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Biomimetic Elastomeric Polypeptide-Based Nanofibrous Matrix for Overcoming Multidrug-Resistant Bacteria and Enhancing Full-Thickness Wound Healing/Skin Regeneration
Abstract
Overcoming the multidrug-resistant (MDR) bacterial infection is a challenge and urgently needed in wound healing. Few wound dressings possess the capacity to treat MDR bacterial infections and enhance wound healing. Herein, we develop an elastomeric, photoluminescent, and antibacterial hybrid polypeptide-based nanofibrous matrix as a multifunctional platform to inhibit the MDR bacteria and enhance wound healing. The hybrid nanofibrous matrix was composed of poly(citrate)-ε-poly lysine (PCE) and poly caprolactone (PCL). The PCL-PCE hybrid nanofibrous matrix showed a biomimetic elastomeric behavior, robust antibacterial activity including killing MDR bacteria capacity, and excellent biocompatibility. PCL-PCE nanofibrous system can efficiently prevent the MDR bacteria-derived wound infection and significantly enhance the complete skin-thickness wound healing and skin regeneration in a mouse model. PCL-PCE hybrid nanofibrous matrix might become a competitive multifunctional dressing for bacteria-infected wound healing and skin regeneration.
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Cites
3 retracted
Zhou, L., Xi, Y., Yu, M., Wang, M., Guo, Y., Li, P., Ma, P. X., & Lei, B. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.06.010 · Cited by 27
Self-citationRetractedZhou, L., Qu, X., Guo, Y., Wang, M., Lei, B., & Ma, P. X. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b17109 · Cited by 24
Self-citationRetractedZhou, L., Xi, Y., Chen, M., Niu, W., Wang, M., Ma, P. X., & Lei, B. (2018) · Nanoscale · doi:10.1039/c8nr03001d · Cited by 23
Self-citationRetractedAntibacterial resistance worldwide: causes, challenges and responses
Levy, S. B., & Marshall, B. (2004) · Nature Medicine · doi:10.1038/nm1145 · Cited by 4,052
PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H., & Tomic‐Canic, M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00410.x · Cited by 3,583
Designing antimicrobial peptides: form follows function
Fjell, C. D., Hiss, J. A., Hancock, R. E. W., & Schneider, G. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3591 · Cited by 2,035
Strain specificity in antimicrobial activity of silver and copper nanoparticles
Ruparelia, J. P., Chatterjee, A. K., Duttagupta, S. P., & Mukherji, S. (2008) · Acta Biomaterialia · doi:10.1016/j.actbio.2007.11.006 · Cited by 1,885
Antibiotics for Emerging Pathogens
Fischbach, M. A., & Walsh, C. T. (2009) · Science · doi:10.1126/science.1176667 · Cited by 1,777
CHONG, E., PHAN, T., LIM, I., ZHANG, Y., BAY, B., RAMAKRISHNA, S., & LIM, C. (2007) · Acta Biomaterialia · doi:10.1016/j.actbio.2007.01.002 · Cited by 919
Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties
Ong, S.-Y., Wu, J., Moochhala, S. M., Tan, M.-H., & Lu, J. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.07.034 · Cited by 830
Mao, C., Xiang, Y., Liu, X., Cui, Z., Yang, X., Yeung, K. W. K., Pan, H., Wang, X., Chu, P. K., & Wu, S. (2017) · ACS Nano · doi:10.1021/acsnano.7b03513 · Cited by 756
Burn injury: Challenges and advances in burn wound healing, infection, pain and scarring
Wang, Y., Beekman, J., Hew, J., Jackson, S., Issler-Fisher, A. C., Parungao, R., Lajevardi, S. S., Li, Z., & Maitz, P. K. M. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.09.018 · Cited by 696
Tissue scaffolds for skin wound healing and dermal reconstruction
Zhong, S. P., Zhang, Y. Z., & Lim, C. T. (2010) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.100 · Cited by 687
Designing electrospun nanofiber mats to promote wound healing – a review
