Redox-Activatable and Acid-Enhanced Nanotheranostics for Second Near-Infrared Photoacoustic Tomography and Combined Photothermal Tumor Therapy
Abstract
Tumor phototheranostics in the second near-infrared window (NIR-II, 1000-1700 nm) holds great promise due to high spatiotemporal precision, enhanced penetration depth, and therapeutic efficacy. However, current "always-on" NIR-II phototheranostic agents remain restricted by the inherent nonspecificity from the pseudosignal readout and undesirable treatment-related side effects. To address these challenges, herein we explore an activatable and biocompatible nanotheranostics that generates diagnostic and therapeutic effects only after specific activation and enhancement by tumor microenvironmental redox and acid while keeping silent at normal tissues. Such an intelligent "turn-on" chromogenic nanotheranostics allows in vivo nearly zero-background photoacoustic tomography (PAT) and combined effective photothermal tumor therapy (PTT) both in the NIR-II range with minimal adverse effects. In light of the high sensitivity, superior penetration depth, and biocompatibility, this stimuli-activatable NIR-II photo-nanotheranostics provides broad prospects for the investigation and intervention of deep-tissue redox and acid-associated physiological and pathological events.
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An activatable and biocompatible NIR-II nanoprobe that is particularly effective in tumor redox and acid microenvironment was developed by Pu's group.
“An activatable and biocompatible NIR-II nanoprobe that particularly effective in tumor redox and acid microenvironment was developed by Pu’s group.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [197]
Cites
(1989) · PubMed · Cited by 3,343 · see citing works
Mesoporous Materials for Drug Delivery
Vallet‐Regí, M., Balas, F., & Arcos, D. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604488 · Cited by 2,519 · see citing works
Hematoxylin and Eosin Staining of Tissue and Cell SectionsPreprint
Fischer, A. H., Jacobson, K. A., Rose, J., & Zeller, R. (2008) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot4986 · Cited by 2,146 · see citing works
Exploiting the enhanced permeability and retention effect for tumor targeting
Iyer, A. K., Khaled, G., Fang, J., & Maeda, H. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.07.005 · Cited by 1,846 · see citing works
The cellular and molecular basis of hyperthermia
Hildebrandt, B. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00179-2 · Cited by 1,714 · see citing works
Acidic extracellular microenvironment and cancer
Kato, Y., Ozawa, S., Miyamoto, C., Maehata, Y., Suzuki, A., Maeda, T., & Baba, Y. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-89 · Cited by 1,294 · see citing works
Nanomaterials for Theranostics: Recent Advances and Future Challenges
Lim, E., Kim, T., Paik, S., Haam, S., Huh, Y., & Lee, K. (2014) · Chemical Reviews · doi:10.1021/cr300213b · Cited by 1,236 · see citing works
Kraupp, B. G., Ruttkay-Nedecký, B., Koudelka, H., Bukowska, K., Bursch, W., & Schulte‐Hermann, R. (1995) · Hepatology · doi:10.1002/hep.1840210534 · Cited by 1,167 · see citing works
Cheng, L., Liu, J., Gu, X., Gong, H., Shi, X., Liu, T., Wang, C., Wang, X., Liu, G., Xing, H., et al. (2013) · Advanced Materials · doi:10.1002/adma.201304497 · Cited by 1,109 · see citing works
Tumour acidosis: from the passenger to the driver's seat
Corbet, C., & Féron, O. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.77 · Cited by 998 · see citing works
Josephy, P. D., Eling, T. E., & Mason, R. P. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34832-4 · Cited by 968 · see citing works
Current Approaches of Photothermal Therapy in Treating Cancer Metastasis with Nanotherapeutics
Zou, L., Wang, H., He, B., Zeng, L., Tan, T., Cao, H., He, X., Zhang, Z., Guo, S., & Li, Y. (2016) · Theranostics · doi:10.7150/thno.14988 · Cited by 917 · see citing works
Pulaski, B. A., & Ostrand‐Rosenberg, S. (2000) · Current Protocols in Immunology · doi:10.1002/0471142735.im2002s39 · Cited by 912 · see citing works
