The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Rapid Photo-Sonotherapy for Clinical Treatment of Bacterial Infected Bone Implants by Creating Oxygen Deficiency Using Sulfur Doping
Abstract
Periprosthetic infection is considered the main cause of implant failure, which is expected to be solved by fabricating an antibacterial coating on the surface of the implant. Nevertheless, systemic antibiotic treatment still represents the mainstream method for preventing infection, and few antibacterial coatings are applied clinically. This is because the externally introduced traditional antibacterial coatings suffer from the risk of invalidation and tissue toxicity induced by the consumption of antibacterial agents, degradation, and shedding. In this work, we proposed a rapid photo-sonotherapy by creating an oxygen deficiency on a titanium (Ti) implant through sulfur (S)-doping (Ti–S–TiO 2– x ), which endowed the implants with great sonodynamic and photothermal ability. Without introducing an external antibacterial coating, it reached a high antibacterial efficiency of 99.995% against Staphylococcus aureus under 15 min near-infrared light and ultrasound treatments. Furthermore, bone infection was successfully treated after combination treatments, and improved osseointegration was observed. Importantly, the S-doped Ti implant immersed in water for 6 months showed an unchanged structure and properties, suggesting that the Ti implant with intrinsic modification showed stable antibacterial performance under exogenous stimuli with a high antibacterial performance in vivo . This photo-sonotherapy based on sulfur doping is also promising for cancer therapy with biosafety.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular mechanisms of antibiotic resistance
Blair, J. M. A., Webber, M. A., Baylay, A. J., Ogbolu, D. O., & Piddock, L. J. V. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3380 · Cited by 4,092
Rapid water disinfection using vertically aligned MoS2 nanofilms and visible light
Liu, C., Kong, D., Hsu, P.-C., Yuan, H., Lee, H.-W., Liu, Y., Wang, H., Wang, S., Yan, K., Lin, D., et al. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.138 · Cited by 845
Antibacterial Coatings: Challenges, Perspectives, and Opportunities
Cloutier, M., Mantovani, D., & Rosei, F. (2015) · Trends in Biotechnology · doi:10.1016/j.tibtech.2015.09.002 · Cited by 813
Association of adverse events with antibiotic use in hospitalized patients.
Tamma, P. D., Avdic, E., Li, D. X., Dzintars, K., & Cosgrove, S. E. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2017.1938 · Cited by 800
Wang, Z., Yang, C., Lin, T., Yin, H., Chen, P., Wan, D., Xu, F., Huang, F., Lin, J., Xie, X., et al. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201300486 · Cited by 719
Wang, Z., Yang, C., Lin, T., Yin, H., Chen, P., Wan, D., Xu, F., Huang, F., Lin, J., Xie, X., et al. (2013) · Energy & Environmental Science · doi:10.1039/c3ee41817k · Cited by 704
Raphel, J., Holodniy, M., Goodman, S. B., & Heilshorn, S. C. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.016 · Cited by 674
Yue, W., Chen, L., Yu, L., Zhou, B., Yin, H., Ren, W., Liu, C., Guo, L., Zhang, Y., Sun, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09760-3 · Cited by 590
Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation
Zhu, P., Chen, Y., & Shi, J. (2018) · ACS Nano · doi:10.1021/acsnano.8b00999 · Cited by 572
Gong, F., Cheng, L., Yang, N., Betzer, O., Feng, L., Zhou, Q., Li, Y., Chen, R., Popovtzer, R., & Liu, Z. (2019) · Advanced Materials · doi:10.1002/adma.201900730 · Cited by 533
Rapid Biofilm Eradication on Bone Implants Using Red Phosphorus and Near‐Infrared Light
Tan, L., Li, J., Liu, X., Cui, Z., Yang, X., Zhu, S., Li, Z., Yuan, X., Zheng, Y., Yeung, K. W. K., et al. (2018) · Advanced Materials · doi:10.1002/adma.201801808 · Cited by 495