Rieger, K. A., Birch, N. P., & Schiffman, J. D. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb20795a · Cited by 479
Xiao, J., Zhu, Y., Huddleston, S., Li, P., Xiao, B., Farha, O. K., & Ameer, G. A. (2018) · ACS Nano · doi:10.1021/acsnano.7b01850 · Cited by 396
Yang, X., Yang, J., Wang, L., Ran, B., Jia, Y., Zhang, L., Yang, G., Shao, H., & Jiang, X. (2017) · ACS Nano · doi:10.1021/acsnano.7b01240 · Cited by 376
Microbial synthesis of poly(ε-lysine) and its various applications
SHIH, I., SHEN, M., & VAN, Y. (2006) · Bioresource Technology · doi:10.1016/j.biortech.2004.08.012 · Cited by 354
Toxicity of various silver nanoparticles compared to silver ions in Daphnia magna
Asghari, S., Johari, S. A., Lee, J. H., Kim, Y. S., Jeon, Y. B., Choi, H. J., Moon, M. C., & Yu, I. J. (2012) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-10-14 · Cited by 318
Chen, W., Chang, H., Lu, J., Huang, Y., Harroun, S. G., Tseng, Y., Li, Y., Huang, C., & Chang, H. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201503248 · Cited by 298
Zhao, F., Lei, B., Li, X., Mo, Y., Wang, R., Chen, D., & Chen, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.004 · Cited by 280
Self-citationAntibacterial activity and mechanism of action of ε-poly-l-lysine
Ye, R., Xu, H., Wan, C., Peng, S., Wang, L., Xu, H., Aguilar, Z. P., Xiong, Y., Zeng, Z., & Wei, H. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.08.001 · Cited by 278
Rahmani Del Bakhshayesh, A., Annabi, N., Khalilov, R., Akbarzadeh, A., Samiei, M., Alizadeh, E., Alizadeh-Ghodsi, M., Davaran, S., & Montaseri, A. (2018) · Artificial Cells, Nanomedicine, and Biotechnology · doi:10.1080/21691401.2017.1349778 · Cited by 250
Song, D. W., Kim, S. H., Kim, H. H., Lee, K. H., Ki, C. S., & Park, Y. H. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.05.008 · Cited by 236
Development of aliphatic biodegradable photoluminescent polymers
Yang, J., Zhang, Y., Gautam, S., Liu, L., Dey, J., Chen, W., Mason, R. P., Serrano, C. A., Schug, K. A., & Tang, L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900004106 · Cited by 234
Wang, X., Lv, F., Li, T., Han, Y., Yi, Z., Liu, M., Chang, J., & Wu, C. (2017) · ACS Nano · doi:10.1021/acsnano.7b05858 · Cited by 226
Li, Y.-Q., Han, Q., Feng, J.-L., Tian, W.-L., & Mo, H.-Z. (2014) · Food Control · doi:10.1016/j.foodcont.2014.02.023 · Cited by 225
Bing, W., Chen, Z., Sun, H., Shi, P., Gao, N., Ren, J., & Qu, X. (2015) · Nano Research · doi:10.1007/s12274-014-0654-1 · Cited by 213
Zinc Oxide Nanorod‐Based Piezoelectric Dermal Patch for Wound Healing
Bhang, S. H., Jang, W. S., Han, J., Yoon, J., La, W., Lee, E., Kim, Y. S., Shin, J., Lee, T., Baik, H. K., et al. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201603497 · Cited by 205
Dhand, C., Venkatesh, M., Barathi, V. A., Harini, S., Bairagi, S., Goh Tze Leng, E., Muruganandham, N., Low, K. Z. W., Fazil, M. H. U. T., Loh, X. J., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.043 · Cited by 189
Dong, R.-H., Jia, Y.-X., Qin, C.-C., Zhan, L., Yan, X., Cui, L., Zhou, Y., Jiang, X., & Long, Y.-Z. (2016) · Nanoscale · doi:10.1039/c5nr08367b · Cited by 174
Du, Y., Ge, J., Li, Y., Ma, P. X., & Lei, B. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.12.005 · Cited by 139
Self-citationLucas, T., Schäfer, F., Müller, P., Eming, S. A., Heckel, A., & Dimmeler, S. (2017) · Nature Communications · doi:10.1038/ncomms15162 · Cited by 137
Kandhasamy, S., Perumal, S., Madhan, B., Maheswari, N. U., Banday, J. A., Perumal, P. T., & Santhanakrishnan, V. P. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b16488 · Cited by 131
Zinc Ion Coordinated Poly(Ionic Liquid) Antimicrobial Membranes for Wound Healing
Xu, Q., Zheng, Z., Wang, B., Mao, H., & Yan, F. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b01677 · Cited by 131
