Highly Effective Photocontrollable Drug Delivery Systems Based on Ultrasensitive Light-Responsive Self-Assembled Polymeric Micelles: An in Vitro Therapeutic Evaluation
Abstract
An ultrasensitive light-responsive block copolymer, a combination of a multiarmed poly(ethylene glycol)- b -poly(caprolactone) polymer as a water-soluble element and maleimide-anthracene linkers as a photosensitive group, was successfully synthesized and rapidly self-assembled to form spherical micellar nanoparticles in aqueous media and phosphate-buffered saline. Their unique characteristics, such as extremely low critical micelle concentration, desirable micellar stability, well-controlled light-responsiveness, tailorable drug-loading content, and ultrasensitive light-induced drug release, make these micelles potential candidates for development of a more effective, safer drug delivery platform for cancer treatment. In vitro studies revealed that the drug-loaded micelles exhibited high structural stability in serum-containing media and very low toxicity toward normal and cancer cells under physiological conditions. Irradiation of cancer cells incubated with the drug-loaded micelles with ultraviolet light at 254 nm for only 10 s triggered rapid and complete release of the drug in the intracellular environment and induced strong antiproliferative/cytotoxic activity. Importantly, real-time cytotoxic assays and fluorescence imaging analysis further demonstrated that the drug-loaded micelles were rapidly taken up into the cytosol or nuclei of the cells, and subsequent ultraviolet exposure induced drug release and apoptotic cell death. Given their simplicity of design, high reliability, and performance, this new light-sensitive micelle may provide a promising route for developing a multifunctional therapeutic nanocarrier system.
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UV radiation caused fast DOX release and cytotoxic study displayed that DOX could be accumulated within the cells under normal tumor conditions.
“Remarkable, UV radiation-caused fast DOX release and cytotoxic study displayed that DOX could be accumulated within the cells under normal tumor conditions, Figure 12B.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [189]
A light-responsive polymeric micelle (3PEG-PCL) with good stability and low CMC values has been developed.
“Recently, light-responsive polymeric micelle (3PEG–PCL) with good stability and low CMC values has been developed (Figure 12A) [189].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [189]
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Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
“Recently, light-responsive polymeric micelle (3PEG–PCL) with good stability and low CMC values has been developed (Figure 12A) [189].”
Background
- Authors
- Cheng, C.-C., Huang, J.-J., Lee, A.-W., Huang, S.-Y., Huang, C.-Y., & Lai, J.-Y.
- Affiliations
- National Taiwan University of Science and Technology (TW)
- Taipei Medical University (TW)
- Chung Yuan Christian University (TW)
- Corresponding author
- Cheng, Chih-Chia
- Venue
- ACS Applied Bio Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-04-03
- Volume
- 2
- Issue
- 5
- Pages
- 2162-2170
- ISSN
- 2576-6422 (ISSN-L)
- OpenAlex
- W2930494723
- Cited by
- 25
- References
- 62
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 1 · 2021: 4 · 2020: 7 · 2019: 1
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Bio Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology, Taiwan (MOST 105-2628-E-011-006-MY2, MOST 107-2221-E-011-041-MY3)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- light-triggered drug release, block copolymer self-assembly, cancer nanocarriers, intracellular drug delivery, apoptosis, cytotoxicity, critical micelle concentration, micellar stability
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