Cited by 102Electrochemical sensors and biosensorsAdvanced biosensing and bioanalysis techniquesAdvanced Sensor and Energy Harvesting Materials

ZnO Nanorod Integrated Flexible Carbon Fibers for Sweat Cortisol Detection

Madhu, Sekar, Anthuuvan, Allen Joseph, Ramasamy, Sriramprabha, Manickam, Pandiaraj, Bhansali, Shekhar, Nagamony, Ponpandian, Chinnuswamy, Viswanathan·2020·ACS Applied Electronic Materials

Abstract

Sensors fabricated on fabrics provide an elevated ease of use for wearable sensors. Such sensors will play a critical role in detecting the elevations in the concentrations of biochemical markers in human sweat. The ability of making such measurements is becoming an important tool for non-invasive and real-time health monitoring. We present a yarn-based flexible and superwettable electrochemical immunosensing strategy for highly selective and sensitive detection of cortisol in sweat. ZnO nanorods (ZnONRs)-coated flexible carbon yarns were prepared by using a hydrothermal method for immobilizing specific anti-cortisol antibodies and used as an immunosensing platform for detecting sweat cortisol levels. The morphology, elemental composition, crystallinity, and specific surface area were analyzed by using analytical techniques such as transmission electron microscopy (TEM), field emission scanning electron microscopy coupled energy-dispersive X-ray analysis (FE-SEM/EDS), X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FT-IR), Raman spectroscopy, and Brunauer–Emmett–Teller (BET) analysis. The ZnONRs integrated carbon yarns showed excellent mechanical stability and superwettable properties. The immunosensor exhibited a wide linear detection range from 1 fg/mL to 1 μg/mL. The detection limits of the immunosensor were calculated to be between 0.45 and 0.098 fg/mL by using CV and DPV techniques, respectively. Additionally, cell viability studies were performed to investigate the biocompatibility and cytotoxicity of this carbon yarn ZnO sensing platform. The immunosensor was applied to measure the cortisol concentration in human sweat samples, and the outcomes were validated by using a chemiluminescent immunoassay system.

Integrity signals

Registry

Crossref · 10.1021/acsaelm.9b00730

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Madhu, S., Anthuuvan, A. J., Ramasamy, S., Manickam, P., Bhansali, S., Nagamony, P., & Chinnuswamy, V.
Affiliations
  • Bharathiar University (IN)
  • Department of Nanoscience and Technology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India
  • Central Electrochemical Research Institute (IN)
  • Florida International University (US)
Corresponding author
Manickam, Pandiaraj
Venue
ACS Applied Electronic Materials
Published
2020-01-30
Volume
2
Issue
2
Pages
499-509
ISSN
2637-6113 (ISSN-L)
OpenAlex
W3003747795
Cited by
102
References
46
Citations by year
2026: 8 · 2025: 10 · 2024: 16 · 2023: 19 · 2022: 23 · 2021: 19 · 2020: 7
FWCI
5.84
Type
journal article
Language
en
Open access
closed
Locations
ACS Applied Electronic Materials (publishedVersion)
Funders
  • Science and Engineering Research Board (CRG/2019/004547)
  • Department of Science and Technology, Ministry of Science and Technology
  • Ministry of Human Resource Development
  • Tamil Nadu State Council for Higher Education
  • Bharathiar Entrepreneurship Innovation and Career Hub
  • Bharathiar Cancer Theranostics Research Centre
Topics
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
Keywords
ZnO nanorods, wearable sensors, electrochemical immunosensor, hydrothermal synthesis, non-invasive health monitoring, cytotoxicity, chemiluminescence immunoassay

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review