Citrate chemistry and biology for biomaterials design
Ma, C., Gerhard, E. M., Lü, D., & Yang, J. Y. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.003 · Cited by 117
Lei, B., Shin, K.-H., Noh, D.-Y., Jo, I.-H., Koh, Y., Choi, W.-Y., & Kim, H. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm31290e · Cited by 115
Self-citationGao, W., Jin, W., Li, Y., Wan, L., Wang, C., Lin, C., Chen, X., Lei, B., & Mao, C. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb01484h · Cited by 102
Self-citationDu, Y., Yu, M., Ge, J., Ma, P. X., Chen, X., & Lei, B. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201501712 · Cited by 95
Self-citationGe, J., Liu, K., Niu, W., Chen, M., Wang, M., Xue, Y., Gao, C., Ma, P. X., & Lei, B. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.027 · Cited by 94
Self-citationYu, M., Lei, B., Gao, C., Yan, J., & Ma, P. X. (2016) · Nano Research · doi:10.1007/s12274-016-1265-9 · Cited by 74
Self-citationPrabhakaran, M. P., Nair, A. S., Kai, D., & Ramakrishna, S. (2012) · Biopolymers · doi:10.1002/bip.22035 · Cited by 71
Xue, Y., Guo, Y., Yu, M., Wang, M., Ma, P. X., & Lei, B. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700630 · Cited by 60
Self-citationVascular scaffolds with enhanced antioxidant activity inhibit graft calcification
Jiang, B., Suen, R. M., Wang, J.-J., Zhang, Z. J., Wertheim, J. A., & Ameer, G. A. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.08.014 · Cited by 57
Li, Y., Guo, Y., Ge, J., Ma, P. X., & Lei, B. (2017) · Applied Materials Today · doi:10.1016/j.apmt.2017.11.007 · Cited by 49
Self-citationWang, M., Guo, Y., Yu, M., Ma, P. X., Mao, C., & Lei, B. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.02.034 · Cited by 48
Self-citationLorden, E. R., Miller, K. J., Ibrahim, M. M., Bashirov, L., Hammett, E., Chakraborty, S., Quiles-Torres, C., Selim, M. A., Leong, K. W., & Levinson, H. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.12.025 · Cited by 39
LIU, J.-Q., ZHAO, K.-B., Feng, Z., & Qi, F. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2465 · Cited by 36
Martín-López, E., Nieto‐Díaz, M., & Nieto‐Sampedro, M. (2010) · Journal of Biomaterials Applications · doi:10.1177/0885328210379928 · Cited by 32
Zhu, L., Zhang, Y., & Ji, Y. (2017) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-017-5906-7 · Cited by 24
Cited by
Wang, C., Wang, M., Xu, T., Zhang, X., Lin, C., Gao, W., Xu, H., Lei, B., & Mao, C. (2019) · Theranostics · doi:10.7150/thno.29766 · Cited by 908
Self-citationWang, S., Zheng, H., Zhou, L., Cheng, F., Liu, Z., Zhang, H., Wang, L., & Zhang, Q. (2020) · Nano Letters · doi:10.1021/acs.nanolett.0c01371 · Cited by 573
A review of current advancements for wound healing: Biomaterial applications and medical devices
Deng, X., Gould, M., & Ali, M. A. (2022) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.35086 · Cited by 355
Xi, Y., Ge, J., Wang, M., Chen, M., Niu, W., Cheng, W., Xue, Y., Lin, C., & Lei, B. (2020) · ACS Nano · doi:10.1021/acsnano.9b07173 · Cited by 346
Self-citationMultifunctional hydrogels for wound healing: Special focus on biomacromolecular based hydrogels
Asadi, N., Pazoki-Toroudi, H., Del Bakhshayesh, A. R., Akbarzadeh, A., Davaran, S., & Annabi, N. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.202 · Cited by 312
Metadata
- Authors
- Xi, Y., Ge, J., Guo, Y., Lei, B., & Ma, P. X.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-10-12
- Volume
- 12
- Issue
- 11
- Pages
- 10772-10784
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2895850379
- Cited by
- 257
- References
- 49
- FWCI
- 20.90
- Type
- journal article
- Language
- en
- Open access
- closed
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