The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Combining Electrospun Scaffolds with Electrosprayed Hydrogels Leads to Three-Dimensional Cellularization of Hybrid Constructs
Abstract
A common problem in the design of tissue engineered scaffolds using electrospun scaffolds is the poor cellular infiltration into the structure. To tackle this issue, three approaches to scaffold design using electrospinning were investigated: selective leaching of a water-soluble fiber phase (poly ethylene oxide (PEO) or gelatin), the use of micron-sized fibers as the scaffold, and a combination of micron-sized fibers with codeposition of a hyaluronic acid-derivative hydrogel, Heprasil. These designs were achieved by modifying a conventional electrospinning system with two charged capillaries and a rotating mandrel collector. Three types of scaffolds were fabricated: medical grade poly(epsilon-caprolactone)/collagen (mPCL/Col) cospun with PEO or gelatin, mPCL/Col meshes with micron-sized fibers, and mPCL/Col microfibers cosprayed with Heprasil. All three scaffold types supported attachment and proliferation of human fetal osteoblasts. However, selective leaching only marginally improved cellular infiltration when compared to meshes obtained by conventional electrospinning. Better cell penetration was seen in mPCL/Col microfibers, and this effect was more pronounced when Heprasil regions were present in the structure. Thus, such techniques could be further exploited for the design of cell permeable fibrous meshes for tissue engineering applications.
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Cites
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Cited by
PCL and PCL-based materials in biomedical applications
Malikmammadov, E., Tanir, T. E., Kiziltay, A., Hasirci, V., & Hasirci, N. (2018) · Journal of Biomaterials Science, Polymer Edition · doi:10.1080/09205063.2017.1394711 · Cited by 894
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Comparative stability studies of poly(2-methyl-2-oxazoline) and poly(ethylene glycol) brush coatings
Pidhatika, B., Rodenstein, M., Chen, Y., Rakhmatullina, E., Mühlebach, A., Acikgöz, C., Textor, M., & Konradi, R. (2012) · Biointerphases · doi:10.1007/s13758-011-0001-y · Cited by 251
Fiber density modulates cell spreading in 3D interstitial matrix mimetics
Matera, D. L., Wang, W. Y., Smith, M. R., Shikanov, A., & Baker, B. M. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00141 · Cited by 75
Zhao, H., Tang, J., Zhou, D., Weng, Y., Qin, W., Liu, C., Lv, S., Wang, W., & Zhao, X. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s238800 · Cited by 51
Metadata
- Authors
- Ekaputra, A. K., Prestwich, G. D., Cool, S. M., & Hutmacher, D. W.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-23
- Volume
- 9
- Issue
- 8
- Pages
- 2097-2103
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1512207636
- Cited by
- 253
- References
- 26
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ekaputra, A. K., Prestwich, G. D., Cool, S. M., & Hutmacher, D. W. (2008). Combining Electrospun Scaffolds with Electrosprayed Hydrogels Leads to Three-Dimensional Cellularization of Hybrid Constructs. Biomacromolecules. https://doi.org/10.1021/bm800565u
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