Near-infrared light-responsive nanomaterials in cancer therapeutics
Shanmugam, V., Selvakumar, S., & Yeh, C. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00011k · Cited by 873 · see citing works
Shen, D., Yang, J., Li, X., Zhou, L., Zhang, R., Li, W., Chen, L., Wang, R., Zhang, F., & Zhao, D. (2014) · Nano Letters · doi:10.1021/nl404316v · Cited by 815 · see citing works
Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy
López‐Lázaro, M. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.10.029 · Cited by 716 · see citing works
Ding, X., Liow, C. H., Zhang, M., Huang, R., Li, C., Shen, H., Liu, M., Zou, Y., Gao, N., Zhang, Z., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja508641z · Cited by 703 · see citing works
Huang, P., Lin, J., Li, W., Rong, P., Wang, Z., Wang, S., Wang, X., Sun, X., Aronova, M. A., Niu, G., et al. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201308986 · Cited by 673 · see citing works
Elucidating the Fundamental Mechanisms of Cell Death Triggered by Photothermal Therapy
Melamed, J. R., Edelstein, R. S., & Day, E. S. (2015) · ACS Nano · doi:10.1021/acsnano.5b00021 · Cited by 667 · see citing works
Jiang, Y., Li, J., Xu, Z. J., Xie, C., & Pu, K. (2018) · Advanced Materials · doi:10.1002/adma.201705980 · Cited by 601 · see citing works
Therapeutic targeting of the tumor microenvironment
Joyce, J. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.024 · Cited by 580 · see citing works
Hydrogen peroxide – production, fate and role in redox signaling of tumor cells
Lennicke, C., Rahn, J., Lichtenfels, R., Wessjohann, L. A., & Seliger, B. (2015) · Cell Communication and Signaling · doi:10.1186/s12964-015-0118-6 · Cited by 572 · see citing works
Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers
Popat, A., Hartono, S. B., Stahr, F., Liu, J., Qiao, S., & Lu, G. Q. (2011) · Nanoscale · doi:10.1039/c1nr10224a · Cited by 549 · see citing works
Improving drug delivery to solid tumors: Priming the tumor microenvironment
Khawar, I. A., Kim, J. H., & Kuh, H.-J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.018 · Cited by 533 · see citing works
Lyu, Y., Fang, Y., Miao, Q., Xu, Z. J., Ding, D., & Pu, K. (2016) · ACS Nano · doi:10.1021/acsnano.6b00168 · Cited by 503 · see citing works
Cancer Theranostics with Near-Infrared Light-Activatable Multimodal Nanoparticles
Melancon, M. P., Zhou, M., & Li, C. (2011) · Accounts of Chemical Research · doi:10.1021/ar200022e · Cited by 501 · see citing works
Cancer and the tumor microenvironment: a review of an essential relationship
Mbeunkui, F., & Johann, D. J. (2008) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-008-0881-9 · Cited by 476 · see citing works
Yang, Y., Shao, Q., Deng, R., Wang, C., Teng, X., Cheng, K., Cheng, Z., Huang, L., Liu, Z., Liu, X., et al. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201107919 · Cited by 467 · see citing works
Upconversion Nanoparticles for Photodynamic Therapy and Other Cancer Therapeutics
Wang, C., Cheng, L., & Liu, Z. (2013) · Theranostics · doi:10.7150/thno.5284 · Cited by 456 · see citing works
Guo, B., Sheng, Z., Hu, D., Liu, C., Zheng, H., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201802591 · Cited by 435 · see citing works
Ai, X., Ho, C. J. H., Aw, J., Attia, A. B. E., Mu, J., Wang, Y., Wang, X., Wang, Y., Liu, X., Chen, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms10432 · Cited by 433 · see citing works
Vijayaraghavan, P., Liu, C., Vankayala, R., Chiang, C., & Hwang, K. C. (2014) · Advanced Materials · doi:10.1002/adma.201400703 · Cited by 372 · see citing works
Compact Plasmonic Blackbody for Cancer Theranosis in the Near-Infrared II Window
Zhou, J., Jiang, Y., Hou, S., Upputuri, P. K., Wu, D., Li, J., Wang, P., Xu, Z. J., Pramanik, M., Pu, K., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b08725 · Cited by 364 · see citing works
Targeting the Tumor Microenvironment for Cancer Therapy
Sounni, N. E., & Noël, A. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2012.185363 · Cited by 344 · see citing works