Self-citationMetal–Organic‐Framework‐Derived Carbon Nanostructure Augmented Sonodynamic Cancer Therapy
Pan, X., Bai, L., Wang, H., Wu, Q., Wang, H., Liu, S., Xu, B., Shi, X., & Liu, H. (2018) · Advanced Materials · doi:10.1002/adma.201800180 · Cited by 488
Yang, C., Wang, Z., Lin, T., Yin, H., Lü, X., Wan, D., Xu, T., Zheng, C., Lin, J., Huang, F., et al. (2013) · Journal of the American Chemical Society · doi:10.1021/ja4076748 · Cited by 474
Han, X., Huang, J., Jing, X., Yang, D., Lin, H., Wang, Z., Li, P., & Chen, Y. (2018) · ACS Nano · doi:10.1021/acsnano.8b00899 · Cited by 437
Enhanced Photoactivity of Oxygen-Deficient Anatase TiO2 Sheets with Dominant {001} Facets
Liu, G., Yang, H. G., Wang, X., Cheng, L., Lu, H., Wang, L., Lu, G. Q. (., & Cheng, H.-M. (2009) · The Journal of Physical Chemistry C · doi:10.1021/jp907749r · Cited by 402
Self-citationLong-Circulating Au-TiO2Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer
Deepagan, V. G., You, D. G., Um, W., Ko, H., Kwon, S., Choi, K. Y., Yi, G.-R., Lee, J. Y., Lee, D. S., Kim, K., et al. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b02547 · Cited by 402
Defect‐Rich Adhesive Nanozymes as Efficient Antibiotics for Enhanced Bacterial Inhibition
Cao, F., Zhang, L., Wang, H., You, Y., Wang, Y., Gao, N., Ren, J., & Qu, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201908289 · Cited by 346
Yang, Y., Yin, L., Gong, Y., Niu, P., Wang, J., Gu, L., Chen, X., Liu, G., Wang, L., & Cheng, H. (2018) · Advanced Materials · doi:10.1002/adma.201704479 · Cited by 330
A new antibacterial titanium–copper sintered alloy: Preparation and antibacterial property
Zhang, E., Li, F., Wang, H., Liu, J., Wang, C., Li, M., & Yang, K. (2013) · Materials Science and Engineering: C · doi:10.1016/j.msec.2013.06.016 · Cited by 325
The Neurotoxicity of Antibacterial Agents
SNAVELY, S. R., & HODGES, G. R. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-1-92 · Cited by 249
Multifunctional Coatings and Nanotopographies: Toward Cell Instructive and Antibacterial Implants
Mas‐Moruno, C., Su, B., & Dalby, M. J. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801103 · Cited by 242
Black anatase titania enabling ultra high cycling rates for rechargeable lithium batteries
Myung, S.-T., Kikuchi, M., Yoon, C. S., Yashiro, H., Kim, S.-J., Sun, Y.-K., & Scrosati, B. (2013) · Energy & Environmental Science · doi:10.1039/c3ee41960f · Cited by 238
Sono‐Immunotherapeutic Nanocapturer to Combat Multidrug‐Resistant Bacterial Infections
Pang, X., Liu, X., Cheng, Y., Zhang, C., Ren, E., Liu, C., Zhang, Y., Zhu, J., Chen, X., & Liu, G. (2019) · Advanced Materials · doi:10.1002/adma.201902530 · Cited by 238
Self-citationGoodman, S. D., Obergfell, K. P., Jurcisek, J. A., Novotny, L. A., Downey, J. S., Ayala, E. A., Tjokro, N., Li, B., Justice, S. S., & Bakaletz, L. O. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.27 · Cited by 225
Self-citationA Biomimetic Non‐Antibiotic Approach to Eradicate Drug‐Resistant Infections
Zhao, Y., Guo, Q., Dai, X., Wei, X., Yu, Y., Chen, X., Li, C., Cao, Z., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201806024 · Cited by 194
Ultrasound activation of TiO2 in melanoma tumors
Harada, Y., Ogawa, K., Irie, Y., Endo, H., Feril, L. B., Uemura, T., & Tachibana, K. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.10.012 · Cited by 191
Kempf, V. A. J., Lebiedziejewski, M., Alitalo, K., Wälzlein, J.-H., Ehehalt, U., Fiebig, J., Huber, S., Schütt, B., Sander, C. A., Müller, S., et al. (2005) · Circulation · doi:10.1161/01.cir.0000155608.07691.b7 · Cited by 164
Tan, L., Li, J., Liu, X., Cui, Z., Yang, X., Yeung, K. W. K., Pan, H., Zheng, Y., Wang, X., & Wu, S. (2018) · Small · doi:10.1002/smll.201703197 · Cited by 158
