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Multifunctional Hydrogel with Good Structure Integrity, Self-Healing, and Tissue-Adhesive Property Formed by Combining Diels–Alder Click Reaction and Acylhydrazone Bond
Abstract
Hydrogel, as a good cartilage tissue-engineered scaffold, not only has to possess robust mechanical property but also has to have an intrinsic self-healing property to integrate itself or the surrounding host cartilage. In this work a double cross-linked network (DN) was designed and prepared by combining Diels-Alder click reaction and acylhydrazone bond. The DA reaction maintained the hydrogel's structural integrity and mechanical strength in physiological environment, while the dynamic covalent acylhydrazone bond resulted in hydrogel's self-healing property and controlled the on-off switch of network cross-link density. At the same time, the aldehyde groups contained in hydrogel further promote good integration of the hydrogel to surrounding tissue based on aldehyde-amine Schiff-base reaction. This kind of hydrogel has good structural integrity, autonomous self-healing, and tissue-adhesive property and simultaneously will have a good application in tissue engineering and tissue repair field.
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Metadata
- Authors
- Yu, F., Cao, X., Du, J., Wang, G., & Chen, X.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-10-23
- Volume
- 7
- Issue
- 43
- Pages
- 24023-24031
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2341963323
- Cited by
- 359
- References
- 41
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- closed
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