioprobes will play vital roles in the exploration of mysterious life processes by integration with various cutting-edge modalities and techniques with an ultimate goal of addressing more healthcare issues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole
Luo, J., Xie, Z., Lam, J. W. Y., Cheng, L., Tang, B. Z., Chen, H., Qiu, C., Kwok, H. S., Zhan, X., Liu, Y., et al. (2001) · Chemical Communications · doi:10.1039/b105159h · Cited by 8,358
Self-citationAggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Self-citationHong, Y., Lam, J. W. Y., & Tang, B. Z. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15113d · Cited by 6,363
Self-citationPhotoacoustic tomography: In vivo imaging from organelles to organs
Wang, L. V., & Hu, S. (2012) · Science · doi:10.1126/science.1216210 · Cited by 4,331
Combination therapy in combating cancer
Mokhtari, R. B., Homayouni, T. S., Baluch, N., Morgatskaya, E., Kumar, S., Das, B., & Yeger, H. (2017) · Oncotarget · doi:10.18632/oncotarget.16723 · Cited by 2,543
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications
Hu, F., Xu, S., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201801350 · Cited by 859
Specific light-up bioprobes based on AIEgen conjugates
Liang, J., Tang, B. Z., & Liu, B. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00444b · Cited by 762
Self-citationNext-generation in vivo optical imaging with short-wave infrared quantum dots
Bruns, O. T., Bischof, T. S., Harris, D. K., Franke, D., Shi, Y., Riedemann, L., Bartelt, A., Jaworski, F. B., Carr, J. A., Rowlands, C. J., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0056 · Cited by 686
Sheng, Z., Guo, B., Hu, D., Xu, S., Wu, W., Liew, W. H., Yao, K., Jiang, J., Liu, C., Zheng, H., et al. (2018) · Advanced Materials · doi:10.1002/adma.201800766 · Cited by 445
Qi, J., Sun, C., Zebibula, A., Zhang, H., Kwok, R. T. K., Zhao, X., Xi, W., Lam, J. W. Y., Qian, J., & Tang, B. Z. (2018) · Advanced Materials · doi:10.1002/adma.201706856 · Cited by 418
Self-citationQi, J., Chen, C., Zhang, X., Hu, X., Ji, S., Kwok, R. T. K., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2018) · Nature Communications · doi:10.1038/s41467-018-04222-8 · Cited by 350
Self-citationZheng, Z., Zhang, T., Liu, H., Chen, Y., Kwok, R. T. K., Ma, C., Zhang, P., Sung, H. H. Y., Williams, I. D., Lam, J. W. Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b03138 · Cited by 340
Self-citationXue, X., Zhao, Y., Dai, L., Zhang, X., Hao, X., Zhang, C., Huo, S., Liu, J., Liu, C., Kumar, A., et al. (2014) · Advanced Materials · doi:10.1002/adma.201302365 · Cited by 206
Wang, Y., Chen, M., Alifu, N., Li, S., Qin, W., Qin, A., Tang, B. Z., & Qian, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b05645 · Cited by 177
Self-citationNi, F., Zhu, Z., Tong, X., Xie, M., Zhao, Q., Zhong, C., Zou, Y., & Yang, C. (2018) · Chemical Science · doi:10.1039/c8sc01485j · Cited by 142
AIE Polymers: Synthesis, Properties, and Biological Applications
Zhan, R., Pan, Y., Manghnani, P. N., & Liu, B. (2017) · Macromolecular Bioscience · doi:10.1002/mabi.201600433 · Cited by 132
Yuan, Y., Kwok, R. T. K., Tang, B. Z., & Liu, B. (2015) · Small · doi:10.1002/smll.201501498 · Cited by 57
Self-citation
Cited by
Aggregation‐Induced Emission: New Vistas at the Aggregate Level
Zhao, Z., Zhang, H., Lam, J. W. Y., & Tang, B. Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201916729 · Cited by 1,428
Self-citationSupramolecular materials based on AIE luminogens (AIEgens): construction and applications
Li, J., Wang, J., Li, H., Song, N., Wang, D., & Tang, B. Z. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00495e · Cited by 741
Self-citationClusterization-triggered emission: Uncommon luminescence from common materials
Zhang, H., Zhao, Z., McGonigal, P. R., Ye, R., Liu, S., Lam, J. W. Y., Kwok, R. T. K., Yuan, W. Z., Xie, J., Rogach, A. L., et al. (2020) · Materials Today · doi:10.1016/j.mattod.2019.08.010 · Cited by 718
Self-citationAggregate Science: From Structures to Properties
Zhang, H., Zhao, Z., Turley, A. T., Wang, L., McGonigal, P. R., Tu, Y., Li, Y., Wang, Z., Kwok, R. T. K., Lam, J. W. Y., et al. (2020) · Advanced Materials · doi:10.1002/adma.202001457 · Cited by 518
Self-citationAggregation‐enhanced theranostics: AIE sparkles in biomedical field
Kang, M., Zhang, Z., Song, N., Li, M., Sun, P., Chen, X., Wang, D., & Tang, B. Z. (2020) · Aggregate · doi:10.1002/agt2.7 · Cited by 485
Self-citation
Metadata
- Authors
- Zhu, C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z.
- Venue
- ACS Applied Bio Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-10-30
- Volume
- 1
- Issue
- 6
- Pages
- 1768-1786
- ISSN
- 2576-6422 (ISSN-L)
- OpenAlex
- W2899516255
- Cited by
- 343
- References
- 18
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