Self-citationOutcome of orthopedic implant infections due to different staphylococci
Teterycz, D., Ferry, T., Lew, D., STERN, R. E., Assal, M., Hoffmeyer, P. J., Bernard, L., & Uçkay, I. (2010) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2010.05.014 · Cited by 148
Influence of material on the development of device-associated infections
Rochford, E. T. J., Richards, R. G., & Moriarty, T. F. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2012.04002.x · Cited by 130
Ultrasound: Mechanical gene transfer into plant cells by sonoporation
Liu, Y., Yang, H., & Sakanishi, A. (2005) · Biotechnology Advances · doi:10.1016/j.biotechadv.2005.04.002 · Cited by 126
Chen, D., Tang, Q., Zou, J., Yang, X., Huang, W., Zhang, Q., Shao, J., & Dong, X. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701272 · Cited by 125
2-Pyridone-functionalized Aza-BODIPY photosensitizer for imaging-guided sustainable phototherapy
Xiao, W., Wang, P., Ou, C., Huang, X., Tang, Y., Wu, M., Si, W., Shao, J., Huang, W., & Dong, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.034 · Cited by 119
Elbanna, O., Kim, S., Fujitsuka, M., & Majima, T. (2017) · Nano Energy · doi:10.1016/j.nanoen.2017.03.014 · Cited by 105
Liang, P., Tang, Q., Cai, Y., Liu, G., Si, W., Shao, J., Huang, W., Zhang, Q., & Dong, X. (2017) · Chemical Science · doi:10.1039/c7sc03351f · Cited by 102
Hong, L., Liu, X., Tan, L., Cui, Z., Yang, X., Liang, Y., Li, Z., Zhu, S., Zheng, Y., Yeung, K., et al. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900835 · Cited by 96
Self-citationMa, M., Liu, X., Tan, L., Cui, Z., Yang, X., Liang, Y., Li, Z., Zheng, Y., Yeung, K., & Wu, S. (2019) · Biomaterials Science · doi:10.1039/c8bm01539b · Cited by 72
Self-citationWu, H., Tan, L., Tang, Z.-W., Yang, M., Xiao, J.-Y., Liu, C., & Zhuo, R. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b01210 · Cited by 69
Self-citationPhotocatalytic Degradation of Cell Membrane Coatings for Controlled Drug Release
Rao, L., Meng, Q., Huang, Q., Liu, P., Bu, L., Kondamareddy, K. K., Guo, S., Liu, W., & Zhao, X. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600303 · Cited by 57
Yang, M., Tan, L., Wu, H., Liu, C., & Zhuo, R. (2015) · Journal of Applied Polymer Science · doi:10.1002/app.42395 · Cited by 29
Self-citationWu, H., Zhang, X.-H., Huang, L., Ma, L., & Liu, C. (2018) · Langmuir · doi:10.1021/acs.langmuir.8b02584 · Cited by 28
Cited by
Liang, Y., Li, Z., Huang, Y., Yu, R., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c00204 · Cited by 1,083
Self-citationEmerging photothermal-derived multimodal synergistic therapy in combating bacterial infections
Huo, J., Jia, Q., Huang, H., Zhang, J., Li, P., Dong, X., & Huang, W. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00074h · Cited by 847
Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies
Li, W., Thian, E. S., Wang, M., Wang, Z., & Ren, L. (2021) · Advanced Science · doi:10.1002/advs.202100368 · Cited by 429
Graphitic carbon nitride-based materials for photocatalytic antibacterial application
Kong, X., Liu, X., Zheng, Y., Chu, P. K., Zhang, Y., & Wu, S. (2021) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2021.100610 · Cited by 259
Self-citationWearable and implantable devices for drug delivery: Applications and challenges
Kar, A., Ahamad, N., Dewani, M., Awasthi, L., Patil, R., & Banerjee, R. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121435 · Cited by 179
Metadata
- Authors
- Su, K., Tan, L., Liu, X., Cui, Z., Zheng, Y., Li, B., Han, Y., Li, Z., Zhu, S., Liang, Y., Feng, X., Wang, X., & Wu, S.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-01-28
- Volume
- 14
- Issue
- 2
- Pages
- 2077-2089
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W3003461805
- Cited by
- 294
- References
- 41
- FWCI
- 34.91
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