Metabolizable Semiconducting Polymer Nanoparticles for Second Near‐Infrared Photoacoustic Imaging
Jiang, Y., Upputuri, P. K., Xie, C., Zeng, Z., Sharma, A., Xu, Z. J., Li, J., Huang, J., Pramanik, M., & Pu, K. (2019) · Advanced Materials · doi:10.1002/adma.201808166 · Cited by 339 · see citing works
Perspectives on the past, present, and future of cancer nanomedicine
Youn, Y. S., & Bae, Y. H. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.05.008 · Cited by 288 · see citing works
Fu, G., Sanjay, S. T., Zhou, W., Brekken, R. A., Kirken, R. A., & Li, X. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b00842 · Cited by 274 · see citing works
Folate-mediated delivery of macromolecular anticancer therapeutic agents
Lu, Y. J., & Low, P. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.020 · Cited by 266 · see citing works
Wang, X., Ma, Y., Sheng, X., Wang, Y., & Xu, H. (2018) · Nano Letters · doi:10.1021/acs.nanolett.7b04675 · Cited by 255 · see citing works
Meng, X., Zhang, J., Sun, Z., Zhou, L., Deng, G., Li, S., Li, W., Gong, P., & Cai, L. (2018) · Theranostics · doi:10.7150/thno.26607 · Cited by 231 · see citing works
Recent Advances of Light-Mediated Theranostics
Ai, X., Mu, J., & Xing, B. (2016) · Theranostics · doi:10.7150/thno.16088 · Cited by 227 · see citing works
Lu, J., Li, Z., Zink, J. I., & Tamanoi, F. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.06.002 · Cited by 224 · see citing works
Recent advances toward preclinical and clinical translation of photoacoustic tomography: a review
Upputuri, P. K., & Pramanik, M. (2016) · Journal of Biomedical Optics · doi:10.1117/1.jbo.22.4.041006 · Cited by 224 · see citing works
Cao, Z., Feng, L., Zhang, G., Wang, J., Shen, S., Li, D., & Yang, X. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.016 · Cited by 212 · see citing works
Photoacoustic imaging in the second near-infrared window: a review
Upputuri, P. K. (2019) · Journal of Biomedical Optics · doi:10.1117/1.jbo.24.4.040901 · Cited by 209 · see citing works
Near-infrared-light responsive nanoscale drug delivery systems for cancer treatment
Yang, G., Liu, J., Wu, Y., Feng, L., & Liu, Z. (2016) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2016.04.004 · Cited by 207 · see citing works
Shi, B., Yan, Q., Tang, J., Xin, K., Zhang, J., Zhu, Y. J., Xu, G., Wang, R., Chen, J., Gao, W., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b02767 · Cited by 185 · see citing works
Near‐infrared light‐responsive nanomaterials for cancer theranostics
Kim, H.-J., Chung, K., Lee, S., Kim, D. H., & Lee, H. (2015) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1347 · Cited by 166 · see citing works
Cancer-Microenvironment-Sensitive Activatable Quantum Dot Probe in the Second Near-Infrared Window
Jeong, S., Song, J., Lee, W., Ryu, Y. M., Jung, Y., Kim, S., Kim, K., Hong, S. C., Myung, S. J., & Kim, S. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b04261 · Cited by 110 · see citing works
Janus-Faced Tumor Microenvironment and Redox
Khramtsov, V. V., & Gillies, R. J. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5864 · Cited by 95 · see citing works
Yue, X., Zhang, Q., & Dai, Z. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.007 · Cited by 93 · see citing works
Nanomaterials for photoacoustic imaging in the second near-infrared window
Huang, K., Zhang, Y., Lin, J., & Huang, P. (2018) · Biomaterials Science · doi:10.1039/c8bm00642c · Cited by 89 · see citing works
Zhao, D., Yang, J., Xia, R., Yao, M., Jin, R., Zhao, Y., & Liu, B. (2017) · Chemical Communications · doi:10.1039/c7cc09266k · Cited by 88 · see citing works
Wang, Z., Upputuri, P. K., Xu, Z. J., Zhang, R., Jiang, Y., Ai, X., Zhang, Z., Hu, M., Meng, Z., Lu, Y., et al. (2018) · Nano Research · doi:10.1007/s12274-018-2175-9 · Cited by 86 · see citing works
Zhang, D., Xu, H., Zhang, X., Liu, Y., Wu, M., Li, J., Yang, H., Liu, G., Liu, X., Liu, J., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b08419 · Cited by 75 · see citing works
Yu, X., Yang, K., Chen, X. S., & Li, W. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.07.037 · Cited by 74 · see citing works
