Double-acceptor conjugated polymers for NIR-II fluorescence imaging and NIR-II photothermal therapy applications
Abstract
Nanoparticles based double-acceptor conjugated polymers were developed by conventional methods. And subsequently NPs with bright NIR-II fluorescence signals and superior NIR-II PTT efficiency were successfully applied for NIR-II FI guided NIR-II PTT.
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These double-acceptor Pdots show Φfl in the range of 0.05-0.10% (0.009-0.019 after correction).
“These Pdots showed Φfl in the range of 0.05–0.10% (0.009–0.019 after correction, Φfl of R1061 = 0.32% in DCE).”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [179]
Pdots consisting of double-acceptor conjugated polymers with varied TTQ/DPP ratios (1:2, 1:1, and 2:1 in P1, P2, and P3) exhibit main absorption peaks at ∼700 nm and corresponding fluorescence maxima at 1257-1272 nm.
“Pdots consisting of the double-acceptor CPs with varied ratios of the two acceptors (TTQ/DPP = 1:2, 1:1, and 2:1 in P1, P2, and P3) exhibited main absorption peaks at ∼700 nm, with corresponding fluorescence maxima at 1257–1272 nm.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [179]
Improved fluorescence of Pdots in the SWIR region has been reported by introducing additional donor or acceptor units that expand a π-conjugation system.
“An improved fluorescence of Pdots in the SWIR region has been reported by introducing additional units (either donor or acceptor) that expand a π-conjugation system.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [179]
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- Authors
- Chen, Y., Sun, B., Jiang, X., Yuan, Z., Chen, S., Sun, P., Fan, Q., & Huang, W.
- Affiliations
- Nanjing University of Posts and Telecommunications (CN)
- Northwestern Polytechnical University (CN)
- Corresponding author
- Sun, Pengfei
- Fan, Quli
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Volume
- 9
- Issue
- 4
- Pages
- 1002-1008
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W3112387390
- Cited by
- 93
- References
- 46
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 13 · 2023: 18 · 2022: 29 · 2021: 17
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21574064, 21674048, 21671109, 21604042)
- Jiangsu Provincial Key Research and Development Program (BE2016770)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- NIR-II fluorescence imaging, NIR-II photothermal therapy, polymeric nanoparticles, tumor targeting, vascular imaging, in vivo imaging, tumour therapy
- MeSH terms
- Photothermal Therapy, Animals, Cell Survival, Drug Screening Assays, Antitumor, Fluorescent Dyes, Hyperthermia, Induced, Infrared Rays, Mammary Neoplasms, Experimental, Particle Size, Polymers, Surface Properties, Molecular Structure, Cell Line, Tumor, Cell Proliferation, Mice, Optical Imaging
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