Cited by 203Nanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic ImagingLuminescence and Fluorescent Materials

Redox-Activatable and Acid-Enhanced Nanotheranostics for Second Near-Infrared Photoacoustic Tomography and Combined Photothermal Tumor Therapy

Wang, Zhimin, Zhen, Xu, Upputuri, Paul Kumar, Jiang, Yuyan, Lau, Junwei, Pramanik, Manojit, Pu, Kanyi, Xing, Bengang·2019·ACS Nano

Abstract

Tumor phototheranostics in the second near-infrared window (NIR-II, 1000-1700 nm) holds great promise due to high spatiotemporal precision, enhanced penetration depth, and therapeutic efficacy. However, current "always-on" NIR-II phototheranostic agents remain restricted by the inherent nonspecificity from the pseudosignal readout and undesirable treatment-related side effects. To address these challenges, herein we explore an activatable and biocompatible nanotheranostics that generates diagnostic and therapeutic effects only after specific activation and enhancement by tumor microenvironmental redox and acid while keeping silent at normal tissues. Such an intelligent "turn-on" chromogenic nanotheranostics allows in vivo nearly zero-background photoacoustic tomography (PAT) and combined effective photothermal tumor therapy (PTT) both in the NIR-II range with minimal adverse effects. In light of the high sensitivity, superior penetration depth, and biocompatibility, this stimuli-activatable NIR-II photo-nanotheranostics provides broad prospects for the investigation and intervention of deep-tissue redox and acid-associated physiological and pathological events.

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Crossref · 10.1021/acsnano.9b01411

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  • An activatable and biocompatible NIR-II nanoprobe that is particularly effective in tumor redox and acid microenvironment was developed by Pu's group.

    “An activatable and biocompatible NIR-II nanoprobe that particularly effective in tumor redox and acid microenvironment was developed by Pu’s group.”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [197]

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Authors
Wang, Z., Zhen, X., Upputuri, P. K., Jiang, Y., Lau, J., Pramanik, M., Pu, K., & Xing, B.
Affiliations
  • Nanyang Technological University (SG)
  • School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, 637459, Singapore
Corresponding author
  • Pu, Kanyi
  • Xing, Bengang
Venue
ACS Nano
Published
2019-04-29
Volume
13
Issue
5
Pages
5816-5825
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
OpenAlex
W2943288317
Cited by
203
References
58
Citations by year
2026: 9 · 2025: 14 · 2024: 27 · 2023: 22 · 2022: 35 · 2021: 44 · 2020: 36 · 2019: 16
FWCI
11.50
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Nano (publishedVersion)
  • PubMed (publishedVersion)
  • DR-NTU (Nanyang Technological University) (submittedVersion)
Funders
  • National Medical Research Council (NMRC/OFIRG/0005/2016: M4062012)
  • Ministry of Education - Singapore (2016-T2-1-098, 2017-T1-002-134-RG147/17, 2017-T2-2-110, 2018-T2-2-042, M4011559, RG133/15)
  • Japan Society for the Promotion of Science (M4082175.110)
  • Nanyang Technological University (203-A018003, M408110000, M4081627.120, M4082175.110, RG5/18, RG110/16)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Keywords
photothermal therapy, nanotheranostics, tumor microenvironment, deep tissue imaging
MeSH terms
Theranostic Nanomedicine, Humans, Neoplasms, Oxidation-Reduction, Photochemotherapy, Phototherapy, Tomography, Nanoparticles, Photoacoustic Techniques

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