Goka, A. K. J., & Farthing, M. J. G. (1987) · Journal of Immunoassay · doi:10.1080/01971528708063053 · Cited by 58 · see citing works
Ariyasu, S., Mu, J., Zhang, X., Huang, Y., Yeow, E. K. L., Zhang, H., & Xing, B. (2017) · Bioconjugate chemistry · doi:10.1021/acs.bioconjchem.6b00741 · Cited by 33 · see citing works
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Second near-infrared photothermal materials for combinational nanotheranostics
Xu, C., & Pu, K. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00664e · Cited by 941 · see citing works
Design of superior phototheranostic agents guided by Jablonski diagrams
Feng, G., Zhang, G., & Ding, D. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00671h · Cited by 794 · see citing works
Liu, Y., Li, Y., Koo, S., Sun, Y., Liu, Y., Liu, X., Pan, Y., Zhang, Z., Du, M., Lu, S., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00553 · Cited by 544 · see citing works
Lin, X., Liu, S., Zhang, X., Zhu, R., Chen, S., Chen, X. S., Song, J., & Yang, H. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201912768 · Cited by 336 · see citing works
Huang, L., Chen, J., Yu, Z., & Tang, D. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05218 · Cited by 321 · see citing works
Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy
Zhang, X., Chen, X., & Zhao, Y. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00828-2 · Cited by 309 · see citing works
Gathering brings strength: How organic aggregates boost disease phototheranostics
Qi, J., Ou, H., Liu, Q., & Ding, D. (2021) · Aggregate · doi:10.1002/agt2.25 · Cited by 284 · see citing works
Multifunctional phototheranostic nanomedicine for cancer imaging and treatment
Gao, D., Guo, X., Zhang, X., Chen, S., Wang, Y., Chen, T., Huang, G. J., Gao, Y. F., Tian, Z., & Yang, Z. (2019) · Materials Today Bio · doi:10.1016/j.mtbio.2019.100035 · Cited by 274 · see citing works
Dong, S., Dong, Y., Zhao, Z., Liu, J., Liu, S., Feng, L., He, F., Gai, S., Xie, Y. H., & Yang, P. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c09608 · Cited by 268 · see citing works
Zhang, Z., Fang, X., Liu, Z., Liu, H., Chen, D., He, S., Zheng, J., Yang, B., Qin, W., Zhang, X., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201914397 · Cited by 242 · see citing works
Ou, C., Na, W., Ge, W., Huang, H., Gao, F., Zhong, L., Zhao, Y., & Dong, X. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202014852 · Cited by 225 · see citing works
Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy
Wang, C., Fan, W., Zhang, Z., Wen, Y., Xiong, L., & Chen, X. S. (2019) · Advanced Materials · doi:10.1002/adma.201904329 · Cited by 215 · see citing works
Ouyang, J., Sun, L., Zeng, Z., Zeng, C., Zeng, F., & Wu, S. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201913149 · Cited by 212 · see citing works
Ultrasound-Based Micro-/Nanosystems for Biomedical Applications
Huang, H. F., Zheng, Y., Chang, M., Song, J., Xia, L., Wu, C., Jia, W., Ren, H., Feng, W., & Chen, Y. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00009 · Cited by 186 · see citing works
Recent advances in the development of NIR-II organic emitters for biomedicine
Li, J., Liu, Y., Xu, Y., Li, L., Sun, Y., & Huang, W. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213318 · Cited by 174 · see citing works
Recent advances in photoacoustic contrast agents for in vivo imaging
Upputuri, P. K., & Pramanik, M. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1618 · Cited by 170 · see citing works
Wang, S., Zhang, L., Zhao, J., He, M., Huang, Y. X., & Zhao, S. (2021) · Science Advances · doi:10.1126/sciadv.abe3588 · Cited by 163 · see citing works
Wang, X., Wu, M., Li, H., Jiang, J., Zhou, S., Chen, W., Xie, C., Xu, Z. C., & Jiang, X. (2022) · Advanced Science · doi:10.1002/advs.202104125 · Cited by 160 · see citing works
Xu, C., Jiang, Y., Huang, J., Huang, J., & Pu, K. (2021) · Advanced Materials · doi:10.1002/adma.202101410 · Cited by 158 · see citing works
Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
“The method has broad prospects in stimuli-activatable NIR-II photo-nanotheranostics (Figure 13d) [197].”
