Flexible Biosensors Based on Colorimetry, Fluorescence, and Electrochemistry for Point-of-Care Testing
Open accessAbstract
With the outbreak and pandemic of COVID-19, point-of-care testing (POCT) systems have been attracted much attention due to their significant advantages of small batches of samples, user-friendliness, easy-to-use and simple detection. Among them, flexible biosensors show practical significance as their outstanding properties in terms of flexibility, portability, and high efficiency, which provide great convenience for users. To construct highly functional flexible biosensors, abundant kinds of polymers substrates have been modified with sufficient properties to address certain needs. Paper-based biosensors gain considerable attention as well, owing to their foldability, lightweight and adaptability. The other important flexible biosensor employs textiles as substrate materials, which has a promising prospect in the area of intelligent wearable devices. In this feature article, we performed a comprehensive review about the applications of flexible biosensors based on the classification of substrate materials (polymers, paper and textiles), and illustrated the strategies to design effective and artificial sensing platforms, including colorimetry, fluorescence, and electrochemistry. It is demonstrated that flexible biosensors play a prominent role in medical diagnosis, prognosis, and healthcare.
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Microfluidics technology has become prominent in wearable intelligent sensor platforms for reducing samples and solvents.
“For reducing samples and solvents, microfluidics technology has become prominent in wearable intelligent sensor platforms [279,280,281].”
From The Current State of Optical Sensors in Medical Wearables (2022) · cites this paper as [281]
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- Authors
- Yan, T., Zhang, G., Chai, H., Qu, L., & Zhang, X.
- Affiliations
- Qingdao University (CN)
- Qingdao University of Technology (CN)
- Shenzhen University (CN)
- Corresponding author
- Zhang, Guangyao
- Qu, Lijun
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2021-09-28
- Volume
- 9
- Pages
- 753692-753692
- ISSN
- 2296-4185 (ISSN-L)
- PMC
- PMC8505690
- OpenAlex
- W3202222343
- Cited by
- 59
- References
- 88
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 12 · 2023: 11 · 2022: 12 · 2021: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Update notices
- corrigendum (2022-11-15)
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Bioengineering and Biotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Science Foundation of Shandong Province (ZR2020QB092)
- China Postdoctoral Science Foundation (2021M691689)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Keywords
- flexible biosensors, point-of-care testing, colorimetric sensing, fluorescence sensing, electrochemical sensing, paper-based biosensor, textile substrates, wearable devices, polymer substrates, COVID-19 diagnosis, diagnosis
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