The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination
Abstract
Photothermal treatment (PTT) involving a combination of therapeutic modalities recently emerged as an efficient alternative for combating biofilm. However, PTT-related local high temperature may destroy the surrounding healthy tissues. Herein, we present an all-in-one phototherapeutic nanoplatform consisting of l -arginine ( l -Arg), indocyanine green (ICG), and mesoporous polydopamine (MPDA), namely, AI-MPDA, to eliminate the already-formed biofilm. The fabrication process included surface modification of MPDA with l -Arg and further adsorption of ICG via π–π stacking. Under near-infrared (NIR) exposure, AI-MPDA not only generated heat but also produced reactive oxygen species, causing a cascade catalysis of l -Arg to release nitric oxide (NO). Under NIR irradiation, biofilm elimination was attributed to the NO-enhanced photodynamic therapy and low-temperature PTT (≤45 °C). Notably, the NIR-triggered all-in-one strategy resulted in severe destruction of bacterial membranes. The phototherapeutic AI-MPDA also displayed good cytocompatibility. NIR-irradiated AI-MPDA nanoparticles not only prevented bacterial colonization but also realized a rapid recovery of infected wounds. More importantly, the all-in-one phototherapeutic platform displayed effective biofilm elimination with an efficiency of around 100% in a abscess formation model. Overall, this low-temperature phototherapeutic platform provides a reliable tool for combating already-formed biofilms in clinical applications.
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Cites
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Fu, Y., Yang, L., Zhang, J., Hu, J., Duan, G., Liu, X., Li, Y., & Gu, Z. (2021) · Materials Horizons · doi:10.1039/d0mh01985b · Cited by 546
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Functional molecule-mediated assembled copper nanozymes for diabetic wound healing
Huang, W., Xu, P., Fu, X., Yang, J., Jing, W., Cai, Y., Zhou, Y., Tao, R., & Yang, Z. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02048-1 · Cited by 47
Metadata
- Authors
- Yuan, Z., Lin, C., He, Y., Tao, B., Chen, M., Zhang, J., Liu, P., & Cai, K.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-02-18
- Volume
- 14
- Issue
- 3
- Pages
- 3546-3562
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W3006762758
- Cited by
- 715
- References
- 8
- FWCI
- 27.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yuan, Z., Lin, C., He, Y., Tao, B., Chen, M., Zhang, J., Liu, P., & Cai, K. (2020). Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination. ACS Nano. https://doi.org/10.1021/acsnano.9b09871
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