MethodActivatable molecular agents for cancer theranostics
Zhang, J., Ning, L., Huang, J., Zhang, C., & Pu, K. (2019) · Chemical Science · doi:10.1039/c9sc05460j · Cited by 154 · see citing works
Another decade of photoacoustic imaging
Das, D., Sharma, A., Rajendran, P., & Pramanik, M. (2020) · Physics in Medicine and Biology · doi:10.1088/1361-6560/abd669 · Cited by 154 · see citing works
Manivasagan, P., Joe, A., Han, H., Thambi, T., Selvaraj, M., Chidambaram, K., Kim, J., & Jang, E. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100197 · Cited by 146 · see citing works
Dai, L., Jiang, H., Zhang, G., Luo, Q., Zhao, Q., & Shi, X. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c04751 · Cited by 129 · see citing works
Organic Photothermal Cocrystals: Rational Design, Controlled Synthesis, and Advanced Application
Chen, Y.-T., Zhuo, M., Wen, X., Chen, W., Zhang, K., & Li, M. (2023) · Advanced Science · doi:10.1002/advs.202206830 · Cited by 125 · see citing works
NIR‐II Organic Nanotheranostics for Precision Oncotherapy
Dai, H., Wang, X., Shao, J., Wang, W., Mou, X., & Dong, X. (2021) · Small · doi:10.1002/smll.202102646 · Cited by 110 · see citing works
Activatable Phototheranostic Materials for Imaging-Guided Cancer Therapy
Cheng, P., & Pu, K. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b15064 · Cited by 107 · see citing works
Li, X., Yin, C., Liew, S. S., Lee, C., & Pu, K. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202106154 · Cited by 107 · see citing works
Teng, L., Han, X., Liu, Y., Lu, C., Yin, B., Huan, S., Yin, X., Zhang, X., & Song, G. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202110427 · Cited by 94 · see citing works
Chen, Y., Sun, B., Jiang, X., Yuan, Z., Chen, S., Sun, P., Fan, Q., & Huang, W. (2021) · Journal of Materials Chemistry B · doi:10.1039/d0tb02499f · Cited by 93 · see citing works
Wu, J., Zhang, Y., Jiang, K., Wang, X., Blum, N. T., Zhang, J., Jiang, S., Lin, J., & Huang, P. (2022) · Advanced Materials · doi:10.1002/adma.202200062 · Cited by 93 · see citing works
In Situ Nanozyme‐Amplified NIR‐II Phototheranostics for Tumor‐Specific Imaging and Therapy
Ma, Z., Foda, M. F., Liang, H., Zhao, Y., & Han, H. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202103765 · Cited by 92 · see citing works
He, X., Hao, Y., Chu, B., Yang, Y., Sun, A., Shi, K., Yang, C., Zhou, K., Qu, Y., Li, H., et al. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101174 · Cited by 91 · see citing works
Park, B., Lee, K. M., Park, S., Yun, M., Choi, H.-J., Kim, J., Lee, C., Kim, H., & Kim, C. (2020) · Theranostics · doi:10.7150/thno.39403 · Cited by 90 · see citing works
Supramolecular systems for bioapplications: recent research progress in China
Liu, Y., Yu, X.-Y., Pan, Y., Yin, H., Chao, S., Li, Y., Ma, H., Zuo, M., Teng, K., Hou, J., et al. (2024) · Science China Chemistry · doi:10.1007/s11426-024-1971-4 · Cited by 90 · see citing works
Wang, C., Lin, H., Ge, X., Mu, J., Su, L., Zhang, X., Niu, M., Yang, H., & Song, J. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202009942 · Cited by 89 · see citing works
Nanoparticle-based Cell Trackers for Biomedical Applications
Ni, J., Li, Y., Yue, W., Liu, B., & Li, K. (2020) · Theranostics · doi:10.7150/thno.39915 · Cited by 87 · see citing works
Gao, H., Duan, X., Jiao, D., Zeng, Y., Zheng, X., Zhang, J., Ou, H., Qi, J., & Ding, D. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202109048 · Cited by 86 · see citing works
Application of nanogenerators in acoustics based on artificial intelligence and machine learning
Yu, X., Ai, T., & Wang, K. (2024) · APL Materials · doi:10.1063/5.0195399 · Cited by 86 · see citing works
Tumor microenvironment-activated NIR-II reagents for tumor imaging and therapy
Zhang, X., An, L., Tian, Q., Lin, J., & Yang, S. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00030b · Cited by 83 · see citing works
Wang, S., Hu, T., Wang, G., Wang, Z., Yan, D., Liang, R., & Tan, C. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.129458 · Cited by 82 · see citing works
Wang, Z., Cong, T. D., Zhong, W., Lau, J. W., Kwek, G., Chan‐Park, M. B. E., & Xing, B. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202104100 · Cited by 81 · see citing works
Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography
Leitgeb, R. A., Placzek, F., Rank, E. A., Krainz, L., Haindl, R., Li, Q., Liu, M., Andreana, M., Unterhuber, A., Schmoll, T., et al. (2021) · Journal of Biomedical Optics · doi:10.1117/1.jbo.26.10.100601 · Cited by 79 · see citing works
Song, X., Lü, X., Sun, B., Zhang, H., Sun, P., Miao, H., Fan, Q., & Huang, W. (2020) · ACS Applied Polymer Materials · doi:10.1021/acsapm.0c00637 · Cited by 78 · see citing works
Dong, Y., Dong, S., Wang, Z., Feng, L., Sun, Q., Chen, G., He, F., Liu, S., Li, W., & Yang, P. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c17923 · Cited by 73 · see citing works
Zhang, R., Wang, Z., Xu, L., Xu, Y., Lin, Y., Zhang, Y., Sun, Y., & Yang, G. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03152 · Cited by 72 · see citing works
Tang, X., Gong, X., Li, A., Lin, H., Peng, C., Zhang, X., Chen, X. S., & Gao, J. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b04016 · Cited by 70 · see citing works
Photothermal‐Amplified Single Atom Nanozyme for Biofouling Control in Seawater
Wang, W., Luo, Q. G., Li, J., Li, L., Li, Y., Huo, X., Du, X., Li, Z., & Wang, N. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202205461 · Cited by 68 · see citing works
Bacterial Metabolism-Initiated Nanocatalytic Tumor Immunotherapy
Wu, W., Pu, Y., Gao, S., Shen, Y., Zhou, M., Yao, H., & Shi, J. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00951-0 · Cited by 67 · see citing works
Self-Assembled Nanomaterials for Enhanced Phototherapy of Cancer
Zhao, L., Xing, Y., Wang, R., Yu, F., & Yu, F. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00843 · Cited by 64 · see citing works
Development of Second Near-Infrared Photoacoustic Imaging Agents
Zhang, J., Ning, L., Zeng, Z., & Pu, K. (2021) · Trends in Chemistry · doi:10.1016/j.trechm.2021.01.002 · Cited by 64 · see citing works
Zheng, Z., Chen, Q., Dai, R., Jia, Z., Yang, C., Peng, X., & Zhang, R. (2020) · Nanoscale · doi:10.1039/d0nr02543g · Cited by 64 · see citing works
Organic Charge‐Transfer Complexes for Near‐Infrared‐Triggered Photothermal Materials
An, L., Zheng, L., Xu, C., Zhao, Z., Gao, F., Wang, W., Ou, C., & Dong, X. (2022) · Small Structures · doi:10.1002/sstr.202200220 · Cited by 60 · see citing works
Ouyang, J., Sun, L., Zeng, Z., Zeng, C., Zeng, F., & Wu, S. (2019) · Angewandte Chemie · doi:10.1002/ange.201913149 · Cited by 60 · see citing works
Lin, X., Liu, S., Zhang, X., Zhu, R., Chen, S., Chen, X. S., Song, J., & Yang, H. (2019) · Angewandte Chemie · doi:10.1002/ange.201912768 · Cited by 60 · see citing works
Li, K., Wang, J., Wang, J., Zheng, Z. G., Liu, X., Wang, J., Zhang, C., He, S., Wei, H., & Yu, C. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c02389 · Cited by 59 · see citing works
ALP-Activated Chemiluminescence PDT Nano-Platform for Liver Cancer-Specific Theranostics
Fan, N., Li, P., Wu, C., Wang, X., Zhou, Y., & Tang, B. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c01504 · Cited by 56 · see citing works
Sun, Q., Wang, Z., Liu, B., Jia, T., Wang, C., Yang, D., He, F., Gai, S., & Yang, P. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.124624 · Cited by 55 · see citing works
Huang, Q., Zhu, W., Gao, X., Liu, X., Zhang, Z., & Xing, B. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114763 · Cited by 55 · see citing works
Leveraging BODIPY nanomaterials for enhanced tumor photothermal therapy
Ma, C., Zhang, T., & Xie, Z. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00855b · Cited by 55 · see citing works
Dirersa, W. B., Kan, T.-C., Getachew, G., Wibrianto, A., Ochirbat, S., Rasal, A. S., Chang, J., & Chang, J. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c10733 · Cited by 54 · see citing works
Guo, W., Chen, Z., Tan, L., Gu, D., Ren, X., Fu, C., Wu, Q., & Meng, X. (2021) · Open Research (University of Surrey) · doi:10.1002/viw.20200174 · Cited by 53 · see citing works
Recent Advances in Gold Nanomaterials for Photothermal Therapy
Chuang, Y.-C., Lee, H., Chiou, J., & Lo, L. (2022) · Journal of Nanotheranostics · doi:10.3390/jnt3020008 · Cited by 53 · see citing works
Zeng, Y., Dou, T., Ma, L., & Ma, J. (2022) · Advanced Science · doi:10.1002/advs.202202384 · Cited by 53 · see citing works
