The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Neutrophil-Mediated Delivery of Therapeutic Nanoparticles across Blood Vessel Barrier for Treatment of Inflammation and Infection
Abstract
Endothelial cells form a monolayer in lumen of blood vessels presenting a great barrier for delivery of therapeutic nanoparticles (NPs) into extravascular tissues where most diseases occur, such as inflammation disorders and infection. Here, we report a strategy for delivering therapeutic NPs across this blood vessel barrier by nanoparticle in situ hitchhiking activated neutrophils. Using intravital microscopy of TNF-α-induced inflammation of mouse cremaster venules and a mouse model of acute lung inflammation, we demonstrated that intravenously (iv) infused NPs made from denatured bovine serum albumin (BSA) were specifically internalized by activated neutrophils, and subsequently, the neutrophils containing NPs migrated across blood vessels into inflammatory tissues. When neutrophils were depleted using anti-Gr-1 in a mouse, the transport of albumin NPs across blood vessel walls was robustly abolished. Furthermore, it was found that albumin nanoparticle internalization did not affect neutrophil mobility and functions. Administration of drug-loaded albumin NPs markedly mitigated the lung inflammation induced by LPS (lipopolysaccharide) or infection by Pseudomonas aeruginosa. These results demonstrate the use of an albumin nanoparticle platform for in situ targeting of activated neutrophils for delivery of therapeutics across the blood vessel barriers into diseased sites. This study demonstrates our ability to hijack neutrophils to deliver nanoparticles to targeted diseased sites.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,679
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,306
Neutrophil recruitment and function in health and inflammation
Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472
Impact of Nanotechnology on Drug Delivery
Farokhzad, O. C., & Langer, R. (2009) · ACS Nano · doi:10.1021/nn900002m · Cited by 3,348
Inflammation 2010: New Adventures of an Old Flame
Medzhitov, R. (2010) · Cell · doi:10.1016/j.cell.2010.03.006 · Cited by 1,834
Signaling Mechanisms Regulating Endothelial Permeability
Mehta, D., & Malik, A. B. (2006) · Physiological Reviews · doi:10.1152/physrev.00012.2005 · Cited by 1,720
The acute respiratory distress syndrome
Matthay, M. A., Ware, L. B., & Zimmerman, G. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60331 · Cited by 1,706
Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies
Mitragotri, S., Burke, P. A., & Langer, R. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4363 · Cited by 1,702
Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery
Torchilin, V. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4333 · Cited by 1,663
The multifaceted functions of neutrophils
Mayadas, T. N., Cullere, X., & Lowell, C. A. (2014) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-164023 · Cited by 1,356
Treating metastatic cancer with nanotechnology
Schroeder, A., Heller, D. A., Winslow, M. M., Dahlman, J. E., Pratt, G. W., Langer, R., Jacks, T., & Anderson, D. G. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3180 · Cited by 1,159
Anti-inflammatory Agents: Present and Future
Dinarello, C. A. (2010) · Cell · doi:10.1016/j.cell.2010.02.043 · Cited by 1,095
The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment
Matthay, M. A., & Zemans, R. L. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130158 · Cited by 1,077
Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles
Rodriguez, P. L., Harada, T., Christian, D. A., Pantano, D. A., Tsai, R. K., & Discher, D. E. (2013) · Science · doi:10.1126/science.1229568 · Cited by 985
Ware, L. B., & Matthay, M. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmcp052699 · Cited by 679
Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways
Komarova, Y., & Malik, A. B. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135833 · Cited by 641
Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G., & Kubes, P. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.01.005 · Cited by 443
Oxidative Stress and Acute Lung Injury
Chow, C.-W., Herrera Abreu, M. T., Suzuki, T., & Downey, G. P. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.f278 · Cited by 372
Size and Dynamics of Caveolae Studied Using Nanoparticles in Living Endothelial Cells
Wang, Z., Tiruppathi, C., Minshall, R. D., & Malik, A. B. (2009) · ACS Nano · doi:10.1021/nn9012274 · Cited by 319
Self-citationPrevention of vascular inflammation by nanoparticle targeting of adherent neutrophils
Wang, Z., Li, J., Cho, J., & Malik, A. B. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.17 · Cited by 300
Self-citationPodolin, P. L., Callahan, J. F., Bolognese, B. J., Li, Y. H., Carlson, K., Davis, T. G., Mellor, G. W., Evans, C., & Roshak, A. K. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.074484 · Cited by 298
Czuprynski, C. J., Brown, J. F., Maroushek, N., Wagner, R. D., & Steinberg, H. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1836 · Cited by 229
Sumagin, R., Prizant, H., Lomakina, E., Waugh, R. E., & Sarelius, I. H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001638 · Cited by 174
Sadikot, R. T., Zeng, H., Joo, M., Everhart, M. B., Sherrill, T. P., Li, B., Cheng, D., Yull, F. E., Christman, J. W., & Blackwell, T. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.8.4923 · Cited by 137
Delivery of nanoparticle‐complexed drugs across the vascular endothelial barrier via caveolae
Wang, Z., Tiruppathì, C., Cho, J., Minshall, R. D., & Malik, A. B. (2011) · IUBMB Life · doi:10.1002/iub.485 · Cited by 124
Self-citationIκB kinase inhibitors for treating autoimmune and inflammatory disorders: potential and challenges
Strnad, J., & Burke, J. R. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.01.005 · Cited by 84
Wang, Y.-L., Malik, A. B., Sun, Y., Hu, S., Reynolds, A. B., Minshall, R. D., & Hu, G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001252 · Cited by 74
Cited by
The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors
Izci, M., Maksoudian, C., Manshian, B. B., & Soenen, S. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00779 · Cited by 506
Neutrophil‐Based Drug Delivery Systems
Chu, D., Dong, X., Shi, X., Zhang, C., & Wang, Z. (2018) · Advanced Materials · doi:10.1002/adma.201706245 · Cited by 386
Self-citationChemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy
Li, M., Li, S., Zhou, H., Tang, X., Wu, Y., Jiang, W., Tian, Z., Zhou, X., Yang, X., & Wang, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-14963-0 · Cited by 300
Constitutional Isomerization Enables Bright NIR‐II AIEgen for Brain‐Inflammation Imaging
Liu, S., Chen, C., Li, Y., Zhang, H., Liu, J., Wang, R., Wong, S. T. H., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201908125 · Cited by 267
Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management
Zhang, C. Y., Gao, J., & Wang, Z. (2018) · Advanced Materials · doi:10.1002/adma.201803618 · Cited by 222
Self-citation
Metadata
- Authors
- Chu, D., Gao, J., & Wang, Z.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-11-05
- Volume
- 9
- Issue
- 12
- Pages
- 11800-11811
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1871753595
- Cited by
- 283
- References
- 27
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