Biomedical applications and prospects of temperature‐orchestrated photothermal therapy
Xu, N., Zhang, X., Qi, T., Wu, Y., Xie, X., Chen, F., Shao, D., & Liao, J. (2022) · MedComm – Biomaterials and Applications · doi:10.1002/mba2.25 · Cited by 53 · see citing works
Biomimetic Mesoporous Silica Nanoparticles for Enhanced Blood Circulation and Cancer Therapy
Peng, H., Xu, Z., Wang, Y., Feng, N., Yang, W., & Tang, J. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c01014 · Cited by 53 · see citing works
NIR-II Functional Materials for Photoacoustic Theranostics
Li, Z., Zhang, C., Zhang, X., Sui, J. H., Jin, L., Lin, L., Fu, Q., Lin, H., & Song, J. (2022) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00520 · Cited by 51 · see citing works
TiO2-based nanocomposites for cancer diagnosis and therapy: A comprehensive review
Pourmadadi, M., Rajabzadeh‐Khosroshahi, M., Eshaghi, M. M., Rahmani, E., Motasadizadeh, H., Arshad, R., Rahdar, A., & Pandey, S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104370 · Cited by 50 · see citing works
Ma, X., Zhang, T., Qiu, W., Liang, M., Gao, Y., Xue, P., Kang, Y., & Xu, Z. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.127657 · Cited by 49 · see citing works
Zhao, M., Lin, X., Zhou, X. W., Zhang, Y., Wu, H., & Liu, Y. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c24042 · Cited by 48 · see citing works
Yuan, X., Jia, Z., Li, J., Liu, Y., Huang, Y., Gong, Y., Guo, X., Chen, X., Cen, J., & Liu, J. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01290h · Cited by 47 · see citing works
Chan, M., Huang, W., Chen, K., Su, T., Chan, Y., Hsiao, M., & Liu, R. (2022) · Nanoscale · doi:10.1039/d2nr00343k · Cited by 47 · see citing works
Stimuli‐Responsive Organic Near‐Infrared Photoacoustic Probes
Shen, Q., Wang, L., Ruan, X., Li, N., Wang, W., Wang, W., Shao, J., & Dong, X. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202300023 · Cited by 47 · see citing works
Wang, Q., Du, J., Ouyang, R., Liu, B., Miao, Y., & Li, Y. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215281 · Cited by 42 · see citing works
Qiao, L., Lang, W., Sun, C., Huang, Y., Wu, P., Cai, C., & Xing, B. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c05474 · Cited by 41 · see citing works
Zang, P., Du, Y., Yu, C., Yang, D., Gai, S., Feng, L., Liu, S., Yang, P., & Lin, J. (2023) · Chemistry of Materials · doi:10.1021/acs.chemmater.3c01637 · Cited by 41 · see citing works
NIR‐Activable Charge Transfer Agents for Synergistic Photoimmunotherapy
Wang, C., Zhong, W., Sun, X., Guo, J., Chen, Y., Zhao, Y., Han, J., & Zhao, Y. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202416828 · Cited by 41 · see citing works
Zhang, Y., Wang, Y., Yang, X., Yang, Q., Li, J., & Tan, W. (2020) · Small · doi:10.1002/smll.202001177 · Cited by 41 · see citing works
Opportunities for nanomaterials in enzyme therapy
Torres‐Herrero, B., Armenia, I., Ortiz, C., de la Fuente, J. M., Betancor, L., & Grazú, V. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.06.035 · Cited by 40 · see citing works
Cancer nanotheranostics in the second near‐infrared window
Jiang, S., Huang, K., Qu, J., Lin, J., & Huang, P. (2020) · Open Research (University of Surrey) · doi:10.1002/viw.20200075 · Cited by 41 · see citing works
Zhang, Z., Fang, X., Liu, Z., Liu, H., Chen, D., He, S., Zheng, J., Yang, B., Qin, W., Zhang, X., et al. (2019) · Angewandte Chemie · doi:10.1002/ange.201914397 · Cited by 40 · see citing works
Jung, D., Park, S., Lee, C., & Kim, H. (2019) · Polymers · doi:10.3390/polym11101693 · Cited by 39 · see citing works
Looking deep inside tissue with photoacoustic molecular probes: a review
Hui, X., Malik, M. O. A., & Pramanik, M. (2022) · Journal of Biomedical Optics · doi:10.1117/1.jbo.27.7.070901 · Cited by 38 · see citing works
Zuo, L., Ding, J., Li, C., Lin, F., Chen, P. R., Wang, P., Lu, G., Zhang, J., Huang, L., & Xie, H. (2020) · Chemical Science · doi:10.1039/c9sc05036a · Cited by 37 · see citing works
Recent progress in development and applications of second near‐infrared (NIR-II) nanoprobes
Shinn, J., Lee, S., Lee, H. K., Ahn, J., Lee, S. A., Lee, S., & Lee, Y. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01313-x · Cited by 37 · see citing works
Hu, Y., Zhang, L., Chen, S., Hou, L., Zhao, S., Huang, Y. X., & Liang, H. (2021) · Nanoscale Advances · doi:10.1039/d1na00595b · Cited by 37 · see citing works
Wen, C., Guo, X., Gao, C., Zhu, Z., Meng, N., Shen, X., & Liang, H. (2022) · Journal of Materials Chemistry B · doi:10.1039/d1tb02807c · Cited by 37 · see citing works
Cai, X., Liu, R., Yan, H., Jiao, L., Sha, M., Chen, Y., Rong, S., Liu, Z., Deng, L., Shen, L., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300516 · Cited by 36 · see citing works
Ni, H., Zhou, H., Liang, X., Ge, Y., Chen, H., Liu, J., Wang, B., Chen, H., Zhang, Y., Luo, S., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c07988 · Cited by 36 · see citing works
Stimuli-activatable nanomaterials for phototherapy of cancer
Zhou, M., Liu, X., Chen, F., Yang, L., Yuan, M., Fu, D., Wang, W., & Yu, H. (2021) · Biomedical Materials · doi:10.1088/1748-605x/abfa6e · Cited by 33 · see citing works
Su, Y., Wang, N., Liu, B., Du, Y., Li, R., Yang, M., Feng, Y., Shan, Z., & Meng, S. (2020) · Dyes and Pigments · doi:10.1016/j.dyepig.2020.108262 · Cited by 32 · see citing works
Photoacoustic-Based Miniature Device with Smartphone Readout for Point-of-Care Testing of Uric Acid
Zhang, Y., Guo, L. Y., Yu, Y., & Wang, J. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c03470 · Cited by 32 · see citing works
Zhang, Y., Zhao, M., Fang, J., Ye, S., Wang, A., Zhao, Y., Cui, C., He, L., & Shi, H. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c22555 · Cited by 32 · see citing works
Ou, C., Na, W., Ge, W., Huang, H., Gao, F., Zhong, L., Zhao, Y., & Dong, X. (2021) · Angewandte Chemie · doi:10.1002/ange.202014852 · Cited by 32 · see citing works
Wen, M., Liu, X., Yu, N., Qiu, P., Macharia, D. K., Li, M., Zhang, H., Chen, Z., & Lian, W. (2022) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2022.06.116 · Cited by 32 · see citing works
Two-dimensional transition metal chalcogenide nanomaterials for cancer diagnosis and treatment
Wu, J., Hu, T., Zhao, G., Li, A., & Liang, R. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.12.080 · Cited by 31 · see citing works
Cong, T. D., Wang, Z., Hu, M., Han, Q., & Xing, B. (2020) · ACS Nano · doi:10.1021/acsnano.0c00951 · Cited by 31 · see citing works
Wang, Z., Ai, X., Zhang, Z., Wang, Y., Wu, X., Haindl, R., Yeow, E. K. L., Drexler, W., Gao, M., & Xing, B. (2019) · Chemical Science · doi:10.1039/c9sc04909f · Cited by 30 · see citing works
Wu, J., You, L., Chaudhry, S. T., He, J., Cheng, J., & Mei, J. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c04601 · Cited by 30 · see citing works
Cheng, Y., Bo, H., Qin, R., Chen, F., Xue, F., An, L., Huang, G., & Tian, Q. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01555-x · Cited by 30 · see citing works
- Authors
- Wang, Z., Zhen, X., Upputuri, P. K., Jiang, Y., Lau, J., Pramanik, M., Pu, K., & Xing, B.
- Affiliations
- Nanyang Technological University (SG)
- School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, 637459, Singapore
- Corresponding author
- Pu, Kanyi
- Xing, Bengang
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-04-29
- Volume
- 13
- Issue
- 5
- Pages
- 5816-5825
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2943288317
- Cited by
- 203
- References
- 58
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 27 · 2023: 22 · 2022: 35 · 2021: 44 · 2020: 36 · 2019: 16
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion)
- Funders
- National Medical Research Council (NMRC/OFIRG/0005/2016: M4062012)
- Ministry of Education - Singapore (2016-T2-1-098, 2017-T1-002-134-RG147/17, 2017-T2-2-110, 2018-T2-2-042, M4011559, RG133/15)
- Japan Society for the Promotion of Science (M4082175.110)
- Nanyang Technological University (203-A018003, M408110000, M4081627.120, M4082175.110, RG5/18, RG110/16)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Keywords
- photothermal therapy, nanotheranostics, tumor microenvironment, deep tissue imaging
- MeSH terms
- Theranostic Nanomedicine, Humans, Neoplasms, Oxidation-Reduction, Photochemotherapy, Phototherapy, Tomography, Nanoparticles, Photoacoustic Techniques
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